Review: taking Simvastatin and Lisinopril together


Summary

Drug interactions are reported among people who take Simvastatin and Lisinopril together. This review analyzes the effectiveness and drug interactions between Simvastatin and Lisinopril. It is created by eHealthMe based on reports of 18,051 people who take the same drugs from FDA and social media, and is updated regularly.

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Simvastatin

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 78,858 users)

Lisinopril

Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. (latest outcomes from Lisinopril 102,210 users)

On Jul, 26, 2016

18,051 people who take Simvastatin, Lisinopril are studied.


Number of reports submitted per year:

Simvastatin and Lisinopril drug interactions.

Drug effectiveness over time:

Simvastatin:
  • < 1 month: 17.0% - (3 of 17 people)
  • 1 - 6 months: 36.0% - (22 of 61 people)
  • 6 - 12 months: 48.0% - (28 of 58 people)
  • 1 - 2 years: 39.0% - (45 of 114 people)
  • 2 - 5 years: 47.0% - (100 of 210 people)
  • 5 - 10 years: 58.0% - (90 of 153 people)
  • 10+ years: 80.0% - (51 of 63 people)
  • not specified: 44.0% - (4 of 9 people)
Lisinopril:
  • < 1 month: 24.0% - (6 of 25 people)
  • 1 - 6 months: 36.0% - (26 of 72 people)
  • 6 - 12 months: 41.0% - (22 of 53 people)
  • 1 - 2 years: 38.0% - (41 of 107 people)
  • 2 - 5 years: 50.0% - (116 of 229 people)
  • 5 - 10 years: 57.0% - (98 of 171 people)
  • 10+ years: 56.0% - (43 of 76 people)
  • not specified: 28.0% - (2 of 7 people)

Drug effectiveness by gender:

Simvastatin:
  • female: 48.0% - (130 of 270 people)
  • male: 51.0% - (213 of 415 people)
Lisinopril:
  • female: 49.0% - (145 of 293 people)
  • male: 46.0% - (209 of 447 people)

Drug effectiveness by age:

Simvastatin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (4 of 8 people)
  • 30-39: 40.0% - (15 of 37 people)
  • 40-49: 46.0% - (41 of 89 people)
  • 50-59: 50.0% - (109 of 216 people)
  • 60+: 51.0% - (174 of 335 people)
Lisinopril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 62.0% - (5 of 8 people)
  • 30-39: 51.0% - (21 of 41 people)
  • 40-49: 51.0% - (53 of 103 people)
  • 50-59: 48.0% - (107 of 221 people)
  • 60+: 45.0% - (168 of 367 people)

Most common drug interactions over time *:

< 1 month:
  • fatigue
  • myalgia
  • oedema mouth
  • eye swelling
  • rash macular
  • chest pain
  • rhabdomyolysis
  • cardiac arrest
  • asthenia
  • blood creatine phosphokinase increased
1 - 6 months:
  • rhabdomyolysis
  • myalgia
  • blood creatine phosphokinase increased
  • renal failure acute
  • dizziness
  • asthenia
  • chest pain
  • cough
  • fatigue
  • nausea
6 - 12 months:
  • fatigue
  • renal failure acute
  • rhabdomyolysis
  • cellulitis
  • diabetic foot infection
  • myalgia
  • osteomyelitis
  • skin ulcer
  • angioedema
  • anxiety
1 - 2 years:
  • rhabdomyolysis
  • renal failure acute
  • myalgia
  • coronary artery disease
  • cardiac failure congestive
  • cerebrovascular accident
  • skin ulcer
  • blood creatine phosphokinase increased
  • asthenia
  • chest pain
2 - 5 years:
  • myocardial infarction
  • rhabdomyolysis
  • muscular weakness
  • oedema peripheral
  • pain
  • myalgia
  • renal failure acute
  • back pain
  • fatigue
  • insomnia
5 - 10 years:
  • hypoglycaemia
  • renal failure acute
  • fatigue
  • diarrhoea
  • insomnia
  • nausea
  • abscess
  • adverse drug reaction
  • asthma
  • bone marrow disorder
10+ years:
  • erectile dysfunction
  • fall
  • femur fracture
  • headache
  • trigger finger
  • depression
  • weight decreased
  • arthralgia
  • drug ineffective
  • fatigue
not specified:
  • pain
  • nausea
  • dyspnoea
  • fatigue
  • dizziness
  • anxiety
  • myocardial infarction
  • asthenia
  • cardiac failure congestive
  • chest pain

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • fatigue
  • dyspnoea
  • dizziness
  • anxiety
  • fall
  • asthenia
  • diarrhoea
  • anaemia
male:
  • pain
  • dyspnoea
  • nausea
  • myocardial infarction
  • dizziness
  • fatigue
  • asthenia
  • chest pain
  • cardiac failure congestive
  • anxiety

Most common drug interactions by age *:

0-1:
  • skin necrosis
  • peripheral ischaemia
2-9:
  • rhabdomyolysis
  • sinus arrhythmia
  • chest pain
  • blood creatine phosphokinase increased
  • ageusia
  • anosmia
  • arthritis bacterial
  • cardiac failure congestive
  • diarrhoea
  • difficulty in walking
10-19:
  • cardiac arrest
  • multiple drug overdose intentional
  • abdominal pain
  • abdominal pain upper
  • aggression
  • back pain
  • colitis
  • confusional state
  • death
  • depression
20-29:
  • pain
  • renal failure acute
  • asthenia
  • fatigue
  • hypotension
  • dehydration
  • injury
  • pruritus
  • anxiety
  • cerebrovascular accident
30-39:
  • agitation
  • white blood cell count increased
  • coma scale abnormal
  • neutrophil count increased
  • overdose
  • pain
  • anxiety
  • dizziness
  • dyspnoea
  • diabetes mellitus
40-49:
  • anxiety
  • chest pain
  • nausea
  • myocardial infarction
  • pain
  • dyspnoea
  • dizziness
  • fatigue
  • vomiting
  • diarrhoea
50-59:
  • nausea
  • myocardial infarction
  • pain
  • dyspnoea
  • anxiety
  • chest pain
  • fatigue
  • dizziness
  • cardiac failure congestive
  • headache
60+:
  • pain
  • nausea
  • fatigue
  • dyspnoea
  • dizziness
  • asthenia
  • renal failure acute
  • cardiac failure congestive
  • hypotension
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Simvastatin (simvastatin) is often used to treat high blood cholesterol. Lisinopril (lisinopril) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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