Review: taking Simvastatin and Lisinopril together


Summary

Drug interactions are reported among people who take Simvastatin and Lisinopril together. This review analyzes the effectiveness and drug interactions between Simvastatin and Lisinopril. It is created by eHealthMe based on reports of 27,490 people who take the same drugs from FDA and social media, and is updated regularly.

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Simvastatin

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 131,417 users)

Lisinopril

Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. (latest outcomes from Lisinopril 164,527 users)

On Sep, 16, 2016

27,490 people who take Simvastatin, Lisinopril are studied.


Number of reports submitted per year:

Simvastatin and Lisinopril drug interactions.

Drug effectiveness over time:

Simvastatin:
  • < 1 month: 23.0% - (3 of 13 people)
  • 1 - 6 months: 32.0% - (16 of 50 people)
  • 6 - 12 months: 48.0% - (26 of 54 people)
  • 1 - 2 years: 40.0% - (39 of 96 people)
  • 2 - 5 years: 46.0% - (79 of 170 people)
  • 5 - 10 years: 60.0% - (71 of 117 people)
  • 10+ years: 79.0% - (42 of 53 people)
  • not specified: 50.0% - (3 of 6 people)
Lisinopril:
  • < 1 month: 21.0% - (4 of 19 people)
  • 1 - 6 months: 37.0% - (23 of 61 people)
  • 6 - 12 months: 37.0% - (17 of 45 people)
  • 1 - 2 years: 39.0% - (36 of 92 people)
  • 2 - 5 years: 49.0% - (90 of 182 people)
  • 5 - 10 years: 57.0% - (80 of 140 people)
  • 10+ years: 60.0% - (34 of 56 people)
  • not specified: 20.0% - (1 of 5 people)

Drug effectiveness by gender:

Simvastatin:
  • female: 48.0% - (104 of 216 people)
  • male: 51.0% - (175 of 343 people)
Lisinopril:
  • female: 48.0% - (115 of 237 people)
  • male: 46.0% - (170 of 363 people)

Drug effectiveness by age:

Simvastatin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (4 of 8 people)
  • 30-39: 53.0% - (15 of 28 people)
  • 40-49: 46.0% - (36 of 77 people)
  • 50-59: 51.0% - (92 of 179 people)
  • 60+: 49.0% - (132 of 267 people)
Lisinopril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 62.0% - (5 of 8 people)
  • 30-39: 59.0% - (19 of 32 people)
  • 40-49: 52.0% - (44 of 84 people)
  • 50-59: 48.0% - (89 of 184 people)
  • 60+: 43.0% - (128 of 292 people)

Most common drug interactions over time *:

< 1 month:
  • myalgia
  • fatigue
  • chest pain
  • oedema mouth
  • rhabdomyolysis
  • arthralgia
  • asthenia
  • eye swelling
  • rash macular
  • pain
1 - 6 months:
  • rhabdomyolysis
  • myalgia
  • cough
  • fatigue
  • blood creatine phosphokinase increased
  • nausea
  • renal failure acute
  • dizziness
  • asthenia
  • malaise
6 - 12 months:
  • renal failure acute
  • fatigue
  • rhabdomyolysis
  • myalgia
  • nausea
  • angioedema
  • cellulitis
  • death
  • depression
  • diabetic foot infection
1 - 2 years:
  • rhabdomyolysis
  • myalgia
  • renal failure acute
  • coronary artery disease
  • cardiac failure congestive
  • cerebrovascular accident
  • skin ulcer
  • asthenia
  • chest pain
  • blood creatine phosphokinase increased
2 - 5 years:
  • muscular weakness
  • pain
  • myalgia
  • myocardial infarction
  • oedema peripheral
  • rhabdomyolysis
  • back pain
  • chest pain
  • dyspnoea
  • pain in extremity
5 - 10 years:
  • diarrhoea
  • fatigue
  • hypotension
  • renal failure acute
  • hypoglycaemia
  • insomnia
  • nausea
  • oedema peripheral
  • asthenia
  • abscess
10+ years:
  • erectile dysfunction
  • fall
  • femur fracture
  • trigger finger
  • depression
  • headache
  • abdominal pain
  • arthralgia
  • osteoarthritis
  • weight decreased
not specified:
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • dizziness
  • diarrhoea
  • drug ineffective
  • asthenia
  • myocardial infarction
  • anxiety

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • fatigue
  • dyspnoea
  • fall
  • diarrhoea
  • dizziness
  • asthenia
  • anxiety
  • drug ineffective
male:
  • dyspnoea
  • fatigue
  • pain
  • nausea
  • dizziness
  • myocardial infarction
  • drug ineffective
  • asthenia
  • diarrhoea
  • renal failure acute

Most common drug interactions by age *:

0-1:
  • skin necrosis
  • peripheral ischaemia
  • abdominal pain
  • convulsion
  • drug ineffective
  • feeling abnormal
  • leiomyosarcoma
  • nervousness
  • syncope
2-9:
  • rhabdomyolysis
  • sinus arrhythmia
  • chest pain
  • blood creatine phosphokinase increased
  • chest discomfort
  • gastrointestinal haemorrhage
  • nausea
  • tic
  • tremor
  • abdominal pain
10-19:
  • dyspnoea
  • pain in extremity
  • abdominal pain
  • dyspepsia
  • fatigue
  • hypotension
  • neuropathy peripheral
  • blood cholesterol increased
  • cardiac arrest
  • chronic obstructive pulmonary disease
20-29:
  • pain
  • asthenia
  • cerebrovascular accident
  • nausea
  • anxiety
  • fatigue
  • deep vein thrombosis
  • renal failure acute
  • abdominal pain
  • drug ineffective
30-39:
  • agitation
  • white blood cell count increased
  • coma scale abnormal
  • neutrophil count increased
  • overdose
  • dizziness
  • pain
  • anxiety
  • nausea
  • dyspnoea
40-49:
  • pain
  • anxiety
  • nausea
  • myocardial infarction
  • chest pain
  • fatigue
  • dyspnoea
  • diarrhoea
  • dizziness
  • depression
50-59:
  • nausea
  • myocardial infarction
  • fatigue
  • pain
  • dyspnoea
  • drug ineffective
  • headache
  • diarrhoea
  • anxiety
  • dizziness
60+:
  • nausea
  • pain
  • fatigue
  • dyspnoea
  • dizziness
  • asthenia
  • diarrhoea
  • fall
  • renal failure acute
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Simvastatin (simvastatin) is often used to treat high blood cholesterol. Lisinopril (lisinopril) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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