Review: taking Simvastatin and Lisinopril together


Summary

Drug interactions are reported among people who take Simvastatin and Lisinopril together. This review analyzes the effectiveness and drug interactions between Simvastatin and Lisinopril. It is created by eHealthMe based on reports of 21,726 people who take the same drugs from FDA and social media, and is updated regularly.

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Simvastatin

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 98,710 users)

Lisinopril

Lisinopril has active ingredients of lisinopril. It is often used in high blood pressure. (latest outcomes from Lisinopril 120,608 users)

On Aug, 26, 2016

21,726 people who take Simvastatin, Lisinopril are studied.


Number of reports submitted per year:

Simvastatin and Lisinopril drug interactions.

Drug effectiveness over time:

Simvastatin:
  • < 1 month: 21.0% - (3 of 14 people)
  • 1 - 6 months: 32.0% - (17 of 52 people)
  • 6 - 12 months: 47.0% - (25 of 53 people)
  • 1 - 2 years: 41.0% - (39 of 95 people)
  • 2 - 5 years: 46.0% - (78 of 168 people)
  • 5 - 10 years: 61.0% - (73 of 119 people)
  • 10+ years: 79.0% - (42 of 53 people)
  • not specified: 50.0% - (3 of 6 people)
Lisinopril:
  • < 1 month: 20.0% - (4 of 20 people)
  • 1 - 6 months: 37.0% - (23 of 62 people)
  • 6 - 12 months: 40.0% - (18 of 45 people)
  • 1 - 2 years: 39.0% - (36 of 91 people)
  • 2 - 5 years: 49.0% - (90 of 181 people)
  • 5 - 10 years: 56.0% - (79 of 140 people)
  • 10+ years: 60.0% - (34 of 56 people)
  • not specified: 20.0% - (1 of 5 people)

Drug effectiveness by gender:

Simvastatin:
  • female: 48.0% - (106 of 217 people)
  • male: 50.0% - (174 of 343 people)
Lisinopril:
  • female: 48.0% - (116 of 237 people)
  • male: 46.0% - (169 of 363 people)

Drug effectiveness by age:

Simvastatin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (4 of 8 people)
  • 30-39: 53.0% - (15 of 28 people)
  • 40-49: 47.0% - (36 of 76 people)
  • 50-59: 51.0% - (92 of 179 people)
  • 60+: 49.0% - (133 of 269 people)
Lisinopril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 62.0% - (5 of 8 people)
  • 30-39: 59.0% - (19 of 32 people)
  • 40-49: 53.0% - (44 of 83 people)
  • 50-59: 48.0% - (89 of 184 people)
  • 60+: 43.0% - (128 of 293 people)

Most common drug interactions over time *:

< 1 month:
  • myalgia
  • fatigue
  • chest pain
  • oedema mouth
  • rhabdomyolysis
  • eye swelling
  • rash macular
  • arthralgia
  • pain
  • asthenia
1 - 6 months:
  • rhabdomyolysis
  • myalgia
  • blood creatine phosphokinase increased
  • renal failure acute
  • dizziness
  • asthenia
  • cough
  • fatigue
  • chest pain
  • malaise
6 - 12 months:
  • renal failure acute
  • fatigue
  • rhabdomyolysis
  • angioedema
  • cellulitis
  • depression
  • diabetic foot infection
  • lactic acidosis
  • myalgia
  • osteomyelitis
1 - 2 years:
  • rhabdomyolysis
  • myalgia
  • renal failure acute
  • coronary artery disease
  • cardiac failure congestive
  • cerebrovascular accident
  • skin ulcer
  • blood creatine phosphokinase increased
  • asthenia
  • chest pain
2 - 5 years:
  • muscular weakness
  • pain
  • myalgia
  • myocardial infarction
  • oedema peripheral
  • back pain
  • rhabdomyolysis
  • chest pain
  • pain in extremity
  • palpitations
5 - 10 years:
  • diarrhoea
  • hypotension
  • hypoglycaemia
  • renal failure acute
  • fatigue
  • insomnia
  • nausea
  • oedema peripheral
  • abscess
  • adverse drug reaction
10+ years:
  • erectile dysfunction
  • fall
  • femur fracture
  • trigger finger
  • depression
  • headache
  • weight decreased
  • cough
  • osteoarthritis
  • arthralgia
not specified:
  • pain
  • nausea
  • dyspnoea
  • fatigue
  • dizziness
  • asthenia
  • myocardial infarction
  • anxiety
  • diarrhoea
  • chest pain

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • dyspnoea
  • fatigue
  • fall
  • dizziness
  • anxiety
  • diarrhoea
  • asthenia
  • anaemia
male:
  • pain
  • dyspnoea
  • nausea
  • myocardial infarction
  • fatigue
  • dizziness
  • asthenia
  • renal failure acute
  • chest pain
  • anxiety

Most common drug interactions by age *:

0-1:
  • skin necrosis
  • peripheral ischaemia
  • convulsion
  • drug ineffective
  • leiomyosarcoma
  • syncope
2-9:
  • rhabdomyolysis
  • sinus arrhythmia
  • chest pain
  • blood creatine phosphokinase increased
  • gastrointestinal haemorrhage
  • nausea
  • tic
  • tremor
  • abdominal pain
  • abscess
10-19:
  • pain in extremity
  • abdominal pain
  • dyspepsia
  • dyspnoea
  • fatigue
  • chronic obstructive pulmonary disease
  • death
  • dysphagia
  • gait disturbance
  • nausea
20-29:
  • pain
  • asthenia
  • anxiety
  • fatigue
  • renal failure acute
  • nausea
  • hypotension
  • dehydration
  • abdominal pain
  • cerebrovascular accident
30-39:
  • agitation
  • white blood cell count increased
  • coma scale abnormal
  • neutrophil count increased
  • overdose
  • pain
  • anxiety
  • dizziness
  • dyspnoea
  • myocardial infarction
40-49:
  • anxiety
  • pain
  • nausea
  • chest pain
  • myocardial infarction
  • dyspnoea
  • fatigue
  • dizziness
  • depression
  • diarrhoea
50-59:
  • nausea
  • myocardial infarction
  • pain
  • dyspnoea
  • fatigue
  • chest pain
  • anxiety
  • diarrhoea
  • headache
  • dizziness
60+:
  • pain
  • nausea
  • fatigue
  • dyspnoea
  • dizziness
  • asthenia
  • renal failure acute
  • fall
  • hypotension
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Simvastatin (simvastatin) is often used to treat high blood cholesterol. Lisinopril (lisinopril) is often used to treat high blood pressure. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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