Review: taking Spironolactone and Benadryl together


Summary

Drug interactions are reported among people who take Spironolactone and Benadryl together. This review analyzes the effectiveness and drug interactions between Spironolactone and Benadryl. It is created by eHealthMe based on reports of 574 people who take the same drugs from FDA and social media, and is updated regularly.

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Spironolactone

Spironolactone has active ingredients of spironolactone. It is often used in high blood pressure. (latest outcomes from Spironolactone 25,994 users)

Benadryl

Benadryl has active ingredients of diphenhydramine. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,241 users)

On Jul, 20, 2016

574 people who take Spironolactone, Benadryl are studied.


Number of reports submitted per year:

Spironolactone and Benadryl drug interactions.

Drug effectiveness over time:

Spironolactone:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 0 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 60.0% - (3 of 5 people)
  • 2 - 5 years: 33.0% - (1 of 3 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 50.0% - (1 of 2 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 75.0% - (3 of 4 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Spironolactone:
  • female: 50.0% - (4 of 8 people)
  • male: 33.0% - (1 of 3 people)
Benadryl:
  • female: 45.0% - (5 of 11 people)
  • male: 33.0% - (1 of 3 people)

Drug effectiveness by age:

Spironolactone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (1 of 3 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 66.0% - (2 of 3 people)
  • 50-59: 0.0% - (0 of 2 people)
  • 60+: 50.0% - (1 of 2 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 66.0% - (2 of 3 people)
  • 30-39: 66.0% - (2 of 3 people)
  • 40-49: 25.0% - (1 of 4 people)
  • 50-59: 50.0% - (1 of 2 people)
  • 60+: 0.0% - (0 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • orthostatic hypotension
  • lethargy
  • hypersensitivity
  • hyponatraemia
  • acute myeloid leukaemia
  • asthenia
  • cardiac failure congestive
  • dermatitis acneiform
  • diarrhoea
  • disease progression
1 - 6 months:
  • arthralgia
  • anger
  • anxiety
  • cardiac failure congestive
  • cardiomyopathy
  • crying
  • depression
  • insomnia
  • myocardial infarction
  • sleep apnoea syndrome
6 - 12 months:
  • nausea
  • death
  • loss of appetite
  • major depressive disorder
  • nasal septum perforation
  • abnormal dreams
  • alopecia
  • anorgasmia
  • apathy
  • asthenia
1 - 2 years:
  • bipolar ii disorder
  • breathing - slowed or stopped
  • chronic insomnia
  • loss of appetite
  • major depressive disorder
  • abnormal dreams
  • alopecia
  • anorgasmia
  • apathy
  • asthenia
2 - 5 years:
  • seroma
5 - 10 years:
  • erectile dysfunction
  • sleep disorder due to general medical condition, insomnia type
not specified:
  • nausea
  • dyspnoea
  • pain
  • cardiac failure congestive
  • fatigue
  • anxiety
  • pneumonia
  • vomiting
  • oedema peripheral
  • asthenia

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • anxiety
  • asthenia
  • fatigue
  • vomiting
  • dyspnoea
  • oedema peripheral
  • urinary tract infection
  • sinusitis
male:
  • cardiac failure congestive
  • dyspnoea
  • hypotension
  • pneumonia
  • nausea
  • pulmonary hypertension
  • arrhythmia
  • fatigue
  • cholelithiasis
  • vomiting

Most common drug interactions by age *:

0-1:
  • tachycardia
  • wheezing
  • cardio-respiratory arrest
  • pyrexia
  • infection
  • respiratory distress
  • vomiting
  • blood magnesium increased
  • blood pressure decreased
  • bradycardia
2-9:
  • tracheobronchitis
  • gastroenteritis viral
  • fall
  • pseudomonal bacteraemia
  • retching
  • central line infection
  • staphylococcal infection
  • upper limb fracture
  • diarrhoea
  • heart rate increased
10-19:
  • abdominal distension
  • dyspnoea exertional
  • fatigue
  • nausea
  • palpitations
  • cardiac arrest
  • chest pain aggravated
  • dizziness
  • implant site infection
  • abdominal pain upper
20-29:
  • bronchitis
  • cardiac failure congestive
  • cholecystitis
  • influenza like illness
  • insomnia
  • urinary tract infection
  • cerebral ischaemia
  • nausea
  • pericardial effusion
  • atrial fibrillation
30-39:
  • nausea
  • chest pain
  • cholelithiasis
  • diarrhoea
  • abdominal pain upper
  • gallbladder disorder
  • headache
  • hypertension
  • injury
  • blood bilirubin increased
40-49:
  • anxiety
  • pain
  • back pain
  • oedema peripheral
  • dyspnoea
  • arthralgia
  • depression
  • ear pain
  • sinusitis
  • uterine leiomyoma
50-59:
  • cardiac failure congestive
  • dyspnoea
  • hepatic failure
  • pain
  • cholelithiasis
  • anxiety
  • deep vein thrombosis
  • azotaemia
  • encephalopathy
  • gastrointestinal haemorrhage
60+:
  • asthenia
  • nausea
  • hypotension
  • vomiting
  • fatigue
  • dyspnoea
  • anaemia
  • cardiac failure congestive
  • dizziness
  • diarrhoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Spironolactone (spironolactone) is often used to treat high blood pressure. Benadryl (diphenhydramine) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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