Review: taking Spironolactone and Omeprazole together


Summary

Drug interactions are reported among people who take Spironolactone and Omeprazole together. This review analyzes the effectiveness and drug interactions between Spironolactone and Omeprazole. It is created by eHealthMe based on reports of 5,381 people who take the same drugs from FDA and social media, and is updated regularly.

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Spironolactone

Spironolactone has active ingredients of spironolactone. It is often used in high blood pressure. (latest outcomes from Spironolactone 29,598 users)

Omeprazole

Omeprazole has active ingredients of omeprazole. It is often used in gastrooesophageal reflux disease. (latest outcomes from Omeprazole 107,016 users)

On Aug, 20, 2016

5,381 people who take Spironolactone, Omeprazole are studied.


Number of reports submitted per year:

Spironolactone and Omeprazole drug interactions.

Drug effectiveness over time:

Spironolactone:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 60.0% - (6 of 10 people)
  • 6 - 12 months: 12.0% - (1 of 8 people)
  • 1 - 2 years: 37.0% - (3 of 8 people)
  • 2 - 5 years: 50.0% - (6 of 12 people)
  • 5 - 10 years: 55.0% - (5 of 9 people)
  • 10+ years: 83.0% - (5 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Omeprazole:
  • < 1 month: 66.0% - (2 of 3 people)
  • 1 - 6 months: 85.0% - (6 of 7 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 55.0% - (5 of 9 people)
  • 2 - 5 years: 71.0% - (10 of 14 people)
  • 5 - 10 years: 66.0% - (8 of 12 people)
  • 10+ years: 57.0% - (4 of 7 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Spironolactone:
  • female: 47.0% - (20 of 42 people)
  • male: 42.0% - (6 of 14 people)
Omeprazole:
  • female: 64.0% - (27 of 42 people)
  • male: 69.0% - (9 of 13 people)

Drug effectiveness by age:

Spironolactone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 60.0% - (3 of 5 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 50.0% - (5 of 10 people)
  • 50-59: 36.0% - (4 of 11 people)
  • 60+: 52.0% - (13 of 25 people)
Omeprazole:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 100.0% - (4 of 4 people)
  • 40-49: 70.0% - (7 of 10 people)
  • 50-59: 33.0% - (4 of 12 people)
  • 60+: 72.0% - (18 of 25 people)

Most common drug interactions over time *:

< 1 month:
  • drug rash with eosinophilia and systemic symptoms
  • hepatic encephalopathy
  • hyperkalaemia
  • malaise
  • pneumonia
  • pyrexia
  • renal failure acute
  • decreased appetite
  • vomiting
  • diarrhoea
1 - 6 months:
  • renal failure acute
  • dyspnoea
  • nausea
  • ascites
  • hyperkalaemia
  • constipation
  • pancytopenia
  • blood alkaline phosphatase increased
  • dehydration
  • liver disorder
6 - 12 months:
  • renal failure acute
  • fatigue
  • hyperkalaemia
  • malaise
  • decreased appetite
  • myalgia
  • oedema peripheral
  • tubulointerstitial nephritis
  • ascites
  • asthenia
1 - 2 years:
  • renal failure acute
  • hyperkalaemia
  • hyponatraemia
  • pulmonary embolism
  • fall
  • dyspnoea
  • acidosis
  • arrhythmia
  • hypotension
  • malaise
2 - 5 years:
  • renal failure acute
  • hyperkalaemia
  • pulmonary embolism
  • pulmonary hypertension
  • hepatic encephalopathy
  • renal impairment
  • abdominal pain
  • anxiety disorder due to a general medical condition
  • cardiac disorder
  • chest pain
5 - 10 years:
  • hypocalcaemia
  • hypokalaemia
  • hypomagnesaemia
  • agitation
  • hallucination
  • muscle disorder
  • hypophosphataemia
  • diarrhoea
  • vomiting
  • decreased appetite
10+ years:
  • nephrotic syndrome
  • fall
  • hyperkalaemia
  • renal failure
  • acute myocardial infarction
  • atrial fibrillation
  • blood calcium decreased
  • bone loss
  • bundle branch block right
  • c-reactive protein increased
not specified:
  • nausea
  • dyspnoea
  • pain
  • fall
  • renal failure acute
  • vomiting
  • fatigue
  • oedema peripheral
  • cardiac failure congestive
  • anxiety

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • pain
  • renal failure acute
  • vomiting
  • fall
  • oedema peripheral
  • anxiety
  • asthenia
  • dehydration
male:
  • dyspnoea
  • nausea
  • hypotension
  • renal failure acute
  • cardiac failure congestive
  • fall
  • vomiting
  • fatigue
  • atrial fibrillation
  • pain

Most common drug interactions by age *:

0-1:
  • chronic obstructive pulmonary disease
  • pyrexia
  • acquired methaemoglobinaemia
  • blood creatine phosphokinase increased
  • blood lactate dehydrogenase increased
  • hepatic failure
  • hepatitis acute
  • blood lactic acid increased
  • blood thyroid stimulating hormone increased
  • central venous pressure increased
2-9:
  • abdominal pain
  • cholecystitis acute
  • crying
  • diarrhoea
  • nightmare
  • screaming
  • cholelithiasis
  • tracheitis
  • pancytopenia
  • hypertension
10-19:
  • drug rash with eosinophilia and systemic symptoms
  • ascites
  • malaise
  • pyrexia
  • abnormal behaviour
  • atelectasis
  • computerised tomogram abnormal
  • convulsion
  • decreased appetite
  • depressed level of consciousness
20-29:
  • abdominal pain
  • anxiety
  • weight decreased
  • anaemia
  • depression
  • gastrooesophageal reflux disease
  • haematochezia
  • colitis
  • colitis ulcerative
  • crohn's disease
30-39:
  • nausea
  • pain
  • cholecystitis chronic
  • pyrexia
  • vomiting
  • anxiety
  • malaise
  • abdominal pain
  • dyspnoea
  • cholelithiasis
40-49:
  • nausea
  • gastrooesophageal reflux disease
  • dehydration
  • back pain
  • pyrexia
  • weight increased
  • pancreatitis
  • hypertension
  • renal failure acute
  • oedema
50-59:
  • nausea
  • dyspnoea
  • vomiting
  • diarrhoea
  • pain
  • ascites
  • fall
  • fatigue
  • abdominal pain
  • anaemia
60+:
  • renal failure acute
  • dyspnoea
  • nausea
  • fall
  • atrial fibrillation
  • cardiac failure congestive
  • pain
  • hypotension
  • vomiting
  • asthenia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Spironolactone (spironolactone) is often used to treat high blood pressure. Omeprazole (omeprazole) is often used to treat gastrooesophageal reflux disease. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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