Review: taking Spironolactone and Omeprazole together


Summary

Drug interactions are reported among people who take Spironolactone and Omeprazole together. This review analyzes the effectiveness and drug interactions between Spironolactone and Omeprazole. It is created by eHealthMe based on reports of 7,501 people who take the same drugs from FDA and social media, and is updated regularly.

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Spironolactone

Spironolactone has active ingredients of spironolactone. It is often used in high blood pressure. (latest outcomes from Spironolactone 41,317 users)

Omeprazole

Omeprazole has active ingredients of omeprazole. It is often used in gastrooesophageal reflux disease. (latest outcomes from Omeprazole 154,416 users)

On Sep, 17, 2016

7,501 people who take Spironolactone, Omeprazole are studied.


Number of reports submitted per year:

Spironolactone and Omeprazole drug interactions.

Drug effectiveness over time:

Spironolactone:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 60.0% - (6 of 10 people)
  • 6 - 12 months: 12.0% - (1 of 8 people)
  • 1 - 2 years: 37.0% - (3 of 8 people)
  • 2 - 5 years: 50.0% - (6 of 12 people)
  • 5 - 10 years: 55.0% - (5 of 9 people)
  • 10+ years: 83.0% - (5 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Omeprazole:
  • < 1 month: 66.0% - (2 of 3 people)
  • 1 - 6 months: 85.0% - (6 of 7 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 55.0% - (5 of 9 people)
  • 2 - 5 years: 71.0% - (10 of 14 people)
  • 5 - 10 years: 66.0% - (8 of 12 people)
  • 10+ years: 57.0% - (4 of 7 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Spironolactone:
  • female: 47.0% - (20 of 42 people)
  • male: 42.0% - (6 of 14 people)
Omeprazole:
  • female: 64.0% - (27 of 42 people)
  • male: 69.0% - (9 of 13 people)

Drug effectiveness by age:

Spironolactone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 60.0% - (3 of 5 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 50.0% - (5 of 10 people)
  • 50-59: 36.0% - (4 of 11 people)
  • 60+: 52.0% - (13 of 25 people)
Omeprazole:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 100.0% - (4 of 4 people)
  • 40-49: 70.0% - (7 of 10 people)
  • 50-59: 33.0% - (4 of 12 people)
  • 60+: 72.0% - (18 of 25 people)

Most common drug interactions over time *:

< 1 month:
  • drug rash with eosinophilia and systemic symptoms
  • hyperkalaemia
  • pneumonia
  • hepatic encephalopathy
  • malaise
  • dyspnoea
  • decreased appetite
  • pyrexia
  • nausea
  • cardiac failure
1 - 6 months:
  • renal failure acute
  • hyperkalaemia
  • dyspnoea
  • nausea
  • ascites
  • stevens-johnson syndrome
  • constipation
  • pancytopenia
  • vomiting
  • pneumonia
6 - 12 months:
  • renal failure acute
  • fatigue
  • hyperkalaemia
  • myalgia
  • ascites
  • malaise
  • asthenia
  • bone disorder
  • decreased appetite
  • hypotension
1 - 2 years:
  • renal failure acute
  • hyperkalaemia
  • hyponatraemia
  • pulmonary embolism
  • fall
  • dyspnoea
  • nausea
  • acidosis
  • anxiety
  • arrhythmia
2 - 5 years:
  • renal failure acute
  • hyperkalaemia
  • pulmonary embolism
  • pulmonary hypertension
  • hepatic encephalopathy
  • gastrointestinal haemorrhage
  • renal impairment
  • abdominal pain
  • dyspnoea
  • anxiety disorder due to a general medical condition
5 - 10 years:
  • hypocalcaemia
  • hypokalaemia
  • hypomagnesaemia
  • agitation
  • hallucination
  • muscle disorder
  • hypophosphataemia
  • diarrhoea
  • vomiting
  • decreased appetite
10+ years:
  • nephrotic syndrome
  • fall
  • hyperkalaemia
  • renal failure
  • acute myocardial infarction
  • atrial fibrillation
  • blood calcium decreased
  • bone loss
  • bundle branch block right
  • c-reactive protein increased
not specified:
  • dyspnoea
  • nausea
  • pain
  • fatigue
  • fall
  • vomiting
  • diarrhoea
  • oedema peripheral
  • anaemia
  • cardiac failure congestive

Most common drug interactions by gender *:

female:
  • nausea
  • dyspnoea
  • pain
  • fatigue
  • fall
  • diarrhoea
  • vomiting
  • renal failure acute
  • oedema peripheral
  • asthenia
male:
  • dyspnoea
  • nausea
  • fatigue
  • fall
  • hypotension
  • cardiac failure congestive
  • pain
  • renal failure acute
  • vomiting
  • ascites

Most common drug interactions by age *:

0-1:
  • blood creatine phosphokinase increased
  • haematuria
  • hypertonia
  • muscle rigidity
  • seizure
  • subdural haemorrhage
  • chronic obstructive pulmonary disease
  • pyrexia
  • acquired methaemoglobinaemia
  • drug withdrawal syndrome neonatal
2-9:
  • abdominal pain
  • cholecystitis acute
  • diarrhoea
  • crying
  • tracheitis
  • nightmare
  • screaming
  • cholelithiasis
  • dehydration
  • pancytopenia
10-19:
  • drug rash with eosinophilia and systemic symptoms
  • malaise
  • pyrexia
  • hypotension
  • ascites
  • abnormal behaviour
  • atelectasis
  • computerised tomogram abnormal
  • convulsion
  • decreased appetite
20-29:
  • anxiety
  • abdominal pain
  • anaemia
  • depression
  • gastrooesophageal reflux disease
  • weight decreased
  • haematochezia
  • colitis
  • colitis ulcerative
  • crohn's disease
30-39:
  • nausea
  • pain
  • anxiety
  • pyrexia
  • malaise
  • vomiting
  • abdominal pain
  • cholecystitis chronic
  • dyspnoea
  • urinary tract infection
40-49:
  • nausea
  • pyrexia
  • back pain
  • dehydration
  • gastrooesophageal reflux disease
  • weight increased
  • oedema
  • pancreatitis
  • hypertension
  • fatigue
50-59:
  • nausea
  • dyspnoea
  • fall
  • fatigue
  • pain
  • vomiting
  • diarrhoea
  • cough
  • ascites
  • abdominal pain
60+:
  • dyspnoea
  • nausea
  • fall
  • renal failure acute
  • fatigue
  • cardiac failure congestive
  • pain
  • diarrhoea
  • atrial fibrillation
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Spironolactone (spironolactone) is often used to treat high blood pressure. Omeprazole (omeprazole) is often used to treat gastrooesophageal reflux disease. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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