Review: taking Suboxone and Diphenhydramine hydrochloride together


Summary

Drug interactions are reported among people who take Suboxone and Diphenhydramine hydrochloride together. This review analyzes the effectiveness and drug interactions between Suboxone and Diphenhydramine hydrochloride. It is created by eHealthMe based on reports of 110 people who take the same drugs from FDA and social media, and is updated regularly.

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Suboxone

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in drug dependence. (latest outcomes from Suboxone 15,624 users)

Diphenhydramine Hydrochloride

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. (latest outcomes from Diphenhydramine hydrochloride 4,549 users)

On Sep, 17, 2016

110 people who take Suboxone, Diphenhydramine Hydrochloride are studied.


Number of reports submitted per year:

Suboxone and Diphenhydramine hydrochloride drug interactions.

Drug effectiveness over time:

Suboxone:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 100.0% - (3 of 3 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 100.0% - (2 of 2 people)
Diphenhydramine Hydrochloride:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 0.0% - (0 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Suboxone:
  • female: 85.0% - (6 of 7 people)
  • male: 50.0% - (3 of 6 people)
Diphenhydramine Hydrochloride:
  • female: 16.0% - (1 of 6 people)
  • male: 20.0% - (1 of 5 people)

Drug effectiveness by age:

Suboxone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 85.0% - (6 of 7 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 100.0% - (1 of 1 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 0.0% - (0 of 0 people)
Diphenhydramine Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 16.0% - (1 of 6 people)
  • 30-39: 33.0% - (1 of 3 people)
  • 40-49: 0.0% - (0 of 0 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • drug withdrawal syndrome
  • vomiting
  • cardiac arrest
  • decreased appetite
  • weight decreased
  • pyrexia
  • agitation
  • aortic aneurysm
  • disorientation
  • drug dependence
1 - 6 months:
  • drug withdrawal syndrome
  • frustration
  • night sweats
  • oil acne
  • suicidal ideation
  • cellulitis
  • chest pressure sensation
  • conjunctivitis
  • depression
  • drug withdrawal syndrome neonatal
6 - 12 months:
  • night sweats
  • oil acne
  • chest pressure sensation
  • headache
  • hives
  • muscle spasms
  • neck pain
  • neck swelling
  • drowsiness
  • nausea
1 - 2 years:
  • pyrexia
  • agitation
  • aortic aneurysm
  • cardiac arrest
  • disorientation
  • lung disorder
  • pneumonia
  • septic shock
  • stress fracture
  • thrombosis
2 - 5 years:
  • drug withdrawal syndrome
  • headache
  • confusion
  • confusional state
  • decreased appetite
  • depression
  • dyspnoea
  • dysstasia
  • feeling abnormal
  • formication
not specified:
  • insomnia
  • drug withdrawal syndrome
  • fatigue
  • depression
  • loss of consciousness
  • back pain
  • hyperhidrosis
  • weight increased
  • toothache
  • death

Most common drug interactions by gender *:

female:
  • depression
  • drug withdrawal syndrome
  • insomnia
  • toothache
  • vomiting
  • pain
  • weight decreased
  • fatigue
  • decreased appetite
  • loss of consciousness
male:
  • death
  • headache
  • drug withdrawal syndrome
  • insomnia
  • chest pressure sensation
  • fatigue
  • hives
  • muscle spasms
  • neck pain
  • neck swelling

Most common drug interactions by age *:

10-19:
  • drowsiness
  • nausea
  • vertigo
20-29:
  • pulmonary embolism
  • chest pain
  • diabetes mellitus
  • gastrooesophageal reflux disease
  • lactic acidosis
  • malaise
  • mouth ulceration
  • night sweats
  • oil acne
  • pain
30-39:
  • depression
  • loss of consciousness
  • euphoric mood
  • insomnia
  • toothache
  • weight increased
  • hyperhidrosis
  • drug withdrawal syndrome
  • headache
  • fatigue
40-49:
  • back pain
  • insomnia
  • drug withdrawal syndrome
  • fatigue
  • arthralgia
  • asthenia
  • death
  • weight decreased
  • abdominal pain upper
  • cardiac disorder
50-59:
  • drug withdrawal syndrome
  • frustration
  • suicidal ideation
  • cellulitis
  • conjunctivitis
  • drug withdrawal syndrome neonatal
  • foetal exposure during pregnancy
  • intracardiac thrombus
  • maternal exposure during pregnancy
  • polycythaemia
60+:
  • agitation
  • aortic aneurysm
  • cardiac arrest
  • cerebrovascular accident
  • disorientation
  • drug dependence
  • lung disorder
  • pharyngitis streptococcal
  • pneumonia
  • pyrexia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) is often used to treat drug dependence. Diphenhydramine hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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