Review: taking Suboxone and Promethazine together


Summary

Drug interactions are reported among people who take Suboxone and Promethazine together. This review analyzes the effectiveness and drug interactions between Suboxone and Promethazine. It is created by eHealthMe based on reports of 59 people who take the same drugs from FDA and social media, and is updated regularly.

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Suboxone

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone. It is often used in drug dependence. (latest outcomes from Suboxone 8,195 users)

Promethazine

Promethazine has active ingredients of promethazine. It is often used in nausea. (latest outcomes from Promethazine 3,973 users)

On Jul, 20, 2016

59 people who take Suboxone, Promethazine are studied.


Number of reports submitted per year:

Suboxone and Promethazine drug interactions.

Drug effectiveness over time:

Suboxone:
  • < 1 month: 80.0% - (4 of 5 people)
  • 1 - 6 months: 100.0% - (2 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 50.0% - (1 of 2 people)
Promethazine:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 33.0% - (2 of 6 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Suboxone:
  • female: 14.0% - (1 of 7 people)
  • male: 100.0% - (8 of 8 people)
Promethazine:
  • female: 33.0% - (2 of 6 people)
  • male: 42.0% - (3 of 7 people)

Drug effectiveness by age:

Suboxone:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (2 of 2 people)
  • 20-29: 75.0% - (3 of 4 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 42.0% - (3 of 7 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 0.0% - (0 of 0 people)
Promethazine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (2 of 2 people)
  • 20-29: 0.0% - (0 of 3 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • insomnia
  • decreased appetite
  • gun shot wound
  • hallucination
  • itching
  • respiratory depression
1 - 6 months:
  • renal infarct
  • sweating increased
  • clamminess
  • sweating fever
  • chest pain
  • endocarditis
6 - 12 months:
  • clamminess
  • sweating fever
  • foetal exposure during pregnancy
  • premature baby
1 - 2 years:
  • clamminess
  • sweating increased
not specified:
  • vomiting
  • dehydration
  • nausea
  • renal failure
  • somnolence
  • malaise
  • maternal exposure during pregnancy
  • weight decreased
  • pancreatitis
  • pancreatitis acute

Most common drug interactions by gender *:

female:
  • vomiting
  • dehydration
  • nausea
  • renal failure
  • somnolence
  • malaise
  • maternal exposure during pregnancy
  • weight decreased
  • clamminess
  • pancreatitis
male:
  • endocarditis
  • insomnia
  • renal infarct
  • accidental drug intake by child
  • chest pain
  • decreased appetite
  • drug toxicity
  • drug withdrawal syndrome neonatal
  • foetal exposure during pregnancy
  • gun shot wound

Most common drug interactions by age *:

2-9:
  • accidental drug intake by child
  • drug maladministration
  • drug toxicity
  • sedation
10-19:
  • chest pain
20-29:
  • nausea
  • pancreatitis
  • pancreatitis acute
  • adverse drug reaction
  • endocarditis
  • insomnia
  • renal infarct
  • maternal exposure during pregnancy
  • placenta praevia
  • vomiting
40-49:
  • dehydration
  • renal failure
  • somnolence
  • clamminess
  • confusional state
  • hyporesponsive to stimuli
  • lethargy
  • mania
  • sweating fever
  • respiratory depression
50-59:
  • clostridium difficile colitis
  • dehydration
  • diarrhoea
  • escherichia infection
  • gastroenteritis viral
  • injection site haematoma
  • listeriosis
  • nasal congestion
  • oral herpes
  • productive cough

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Suboxone (buprenorphine hydrochloride; naloxone) is often used to treat drug dependence. Promethazine (promethazine) is often used to treat nausea. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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