Review: taking Synthroid and Lipitor together


Summary

Drug interactions are reported among people who take Synthroid and Lipitor together. This review analyzes the effectiveness and drug interactions between Synthroid and Lipitor. It is created by eHealthMe based on reports of 18,984 people who take the same drugs from FDA and social media, and is updated regularly.

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Synthroid

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 104,321 users)

Lipitor

Lipitor has active ingredients of atorvastatin calcium. It is often used in high blood cholesterol. (latest outcomes from Lipitor 143,537 users)

On Aug, 21, 2016

18,984 people who take Synthroid, Lipitor are studied.


Number of reports submitted per year:

Synthroid and Lipitor drug interactions.

Drug effectiveness over time:

Synthroid:
  • < 1 month: 33.0% - (1 of 3 people)
  • 1 - 6 months: 20.0% - (6 of 29 people)
  • 6 - 12 months: 47.0% - (10 of 21 people)
  • 1 - 2 years: 57.0% - (26 of 45 people)
  • 2 - 5 years: 54.0% - (47 of 87 people)
  • 5 - 10 years: 65.0% - (79 of 120 people)
  • 10+ years: 80.0% - (143 of 178 people)
  • not specified: 50.0% - (1 of 2 people)
Lipitor:
  • < 1 month: 0.0% - (0 of 5 people)
  • 1 - 6 months: 41.0% - (16 of 39 people)
  • 6 - 12 months: 46.0% - (13 of 28 people)
  • 1 - 2 years: 53.0% - (36 of 67 people)
  • 2 - 5 years: 62.0% - (86 of 137 people)
  • 5 - 10 years: 71.0% - (70 of 98 people)
  • 10+ years: 77.0% - (59 of 76 people)
  • not specified: 50.0% - (1 of 2 people)

Drug effectiveness by gender:

Synthroid:
  • female: 63.0% - (210 of 330 people)
  • male: 66.0% - (103 of 155 people)
Lipitor:
  • female: 57.0% - (174 of 305 people)
  • male: 72.0% - (107 of 147 people)

Drug effectiveness by age:

Synthroid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (1 of 3 people)
  • 30-39: 27.0% - (3 of 11 people)
  • 40-49: 60.0% - (42 of 69 people)
  • 50-59: 63.0% - (90 of 142 people)
  • 60+: 68.0% - (177 of 260 people)
Lipitor:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (1 of 3 people)
  • 30-39: 30.0% - (3 of 10 people)
  • 40-49: 61.0% - (39 of 63 people)
  • 50-59: 57.0% - (73 of 126 people)
  • 60+: 66.0% - (165 of 250 people)

Most common drug interactions over time *:

< 1 month:
  • headache
  • myalgia
  • fatigue
  • dyspnoea
  • arthralgia
  • pain in extremity
  • dizziness
  • muscular weakness
  • insomnia
  • muscle spasms
1 - 6 months:
  • fatigue
  • myalgia
  • nausea
  • pain in extremity
  • arthralgia
  • dyspnoea
  • depression
  • malaise
  • pain
  • oedema peripheral
6 - 12 months:
  • myalgia
  • arthralgia
  • blood cholesterol increased
  • insomnia
  • pain in extremity
  • fatigue
  • pain
  • asthenia
  • headache
  • muscular weakness
1 - 2 years:
  • myalgia
  • depression
  • fatigue
  • pain in extremity
  • muscle spasms
  • arthralgia
  • chest pain
  • muscular weakness
  • nausea
  • fall
2 - 5 years:
  • fatigue
  • insomnia
  • myalgia
  • pain
  • arthralgia
  • depression
  • dizziness
  • anxiety
  • fibromyalgia
  • back pain
5 - 10 years:
  • fatigue
  • myalgia
  • nausea
  • blood creatine phosphokinase increased
  • ringing in the ears
  • high blood sugar
  • insomnia
  • muscular weakness
  • pain
  • high blood cholesterol
10+ years:
  • insomnia
  • pain in extremity
  • fall
  • arthritis
  • depression
  • dizziness
  • fibromyalgia
  • hypersomnia
  • nausea
  • pain exacerbated
not specified:
  • nausea
  • fatigue
  • dyspnoea
  • pain
  • dizziness
  • asthenia
  • drug ineffective
  • fall
  • arthralgia
  • diarrhoea

Most common drug interactions by gender *:

female:
  • nausea
  • fatigue
  • pain
  • dyspnoea
  • asthenia
  • fall
  • arthralgia
  • dizziness
  • myalgia
  • diarrhoea
male:
  • fatigue
  • dizziness
  • dyspnoea
  • nausea
  • drug ineffective
  • asthenia
  • myocardial infarction
  • pain
  • chest pain
  • pneumonia

Most common drug interactions by age *:

0-1:
  • osteoarthritis
  • arthralgia
  • blood cholesterol increased
  • blood triglycerides increased
  • hyperprolactinaemia
  • lactic acidosis
  • leiomyoma
  • lupus-like syndrome
  • obesity
  • oedema peripheral
2-9:
  • contusion
  • fall
  • tremor
  • asthenia
  • confusional state
  • constipation
  • feeling abnormal
  • hallucination, visual
  • nausea
  • road traffic accident
10-19:
  • pyrexia
  • blood creatinine increased
  • nausea
  • pain
  • renal failure chronic
  • cholecystitis chronic
  • cholelithiasis
  • gallbladder cholesterolosis
  • kidney transplant rejection
  • leukopenia
20-29:
  • anxiety
  • pyrexia
  • pain
  • back pain
  • blood creatinine increased
  • dysphagia
  • dizziness
  • renal failure acute
  • nausea
  • pulmonary embolism
30-39:
  • fatigue
  • type 2 diabetes mellitus
  • depression
  • blood cholesterol increased
  • diabetes mellitus
  • blood glucose increased
  • pain in extremity
  • abdominal pain
  • insomnia
  • weight increased
40-49:
  • chest pain
  • nausea
  • pain
  • fatigue
  • anxiety
  • headache
  • dizziness
  • pain in extremity
  • type 2 diabetes mellitus
  • myalgia
50-59:
  • nausea
  • fatigue
  • dyspnoea
  • anxiety
  • pain
  • headache
  • myocardial infarction
  • arthralgia
  • chest pain
  • asthenia
60+:
  • nausea
  • fatigue
  • dizziness
  • dyspnoea
  • asthenia
  • pain
  • drug ineffective
  • fall
  • diarrhoea
  • myalgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Lipitor (atorvastatin calcium) is often used to treat high blood cholesterol. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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