Review: taking Synthroid and Melatonin together


Summary

Drug interactions are reported among people who take Synthroid and Melatonin together. This review analyzes the effectiveness and drug interactions between Synthroid and Melatonin. It is created by eHealthMe based on reports of 1,268 people who take the same drugs from FDA and social media, and is updated regularly.

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Synthroid

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 133,829 users)

Melatonin

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 8,403 users)

On Sep, 16, 2016

1,268 people who take Synthroid, Melatonin are studied.


Number of reports submitted per year:

Synthroid and Melatonin drug interactions.

Drug effectiveness over time:

Synthroid:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 50.0% - (1 of 2 people)
  • 6 - 12 months: 50.0% - (2 of 4 people)
  • 1 - 2 years: 14.0% - (1 of 7 people)
  • 2 - 5 years: 50.0% - (7 of 14 people)
  • 5 - 10 years: 50.0% - (5 of 10 people)
  • 10+ years: 70.0% - (17 of 24 people)
  • not specified: 0.0% - (0 of 0 people)
Melatonin:
  • < 1 month: 0.0% - (0 of 5 people)
  • 1 - 6 months: 21.0% - (3 of 14 people)
  • 6 - 12 months: 0.0% - (0 of 4 people)
  • 1 - 2 years: 27.0% - (3 of 11 people)
  • 2 - 5 years: 53.0% - (7 of 13 people)
  • 5 - 10 years: 33.0% - (2 of 6 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Synthroid:
  • female: 54.0% - (29 of 53 people)
  • male: 50.0% - (4 of 8 people)
Melatonin:
  • female: 30.0% - (15 of 49 people)
  • male: 14.0% - (1 of 7 people)

Drug effectiveness by age:

Synthroid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 100.0% - (3 of 3 people)
  • 30-39: 100.0% - (2 of 2 people)
  • 40-49: 60.0% - (9 of 15 people)
  • 50-59: 46.0% - (7 of 15 people)
  • 60+: 48.0% - (12 of 25 people)
Melatonin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 0.0% - (0 of 3 people)
  • 30-39: 0.0% - (0 of 2 people)
  • 40-49: 16.0% - (2 of 12 people)
  • 50-59: 46.0% - (7 of 15 people)
  • 60+: 26.0% - (6 of 23 people)

Most common drug interactions over time *:

< 1 month:
  • nosebleed
  • antepartum haemorrhage
  • arrhythmia
  • dehydration
  • fatigue
  • headache
  • nasopharyngitis
  • plasma cell myeloma
  • pruritus
  • rash maculo-papular
1 - 6 months:
  • alopecia
  • diarrhoea
  • bloating
  • constipation
  • weight gain
  • anxiety
  • insomnia
  • arthralgia
  • blood thyroid stimulating hormone increased
  • dry eye
6 - 12 months:
  • alopecia
  • change of bowel habit
  • constipation
  • cough
  • diarrhoea
  • flatulence
  • irritable bowel syndrome
  • bipolar
  • blood thyroid stimulating hormone increased
  • cavities - tooth
1 - 2 years:
  • insomnia
  • constipation aggravated
  • heat intolerance
  • dark circles under eyes
  • insomnia related to another mental condition
  • loss of taste
  • movement - uncoordinated
  • nightmares - repeated
  • supraventricular tachycardia
  • teeth grinding and clenching
2 - 5 years:
  • nosebleed
  • dark circles under eyes
  • insomnia related to another mental condition
  • loss of taste
  • movement - uncoordinated
  • nightmares - repeated
  • supraventricular tachycardia
  • teeth grinding and clenching
  • vision blurred
  • cough
5 - 10 years:
  • bone and joint pain
  • dry skin
  • earache
  • herpes simplex
  • itchiness
  • muscle pain
  • muscle spasms
  • skin blushing/flushing
  • stomach upset
  • sweating - excessive
10+ years:
  • insomnia
  • bloating
  • weight gain
  • constipation aggravated
  • depression
  • heat intolerance
  • frequent headaches
  • joint dislocation
  • postnasal drip
  • stomach upset
not specified:
  • fatigue
  • nausea
  • headache
  • diarrhoea
  • pain
  • fall
  • drug ineffective
  • dyspnoea
  • insomnia
  • dizziness

Most common drug interactions by gender *:

female:
  • fatigue
  • nausea
  • headache
  • diarrhoea
  • insomnia
  • pain
  • drug ineffective
  • fall
  • dyspnoea
  • malaise
male:
  • fatigue
  • dyspnoea
  • fall
  • asthenia
  • pyrexia
  • diarrhoea
  • nausea
  • pneumonia
  • decreased appetite
  • drug ineffective

Most common drug interactions by age *:

0-1:
  • blood thyroid stimulating hormone decreased
  • hypopnoea
  • pneumonia
  • respiratory depression
  • respiratory distress
2-9:
  • abdominal pain
  • arterial occlusive disease
  • cerebrovascular accident
  • dehydration
  • diarrhoea
  • pulmonary oedema
  • radiation injury
  • skin hypertrophy
  • vasculitis
  • abnormal behaviour
10-19:
  • headache
  • anal fistula
  • crohn's disease
  • pyrexia
  • acne
  • adrenal insufficiency
  • confusional state
  • constipation
  • convulsion
  • epistaxis
20-29:
  • hyponatraemia
  • seizure
  • gastrooesophageal reflux disease
  • hypothyroidism
  • depression
  • diarrhoea
  • hypotension
  • malaise
  • pyrexia
  • back pain
30-39:
  • headache
  • pain
  • convulsion
  • insomnia
  • cough
  • ovarian hyperstimulation syndrome
  • injection site pain
  • abdominal pain upper
  • dark circles under eyes
  • epilepsy
40-49:
  • fatigue
  • decreased appetite
  • asthenia
  • diarrhoea
  • completed suicide
  • pyrexia
  • hypothyroidism
  • nausea
  • neuropathy peripheral
  • drug ineffective
50-59:
  • fatigue
  • insomnia
  • drug ineffective
  • headache
  • gastrooesophageal reflux disease
  • diarrhoea
  • dyspnoea
  • nausea
  • pain in extremity
  • arthralgia
60+:
  • fatigue
  • nausea
  • diarrhoea
  • dyspnoea
  • fall
  • headache
  • pain
  • dizziness
  • drug ineffective
  • malaise

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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