Review: taking Synthroid and Metformin together


Summary

Drug interactions are reported among people who take Synthroid and Metformin together. This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 12,257 people who take the same drugs from FDA and social media, and is updated regularly.

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Synthroid

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 92,449 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 99,381 users)

On Jul, 27, 2016

12,257 people who take Synthroid, Metformin are studied.


Number of reports submitted per year:

Synthroid and Metformin drug interactions.

Drug effectiveness over time:

Synthroid:
  • < 1 month: 15.0% - (2 of 13 people)
  • 1 - 6 months: 27.0% - (13 of 48 people)
  • 6 - 12 months: 41.0% - (15 of 36 people)
  • 1 - 2 years: 35.0% - (25 of 71 people)
  • 2 - 5 years: 60.0% - (82 of 135 people)
  • 5 - 10 years: 71.0% - (86 of 120 people)
  • 10+ years: 69.0% - (201 of 288 people)
  • not specified: 100.0% - (2 of 2 people)
Metformin:
  • < 1 month: 21.0% - (5 of 23 people)
  • 1 - 6 months: 20.0% - (21 of 101 people)
  • 6 - 12 months: 40.0% - (26 of 64 people)
  • 1 - 2 years: 30.0% - (37 of 120 people)
  • 2 - 5 years: 40.0% - (55 of 137 people)
  • 5 - 10 years: 57.0% - (85 of 148 people)
  • 10+ years: 48.0% - (51 of 106 people)
  • not specified: 25.0% - (1 of 4 people)

Drug effectiveness by gender:

Synthroid:
  • female: 57.0% - (338 of 586 people)
  • male: 69.0% - (88 of 127 people)
Metformin:
  • female: 38.0% - (223 of 575 people)
  • male: 45.0% - (58 of 128 people)

Drug effectiveness by age:

Synthroid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 6 people)
  • 20-29: 60.0% - (18 of 30 people)
  • 30-39: 50.0% - (48 of 95 people)
  • 40-49: 42.0% - (60 of 141 people)
  • 50-59: 60.0% - (123 of 205 people)
  • 60+: 75.0% - (177 of 236 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 5 people)
  • 20-29: 22.0% - (6 of 27 people)
  • 30-39: 37.0% - (37 of 100 people)
  • 40-49: 35.0% - (50 of 142 people)
  • 50-59: 46.0% - (93 of 202 people)
  • 60+: 41.0% - (95 of 227 people)

Most common drug interactions over time *:

< 1 month:
  • intentional overdose
  • nausea
  • hypotension
  • suicide attempt
  • diarrhoea
  • blood glucose increased
  • cardiac arrest
  • somnolence
  • pain
  • international normalised ratio increased
1 - 6 months:
  • fatigue
  • night sweats
  • nausea
  • dizziness
  • dyspnoea
  • abdominal pain
  • diarrhoea
  • constipation
  • pain
  • vomiting
6 - 12 months:
  • hypoplastic left heart syndrome
  • depression
  • dizziness
  • weakness
  • cognitive deterioration
  • fatigue - chronic
  • gait abnormal
  • hyperacusis
  • hyporeflexia
  • loss of sensation, numbness and tingling, paresthesias, sensory loss, tingling and numbness
1 - 2 years:
  • nausea
  • chest pain
  • pain
  • anxiety
  • dry skin
  • feeling cold
  • blood glucose increased
  • diarrhoea
  • dizziness
  • dyspnoea
2 - 5 years:
  • nausea
  • cholecystitis chronic
  • abdominal pain upper
  • anxiety
  • depression
  • pain
  • dizziness
  • cholelithiasis
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • muscle twitching
5 - 10 years:
  • insomnia
  • arthritis
  • chronic sinusitis
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • fibromyalgia
  • headache - mixed tension migraine
  • hypersomnia
  • pain exacerbated
  • rheumatoid factor positive
  • fatigue
10+ years:
  • insomnia
  • low platelet count
  • fatigue
  • nausea
  • pain exacerbated
  • arthritis
  • chronic sinusitis
  • fibromyalgia
  • headache - mixed tension migraine
  • hypersomnia
not specified:
  • nausea
  • blood glucose increased
  • fatigue
  • weight decreased
  • diarrhoea
  • pain
  • dyspnoea
  • vomiting
  • headache
  • asthenia

Most common drug interactions by gender *:

female:
  • nausea
  • fatigue
  • blood glucose increased
  • pain
  • diarrhoea
  • weight decreased
  • dyspnoea
  • vomiting
  • headache
  • dizziness
male:
  • blood glucose increased
  • nausea
  • myocardial infarction
  • renal failure acute
  • asthenia
  • fatigue
  • weight decreased
  • cardiac failure congestive
  • diarrhoea
  • dizziness

Most common drug interactions by age *:

0-1:
  • blood cholesterol increased
  • type 2 diabetes mellitus
  • transposition of the great vessels
  • ventricular septal defect
  • gallbladder operation
  • sensation of foreign body
  • acquired tracheo-oesophageal fistula
  • anomaly of external ear congenital
  • blood triglycerides increased
  • cardiac murmur
10-19:
  • cholecystitis chronic
  • nausea
  • vomiting
  • abdominal pain upper
  • cholelithiasis
  • headache
  • gallbladder cholesterolosis
  • arthralgia
  • gastric disorder
  • rectal haemorrhage
20-29:
  • cholecystitis chronic
  • anxiety
  • nausea
  • pain
  • abdominal pain
  • pulmonary embolism
  • chest pain
  • deep vein thrombosis
  • cholelithiasis
  • injury
30-39:
  • pain
  • nausea
  • anxiety
  • type 2 diabetes mellitus
  • chest pain
  • headache
  • pulmonary embolism
  • diabetes mellitus
  • deep vein thrombosis
  • diarrhoea
40-49:
  • nausea
  • diabetes mellitus
  • type 2 diabetes mellitus
  • weight decreased
  • diarrhoea
  • vomiting
  • headache
  • blood glucose increased
  • pain
  • dyspnoea
50-59:
  • nausea
  • blood glucose increased
  • weight decreased
  • headache
  • asthenia
  • myocardial infarction
  • diarrhoea
  • dizziness
  • dyspnoea
  • fatigue
60+:
  • nausea
  • fatigue
  • blood glucose increased
  • diarrhoea
  • pain
  • asthenia
  • dyspnoea
  • vomiting
  • weight decreased
  • dizziness

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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