Review: taking Synthroid and Metformin together


Summary

Drug interactions are reported among people who take Synthroid and Metformin together. This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 20,169 people who take the same drugs from FDA and social media, and is updated regularly.

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Synthroid

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 133,829 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 174,670 users)

On Sep, 16, 2016

20,169 people who take Synthroid, Metformin are studied.


Number of reports submitted per year:

Synthroid and Metformin drug interactions.

Drug effectiveness over time:

Synthroid:
  • < 1 month: 16.0% - (2 of 12 people)
  • 1 - 6 months: 24.0% - (10 of 41 people)
  • 6 - 12 months: 43.0% - (14 of 32 people)
  • 1 - 2 years: 35.0% - (19 of 53 people)
  • 2 - 5 years: 59.0% - (60 of 101 people)
  • 5 - 10 years: 71.0% - (75 of 105 people)
  • 10+ years: 70.0% - (135 of 192 people)
  • not specified: 100.0% - (2 of 2 people)
Metformin:
  • < 1 month: 22.0% - (5 of 22 people)
  • 1 - 6 months: 21.0% - (17 of 78 people)
  • 6 - 12 months: 38.0% - (19 of 49 people)
  • 1 - 2 years: 34.0% - (28 of 82 people)
  • 2 - 5 years: 43.0% - (49 of 112 people)
  • 5 - 10 years: 59.0% - (59 of 100 people)
  • 10+ years: 40.0% - (30 of 74 people)
  • not specified: 25.0% - (1 of 4 people)

Drug effectiveness by gender:

Synthroid:
  • female: 57.0% - (255 of 444 people)
  • male: 65.0% - (62 of 94 people)
Metformin:
  • female: 39.0% - (167 of 427 people)
  • male: 43.0% - (41 of 94 people)

Drug effectiveness by age:

Synthroid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 6 people)
  • 20-29: 61.0% - (16 of 26 people)
  • 30-39: 48.0% - (41 of 84 people)
  • 40-49: 47.0% - (51 of 108 people)
  • 50-59: 62.0% - (93 of 148 people)
  • 60+: 69.0% - (116 of 166 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 5 people)
  • 20-29: 26.0% - (6 of 23 people)
  • 30-39: 38.0% - (31 of 80 people)
  • 40-49: 39.0% - (43 of 108 people)
  • 50-59: 44.0% - (64 of 144 people)
  • 60+: 39.0% - (64 of 161 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • intentional overdose
  • diarrhoea
  • dyspnoea
  • hypotension
  • suicide attempt
  • cardiac arrest
  • pain
  • vomiting
  • weight decreased
1 - 6 months:
  • fatigue
  • dyspnoea
  • nausea
  • insomnia
  • night sweats
  • dizziness
  • abdominal pain
  • diarrhoea
  • vomiting
  • pain
6 - 12 months:
  • hypoplastic left heart syndrome
  • depression
  • dizziness
  • weakness
  • cognitive deterioration
  • fatigue - chronic
  • foetal exposure during pregnancy
  • gait abnormal
  • gestational diabetes
  • hyperacusis
1 - 2 years:
  • nausea
  • pain
  • chest pain
  • anxiety
  • blood glucose increased
  • dizziness
  • dry skin
  • diarrhoea
  • fatigue
  • feeling cold
2 - 5 years:
  • nausea
  • pain
  • cholecystitis chronic
  • anxiety
  • abdominal pain upper
  • depression
  • dizziness
  • injury
  • cholelithiasis
  • dyspnoea
5 - 10 years:
  • insomnia
  • arthritis
  • chronic sinusitis
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • fibromyalgia
  • headache - mixed tension migraine
  • hypersomnia
  • pain exacerbated
  • rheumatoid factor positive
  • anxiety
10+ years:
  • insomnia
  • fatigue
  • low platelet count
  • nausea
  • pain exacerbated
  • hypersomnia
  • arthritis
  • chronic sinusitis
  • fibromyalgia
  • headache - mixed tension migraine
not specified:
  • nausea
  • fatigue
  • diarrhoea
  • blood glucose increased
  • pain
  • dyspnoea
  • weight decreased
  • headache
  • drug ineffective
  • vomiting

Most common drug interactions by gender *:

female:
  • nausea
  • fatigue
  • diarrhoea
  • pain
  • blood glucose increased
  • headache
  • dyspnoea
  • vomiting
  • weight decreased
  • drug ineffective
male:
  • fatigue
  • blood glucose increased
  • nausea
  • dyspnoea
  • asthenia
  • diarrhoea
  • weight decreased
  • drug ineffective
  • dizziness
  • myocardial infarction

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • ventricular septal defect
  • atrial septal defect
  • blood cholesterol increased
  • type 2 diabetes mellitus
  • pulmonary valve stenosis congenital
  • transposition of the great vessels
  • gallbladder operation
  • sensation of foreign body
  • accident
2-9:
  • headache
  • abdominal distension
  • abdominal pain upper
  • accident at work
  • alanine aminotransferase increased
  • angioedema
  • arrhythmia
  • aspartate aminotransferase increased
  • asthenia
  • back pain
10-19:
  • headache
  • arthralgia
  • nausea
  • pain
  • cholecystitis chronic
  • vomiting
  • anxiety
  • abdominal pain upper
  • chills
  • pyrexia
20-29:
  • pain
  • nausea
  • cholecystitis chronic
  • anxiety
  • pulmonary embolism
  • injury
  • abdominal pain
  • deep vein thrombosis
  • fatigue
  • emotional distress
30-39:
  • pain
  • nausea
  • anxiety
  • pulmonary embolism
  • injury
  • deep vein thrombosis
  • emotional distress
  • chest pain
  • headache
  • dyspnoea
40-49:
  • nausea
  • pain
  • headache
  • diarrhoea
  • vomiting
  • weight decreased
  • fatigue
  • blood glucose increased
  • diabetes mellitus
  • dyspnoea
50-59:
  • nausea
  • blood glucose increased
  • headache
  • weight decreased
  • diarrhoea
  • fatigue
  • dyspnoea
  • pain
  • dizziness
  • asthenia
60+:
  • nausea
  • fatigue
  • diarrhoea
  • blood glucose increased
  • dyspnoea
  • pain
  • asthenia
  • vomiting
  • weight decreased
  • dizziness

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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