Review: taking Synthroid and Metformin together


Summary

Drug interactions are reported among people who take Synthroid and Metformin together. This review analyzes the effectiveness and drug interactions between Synthroid and Metformin. It is created by eHealthMe based on reports of 14,807 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone

Join a support group for people who take Synthroid and Metformin >>>

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Synthroid

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 107,543 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 122,704 users)

On Aug, 26, 2016

14,807 people who take Synthroid, Metformin are studied.


Number of reports submitted per year:

Synthroid and Metformin drug interactions.

Drug effectiveness over time:

Synthroid:
  • < 1 month: 16.0% - (2 of 12 people)
  • 1 - 6 months: 24.0% - (10 of 41 people)
  • 6 - 12 months: 43.0% - (14 of 32 people)
  • 1 - 2 years: 36.0% - (19 of 52 people)
  • 2 - 5 years: 59.0% - (60 of 101 people)
  • 5 - 10 years: 71.0% - (74 of 104 people)
  • 10+ years: 70.0% - (135 of 192 people)
  • not specified: 100.0% - (2 of 2 people)
Metformin:
  • < 1 month: 22.0% - (5 of 22 people)
  • 1 - 6 months: 21.0% - (17 of 78 people)
  • 6 - 12 months: 38.0% - (19 of 49 people)
  • 1 - 2 years: 34.0% - (28 of 82 people)
  • 2 - 5 years: 44.0% - (49 of 111 people)
  • 5 - 10 years: 59.0% - (59 of 100 people)
  • 10+ years: 41.0% - (30 of 73 people)
  • not specified: 25.0% - (1 of 4 people)

Drug effectiveness by gender:

Synthroid:
  • female: 57.0% - (254 of 442 people)
  • male: 65.0% - (62 of 94 people)
Metformin:
  • female: 39.0% - (167 of 425 people)
  • male: 43.0% - (41 of 94 people)

Drug effectiveness by age:

Synthroid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 6 people)
  • 20-29: 61.0% - (16 of 26 people)
  • 30-39: 48.0% - (41 of 84 people)
  • 40-49: 47.0% - (51 of 107 people)
  • 50-59: 62.0% - (93 of 148 people)
  • 60+: 69.0% - (115 of 165 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 5 people)
  • 20-29: 26.0% - (6 of 23 people)
  • 30-39: 38.0% - (31 of 80 people)
  • 40-49: 39.0% - (43 of 108 people)
  • 50-59: 44.0% - (64 of 144 people)
  • 60+: 40.0% - (64 of 159 people)

Most common drug interactions over time *:

< 1 month:
  • intentional overdose
  • nausea
  • hypotension
  • suicide attempt
  • cardiac arrest
  • diarrhoea
  • pain
  • blood glucose increased
  • somnolence
  • weight decreased
1 - 6 months:
  • fatigue
  • nausea
  • night sweats
  • dizziness
  • diarrhoea
  • dyspnoea
  • abdominal pain
  • pain
  • vomiting
  • anaemia
6 - 12 months:
  • hypoplastic left heart syndrome
  • depression
  • dizziness
  • weakness
  • cognitive deterioration
  • fatigue - chronic
  • gait abnormal
  • hyperacusis
  • hyporeflexia
  • loss of sensation, numbness and tingling, paresthesias, sensory loss, tingling and numbness
1 - 2 years:
  • nausea
  • chest pain
  • pain
  • anxiety
  • blood glucose increased
  • dry skin
  • feeling cold
  • cholecystitis chronic
  • diarrhoea
  • dizziness
2 - 5 years:
  • nausea
  • cholecystitis chronic
  • pain
  • anxiety
  • abdominal pain upper
  • depression
  • dizziness
  • injury
  • cholelithiasis
  • dyspnoea
5 - 10 years:
  • insomnia
  • arthritis
  • chronic sinusitis
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • fibromyalgia
  • headache - mixed tension migraine
  • hypersomnia
  • pain exacerbated
  • rheumatoid factor positive
  • anxiety
10+ years:
  • insomnia
  • low platelet count
  • fatigue
  • nausea
  • pain exacerbated
  • hypersomnia
  • arthritis
  • chronic sinusitis
  • fibromyalgia
  • headache - mixed tension migraine
not specified:
  • nausea
  • fatigue
  • blood glucose increased
  • pain
  • diarrhoea
  • dyspnoea
  • weight decreased
  • headache
  • vomiting
  • asthenia

Most common drug interactions by gender *:

female:
  • nausea
  • fatigue
  • pain
  • blood glucose increased
  • diarrhoea
  • dyspnoea
  • weight decreased
  • headache
  • vomiting
  • dizziness
male:
  • nausea
  • blood glucose increased
  • asthenia
  • fatigue
  • myocardial infarction
  • renal failure acute
  • weight decreased
  • diarrhoea
  • dyspnoea
  • dizziness

Most common drug interactions by age *:

0-1:
  • blood cholesterol increased
  • type 2 diabetes mellitus
  • transposition of the great vessels
  • ventricular septal defect
  • gallbladder operation
  • sensation of foreign body
  • accident
  • acquired tracheo-oesophageal fistula
  • anomaly of external ear congenital
  • arthritis
2-9:
  • headache
  • abdominal distension
  • abdominal pain upper
  • accident at work
  • angioedema
  • arrhythmia
  • asthenia
  • back pain
  • blood glucose increased
  • blood pressure increased
10-19:
  • nausea
  • cholecystitis chronic
  • vomiting
  • abdominal pain upper
  • cholelithiasis
  • headache
  • deep vein thrombosis
  • gallbladder cholesterolosis
  • pulmonary embolism
  • arthralgia
20-29:
  • cholecystitis chronic
  • pain
  • anxiety
  • injury
  • nausea
  • deep vein thrombosis
  • pulmonary embolism
  • abdominal pain
  • emotional distress
  • fatigue
30-39:
  • pain
  • nausea
  • anxiety
  • pulmonary embolism
  • chest pain
  • deep vein thrombosis
  • type 2 diabetes mellitus
  • headache
  • emotional distress
  • injury
40-49:
  • nausea
  • pain
  • diarrhoea
  • headache
  • weight decreased
  • diabetes mellitus
  • type 2 diabetes mellitus
  • fatigue
  • vomiting
  • blood glucose increased
50-59:
  • nausea
  • blood glucose increased
  • weight decreased
  • headache
  • diarrhoea
  • dyspnoea
  • fatigue
  • pain
  • asthenia
  • dizziness
60+:
  • nausea
  • fatigue
  • diarrhoea
  • blood glucose increased
  • pain
  • asthenia
  • dyspnoea
  • vomiting
  • weight decreased
  • dizziness

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Synthroid and Metformin?

Can you answer these questions?

More questions for: Synthroid, Metformin

You may be interested in these reviews

More reviews for: Synthroid, Metformin

On eHealthMe, Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.