Review: taking Tizanidine hydrochloride and Gabapentin together


Summary

Drug interactions are reported among people who take Tizanidine hydrochloride and Gabapentin together. This review analyzes the effectiveness and drug interactions between Tizanidine hydrochloride and Gabapentin. It is created by eHealthMe based on reports of 2,451 people who take the same drugs from FDA and social media, and is updated regularly.

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Tizanidine Hydrochloride

Tizanidine hydrochloride has active ingredients of tizanidine. It is often used in muscle spasms. (latest outcomes from Tizanidine hydrochloride 1,358 users)

Gabapentin

Gabapentin has active ingredients of gabapentin. It is often used in pain. (latest outcomes from Gabapentin 38,775 users)

On Jul, 20, 2016

2,451 people who take Tizanidine Hydrochloride, Gabapentin are studied.


Number of reports submitted per year:

Tizanidine hydrochloride and Gabapentin drug interactions.

Drug effectiveness over time:

Tizanidine Hydrochloride:
  • < 1 month: 21.0% - (3 of 14 people)
  • 1 - 6 months: 15.0% - (4 of 26 people)
  • 6 - 12 months: 35.0% - (11 of 31 people)
  • 1 - 2 years: 34.0% - (15 of 44 people)
  • 2 - 5 years: 44.0% - (12 of 27 people)
  • 5 - 10 years: 33.0% - (4 of 12 people)
  • 10+ years: 75.0% - (3 of 4 people)
  • not specified: 0.0% - (0 of 0 people)
Gabapentin:
  • < 1 month: 15.0% - (2 of 13 people)
  • 1 - 6 months: 21.0% - (6 of 28 people)
  • 6 - 12 months: 7.0% - (1 of 14 people)
  • 1 - 2 years: 35.0% - (11 of 31 people)
  • 2 - 5 years: 32.0% - (17 of 53 people)
  • 5 - 10 years: 33.0% - (5 of 15 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Tizanidine Hydrochloride:
  • female: 33.0% - (45 of 135 people)
  • male: 30.0% - (7 of 23 people)
Gabapentin:
  • female: 29.0% - (40 of 135 people)
  • male: 20.0% - (5 of 24 people)

Drug effectiveness by age:

Tizanidine Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 36.0% - (4 of 11 people)
  • 30-39: 29.0% - (12 of 41 people)
  • 40-49: 34.0% - (16 of 47 people)
  • 50-59: 40.0% - (20 of 50 people)
  • 60+: 0.0% - (0 of 9 people)
Gabapentin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 33.0% - (4 of 12 people)
  • 30-39: 21.0% - (9 of 42 people)
  • 40-49: 22.0% - (11 of 48 people)
  • 50-59: 39.0% - (19 of 48 people)
  • 60+: 22.0% - (2 of 9 people)

Most common drug interactions over time *:

< 1 month:
  • fall
  • confusional state
  • nausea
  • dizziness
  • dry mouth
  • fatigue
  • insomnia
  • somnolence
  • vision blurred
  • abnormal behaviour
1 - 6 months:
  • depression
  • anxiety
  • headache
  • atelectasis
  • confusion
  • diabetic gastroparesis
  • mental disorder
  • pain
  • pleural effusion
  • pulmonary embolism
6 - 12 months:
  • anxiety
  • dehydration
  • arthralgia
  • cushingoid
  • drug withdrawal syndrome
  • duodenal ulcer
  • dyspnoea
  • emotional distress
  • fatigue
  • insomnia
1 - 2 years:
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • iron deficiency anemia
  • pain inflammation activated
  • weight loss
  • vertigo
  • anxiety
  • neck pain
  • rigors
  • acid reflux
  • allergy to animal
2 - 5 years:
  • insomnia
  • pain
  • suicide attempt
  • pain inflammation activated
  • anxiety
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • iron deficiency anemia
  • road traffic accident
  • weight loss
  • abdominal pain upper
5 - 10 years:
  • mottled skin
  • skin burning sensation
  • depression
  • anxiety
  • fatigue
  • loss of consciousness
  • pain disorder
  • suicide attempt
  • abasia
  • alcohol interaction
10+ years:
  • activities of daily living impaired
  • adverse reaction
  • anorexia
  • bladder prolapse
  • blood pressure increased
  • muscle atrophy
  • oedema
  • paraesthesia
  • syncope
  • tremor
not specified:
  • pain
  • anxiety
  • depression
  • fall
  • dyspnoea
  • headache
  • nausea
  • asthenia
  • fatigue
  • drug ineffective

Most common drug interactions by gender *:

female:
  • pain
  • fall
  • anxiety
  • fatigue
  • headache
  • nausea
  • depression
  • dyspnoea
  • asthenia
  • drug ineffective
male:
  • pain
  • anxiety
  • depression
  • back pain
  • hypoaesthesia
  • dyspnoea
  • arthralgia
  • drug dependence
  • constipation
  • emotional distress

Most common drug interactions by age *:

0-1:
  • alanine aminotransferase increased
  • aspartate aminotransferase increased
  • blood alkaline phosphatase increased
  • blood lactate dehydrogenase increased
  • bradycardia
  • dehydration
  • diarrhoea
  • drug effect decreased
  • epilepsy
  • general physical health deterioration
10-19:
  • constipation
  • ileus
  • serotonin syndrome
  • accommodation disorder
  • blepharospasm
  • dystonia
  • pyrexia
20-29:
  • anxiety
  • completed suicide
  • depression
  • confusional state
  • muscle spasms
  • drug ineffective
  • headache
  • metabolic acidosis
  • nausea
  • urinary tract infection
30-39:
  • anxiety
  • pain
  • arthralgia
  • nausea
  • headache
  • dyspnoea
  • drug withdrawal syndrome
  • asthenia
  • depression
  • fatigue
40-49:
  • pain
  • depression
  • headache
  • anxiety
  • chest pain
  • fall
  • muscle spasms
  • nausea
  • drug ineffective
  • asthenia
50-59:
  • pain
  • depression
  • anxiety
  • fatigue
  • dyspnoea
  • fall
  • hypertension
  • arthralgia
  • back pain
  • emotional distress
60+:
  • pain
  • anxiety
  • dyspnoea
  • fall
  • hypotension
  • myocardial infarction
  • urinary tract infection
  • asthenia
  • confusional state
  • back pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tizanidine hydrochloride (tizanidine) is often used to treat muscle spasms. Gabapentin (gabapentin) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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