Review: taking Tizanidine hydrochloride and Methotrexate together


Summary

Drug interactions are reported among people who take Tizanidine hydrochloride and Methotrexate together. This review analyzes the effectiveness and drug interactions between Tizanidine hydrochloride and Methotrexate. It is created by eHealthMe based on reports of 697 people who take the same drugs from FDA and social media, and is updated regularly.

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Tizanidine Hydrochloride

Tizanidine hydrochloride has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Tizanidine hydrochloride 1,917 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 205,731 users)

On Sep, 15, 2016

697 people who take Tizanidine Hydrochloride, Methotrexate are studied.


Number of reports submitted per year:

Tizanidine hydrochloride and Methotrexate drug interactions.

Drug effectiveness over time:

Tizanidine Hydrochloride:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 100.0% - (2 of 2 people)
  • 2 - 5 years: 0.0% - (0 of 5 people)
  • 5 - 10 years: 0.0% - (0 of 0 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 3 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 25.0% - (1 of 4 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Tizanidine Hydrochloride:
  • female: 33.0% - (2 of 6 people)
  • male: 25.0% - (1 of 4 people)
Methotrexate:
  • female: 20.0% - (1 of 5 people)
  • male: 40.0% - (2 of 5 people)

Drug effectiveness by age:

Tizanidine Hydrochloride:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 0.0% - (0 of 5 people)
  • 50-59: 66.0% - (2 of 3 people)
  • 60+: 0.0% - (0 of 1 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 100.0% - (1 of 1 people)
  • 40-49: 0.0% - (0 of 6 people)
  • 50-59: 50.0% - (1 of 2 people)
  • 60+: 100.0% - (1 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • pneumonia
  • abasia
  • blood creatine phosphokinase increased
  • fall
  • hypersomnia
  • rhabdomyolysis
  • anaemia
  • atelectasis
  • cough
  • hypertension
1 - 6 months:
  • acute myocardial infarction
  • asthenia
  • atelectasis
  • blood culture positive
  • bone cyst
  • bronchitis
  • catheter site infection
  • cervix carcinoma
  • chest pain
  • chills
6 - 12 months:
  • urine phosphate abnormal
  • antinuclear antibody increased
  • blood creatinine increased
  • dizziness
  • fall
  • genital herpes
  • herpes zoster
  • injection site pain
  • laboratory test abnormal
  • loss of consciousness
1 - 2 years:
  • stomach pain
  • adrenal insufficiency
  • b-cell lymphoma
  • blood pressure decreased
  • difficulty breathing while lying down
  • difficulty falling asleep
  • difficulty in walking
  • difficulty initiating urination
  • difficulty passing stool
  • hypopituitarism
2 - 5 years:
  • fatigue
  • arthritis
  • haemolytic anaemia
  • insomnia
  • osteoarthritis
  • pain
  • anaphylactic shock
  • ankle fracture
  • anorexia
  • anxiety
5 - 10 years:
  • stomach pain
not specified:
  • pain
  • arthralgia
  • fall
  • fatigue
  • drug ineffective
  • headache
  • injection site pain
  • nausea
  • pneumonia
  • intervertebral discitis

Most common drug interactions by gender *:

female:
  • arthralgia
  • pain
  • fall
  • fatigue
  • drug ineffective
  • nausea
  • pneumonia
  • injection site pain
  • headache
  • intervertebral discitis
male:
  • pneumonia
  • intervertebral disc protrusion
  • muscle spasms
  • myalgia
  • headache
  • influenza like illness
  • injection site pain
  • nasopharyngitis
  • sepsis
  • splenomegaly

Most common drug interactions by age *:

10-19:
  • headache
20-29:
  • nausea
  • vomiting
  • cough
  • diarrhoea
  • drug ineffective
  • productive cough
  • abdominal pain upper
  • acne
  • contusion
  • infection susceptibility increased
30-39:
  • pain
  • sinusitis
  • arthralgia
  • fatigue
  • headache
  • pyrexia
  • drug ineffective
  • sepsis
  • fibromyalgia
  • pneumonia
40-49:
  • intervertebral discitis
  • pneumonia
  • bronchitis
  • cystitis
  • nausea
  • pneumonia aspiration
  • arthralgia
  • cystitis haemorrhagic
  • hip arthroplasty
  • urinary bladder haemorrhage
50-59:
  • fall
  • pain
  • hypertension
  • fatigue
  • pyrexia
  • headache
  • back pain
  • cough
  • anaemia
  • diarrhoea
60+:
  • arthralgia
  • pain
  • drug ineffective
  • fall
  • peripheral swelling
  • nausea
  • back pain
  • pain in extremity
  • contusion
  • injection site pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tizanidine hydrochloride (tizanidine hydrochloride) is often used to treat muscle spasms. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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