Review: taking Tramadol and Ambien together


Summary

Drug interactions are reported among people who take Tramadol and Ambien together. This review analyzes the effectiveness and drug interactions between Tramadol and Ambien. It is created by eHealthMe based on reports of 4,042 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 49,036 users)

Ambien

Ambien has active ingredients of zolpidem tartrate. It is often used in insomnia. (latest outcomes from Ambien 51,333 users)

On Aug, 19, 2016

4,042 people who take Tramadol, Ambien are studied.


Number of reports submitted per year:

Tramadol and Ambien drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 11.0% - (2 of 17 people)
  • 1 - 6 months: 15.0% - (7 of 46 people)
  • 6 - 12 months: 18.0% - (4 of 22 people)
  • 1 - 2 years: 24.0% - (8 of 33 people)
  • 2 - 5 years: 30.0% - (9 of 30 people)
  • 5 - 10 years: 40.0% - (10 of 25 people)
  • 10+ years: 27.0% - (3 of 11 people)
  • not specified: 0.0% - (0 of 0 people)
Ambien:
  • < 1 month: 7.0% - (1 of 13 people)
  • 1 - 6 months: 50.0% - (17 of 34 people)
  • 6 - 12 months: 52.0% - (10 of 19 people)
  • 1 - 2 years: 61.0% - (19 of 31 people)
  • 2 - 5 years: 52.0% - (23 of 44 people)
  • 5 - 10 years: 65.0% - (19 of 29 people)
  • 10+ years: 71.0% - (10 of 14 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Tramadol:
  • female: 25.0% - (36 of 140 people)
  • male: 15.0% - (7 of 44 people)
Ambien:
  • female: 54.0% - (77 of 141 people)
  • male: 51.0% - (22 of 43 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 3 people)
  • 20-29: 13.0% - (2 of 15 people)
  • 30-39: 24.0% - (9 of 37 people)
  • 40-49: 13.0% - (5 of 38 people)
  • 50-59: 34.0% - (20 of 58 people)
  • 60+: 21.0% - (7 of 33 people)
Ambien:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 3 people)
  • 20-29: 73.0% - (11 of 15 people)
  • 30-39: 47.0% - (19 of 40 people)
  • 40-49: 50.0% - (19 of 38 people)
  • 50-59: 57.0% - (32 of 56 people)
  • 60+: 56.0% - (18 of 32 people)

Most common drug interactions over time *:

< 1 month:
  • diarrhoea
  • pneumonia
  • drug rash with eosinophilia and systemic symptoms
  • liver injury
  • neutropenia
  • rash
  • urinary tract infection
  • dermatitis exfoliative
  • gastric ulcer
  • varices oesophageal
1 - 6 months:
  • abdominal pain
  • pain
  • headache
  • depression
  • dizziness
  • insomnia
  • nausea
  • anxiety
  • dry mouth
  • febrile neutropenia
6 - 12 months:
  • depression
  • dizziness
  • chest pain
  • dehydration
  • emotional distress
  • fatigue
  • lip dry
  • mitral valve incompetence
  • myocardial infarction
  • short-term memory loss
1 - 2 years:
  • dizziness
  • anxiety
  • injury
  • depression
  • deep vein thrombosis
  • mitral valve incompetence
  • myocardial infarction
  • pain
  • asthenia
  • dry mouth
2 - 5 years:
  • cognitive deterioration
  • basilar migraine
  • head injury
  • occipital neuralgia
  • memory impairment
  • depression
  • urinary tract infection
  • abdominal pain
  • nausea
  • fatigue
5 - 10 years:
  • pain
  • anxiety
  • fatigue
  • cholecystitis
  • deep vein thrombosis
  • emotional distress
  • gallbladder disorder
  • libido decreased
  • neuropathy - sciatic nerve
  • pain - back
10+ years:
  • diazepam overdose
  • insomnia exacerbated
  • anxiety disorder
  • body dysmorphic disorder
  • body temperature fluctuation
  • borderline personality disorder
  • confusion
  • degenerative joint disease
  • drug-induced tremor
  • fatigue aggravated
not specified:
  • pain
  • nausea
  • anxiety
  • fatigue
  • dyspnoea
  • fall
  • arthralgia
  • back pain
  • diarrhoea
  • headache

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • anxiety
  • fatigue
  • dyspnoea
  • arthralgia
  • back pain
  • fall
  • diarrhoea
  • headache
male:
  • depression
  • anxiety
  • pain
  • nausea
  • dyspnoea
  • fall
  • fatigue
  • chest pain
  • dizziness
  • drug ineffective

Most common drug interactions by age *:

0-1:
  • blood cholesterol increased
  • blood triglycerides increased
  • cerebrovascular accident
  • diabetes mellitus
  • drug exposure during pregnancy
  • hyperprolactinaemia
  • leiomyoma
  • obesity
  • osteoarthritis
  • patellofemoral pain syndrome
2-9:
  • abdominal pain upper
  • dyspnoea
  • hyperkalaemia
  • splenic infarction
  • thrombotic thrombocytopenic purpura
  • pyrexia
  • rash
  • swelling
  • emotional disorder
  • scar
10-19:
  • completed suicide
  • cardiac arrest
  • vomiting
  • arthralgia
  • cardio-respiratory arrest
  • fatigue
  • respiratory arrest
  • abdominal pain
  • convulsion
  • headache
20-29:
  • cardiac arrest
  • torsade de pointes
  • pain
  • vomiting
  • abdominal pain upper
  • anxiety
  • emotional distress
  • loss of consciousness
  • nausea
  • ventricular fibrillation
30-39:
  • arthralgia
  • nausea
  • pain
  • headache
  • anxiety
  • depression
  • drug dependence
  • drug ineffective
  • drug withdrawal syndrome
  • vomiting
40-49:
  • nausea
  • pain
  • back pain
  • chest pain
  • fatigue
  • dyspnoea
  • headache
  • depression
  • drug ineffective
  • fall
50-59:
  • nausea
  • pain
  • anxiety
  • fatigue
  • arthralgia
  • depression
  • diarrhoea
  • fall
  • oedema peripheral
  • headache
60+:
  • pain
  • dyspnoea
  • fatigue
  • anxiety
  • fall
  • diarrhoea
  • back pain
  • nausea
  • arthralgia
  • asthenia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Ambien (zolpidem tartrate) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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