Review: taking Tramadol and Melatonin together


Summary

Drug interactions are reported among people who take Tramadol and Melatonin together. This review analyzes the effectiveness and drug interactions between Tramadol and Melatonin. It is created by eHealthMe based on reports of 242 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 49,036 users)

Melatonin

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 4,179 users)

On Aug, 22, 2016

242 people who take Tramadol, Melatonin are studied.


Number of reports submitted per year:

Tramadol and Melatonin drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 40.0% - (2 of 5 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 100.0% - (1 of 1 people)
Melatonin:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 42.0% - (3 of 7 people)
  • 6 - 12 months: 50.0% - (3 of 6 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Tramadol:
  • female: 20.0% - (4 of 20 people)
  • male: 50.0% - (1 of 2 people)
Melatonin:
  • female: 38.0% - (7 of 18 people)
  • male: 50.0% - (1 of 2 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (2 of 2 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 0.0% - (0 of 6 people)
  • 50-59: 33.0% - (1 of 3 people)
  • 60+: 0.0% - (0 of 3 people)
Melatonin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 66.0% - (4 of 6 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 33.0% - (1 of 3 people)
  • 60+: 33.0% - (1 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • restlessness
  • panic attacks
  • acne
  • depression
  • excoriation
  • fatigue
  • fear of public speaking
  • inability to crawl
  • insomnia
  • loss of appetite
1 - 6 months:
  • restlessness
  • autonomic neuropathy
  • blood cortisol abnormal
  • blood cortisol decreased
  • blood cortisol increased
  • drowsiness
  • hair loss
  • long-term memory loss
  • neuropathy peripheral
  • short-term memory loss
6 - 12 months:
  • thrombocytopenia
  • abnormal weight gain
  • appetite increased
  • bone pain
  • decreased activity
  • decreased interest
  • exercise tolerance decreased
  • fall
  • heat intolerance
  • increased tendency to bruise
1 - 2 years:
  • insomnia
  • restlessness
  • acne
  • depression
  • drowsiness
  • excoriation
  • fatigue
  • fear of public speaking
  • inability to crawl
  • migraine
2 - 5 years:
  • drowsiness
  • dry mouth
  • headache
  • heartburn - chronic
  • increased tendency to bruise
  • insomnia
  • itching
  • long-term memory loss
  • lung nodule
  • malaise
5 - 10 years:
  • bone pain
  • decreased activity
  • decreased interest
  • exercise tolerance decreased
  • fall
  • heat intolerance
  • increased tendency to bruise
  • livedo reticularis
  • abnormal weight gain
  • appetite increased
10+ years:
  • dizziness aggravated
  • night sweats
  • pruritus aggravated
  • restless leg syndrome
  • weight above normal
  • lethargy
  • recurrent leg pain and cramping
  • vision blurred
not specified:
  • anxiety
  • depression
  • nausea
  • insomnia
  • arthralgia
  • back pain
  • fatigue
  • gait disturbance
  • pain
  • impaired healing

Most common drug interactions by gender *:

female:
  • depression
  • insomnia
  • anxiety
  • nausea
  • fatigue
  • arthralgia
  • impaired healing
  • pain
  • back pain
  • gait disturbance
male:
  • anxiety
  • gait disturbance
  • hypertension
  • back pain
  • gastrooesophageal reflux disease
  • metastases to bone
  • nausea
  • arthralgia
  • dyspnoea
  • pain in extremity

Most common drug interactions by age *:

10-19:
  • arthralgia
  • headache
  • anxiety
  • dyspepsia
  • epistaxis
  • gait disturbance
  • abdominal pain upper
  • amnesia
  • anhedonia
  • constipation
20-29:
  • nausea
  • loss of appetite
  • major depressive disorder
  • muscle spasms
  • asthenia
  • dizziness
  • abdominal pain
  • chills
  • cholecystitis chronic
  • hypertension
30-39:
  • insomnia
  • depression
  • pain
  • arthralgia
  • tremor
  • accident at work
  • anger
  • blood creatinine increased
  • cervicobrachial syndrome
  • feeling abnormal
40-49:
  • fatigue
  • nausea
  • anxiety
  • pain
  • decreased appetite
  • hypoaesthesia
  • arthralgia
  • insomnia
  • muscular weakness
  • weight increased
50-59:
  • gastrooesophageal reflux disease
  • metastases to bone
  • back pain
  • depression
  • cough
  • gait disturbance
  • mental status changes
  • muscular weakness
  • anxiety
  • impaired healing
60+:
  • arthralgia
  • nausea
  • vomiting
  • abdominal pain upper
  • fall
  • fatigue
  • depression
  • anxiety
  • abdominal pain
  • dyspnoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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