Review: taking Tramadol and Melatonin together


Summary

Drug interactions are reported among people who take Tramadol and Melatonin together. This review analyzes the effectiveness and drug interactions between Tramadol and Melatonin. It is created by eHealthMe based on reports of 507 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information

On eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 86 million people have used us. 300+ peer-reviewed medical journals have referenced our original studies. Start now >>>


Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 73,716 users)

Melatonin

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from Melatonin 8,403 users)

On Sep, 15, 2016

507 people who take Tramadol, Melatonin are studied.


Number of reports submitted per year:

Tramadol and Melatonin drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 25.0% - (1 of 4 people)
  • 2 - 5 years: 40.0% - (2 of 5 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 0.0% - (0 of 2 people)
  • not specified: 100.0% - (1 of 1 people)
Melatonin:
  • < 1 month: 0.0% - (0 of 3 people)
  • 1 - 6 months: 42.0% - (3 of 7 people)
  • 6 - 12 months: 50.0% - (3 of 6 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 100.0% - (1 of 1 people)
  • 10+ years: 0.0% - (0 of 2 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Tramadol:
  • female: 19.0% - (4 of 21 people)
  • male: 50.0% - (1 of 2 people)
Melatonin:
  • female: 36.0% - (7 of 19 people)
  • male: 50.0% - (1 of 2 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (2 of 2 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 0.0% - (0 of 6 people)
  • 50-59: 25.0% - (1 of 4 people)
  • 60+: 0.0% - (0 of 3 people)
Melatonin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 66.0% - (4 of 6 people)
  • 40-49: 16.0% - (1 of 6 people)
  • 50-59: 25.0% - (1 of 4 people)
  • 60+: 33.0% - (1 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • neutropenic sepsis
  • restlessness
  • migraine
  • oculogyric crisis
  • panic attacks
  • visual impairment
  • acne
  • depression
  • excoriation
  • fatigue
1 - 6 months:
  • restlessness
  • autonomic neuropathy
  • blood cortisol abnormal
  • blood cortisol decreased
  • blood cortisol increased
  • drowsiness
  • hair loss
  • heart rate irregular
  • long-term memory loss
  • neuropathy peripheral
6 - 12 months:
  • thrombocytopenia
  • abnormal weight gain
  • appetite increased
  • bone pain
  • decreased activity
  • decreased interest
  • exercise tolerance decreased
  • fall
  • heat intolerance
  • increased tendency to bruise
1 - 2 years:
  • insomnia
  • restlessness
  • acne
  • anaemia
  • depression
  • drowsiness
  • excoriation
  • fatigue
  • fear of public speaking
  • gastrointestinal haemorrhage
2 - 5 years:
  • fall
  • headache
  • patella fracture
  • viral infection
  • abdominal pain
  • anxiety
  • blood calcium increased
  • diarrhoea
  • drowsiness
  • dry mouth
5 - 10 years:
  • bone pain
  • decreased activity
  • decreased interest
  • exercise tolerance decreased
  • fall
  • heat intolerance
  • increased tendency to bruise
  • livedo reticularis
  • abnormal weight gain
  • appetite increased
10+ years:
  • dizziness aggravated
  • night sweats
  • pruritus aggravated
  • restless leg syndrome
  • weight above normal
  • lethargy
  • recurrent leg pain and cramping
  • vision blurred
not specified:
  • pain
  • arthralgia
  • fatigue
  • depression
  • insomnia
  • nausea
  • back pain
  • anxiety
  • fall
  • pain in extremity

Most common drug interactions by gender *:

female:
  • pain
  • insomnia
  • arthralgia
  • depression
  • nausea
  • fatigue
  • anxiety
  • back pain
  • fall
  • headache
male:
  • fatigue
  • asthenia
  • pain
  • back pain
  • arthralgia
  • diarrhoea
  • depression
  • gastrooesophageal reflux disease
  • anxiety
  • tachycardia

Most common drug interactions by age *:

10-19:
  • anxiety
  • arthralgia
  • dysuria
  • headache
  • dyspepsia
  • fatigue
  • pain
  • epistaxis
  • gait disturbance
  • oculogyric crisis
20-29:
  • nausea
  • loss of appetite
  • major depressive disorder
  • muscle spasms
  • pain
  • vomiting
  • asthenia
  • dizziness
  • abdominal pain
  • chills
30-39:
  • insomnia
  • pain
  • arthralgia
  • depression
  • headache
  • fatigue
  • feeling abnormal
  • fall
  • tremor
  • accident at work
40-49:
  • fatigue
  • pain
  • arthralgia
  • nausea
  • decreased appetite
  • anxiety
  • back pain
  • chest pain
  • headache
  • insomnia
50-59:
  • insomnia
  • back pain
  • depression
  • gastrooesophageal reflux disease
  • metastases to bone
  • anxiety
  • gait disturbance
  • cough
  • mental status changes
  • muscular weakness
60+:
  • fall
  • fatigue
  • asthenia
  • arthralgia
  • weight decreased
  • nausea
  • abdominal pain upper
  • diarrhoea
  • depression
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tramadol and Melatonin?

Can you answer these questions?

More questions for: Tramadol, Melatonin

You may be interested in these reviews

More reviews for: Tramadol, Melatonin

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.