Review: taking Tramadol and Metformin together


Summary

Drug interactions are reported among people who take Tramadol and Metformin together. This review analyzes the effectiveness and drug interactions between Tramadol and Metformin. It is created by eHealthMe based on reports of 3,505 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 49,036 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 117,555 users)

On Aug, 19, 2016

3,505 people who take Tramadol, Metformin are studied.


Number of reports submitted per year:

Tramadol and Metformin drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 40.0% - (2 of 5 people)
  • 1 - 6 months: 60.0% - (3 of 5 people)
  • 6 - 12 months: 50.0% - (6 of 12 people)
  • 1 - 2 years: 16.0% - (1 of 6 people)
  • 2 - 5 years: 33.0% - (5 of 15 people)
  • 5 - 10 years: 27.0% - (3 of 11 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 0.0% - (0 of 1 people)
Metformin:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 42.0% - (3 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 5 people)
  • 1 - 2 years: 27.0% - (3 of 11 people)
  • 2 - 5 years: 45.0% - (5 of 11 people)
  • 5 - 10 years: 66.0% - (8 of 12 people)
  • 10+ years: 42.0% - (3 of 7 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Tramadol:
  • female: 32.0% - (13 of 40 people)
  • male: 52.0% - (9 of 17 people)
Metformin:
  • female: 32.0% - (12 of 37 people)
  • male: 61.0% - (11 of 18 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 28.0% - (2 of 7 people)
  • 40-49: 26.0% - (4 of 15 people)
  • 50-59: 47.0% - (9 of 19 people)
  • 60+: 40.0% - (6 of 15 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 37.0% - (6 of 16 people)
  • 50-59: 52.0% - (10 of 19 people)
  • 60+: 42.0% - (6 of 14 people)

Most common drug interactions over time *:

< 1 month:
  • fall
  • pulmonary embolism
  • renal failure acute
  • deep vein thrombosis
  • ketosis
  • confusional state
  • jaundice
  • abdominal pain upper
  • diabetes mellitus
  • rash
1 - 6 months:
  • hyperglycaemia
  • blood glucose increased
  • confusional state
  • hallucinations, mixed
  • serotonin syndrome
  • dyskinesia
  • nystagmus
  • weight bearing difficulty
  • emotional distress
  • pulmonary embolism
6 - 12 months:
  • malaise
  • vomiting
  • nausea
  • depression
  • pancreatitis chronic
  • pyrexia
  • back pain
  • colitis
  • constipation
  • diarrhoea
1 - 2 years:
  • renal failure acute
  • diabetes mellitus
  • chronic fatigue syndrome
  • deep vein thrombosis
  • dizziness
  • ketosis
  • pulmonary embolism
  • acute myocardial infarction
  • amnesia
  • angina unstable
2 - 5 years:
  • anxiety
  • anaemia
  • pancytopenia
  • renal failure acute
  • renal impairment
  • aggression
  • cerebrovascular accident
  • depression
  • emotional distress
  • hyperkalaemia
5 - 10 years:
  • cerebrovascular accident
  • hypoaesthesia
  • myocardial infarction
  • swelling
  • back pain
  • diarrhoea
  • anaemia
  • colitis
  • constipation
  • dehydration
10+ years:
  • pancytopenia
  • anaemia
  • electrocardiogram pr prolongation
  • fatigue
  • hyperkalaemia
  • metabolic acidosis
  • renal impairment
  • diabetes mellitus management
  • dizziness
  • dry mouth
not specified:
  • pain
  • fatigue
  • nausea
  • dyspnoea
  • vomiting
  • anaemia
  • diabetes mellitus
  • asthenia
  • chest pain
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • fatigue
  • nausea
  • anaemia
  • dyspnoea
  • vomiting
  • diabetes mellitus
  • chest pain
  • dizziness
  • pain in extremity
male:
  • nausea
  • fatigue
  • asthenia
  • dyspnoea
  • vomiting
  • pain
  • diarrhoea
  • diabetes mellitus
  • myocardial infarction
  • blood glucose increased

Most common drug interactions by age *:

0-1:
  • muscular weakness
  • tremor
  • type 2 diabetes mellitus
  • diabetes mellitus
  • blood cholesterol increased
  • blood triglycerides increased
  • cerebrovascular accident
  • chest pain
  • hyperprolactinaemia
  • leiomyoma
2-9:
  • accidental drug intake by child
  • arthritis bacterial
  • influenza like illness
  • joint swelling
  • lethargy
  • multiple drug overdose accidental
  • myositis
  • somnolence
10-19:
  • biliary dyskinesia
  • cholecystitis chronic
  • gallbladder disorder
  • back pain
  • cough
  • deep vein thrombosis
  • diabetes mellitus
  • dyshidrosis
  • hypertension
  • hypoglycaemia
20-29:
  • dyspnoea
  • pulmonary embolism
  • nausea
  • chest pain
  • cholelithiasis
  • diabetes mellitus
  • palpitations
  • vomiting
  • back pain
  • cholecystitis chronic
30-39:
  • diabetes mellitus
  • pain
  • type 2 diabetes mellitus
  • deep vein thrombosis
  • pulmonary embolism
  • headache
  • fatigue
  • feeling abnormal
  • depression
  • dehydration
40-49:
  • nausea
  • diabetes mellitus
  • pain
  • vomiting
  • headache
  • fatigue
  • type 2 diabetes mellitus
  • chest pain
  • back pain
  • diarrhoea
50-59:
  • nausea
  • pain
  • depression
  • diarrhoea
  • vomiting
  • anxiety
  • myocardial infarction
  • arthralgia
  • dizziness
  • chest pain
60+:
  • fatigue
  • pain
  • anaemia
  • nausea
  • dyspnoea
  • haemorrhoids
  • vomiting
  • pleural effusion
  • colonic polyp
  • gastritis erosive

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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