Review: taking Tramadol and Metformin together


Summary

Drug interactions are reported among people who take Tramadol and Metformin together. This review analyzes the effectiveness and drug interactions between Tramadol and Metformin. It is created by eHealthMe based on reports of 2,664 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 42,204 users)

Metformin

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 99,381 users)

On Jul, 27, 2016

2,664 people who take Tramadol, Metformin are studied.


Number of reports submitted per year:

Tramadol and Metformin drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 40.0% - (2 of 5 people)
  • 1 - 6 months: 42.0% - (3 of 7 people)
  • 6 - 12 months: 62.0% - (10 of 16 people)
  • 1 - 2 years: 16.0% - (1 of 6 people)
  • 2 - 5 years: 23.0% - (6 of 26 people)
  • 5 - 10 years: 32.0% - (8 of 25 people)
  • 10+ years: 100.0% - (3 of 3 people)
  • not specified: 0.0% - (0 of 1 people)
Metformin:
  • < 1 month: 0.0% - (0 of 2 people)
  • 1 - 6 months: 42.0% - (3 of 7 people)
  • 6 - 12 months: 0.0% - (0 of 5 people)
  • 1 - 2 years: 13.0% - (3 of 22 people)
  • 2 - 5 years: 53.0% - (7 of 13 people)
  • 5 - 10 years: 66.0% - (10 of 15 people)
  • 10+ years: 66.0% - (8 of 12 people)
  • not specified: 100.0% - (1 of 1 people)

Drug effectiveness by gender:

Tramadol:
  • female: 25.0% - (16 of 63 people)
  • male: 65.0% - (17 of 26 people)
Metformin:
  • female: 28.0% - (14 of 50 people)
  • male: 66.0% - (18 of 27 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 100.0% - (1 of 1 people)
  • 30-39: 28.0% - (2 of 7 people)
  • 40-49: 14.0% - (5 of 35 people)
  • 50-59: 54.0% - (12 of 22 people)
  • 60+: 54.0% - (13 of 24 people)
Metformin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 1 people)
  • 30-39: 20.0% - (1 of 5 people)
  • 40-49: 23.0% - (6 of 26 people)
  • 50-59: 54.0% - (12 of 22 people)
  • 60+: 56.0% - (13 of 23 people)

Most common drug interactions over time *:

< 1 month:
  • fall
  • pulmonary embolism
  • deep vein thrombosis
  • ketosis
  • jaundice
  • abdominal pain upper
  • diabetes mellitus
  • rash
  • hepatic enzyme increased
  • hepatic steatosis
1 - 6 months:
  • anaemia
  • depression
  • emotional distress
  • hypersexuality
  • obsessive-compulsive personality disorder
  • pathological gambling
  • pulmonary embolism
  • restlessness
  • skin exfoliation
  • suicidal ideation
6 - 12 months:
  • malaise
  • vomiting
  • nausea
  • pancreatitis chronic
  • pyrexia
  • back pain
  • colitis
  • constipation
  • diarrhoea
  • dyspepsia
1 - 2 years:
  • diabetes mellitus
  • renal failure acute
  • chronic fatigue syndrome
  • deep vein thrombosis
  • ketosis
  • pulmonary embolism
  • amnesia
  • angina unstable
  • atrioventricular block
  • cerebrovascular accident
2 - 5 years:
  • anxiety
  • renal failure acute
  • aggression
  • depression
  • hyperkalaemia
  • mental disorder
  • cerebrovascular accident
  • confusional state
  • forgetfulness
  • muscle spasms
5 - 10 years:
  • cerebrovascular accident
  • hypoaesthesia
  • myocardial infarction
  • swelling
  • back pain
  • diarrhoea
  • anaemia
  • colitis
  • constipation
  • dehydration
10+ years:
  • electrocardiogram pr prolongation
  • fatigue
  • hyperkalaemia
  • metabolic acidosis
  • diabetes mellitus management
  • dizziness
  • dry mouth
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • heart pounding
  • heart racing
not specified:
  • pain
  • fatigue
  • nausea
  • dyspnoea
  • vomiting
  • anaemia
  • diabetes mellitus
  • asthenia
  • chest pain
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • fatigue
  • nausea
  • anaemia
  • dyspnoea
  • diabetes mellitus
  • vomiting
  • chest pain
  • pleural effusion
  • haemorrhoids
male:
  • nausea
  • fatigue
  • asthenia
  • vomiting
  • dyspnoea
  • myocardial infarction
  • diabetes mellitus
  • depression
  • pain
  • diarrhoea

Most common drug interactions by age *:

0-1:
  • muscular weakness
  • tremor
  • type 2 diabetes mellitus
  • diabetes mellitus
  • blood cholesterol increased
  • blood triglycerides increased
  • cerebrovascular accident
  • chest pain
  • hyperprolactinaemia
  • leiomyoma
2-9:
  • accidental drug intake by child
  • arthritis bacterial
  • influenza like illness
  • joint swelling
  • lethargy
  • multiple drug overdose accidental
  • myositis
  • somnolence
10-19:
  • biliary dyskinesia
  • cholecystitis chronic
  • gallbladder disorder
  • back pain
  • cough
  • diabetes mellitus
  • dyshidrosis
  • hypertension
  • hypoglycaemia
  • oropharyngeal pain
20-29:
  • dyspnoea
  • nausea
  • pulmonary embolism
  • chest pain
  • cholelithiasis
  • diabetes mellitus
  • back pain
  • cholecystitis chronic
  • abdominal pain
  • deep vein thrombosis
30-39:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • pain
  • deep vein thrombosis
  • headache
  • pulmonary embolism
  • dehydration
  • depression
  • diabetic neuropathy
  • feeling abnormal
40-49:
  • diabetes mellitus
  • nausea
  • pain
  • vomiting
  • type 2 diabetes mellitus
  • back pain
  • headache
  • chest pain
  • diarrhoea
  • dyspnoea
50-59:
  • nausea
  • depression
  • anxiety
  • myocardial infarction
  • pain
  • diarrhoea
  • vomiting
  • arthralgia
  • dizziness
  • chest pain
60+:
  • fatigue
  • anaemia
  • pain
  • haemorrhoids
  • colonic polyp
  • nausea
  • pleural effusion
  • gastritis erosive
  • hepatic enzyme increased
  • rectal haemorrhage

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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