Review: taking Tramadol and Methotrexate together


Summary

Drug interactions are reported among people who take Tramadol and Methotrexate together. This review analyzes the effectiveness and drug interactions between Tramadol and Methotrexate. It is created by eHealthMe based on reports of 3,227 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 42,204 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 129,243 users)

On Jul, 27, 2016

3,227 people who take Tramadol, Methotrexate are studied.


Number of reports submitted per year:

Tramadol and Methotrexate drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 50.0% - (1 of 2 people)
  • 1 - 6 months: 40.0% - (4 of 10 people)
  • 6 - 12 months: 25.0% - (4 of 16 people)
  • 1 - 2 years: 16.0% - (2 of 12 people)
  • 2 - 5 years: 27.0% - (5 of 18 people)
  • 5 - 10 years: 38.0% - (7 of 18 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 1 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 21.0% - (3 of 14 people)
  • 6 - 12 months: 12.0% - (1 of 8 people)
  • 1 - 2 years: 18.0% - (2 of 11 people)
  • 2 - 5 years: 23.0% - (5 of 21 people)
  • 5 - 10 years: 42.0% - (6 of 14 people)
  • 10+ years: 40.0% - (2 of 5 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Tramadol:
  • female: 26.0% - (16 of 61 people)
  • male: 44.0% - (8 of 18 people)
Methotrexate:
  • female: 26.0% - (16 of 60 people)
  • male: 17.0% - (3 of 17 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 44.0% - (4 of 9 people)
  • 40-49: 15.0% - (3 of 20 people)
  • 50-59: 33.0% - (8 of 24 people)
  • 60+: 35.0% - (7 of 20 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 28.0% - (2 of 7 people)
  • 40-49: 15.0% - (3 of 19 people)
  • 50-59: 36.0% - (9 of 25 people)
  • 60+: 15.0% - (3 of 20 people)

Most common drug interactions over time *:

< 1 month:
  • drug ineffective
  • fatigue
  • thrombocytopenia
  • febrile bone marrow aplasia
  • febrile neutropenia
  • mucosal inflammation
  • vomiting
  • pneumonia
  • nausea
  • renal failure acute
1 - 6 months:
  • anaemia
  • dyspnoea
  • vomiting
  • leukopenia
  • pain
  • pneumonia
  • gout - chronic
  • nausea
  • night sweats
  • pleural effusion
6 - 12 months:
  • headache - mixed tension migraine
  • lightheadedness - dizzy
  • nausea
  • coronary artery embolism
  • embolism
  • pulmonary embolism
  • arterial thrombosis
  • vomiting
  • atrial fibrillation
  • blood cholesterol increased
1 - 2 years:
  • cerebrovascular accident
  • general physical health deterioration
  • haematoma
  • lumbar spinal stenosis
  • back pain
  • basal cell carcinoma
  • drug ineffective
  • hair loss
  • headache
  • high blood pressure
2 - 5 years:
  • pulmonary embolism
  • alanine aminotransferase increased
  • coronary artery embolism
  • embolism
  • nausea
  • arterial thrombosis
  • asthenia
  • bone cyst
  • fatigue
  • headaches
5 - 10 years:
  • arthritis bacterial
  • headache - mixed tension migraine
  • lightheadedness - dizzy
  • systemic lupus erythematosus
  • affect lability
  • akathisia
  • disseminated tuberculosis
  • pancytopenia
  • cytomegalovirus test positive
  • diverticulitis
10+ years:
  • cellulitis
  • hip fracture
  • impaired healing
  • pancytopenia
  • sepsis
  • fall
  • lung cancer metastatic
  • oedema peripheral
  • anorexia
  • arthralgia
not specified:
  • nausea
  • arthralgia
  • pain
  • headache
  • fatigue
  • vomiting
  • pyrexia
  • pneumonia
  • dyspnoea
  • diarrhoea

Most common drug interactions by gender *:

female:
  • arthralgia
  • nausea
  • pain
  • vomiting
  • headache
  • fatigue
  • diarrhoea
  • fall
  • pyrexia
  • dyspnoea
male:
  • pneumonia
  • dyspnoea
  • pyrexia
  • nausea
  • headache
  • arthralgia
  • dizziness
  • anaemia
  • drug ineffective
  • rheumatoid arthritis

Most common drug interactions by age *:

2-9:
  • abdominal pain
  • somnolence
  • agitation
  • depressed level of consciousness
  • graft versus host disease
  • irritability
  • sepsis
  • tachycardia
  • vision blurred
  • altered state of consciousness
10-19:
  • vomiting
  • weight decreased
  • febrile bone marrow aplasia
  • febrile neutropenia
  • mucosal inflammation
  • abortion spontaneous
  • pregnancy
  • pyrexia
  • decreased appetite
  • dehydration
20-29:
  • headache
  • nausea
  • pain
  • arthralgia
  • diarrhoea
  • abdominal pain
  • biliary dyskinesia
  • vomiting
  • back pain
  • pyrexia
30-39:
  • fatigue
  • nausea
  • dizziness
  • vomiting
  • fall
  • headache
  • arthralgia
  • cough
  • decreased appetite
  • myalgia
40-49:
  • uterine leiomyoma
  • dysfunctional uterine bleeding
  • nausea
  • rectal haemorrhage
  • arthralgia
  • pneumonia
  • headache
  • chest pain
  • pain
  • asthenia
50-59:
  • arthralgia
  • nausea
  • pain
  • diarrhoea
  • headache
  • vomiting
  • dyspnoea
  • pyrexia
  • abdominal pain
  • anaemia
60+:
  • pain
  • fall
  • arthralgia
  • pneumonia
  • drug ineffective
  • anaemia
  • asthenia
  • dyspnoea
  • headache
  • fatigue

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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