Review: taking Tramadol and Methotrexate together


Summary

Drug interactions are reported among people who take Tramadol and Methotrexate together. This review analyzes the effectiveness and drug interactions between Tramadol and Methotrexate. It is created by eHealthMe based on reports of 4,432 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 52,446 users)

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 160,929 users)

On Aug, 26, 2016

4,432 people who take Tramadol, Methotrexate are studied.


Number of reports submitted per year:

Tramadol and Methotrexate drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 50.0% - (1 of 2 people)
  • 1 - 6 months: 33.0% - (3 of 9 people)
  • 6 - 12 months: 22.0% - (2 of 9 people)
  • 1 - 2 years: 18.0% - (2 of 11 people)
  • 2 - 5 years: 31.0% - (5 of 16 people)
  • 5 - 10 years: 33.0% - (4 of 12 people)
  • 10+ years: 50.0% - (1 of 2 people)
  • not specified: 0.0% - (0 of 1 people)
Methotrexate:
  • < 1 month: 0.0% - (0 of 4 people)
  • 1 - 6 months: 27.0% - (3 of 11 people)
  • 6 - 12 months: 14.0% - (1 of 7 people)
  • 1 - 2 years: 20.0% - (2 of 10 people)
  • 2 - 5 years: 29.0% - (5 of 17 people)
  • 5 - 10 years: 14.0% - (1 of 7 people)
  • 10+ years: 40.0% - (2 of 5 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Tramadol:
  • female: 26.0% - (13 of 49 people)
  • male: 38.0% - (5 of 13 people)
Methotrexate:
  • female: 22.0% - (11 of 49 people)
  • male: 25.0% - (3 of 12 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 50.0% - (1 of 2 people)
  • 20-29: 25.0% - (1 of 4 people)
  • 30-39: 37.0% - (3 of 8 people)
  • 40-49: 15.0% - (3 of 19 people)
  • 50-59: 37.0% - (6 of 16 people)
  • 60+: 30.0% - (4 of 13 people)
Methotrexate:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 28.0% - (2 of 7 people)
  • 40-49: 16.0% - (3 of 18 people)
  • 50-59: 23.0% - (4 of 17 people)
  • 60+: 23.0% - (3 of 13 people)

Most common drug interactions over time *:

< 1 month:
  • drug ineffective
  • vomiting
  • fatigue
  • thrombocytopenia
  • febrile neutropenia
  • pneumonia
  • febrile bone marrow aplasia
  • mucosal inflammation
  • hot flush
  • muscle twitching
1 - 6 months:
  • anaemia
  • dyspnoea
  • pleural effusion
  • pneumonia
  • leukopenia
  • pain
  • vomiting
  • blood creatinine increased
  • nausea
  • respiratory failure
6 - 12 months:
  • headache - mixed tension migraine
  • lightheadedness - dizzy
  • nausea
  • coronary artery embolism
  • embolism
  • pulmonary embolism
  • alopecia
  • arterial thrombosis
  • blood cholesterol increased
  • rash
1 - 2 years:
  • cerebrovascular accident
  • general physical health deterioration
  • haematoma
  • lumbar spinal stenosis
  • nausea
  • back pain
  • basal cell carcinoma
  • diarrhoea
  • dizziness
  • drug ineffective
2 - 5 years:
  • pulmonary embolism
  • dyspnoea
  • asthenia
  • fatigue
  • gait disturbance
  • pyrexia
  • vomiting
  • alanine aminotransferase increased
  • nausea
  • arthralgia
5 - 10 years:
  • arthritis bacterial
  • headache - mixed tension migraine
  • lightheadedness - dizzy
  • systemic lupus erythematosus
  • affect lability
  • akathisia
  • disseminated tuberculosis
  • hypertension
  • pancytopenia
  • cytomegalovirus test positive
10+ years:
  • cellulitis
  • pancytopenia
  • hip fracture
  • impaired healing
  • sepsis
  • arthralgia
  • fall
  • lung cancer metastatic
  • oedema peripheral
  • pyrexia
not specified:
  • arthralgia
  • nausea
  • pain
  • headache
  • fatigue
  • drug ineffective
  • vomiting
  • dyspnoea
  • pyrexia
  • pneumonia

Most common drug interactions by gender *:

female:
  • arthralgia
  • nausea
  • pain
  • headache
  • fatigue
  • vomiting
  • drug ineffective
  • pain in extremity
  • diarrhoea
  • injection site pain
male:
  • pneumonia
  • arthralgia
  • drug ineffective
  • dyspnoea
  • nausea
  • pyrexia
  • rheumatoid arthritis
  • headache
  • pain
  • dizziness

Most common drug interactions by age *:

2-9:
  • abdominal pain
  • somnolence
  • agitation
  • depressed level of consciousness
  • gastroenteritis viral
  • graft versus host disease
  • headache
  • irritability
  • sepsis
  • tachycardia
10-19:
  • vomiting
  • febrile neutropenia
  • weight decreased
  • febrile bone marrow aplasia
  • mucosal inflammation
  • pyrexia
  • abortion spontaneous
  • pregnancy
  • nausea
  • abdominal pain
20-29:
  • nausea
  • headache
  • diarrhoea
  • abdominal pain
  • pain
  • vomiting
  • arthralgia
  • biliary dyskinesia
  • back pain
  • fatigue
30-39:
  • fatigue
  • nausea
  • vomiting
  • dizziness
  • headache
  • arthralgia
  • fall
  • diarrhoea
  • cough
  • decreased appetite
40-49:
  • uterine leiomyoma
  • nausea
  • injection site pain
  • arthralgia
  • headache
  • dysfunctional uterine bleeding
  • drug ineffective
  • rectal haemorrhage
  • pneumonia
  • fatigue
50-59:
  • arthralgia
  • nausea
  • pain
  • headache
  • dyspnoea
  • diarrhoea
  • pain in extremity
  • fatigue
  • vomiting
  • drug ineffective
60+:
  • pain
  • arthralgia
  • fall
  • headache
  • drug ineffective
  • pneumonia
  • rheumatoid arthritis
  • dyspnoea
  • fatigue
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Methotrexate (methotrexate sodium) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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