Review: taking Tramadol and Omeprazole together


Summary

Drug interactions are reported among people who take Tramadol and Omeprazole together. This review analyzes the effectiveness and drug interactions between Tramadol and Omeprazole. It is created by eHealthMe based on reports of 5,861 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 42,204 users)

Omeprazole

Omeprazole has active ingredients of omeprazole. It is often used in gastrooesophageal reflux disease. (latest outcomes from Omeprazole 94,637 users)

On Jul, 24, 2016

5,861 people who take Tramadol, Omeprazole are studied.


Number of reports submitted per year:

Tramadol and Omeprazole drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 18.0% - (4 of 22 people)
  • 1 - 6 months: 35.0% - (14 of 40 people)
  • 6 - 12 months: 26.0% - (13 of 50 people)
  • 1 - 2 years: 35.0% - (15 of 42 people)
  • 2 - 5 years: 37.0% - (11 of 29 people)
  • 5 - 10 years: 21.0% - (6 of 28 people)
  • 10+ years: 11.0% - (2 of 17 people)
  • not specified: 0.0% - (0 of 1 people)
Omeprazole:
  • < 1 month: 40.0% - (2 of 5 people)
  • 1 - 6 months: 33.0% - (9 of 27 people)
  • 6 - 12 months: 31.0% - (7 of 22 people)
  • 1 - 2 years: 70.0% - (26 of 37 people)
  • 2 - 5 years: 67.0% - (35 of 52 people)
  • 5 - 10 years: 83.0% - (36 of 43 people)
  • 10+ years: 74.0% - (32 of 43 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Tramadol:
  • female: 32.0% - (55 of 167 people)
  • male: 16.0% - (10 of 62 people)
Omeprazole:
  • female: 63.0% - (107 of 169 people)
  • male: 64.0% - (40 of 62 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (4 of 4 people)
  • 20-29: 60.0% - (9 of 15 people)
  • 30-39: 33.0% - (11 of 33 people)
  • 40-49: 17.0% - (11 of 63 people)
  • 50-59: 25.0% - (14 of 55 people)
  • 60+: 27.0% - (16 of 59 people)
Omeprazole:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 25.0% - (1 of 4 people)
  • 20-29: 40.0% - (6 of 15 people)
  • 30-39: 57.0% - (19 of 33 people)
  • 40-49: 59.0% - (37 of 62 people)
  • 50-59: 77.0% - (44 of 57 people)
  • 60+: 66.0% - (40 of 60 people)

Most common drug interactions over time *:

< 1 month:
  • neutropenia
  • pneumonia
  • anaemia
  • confusional state
  • sepsis
  • pyrexia
  • thrombocytopenia
  • respiratory failure
  • vomiting
  • dyspnoea
1 - 6 months:
  • abdominal pain
  • vomiting
  • anaemia
  • hyperkalaemia
  • muscle spasms
  • septic shock
  • burning sensation
  • hypoaesthesia
  • paraesthesia
  • pyrexia
6 - 12 months:
  • nausea
  • depression
  • constipation
  • fibromyalgia
  • rls
  • deep vein thrombosis
  • diarrhoea
  • back pain
  • headache - mixed tension migraine
  • lightheadedness - dizzy
1 - 2 years:
  • erectile dysfunction
  • depression
  • dry mouth
  • nausea
  • arrhythmia
  • chest pain
  • muscle twitching
  • myocardial infarction
  • paraesthesia
  • diarrhea
2 - 5 years:
  • depression
  • anxiety
  • asthenia
  • suicidal ideation
  • dizziness
  • fatigue
  • headache
  • incontinence
  • nightmare
  • agitation
5 - 10 years:
  • tinnitus
  • anxiety
  • short-term memory loss
  • depression
  • disseminated tuberculosis
  • pancytopenia
  • acid reflux
  • aggression
  • cerebral haemorrhage
  • confusion
10+ years:
  • headache - mixed tension migraine
  • lightheadedness - dizzy
  • shortness of breath
  • restless leg syndrome
  • aggression
  • depression
  • hair loss
  • libido decreased
  • neuropathy peripheral
  • suicidal ideation
not specified:
  • pain
  • nausea
  • arthralgia
  • fatigue
  • dyspnoea
  • anxiety
  • diarrhoea
  • vomiting
  • fall
  • back pain

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • arthralgia
  • anxiety
  • fatigue
  • diarrhoea
  • vomiting
  • back pain
  • dyspnoea
  • fall
male:
  • dyspnoea
  • nausea
  • anaemia
  • pain
  • vomiting
  • confusional state
  • asthenia
  • fatigue
  • arthralgia
  • pneumonia

Most common drug interactions by age *:

0-1:
  • leukocytoclastic vasculitis
  • muscular weakness
  • pain
  • pain of skin
  • proteinuria
  • renal failure acute
  • skin swelling
  • skin wrinkling
2-9:
  • sepsis
  • arthralgia
  • bone pain
  • respiratory failure
  • tumour lysis syndrome
  • pneumonia
  • renal failure
  • abdominal pain
  • somnolence
  • agitation
10-19:
  • rash
  • tremor
  • headache
  • flushing
  • confusional state
  • hallucination, visual
  • suicidal ideation
  • emotional distress
  • biliary dyskinesia
  • cholecystitis chronic
20-29:
  • cholecystitis chronic
  • nausea
  • diarrhoea
  • cholelithiasis
  • dyspnoea
  • gallbladder disorder
  • vomiting
  • pain
  • depression
  • anxiety
30-39:
  • headache
  • arthralgia
  • depression
  • anxiety
  • pyrexia
  • suicidal ideation
  • malaise
  • paraesthesia
  • vomiting
  • convulsion
40-49:
  • pain
  • chest pain
  • nausea
  • depression
  • back pain
  • arthralgia
  • anxiety
  • abdominal pain
  • pain in extremity
  • oedema peripheral
50-59:
  • nausea
  • pain
  • anxiety
  • diarrhoea
  • depression
  • fatigue
  • pyrexia
  • anaemia
  • constipation
  • arthralgia
60+:
  • pain
  • fall
  • dyspnoea
  • nausea
  • fatigue
  • diarrhoea
  • arthralgia
  • asthenia
  • anxiety
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Omeprazole (omeprazole) is often used to treat gastrooesophageal reflux disease. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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