Review: taking Tramadol and Omeprazole together


Summary

Drug interactions are reported among people who take Tramadol and Omeprazole together. This review analyzes the effectiveness and drug interactions between Tramadol and Omeprazole. It is created by eHealthMe based on reports of 7,787 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 52,446 users)

Omeprazole

Omeprazole has active ingredients of omeprazole. It is often used in gastrooesophageal reflux disease. (latest outcomes from Omeprazole 112,454 users)

On Aug, 26, 2016

7,787 people who take Tramadol, Omeprazole are studied.


Number of reports submitted per year:

Tramadol and Omeprazole drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 18.0% - (3 of 16 people)
  • 1 - 6 months: 35.0% - (11 of 31 people)
  • 6 - 12 months: 20.0% - (6 of 29 people)
  • 1 - 2 years: 37.0% - (13 of 35 people)
  • 2 - 5 years: 30.0% - (7 of 23 people)
  • 5 - 10 years: 16.0% - (3 of 18 people)
  • 10+ years: 20.0% - (2 of 10 people)
  • not specified: 0.0% - (0 of 1 people)
Omeprazole:
  • < 1 month: 40.0% - (2 of 5 people)
  • 1 - 6 months: 31.0% - (7 of 22 people)
  • 6 - 12 months: 41.0% - (7 of 17 people)
  • 1 - 2 years: 65.0% - (17 of 26 people)
  • 2 - 5 years: 62.0% - (25 of 40 people)
  • 5 - 10 years: 79.0% - (23 of 29 people)
  • 10+ years: 66.0% - (16 of 24 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Tramadol:
  • female: 30.0% - (35 of 115 people)
  • male: 20.0% - (10 of 48 people)
Omeprazole:
  • female: 58.0% - (69 of 117 people)
  • male: 58.0% - (28 of 48 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (3 of 3 people)
  • 20-29: 50.0% - (4 of 8 people)
  • 30-39: 40.0% - (10 of 25 people)
  • 40-49: 17.0% - (8 of 45 people)
  • 50-59: 26.0% - (10 of 38 people)
  • 60+: 22.0% - (10 of 44 people)
Omeprazole:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 50.0% - (4 of 8 people)
  • 30-39: 48.0% - (12 of 25 people)
  • 40-49: 47.0% - (21 of 44 people)
  • 50-59: 70.0% - (28 of 40 people)
  • 60+: 68.0% - (31 of 45 people)

Most common drug interactions over time *:

< 1 month:
  • pneumonia
  • vomiting
  • neutropenia
  • sepsis
  • anaemia
  • confusional state
  • pyrexia
  • thrombocytopenia
  • renal failure acute
  • respiratory failure
1 - 6 months:
  • abdominal pain
  • vomiting
  • serotonin syndrome
  • septic shock
  • anaemia
  • hyperkalaemia
  • muscle spasms
  • pneumonia
  • burning sensation
  • confusional state
6 - 12 months:
  • depression
  • nausea
  • constipation
  • bone pain
  • fibromyalgia
  • rls
  • vomiting
  • multiple fractures
  • osteoporosis
  • deep vein thrombosis
1 - 2 years:
  • depression
  • osteoporosis
  • erectile dysfunction
  • chest pain
  • myocardial infarction
  • nausea
  • dry mouth
  • anxiety
  • arrhythmia
  • arthritis
2 - 5 years:
  • depression
  • headache
  • anxiety
  • suicidal ideation
  • dizziness
  • asthenia
  • fatigue
  • serotonin syndrome
  • incontinence
  • pyrexia
5 - 10 years:
  • tinnitus
  • fibromyalgia
  • pain
  • asthma
  • coagulopathy
  • dementia
  • drug ineffective
  • lung abscess
  • lung disorder
  • pneumonia necrotising
10+ years:
  • depression
  • headache - mixed tension migraine
  • lightheadedness - dizzy
  • shortness of breath
  • anxiety
  • osteoporosis
  • restless leg syndrome
  • aggression
  • ankle fracture
  • arthritis
not specified:
  • pain
  • nausea
  • arthralgia
  • fatigue
  • dyspnoea
  • anxiety
  • diarrhoea
  • vomiting
  • fall
  • headache

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • arthralgia
  • fatigue
  • anxiety
  • dyspnoea
  • diarrhoea
  • headache
  • vomiting
  • fall
male:
  • dyspnoea
  • nausea
  • arthralgia
  • pain
  • fatigue
  • anaemia
  • vomiting
  • asthenia
  • depression
  • pneumonia

Most common drug interactions by age *:

0-1:
  • leukocytoclastic vasculitis
  • muscular weakness
  • pain
  • pain of skin
  • proteinuria
  • renal failure acute
  • skin swelling
  • skin wrinkling
2-9:
  • sepsis
  • arthralgia
  • bone pain
  • respiratory failure
  • tumour lysis syndrome
  • pneumonia
  • renal failure
  • abdominal pain
  • somnolence
  • hypertension
10-19:
  • headache
  • rash
  • tremor
  • suicidal ideation
  • flushing
  • anxiety
  • confusional state
  • emotional distress
  • hallucination, visual
  • pain
20-29:
  • cholecystitis chronic
  • diarrhoea
  • dyspnoea
  • pain
  • anxiety
  • depression
  • headache
  • nausea
  • tachycardia
  • cholelithiasis
30-39:
  • headache
  • arthralgia
  • pyrexia
  • vomiting
  • depression
  • dizziness
  • anxiety
  • malaise
  • suicidal ideation
  • fatigue
40-49:
  • pain
  • nausea
  • chest pain
  • depression
  • arthralgia
  • fatigue
  • back pain
  • anxiety
  • vomiting
  • abdominal pain
50-59:
  • pain
  • nausea
  • fatigue
  • diarrhoea
  • anxiety
  • arthralgia
  • depression
  • vomiting
  • pyrexia
  • fall
60+:
  • fall
  • dyspnoea
  • pain
  • arthralgia
  • nausea
  • diarrhoea
  • fatigue
  • asthenia
  • anxiety
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Omeprazole (omeprazole) is often used to treat gastrooesophageal reflux disease. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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