Review: taking Tramadol and Paxil together


Summary

Drug interactions are reported among people who take Tramadol and Paxil together. This review analyzes the effectiveness and drug interactions between Tramadol and Paxil. It is created by eHealthMe based on reports of 2,307 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 73,714 users)

Paxil

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. (latest outcomes from Paxil 78,933 users)

On Sep, 19, 2016

2,307 people who take Tramadol, Paxil are studied.


Number of reports submitted per year:

Tramadol and Paxil drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 23.0% - (3 of 13 people)
  • 1 - 6 months: 0.0% - (0 of 7 people)
  • 6 - 12 months: 28.0% - (2 of 7 people)
  • 1 - 2 years: 0.0% - (0 of 4 people)
  • 2 - 5 years: 0.0% - (0 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 5 people)
  • 10+ years: 0.0% - (0 of 1 people)
  • not specified: 50.0% - (1 of 2 people)
Paxil:
  • < 1 month: 25.0% - (1 of 4 people)
  • 1 - 6 months: 22.0% - (2 of 9 people)
  • 6 - 12 months: 12.0% - (1 of 8 people)
  • 1 - 2 years: 100.0% - (2 of 2 people)
  • 2 - 5 years: 40.0% - (2 of 5 people)
  • 5 - 10 years: 60.0% - (3 of 5 people)
  • 10+ years: 62.0% - (5 of 8 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Tramadol:
  • female: 10.0% - (3 of 28 people)
  • male: 23.0% - (3 of 13 people)
Paxil:
  • female: 32.0% - (9 of 28 people)
  • male: 53.0% - (7 of 13 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 16.0% - (1 of 6 people)
  • 40-49: 9.0% - (1 of 11 people)
  • 50-59: 20.0% - (2 of 10 people)
  • 60+: 0.0% - (0 of 8 people)
Paxil:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 33.0% - (1 of 3 people)
  • 30-39: 25.0% - (2 of 8 people)
  • 40-49: 45.0% - (5 of 11 people)
  • 50-59: 50.0% - (5 of 10 people)
  • 60+: 42.0% - (3 of 7 people)

Most common drug interactions over time *:

< 1 month:
  • pyrexia
  • tachycardia
  • gastrointestinal perforation
  • serotonin syndrome
  • hallucination
  • pain
  • nausea
  • gastrooesophageal reflux disease
  • abdominal pain
  • anaemia
1 - 6 months:
  • constipation
  • gastrooesophageal reflux disease
  • nausea
  • pain
  • anxiety
  • oedema peripheral
  • diarrhoea
  • oedema
  • pruritus
  • abdominal distension
6 - 12 months:
  • depression
  • constipation
  • anxiety
  • gastrooesophageal reflux disease
  • mitral valve incompetence
  • dizziness
  • drug ineffective
  • dry mouth
  • dyspepsia
  • ear pruritus
1 - 2 years:
  • depression
  • abdominal pain
  • anxiety
  • diabetes mellitus
  • chest pain
  • constipation
  • coronary artery disease
  • diarrhoea
  • gastroenteritis
  • insomnia
2 - 5 years:
  • depression
  • suicidal ideation
  • anxiety
  • dizziness
  • drug withdrawal syndrome
  • serotonin syndrome
  • fatigue
  • mood swings
  • pyrexia
  • cyanosis
5 - 10 years:
  • abnormal behaviour
  • anger
  • breast cancer female
  • depressive symptom
  • drug ineffective
  • mania
  • mood altered
  • nervous system disorder
  • premature menopause
  • psychomotor hyperactivity
10+ years:
  • serotonin syndrome
  • depression
  • headache
  • incontinence
  • dizziness
  • suicidal ideation
  • visual impairment
  • arthralgia
  • blood sodium decreased
  • eye pain
not specified:
  • anxiety
  • pain
  • nausea
  • depression
  • back pain
  • diarrhoea
  • fall
  • fatigue
  • arthralgia
  • dizziness

Most common drug interactions by gender *:

female:
  • anxiety
  • pain
  • nausea
  • depression
  • diarrhoea
  • dizziness
  • fatigue
  • dyspnoea
  • arthralgia
  • headache
male:
  • depression
  • anxiety
  • chest pain
  • pain
  • headache
  • suicidal ideation
  • drug ineffective
  • nausea
  • fatigue
  • dizziness

Most common drug interactions by age *:

0-1:
  • atrial septal defect
  • ventricular septal defect
  • heart disease congenital
  • maternal drugs affecting foetus
  • foetal exposure during pregnancy
  • tricuspid valve incompetence
  • chest pain
  • nephrolithiasis
  • pericardial effusion
  • pulmonary hypertension
10-19:
  • depression
  • completed suicide
  • suicidal ideation
  • abdominal distension
  • constipation
  • dyspepsia
  • faeces hard
  • gastrooesophageal reflux disease
  • haemorrhoids
  • oedema
20-29:
  • headache
  • depression
  • anxiety
  • suicidal ideation
  • swelling face
  • abdominal distension
  • dizziness
  • constipation
  • dyspepsia
  • vomiting
30-39:
  • headache
  • depression
  • anxiety
  • suicidal ideation
  • dizziness
  • paraesthesia
  • asthenia
  • hyperhidrosis
  • arthralgia
  • malaise
40-49:
  • anxiety
  • nausea
  • back pain
  • pain
  • depression
  • gastrooesophageal reflux disease
  • hypertension
  • fatigue
  • abdominal pain
  • neck pain
50-59:
  • pain
  • anxiety
  • fall
  • diarrhoea
  • nausea
  • anaemia
  • bone disorder
  • pyrexia
  • hypertension
  • constipation
60+:
  • pain
  • anxiety
  • fall
  • anaemia
  • dyspnoea
  • weight decreased
  • back pain
  • diarrhoea
  • pain in extremity
  • nausea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Paxil (paroxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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