Review: taking Tramadol and Prozac together


Summary

Drug interactions are reported among people who take Tramadol and Prozac together. This review analyzes the effectiveness and drug interactions between Tramadol and Prozac. It is created by eHealthMe based on reports of 2,435 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 49,036 users)

Prozac

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. (latest outcomes from Prozac 45,637 users)

On Aug, 20, 2016

2,435 people who take Tramadol, Prozac are studied.


Number of reports submitted per year:

Tramadol and Prozac drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 15.0% - (4 of 26 people)
  • 1 - 6 months: 26.0% - (4 of 15 people)
  • 6 - 12 months: 28.0% - (4 of 14 people)
  • 1 - 2 years: 16.0% - (3 of 18 people)
  • 2 - 5 years: 27.0% - (5 of 18 people)
  • 5 - 10 years: 46.0% - (6 of 13 people)
  • 10+ years: 100.0% - (3 of 3 people)
  • not specified: 0.0% - (0 of 2 people)
Prozac:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 25.0% - (6 of 24 people)
  • 6 - 12 months: 28.0% - (2 of 7 people)
  • 1 - 2 years: 36.0% - (8 of 22 people)
  • 2 - 5 years: 50.0% - (7 of 14 people)
  • 5 - 10 years: 50.0% - (10 of 20 people)
  • 10+ years: 58.0% - (10 of 17 people)
  • not specified: 50.0% - (1 of 2 people)

Drug effectiveness by gender:

Tramadol:
  • female: 22.0% - (19 of 84 people)
  • male: 40.0% - (10 of 25 people)
Prozac:
  • female: 42.0% - (37 of 88 people)
  • male: 30.0% - (8 of 26 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 1 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 40.0% - (4 of 10 people)
  • 30-39: 30.0% - (6 of 20 people)
  • 40-49: 31.0% - (11 of 35 people)
  • 50-59: 14.0% - (4 of 28 people)
  • 60+: 30.0% - (4 of 13 people)
Prozac:
  • 0-1: 0.0% - (0 of 1 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 66.0% - (8 of 12 people)
  • 30-39: 34.0% - (8 of 23 people)
  • 40-49: 47.0% - (16 of 34 people)
  • 50-59: 24.0% - (7 of 29 people)
  • 60+: 41.0% - (5 of 12 people)

Most common drug interactions over time *:

< 1 month:
  • hallucination
  • nausea
  • anaemia
  • cardiac arrest
  • hypokalaemia
  • malnutrition
  • memory impairment
  • oedema peripheral
  • thrombocytopenia
  • tremor
1 - 6 months:
  • pain
  • joint sprain
  • anxiety
  • depression
  • cholestasis
  • cyanosis
  • emotional distress
  • hepatitis
  • peripheral ischaemia
  • abdominal pain upper
6 - 12 months:
  • pancreatitis chronic
  • convulsion
  • increased tendency to bruise
  • tremor
  • abnormal weight gain
  • appetite increased
  • bone pain
  • decreased activity
  • decreased interest
  • diarrhoea
1 - 2 years:
  • hypertension
  • depression
  • hypoaesthesia
  • muscular weakness
  • pain in extremity
  • convulsion
  • completed suicide
  • hypoglycaemia
  • memory impairment
  • thinking abnormal
2 - 5 years:
  • depression
  • migraine
  • oedema peripheral
  • arthralgia
  • coronary artery disease
  • fatigue
  • headache
  • urinary tract infection
  • acute coronary syndrome
  • acute myocardial infarction
5 - 10 years:
  • anxiety
  • cyanosis
  • emotional distress
  • pain
  • peripheral ischaemia
  • arterial thrombosis
  • drug hypersensitivity
  • caries
  • depression
  • eosinophilic pustular foliculitis
10+ years:
  • depression
  • suicidal ideation
  • constipation
  • abnormal dreams
  • aggression
  • anxiety
  • crying
  • headache
  • hyperhidrosis
  • nausea
not specified:
  • pain
  • nausea
  • depression
  • fall
  • anxiety
  • back pain
  • dyspnoea
  • headache
  • fatigue
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • depression
  • nausea
  • fall
  • anxiety
  • headache
  • back pain
  • abdominal pain
  • arthralgia
  • dyspnoea
male:
  • nausea
  • depression
  • back pain
  • drug dependence
  • vomiting
  • dyspnoea
  • memory impairment
  • fatigue
  • anxiety
  • headache

Most common drug interactions by age *:

0-1:
  • atrial septal defect
  • heart disease congenital
  • maternal drugs affecting foetus
  • ventricular septal defect
  • blood chromogranin a increased
2-9:
  • abdominal pain
  • actinic keratosis
  • anaemia
  • appendicitis
  • bone disorder
  • cardiac failure congestive
  • cardiac murmur
  • cardiomyopathy
  • carpal tunnel syndrome
  • cerebral calcification
10-19:
  • depression
  • cholecystitis chronic
  • gallbladder disorder
  • aphasia
  • pain
  • pancreatitis
  • sphincter of oddi dysfunction
  • cholecystitis
  • biliary dyskinesia
  • cholelithiasis
20-29:
  • serotonin syndrome
  • multiple drug overdose
  • drug toxicity
  • headache
  • pulmonary oedema
  • pain
  • completed suicide
  • nausea
  • dyspnoea
  • dizziness
30-39:
  • depression
  • nausea
  • headache
  • hypertension
  • anxiety
  • arthralgia
  • dizziness
  • pain
  • bronchitis
  • pyrexia
40-49:
  • pain
  • depression
  • nausea
  • back pain
  • arthralgia
  • headache
  • fatigue
  • abdominal pain
  • tremor
  • sinusitis
50-59:
  • nausea
  • depression
  • fall
  • pain
  • anxiety
  • diarrhoea
  • hypertension
  • oedema peripheral
  • cough
  • anaemia
60+:
  • fall
  • pain
  • nausea
  • back pain
  • anxiety
  • dyspnoea
  • asthenia
  • diarrhoea
  • constipation
  • abdominal pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Prozac (fluoxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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