Review: taking Tramadol and Prozac together


Summary

Drug interactions are reported among people who take Tramadol and Prozac together. This review analyzes the effectiveness and drug interactions between Tramadol and Prozac. It is created by eHealthMe based on reports of 3,154 people who take the same drugs from FDA and social media, and is updated regularly.

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Tramadol

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 73,714 users)

Prozac

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. (latest outcomes from Prozac 55,554 users)

On Sep, 19, 2016

3,154 people who take Tramadol, Prozac are studied.


Number of reports submitted per year:

Tramadol and Prozac drug interactions.

Drug effectiveness over time:

Tramadol:
  • < 1 month: 15.0% - (4 of 26 people)
  • 1 - 6 months: 26.0% - (4 of 15 people)
  • 6 - 12 months: 28.0% - (4 of 14 people)
  • 1 - 2 years: 16.0% - (3 of 18 people)
  • 2 - 5 years: 27.0% - (5 of 18 people)
  • 5 - 10 years: 46.0% - (6 of 13 people)
  • 10+ years: 100.0% - (3 of 3 people)
  • not specified: 0.0% - (0 of 2 people)
Prozac:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 25.0% - (6 of 24 people)
  • 6 - 12 months: 28.0% - (2 of 7 people)
  • 1 - 2 years: 36.0% - (8 of 22 people)
  • 2 - 5 years: 50.0% - (7 of 14 people)
  • 5 - 10 years: 50.0% - (10 of 20 people)
  • 10+ years: 58.0% - (10 of 17 people)
  • not specified: 50.0% - (1 of 2 people)

Drug effectiveness by gender:

Tramadol:
  • female: 22.0% - (19 of 84 people)
  • male: 40.0% - (10 of 25 people)
Prozac:
  • female: 42.0% - (37 of 88 people)
  • male: 30.0% - (8 of 26 people)

Drug effectiveness by age:

Tramadol:
  • 0-1: 0.0% - (0 of 1 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 2 people)
  • 20-29: 40.0% - (4 of 10 people)
  • 30-39: 30.0% - (6 of 20 people)
  • 40-49: 31.0% - (11 of 35 people)
  • 50-59: 14.0% - (4 of 28 people)
  • 60+: 30.0% - (4 of 13 people)
Prozac:
  • 0-1: 0.0% - (0 of 1 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (1 of 3 people)
  • 20-29: 66.0% - (8 of 12 people)
  • 30-39: 34.0% - (8 of 23 people)
  • 40-49: 47.0% - (16 of 34 people)
  • 50-59: 24.0% - (7 of 29 people)
  • 60+: 41.0% - (5 of 12 people)

Most common drug interactions over time *:

< 1 month:
  • hallucination
  • nausea
  • anaemia
  • hypokalaemia
  • malnutrition
  • memory impairment
  • oedema peripheral
  • thrombocytopenia
  • psychotic disorder
  • cardiac arrest
1 - 6 months:
  • pain
  • anxiety
  • joint sprain
  • cyanosis
  • depression
  • diarrhoea
  • emotional distress
  • peripheral ischaemia
  • abdominal pain upper
  • back pain
6 - 12 months:
  • pancreatitis chronic
  • convulsion
  • dyspepsia
  • increased tendency to bruise
  • salivary hypersecretion
  • tremor
  • abnormal weight gain
  • appetite increased
  • bone pain
  • cardiac failure congestive
1 - 2 years:
  • hypertension
  • hypoaesthesia
  • muscular weakness
  • pain in extremity
  • depression
  • convulsion
  • completed suicide
  • hypoglycaemia
  • memory impairment
  • thinking abnormal
2 - 5 years:
  • aggression
  • depression
  • migraine
  • oedema peripheral
  • arthralgia
  • coronary artery disease
  • fatigue
  • headache
  • urinary tract infection
  • acute coronary syndrome
5 - 10 years:
  • anxiety
  • cyanosis
  • emotional distress
  • pain
  • peripheral ischaemia
  • drug hypersensitivity
  • arterial thrombosis
  • myocardial infarction
  • caries
  • depression
10+ years:
  • depression
  • headache
  • suicidal ideation
  • constipation
  • abnormal dreams
  • aggression
  • anxiety
  • crying
  • hyperhidrosis
  • nausea
not specified:
  • pain
  • nausea
  • depression
  • fall
  • anxiety
  • back pain
  • headache
  • dyspnoea
  • fatigue
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • depression
  • fall
  • anxiety
  • headache
  • arthralgia
  • diarrhoea
  • dyspnoea
  • pain in extremity
male:
  • nausea
  • depression
  • memory impairment
  • back pain
  • vomiting
  • fatigue
  • dyspnoea
  • drug dependence
  • anxiety
  • pain

Most common drug interactions by age *:

0-1:
  • atrial septal defect
  • heart disease congenital
  • maternal drugs affecting foetus
  • ventricular septal defect
  • blood chromogranin a increased
2-9:
  • decreased appetite
  • abdominal pain
  • actinic keratosis
  • anaemia
  • appendicitis
  • bone disorder
  • cardiac failure congestive
  • cardiac murmur
  • cardiomyopathy
  • carpal tunnel syndrome
10-19:
  • depression
  • cholecystitis chronic
  • gallbladder disorder
  • aphasia
  • pain
  • somnolence
  • bone pain
  • cataract
  • convulsion
  • osteoporosis
20-29:
  • serotonin syndrome
  • dyspnoea
  • multiple drug overdose
  • pain
  • urinary tract infection
  • headache
  • drug toxicity
  • pulmonary oedema
  • arthritis
  • depression
30-39:
  • depression
  • anxiety
  • nausea
  • dizziness
  • hypertension
  • arthralgia
  • headache
  • pyrexia
  • pain
  • bronchitis
40-49:
  • pain
  • depression
  • nausea
  • back pain
  • arthralgia
  • headache
  • fatigue
  • abdominal pain
  • tremor
  • sinusitis
50-59:
  • nausea
  • pain
  • fall
  • anxiety
  • depression
  • diarrhoea
  • oedema peripheral
  • headache
  • anaemia
  • hypertension
60+:
  • fall
  • pain
  • nausea
  • diarrhoea
  • asthenia
  • back pain
  • dyspnoea
  • anxiety
  • constipation
  • abdominal pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Prozac (fluoxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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