Review: taking Valium and Benadryl together


Summary

Drug interactions are reported among people who take Valium and Benadryl together. This review analyzes the effectiveness and drug interactions between Valium and Benadryl. It is created by eHealthMe based on reports of 1,336 people who take the same drugs from FDA and social media, and is updated regularly.

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Valium

Valium has active ingredients of diazepam. It is often used in stress and anxiety. (latest outcomes from Valium 21,503 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 29,242 users)

On Jul, 27, 2016

1,336 people who take Valium, Benadryl are studied.


Number of reports submitted per year:

Valium and Benadryl drug interactions.

Drug effectiveness over time:

Valium:
  • < 1 month: 33.0% - (6 of 18 people)
  • 1 - 6 months: 16.0% - (1 of 6 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 22.0% - (2 of 9 people)
  • 2 - 5 years: 45.0% - (5 of 11 people)
  • 5 - 10 years: 33.0% - (3 of 9 people)
  • 10+ years: 100.0% - (2 of 2 people)
  • not specified: 33.0% - (1 of 3 people)
Benadryl:
  • < 1 month: 22.0% - (4 of 18 people)
  • 1 - 6 months: 0.0% - (0 of 9 people)
  • 6 - 12 months: 0.0% - (0 of 3 people)
  • 1 - 2 years: 50.0% - (1 of 2 people)
  • 2 - 5 years: 16.0% - (2 of 12 people)
  • 5 - 10 years: 77.0% - (7 of 9 people)
  • 10+ years: 100.0% - (4 of 4 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Valium:
  • female: 27.0% - (12 of 44 people)
  • male: 47.0% - (8 of 17 people)
Benadryl:
  • female: 37.0% - (16 of 43 people)
  • male: 12.0% - (2 of 16 people)

Drug effectiveness by age:

Valium:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 1 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 30.0% - (3 of 10 people)
  • 30-39: 36.0% - (7 of 19 people)
  • 40-49: 36.0% - (4 of 11 people)
  • 50-59: 20.0% - (3 of 15 people)
  • 60+: 75.0% - (3 of 4 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 1 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 30.0% - (3 of 10 people)
  • 30-39: 50.0% - (9 of 18 people)
  • 40-49: 9.0% - (1 of 11 people)
  • 50-59: 21.0% - (3 of 14 people)
  • 60+: 50.0% - (2 of 4 people)

Most common drug interactions over time *:

< 1 month:
  • pain
  • renal failure
  • multi-organ failure
  • injury
  • chest pain
  • death
  • anxiety
  • emotional distress
  • renal injury
  • arthralgia
1 - 6 months:
  • vision blurred
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • chest tightness
  • diaphoresis
  • flushing
  • headache
  • hypernatraemia
  • hypertension aggravated
  • hypotension
6 - 12 months:
  • anhedonia
  • fever
  • inflammatory bowel disease
  • malaise
  • nausea postoperative
  • pancreatic pseudocyst
  • pulmonary embolism
  • tardive dyskinesia
1 - 2 years:
  • fatigue
  • constipation
  • dizziness
  • insomnia
  • loss of libido
  • rash
  • restlessness
  • accidental death
  • adjustment disorder with mixed anxiety and depressed mood
  • adrenal mass
2 - 5 years:
  • constipation
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • burning eyes
  • chronic pain
  • chronic pancreatitis
  • chronic sinusitis
  • cognitive deterioration
  • depression
  • diarrhea
  • dry mouth
5 - 10 years:
  • chest tightness
  • diaphoresis
  • flushing
  • headache
  • hypertension aggravated
  • muscle tightness
  • nervousness
  • reactive arthritis
  • skin burning sensation
  • tachycardia
10+ years:
  • folliculitis
  • insomnia
  • rash
  • adjustment disorder with mixed anxiety and depressed mood
  • adrenal mass
  • anhidrosis
  • appetite - decreased
  • arthritis
  • back pain
  • blepharitis
not specified:
  • pain
  • headache
  • anxiety
  • nausea
  • depression
  • fall
  • insomnia
  • back pain
  • dyspnoea
  • fatigue

Most common drug interactions by gender *:

female:
  • pain
  • headache
  • dyspnoea
  • fall
  • nausea
  • anxiety
  • depression
  • back pain
  • insomnia
  • chest pain
male:
  • anxiety
  • depression
  • pain
  • headache
  • nausea
  • asthenia
  • fatigue
  • insomnia
  • vomiting
  • back pain

Most common drug interactions by age *:

0-1:
  • bradycardia
  • brain hypoxia
  • cardio-respiratory arrest
  • circulatory collapse
  • constipation
  • convulsion
  • cyanosis
  • diarrhoea
  • ejection fraction decreased
  • hypoxia
2-9:
  • dyskinesia
  • dystonia
  • oculogyric crisis
  • aphasia
  • akinesia
  • epidermal necrolysis
  • haemorrhagic stroke
  • pyrexia
  • thrombocytopenia
  • blister
10-19:
  • overdose
  • acute respiratory distress syndrome
  • blood bilirubin increased
  • hypernatraemia
  • hypotension
  • pneumonia respiratory syncytial viral
  • pneumonitis
  • insomnia
  • mood swings
  • suicidal ideation
20-29:
  • death
  • multiple drug overdose
  • chest pain
  • drug abuse
  • accidental overdose
  • fatigue
  • pulmonary embolism
  • urticaria
  • asthenia
  • coma
30-39:
  • nausea
  • headache
  • pain
  • malaise
  • fatigue
  • dehydration
  • weight increased
  • cardio-respiratory arrest
  • insomnia
  • pyrexia
40-49:
  • depression
  • back pain
  • asthenia
  • headache
  • nausea
  • pain
  • anxiety
  • fall
  • insomnia
  • drug withdrawal syndrome
50-59:
  • chest pain
  • nausea
  • depression
  • pain
  • anxiety
  • fall
  • atelectasis
  • headache
  • insomnia
  • renal failure acute
60+:
  • dyspnoea
  • hypotension
  • pain
  • fall
  • fatigue
  • anxiety
  • osteonecrosis of jaw
  • osteomyelitis
  • chest pain
  • osteoarthritis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Valium (diazepam) is often used to treat stress and anxiety. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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