Valproate sodium and Topiramate drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Valproate sodium and Topiramate together. This review analyzes the effectiveness and drug interactions between Valproate sodium and Topiramate. It is created by eHealthMe based on reports of 1,052 people who take the same drugs from FDA, and is updated regularly.

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Valproate Sodium

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. (latest outcomes from Valproate sodium 13,330 users)

Topiramate

Topiramate has active ingredients of topiramate. It is often used in migraine. (latest outcomes from Topiramate 17,019 users)

On Feb, 18, 2017

1,052 people who take Valproate Sodium, Topiramate are studied.


Number of reports submitted per year:

Valproate sodium and Topiramate drug interactions.

Most common drug interactions over time *:

< 1 month:
  • dizziness
  • palpitations
  • chest discomfort
  • heart rate increased
  • hyperventilation
  • malaise
  • speech disorder
  • supraventricular tachycardia
  • tremor
  • drug ineffective
1 - 6 months:
  • convulsion
  • loss of consciousness
  • status epilepticus
  • cytomegalovirus infection
  • gamma-glutamyltransferase increased
  • hallucination
  • hiv infection
  • paranoia
  • drug ineffective
  • drug-induced liver injury
6 - 12 months:
  • drug rash with eosinophilia and systemic symptoms
  • hypersomnia
  • myocarditis
  • pyrexia
  • rash
  • thyroiditis
  • blood creatine phosphokinase increased
  • cardiac failure
  • cardiomegaly
  • erythema
1 - 2 years:
  • hypothyroidism
  • blood immunoglobulin a decreased
  • blood immunoglobulin g decreased
  • drug rash with eosinophilia and systemic symptoms
  • myocarditis
  • pyrexia
  • rash
  • subcutaneous abscess
  • thyroiditis
  • blood creatine phosphokinase increased
2 - 5 years:
  • memory impairment
  • psychotic disorder
  • anxiety
  • depression
  • loss of consciousness
  • abortion induced
  • acute respiratory distress syndrome
  • cardio-respiratory arrest
  • deafness
  • diplopia
5 - 10 years:
  • c-reactive protein increased
  • influenza a virus test positive
  • platelet count decreased
  • pyrexia
  • white blood cell count decreased
  • drug effect decreased
  • electroencephalogram abnormal
  • pain in extremity
  • sleep phase rhythm disturbance
10+ years:
  • anaemia
  • cerebral haemorrhage
  • cholestasis
  • depression
  • dermatitis medicamentosa
  • disseminated intravascular coagulation
  • dizziness
  • eosinophilia
  • epilepsy
  • exanthem
not specified:
  • drug ineffective
  • convulsion
  • status epilepticus
  • somnolence
  • epilepsy
  • grand mal convulsion
  • weight decreased
  • pyrexia
  • malaise
  • aggression

Most common drug interactions by gender *:

female:
  • drug ineffective
  • status epilepticus
  • convulsion
  • grand mal convulsion
  • tremor
  • malaise
  • epilepsy
  • speech disorder
  • dizziness
  • depression
male:
  • convulsion
  • drug ineffective
  • somnolence
  • aggression
  • sepsis
  • epilepsy
  • loss of consciousness
  • pyrexia
  • weight decreased
  • decreased appetite

Most common drug interactions by age *:

0-1:
  • convulsion
  • depressed level of consciousness
  • drug exposure during pregnancy
  • irritability
  • plasmodium falciparum infection
  • cleft palate
  • foetal anticonvulsant syndrome
  • pyrexia
  • atrial septal defect
  • disease recurrence
2-9:
  • drug ineffective
  • pyrexia
  • status epilepticus
  • rash
  • erythema
  • anorexia
  • hyperammonaemia
  • vomiting
  • convulsion
  • myocarditis
10-19:
  • drug ineffective
  • convulsion
  • loss of consciousness
  • epilepsy
  • cataract
  • grand mal convulsion
  • speech disorder
  • orthostatic hypotension
  • thyroiditis subacute
  • psychotic disorder
20-29:
  • aggression
  • abnormal behaviour
  • drug ineffective
  • epilepsy
  • disturbance in attention
  • convulsion
  • impulse-control disorder
  • weight decreased
  • memory impairment
  • weight increased
30-39:
  • psychotic disorder
  • drug ineffective
  • convulsion
  • hallucination, auditory
  • malaise
  • mental disorder
  • blood cholesterol increased
  • decreased appetite
  • weight decreased
  • somnolence
40-49:
  • somnolence
  • drug ineffective
  • weight increased
  • haemoglobin decreased
  • aggression
  • blood glucose increased
  • cardiac failure
  • gaze palsy
  • thrombocytopenia
  • convulsion
50-59:
  • tremor
  • chest discomfort
  • dizziness
  • heart rate increased
  • hyperventilation
  • malaise
  • palpitations
  • speech disorder
  • supraventricular tachycardia
  • hyperammonaemic encephalopathy
60+:
  • drug ineffective
  • electroencephalogram abnormal
  • erythema
  • agitation
  • somnolence
  • convulsion
  • aggression
  • blood creatinine increased
  • cardiac arrest
  • ileus

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Valproate sodium and Topiramate?

Interactions between Valproate sodium and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Topiramate and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Valproate sodium (valproate sodium) is often used to treat epilepsy. Topiramate (topiramate) is often used to treat epilepsy. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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