Review: taking Valproate sodium and Topiramate together


Summary

Drug interactions are reported among people who take Valproate sodium and Topiramate together. This review analyzes the effectiveness and drug interactions between Valproate sodium and Topiramate. It is created by eHealthMe based on reports of 719 people who take the same drugs from FDA and social media, and is updated regularly.

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Valproate Sodium

Valproate sodium has active ingredients of valproate sodium. It is often used in epilepsy. (latest outcomes from Valproate sodium 11,918 users)

Topiramate

Topiramate has active ingredients of topiramate. It is often used in epilepsy. (latest outcomes from Topiramate 8,515 users)

On Jul, 30, 2016

719 people who take Valproate Sodium, Topiramate are studied.


Number of reports submitted per year:

Valproate sodium and Topiramate drug interactions.

Drug effectiveness over time:

Valproate Sodium:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 0 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 50.0% - (1 of 2 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 0 people)
Topiramate:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 75.0% - (3 of 4 people)
  • 2 - 5 years: 50.0% - (1 of 2 people)
  • 5 - 10 years: 0.0% - (0 of 1 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Valproate Sodium:
  • female: 42.0% - (3 of 7 people)
  • male: 50.0% - (1 of 2 people)
Topiramate:
  • female: 42.0% - (3 of 7 people)
  • male: 100.0% - (1 of 1 people)

Drug effectiveness by age:

Valproate Sodium:
  • 0-1: 100.0% - (1 of 1 people)
  • 2-9: 100.0% - (1 of 1 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 66.0% - (2 of 3 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 0.0% - (0 of 1 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 1 people)
Topiramate:
  • 0-1: 0.0% - (0 of 1 people)
  • 2-9: 100.0% - (1 of 1 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 100.0% - (3 of 3 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 0.0% - (0 of 0 people)
  • 50-59: 0.0% - (0 of 0 people)
  • 60+: 0.0% - (0 of 1 people)

Most common drug interactions over time *:

< 1 month:
  • drug ineffective
  • gamma-glutamyltransferase increased
  • platelet count decreased
  • systemic lupus erythematosus
  • white blood cell count decreased
  • dizziness
  • bradycardia
  • convulsion
  • nausea
  • orthostatic hypotension
1 - 6 months:
  • convulsion
  • status epilepticus
  • cytomegalovirus infection
  • gamma-glutamyltransferase increased
  • hiv infection
  • drug ineffective
  • drug-induced liver injury
  • hypertonia
  • intentional self-injury
  • muscle rigidity
6 - 12 months:
  • drug rash with eosinophilia and systemic symptoms
  • myocarditis
  • pyrexia
  • rash
  • thyroiditis
  • blood creatine phosphokinase increased
  • cardiac failure
  • cardiomegaly
  • erythema
  • hepatic function abnormal
1 - 2 years:
  • hypothyroidism
  • drug rash with eosinophilia and systemic symptoms
  • myocarditis
  • pyrexia
  • rash
  • thyroiditis
  • blood creatine phosphokinase increased
  • cardiac failure
  • cardiomegaly
  • drug ineffective
2 - 5 years:
  • memory impairment
  • psychotic disorder
  • headache
  • abortion induced
  • anxiety
  • deafness
  • depression
  • diplopia
  • disturbance in attention
  • dysarthria
5 - 10 years:
  • c-reactive protein increased
  • influenza a virus test positive
  • platelet count decreased
  • pyrexia
  • white blood cell count decreased
  • confusion
  • drug effect decreased
  • electroencephalogram abnormal
  • foetal valproate syndrome
  • memory impairment
10+ years:
  • anaemia
  • cerebral haemorrhage
  • cholestasis
  • depression
  • dermatitis medicamentosa
  • disseminated intravascular coagulation
  • eosinophilia
  • epilepsy
  • exanthem
  • hepatic failure
not specified:
  • drug ineffective
  • convulsion
  • status epilepticus
  • somnolence
  • grand mal convulsion
  • weight decreased
  • pyrexia
  • drug exposure during pregnancy
  • epilepsy
  • aggression

Most common drug interactions by gender *:

female:
  • drug ineffective
  • status epilepticus
  • convulsion
  • grand mal convulsion
  • pyrexia
  • epilepsy
  • weight decreased
  • drug exposure during pregnancy
  • malaise
  • gait disturbance
male:
  • convulsion
  • somnolence
  • drug ineffective
  • sepsis
  • aggression
  • blood glucose increased
  • platelet count decreased
  • pyrexia
  • weight decreased
  • renal failure

Most common drug interactions by age *:

0-1:
  • depressed level of consciousness
  • drug exposure during pregnancy
  • convulsion
  • irritability
  • plasmodium falciparum infection
  • cleft palate
  • foetal anticonvulsant syndrome
  • pyrexia
  • atrial septal defect
  • disease recurrence
2-9:
  • status epilepticus
  • pyrexia
  • drug ineffective
  • anorexia
  • rash
  • erythema
  • hyperammonaemia
  • vomiting
  • asthenia
  • convulsion
10-19:
  • drug ineffective
  • convulsion
  • epilepsy
  • loss of consciousness
  • grand mal convulsion
  • orthostatic hypotension
  • thyroiditis subacute
  • weight decreased
  • malaise
  • complex partial seizures
20-29:
  • aggression
  • abnormal behaviour
  • disturbance in attention
  • convulsion
  • impulse-control disorder
  • grand mal convulsion
  • sudden unexplained death in epilepsy
  • mood altered
  • cognitive disorder
  • confusional state
30-39:
  • psychotic disorder
  • drug ineffective
  • convulsion
  • hallucination, auditory
  • mental disorder
  • blood cholesterol increased
  • malaise
  • weight decreased
  • blood glucose increased
  • decreased appetite
40-49:
  • somnolence
  • blood glucose increased
  • cardiac failure
  • gaze palsy
  • haemoglobin decreased
  • thrombocytopenia
  • weight decreased
  • blood potassium increased
  • depression
  • memory impairment
50-59:
  • hemiparesis
  • alopecia
  • anticonvulsant drug level increased
  • convulsion
  • dyspnoea
  • hyperammonaemic encephalopathy
  • arteriosclerosis
  • astrocytoma malignant
  • bradycardia
  • cardiac arrest
60+:
  • agitation
  • electroencephalogram abnormal
  • aggression
  • blood creatinine increased
  • cardiac arrest
  • ileus
  • myocardial infarction
  • somnolence
  • abdominal distension
  • biliary tract disorder

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Valproate sodium (valproate sodium) is often used to treat epilepsy. Topiramate (topiramate) is often used to treat epilepsy. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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