Review: taking Vicodin and Benadryl together


Summary

Drug interactions are reported among people who take Vicodin and Benadryl together. This review analyzes the effectiveness and drug interactions between Vicodin and Benadryl. It is created by eHealthMe based on reports of 4,694 people who take the same drugs from FDA and social media, and is updated regularly.

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Vicodin

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from Vicodin 45,484 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 18, 2016

4,694 people who take Vicodin, Benadryl are studied.


Number of reports submitted per year:

Vicodin and Benadryl drug interactions.

Drug effectiveness over time:

Vicodin:
  • < 1 month: 44.0% - (11 of 25 people)
  • 1 - 6 months: 37.0% - (6 of 16 people)
  • 6 - 12 months: 28.0% - (2 of 7 people)
  • 1 - 2 years: 38.0% - (5 of 13 people)
  • 2 - 5 years: 42.0% - (6 of 14 people)
  • 5 - 10 years: 55.0% - (5 of 9 people)
  • 10+ years: 25.0% - (1 of 4 people)
  • not specified: 0.0% - (0 of 0 people)
Benadryl:
  • < 1 month: 24.0% - (7 of 29 people)
  • 1 - 6 months: 33.0% - (4 of 12 people)
  • 6 - 12 months: 60.0% - (3 of 5 people)
  • 1 - 2 years: 18.0% - (2 of 11 people)
  • 2 - 5 years: 25.0% - (3 of 12 people)
  • 5 - 10 years: 40.0% - (4 of 10 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Vicodin:
  • female: 40.0% - (27 of 67 people)
  • male: 42.0% - (9 of 21 people)
Benadryl:
  • female: 29.0% - (19 of 64 people)
  • male: 33.0% - (7 of 21 people)

Drug effectiveness by age:

Vicodin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 50.0% - (8 of 16 people)
  • 30-39: 37.0% - (9 of 24 people)
  • 40-49: 41.0% - (10 of 24 people)
  • 50-59: 41.0% - (5 of 12 people)
  • 60+: 33.0% - (4 of 12 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 46.0% - (7 of 15 people)
  • 30-39: 29.0% - (7 of 24 people)
  • 40-49: 17.0% - (4 of 23 people)
  • 50-59: 45.0% - (5 of 11 people)
  • 60+: 25.0% - (3 of 12 people)

Most common drug interactions over time *:

< 1 month:
  • pain
  • anxiety
  • pruritus
  • injury
  • pain in extremity
  • oedema peripheral
  • emotional distress
  • burning sensation
  • erythema
  • dermatitis
1 - 6 months:
  • haemorrhage intracranial
  • hypotension
  • sepsis
  • acute respiratory failure
  • death
  • failure to thrive
  • convulsion
  • pneumonia streptococcal
  • pulmonary embolism
  • nausea
6 - 12 months:
  • constipation
  • ileus
  • abnormal dreams
  • fall
  • pain
  • abdominal pain
  • adrenal insufficiency
  • anxiety
  • confusional state
  • dizziness postural
1 - 2 years:
  • iron deficiency anemia
  • chills
  • flank pain
  • headache
  • nausea
  • anaemia
  • arthritis
  • blood pressure increased
  • body overheating
  • chest discomfort
2 - 5 years:
  • hematospermia
  • dizziness
  • abdominal distension
  • agitation aggravated
  • chest wall pain
  • crying
  • impaired memory
  • insomnia
  • oedema
  • stomach discomfort
5 - 10 years:
  • anxiety
  • acid reflux
  • allergy to animal
  • allergy to chemicals
  • allergy to plants
  • back pain - low
  • eczema
  • excessive thirst
  • genital pain
  • high blood pressure
10+ years:
  • cough
  • decreased appetite
  • diarrhoea
  • fatigue
  • suicidal ideation
  • alopecia
  • balance disorder
  • decreased interest
  • depression
  • depression aggravated
not specified:
  • pain
  • anxiety
  • nausea
  • fatigue
  • dyspnoea
  • back pain
  • arthralgia
  • anaemia
  • fall
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fatigue
  • fall
  • arthralgia
  • back pain
  • anaemia
  • pain in extremity
male:
  • pain
  • anxiety
  • fatigue
  • nausea
  • back pain
  • dyspnoea
  • asthenia
  • arthralgia
  • anaemia
  • depression

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • abdominal pain
  • agitation
  • antepartum haemorrhage
  • apnoea
  • choking
  • cleft palate
  • cough
  • crying
  • deafness
2-9:
  • anaemia
  • heart rate increased
  • hypotension
  • overdose
  • pneumonitis
  • pyrexia
  • respiratory depression
  • respiratory failure
  • somnolence
  • aortic disorder
10-19:
  • hypotension
  • pain
  • blood bilirubin increased
  • acute respiratory failure
  • deep vein thrombosis
  • haemorrhage intracranial
  • nausea
  • cholecystitis chronic
  • convulsion
  • headache
20-29:
  • pain
  • nausea
  • back pain
  • abdominal pain upper
  • injury
  • pulmonary embolism
  • vomiting
  • headache
  • anxiety
  • fatigue
30-39:
  • pain
  • fatigue
  • drug abuse
  • nausea
  • anaemia
  • depression
  • dyspnoea
  • weight increased
  • abdominal pain
  • arthralgia
40-49:
  • pain
  • anxiety
  • nausea
  • back pain
  • dyspnoea
  • fatigue
  • arthralgia
  • vomiting
  • chest pain
  • headache
50-59:
  • pain
  • anxiety
  • nausea
  • injury
  • fall
  • pyrexia
  • back pain
  • pain in extremity
  • diarrhoea
  • osteoarthritis
60+:
  • pain
  • dyspnoea
  • anaemia
  • fatigue
  • anxiety
  • fall
  • asthenia
  • nausea
  • pneumonia
  • arthralgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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