Vicodin and Benadryl drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Vicodin and Benadryl together. This review analyzes the effectiveness and drug interactions between Vicodin and Benadryl. It is created by eHealthMe based on reports of 4,752 people who take the same drugs from FDA, and is updated regularly.

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Vicodin

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from Vicodin 46,134 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 44,710 users)

On Feb, 08, 2017

4,752 people who take Vicodin, Benadryl are studied.


Number of reports submitted per year:

Vicodin and Benadryl drug interactions.

Most common drug interactions over time *:

< 1 month:
  • pain
  • anxiety
  • pruritus
  • injury
  • pain in extremity
  • oedema peripheral
  • emotional distress
  • burning sensation
  • erythema
  • dermatitis
1 - 6 months:
  • haemorrhage intracranial
  • hypotension
  • sepsis
  • acute respiratory failure
  • death
  • failure to thrive
  • convulsion
  • pneumonia streptococcal
  • pulmonary embolism
  • nausea
6 - 12 months:
  • constipation
  • ileus
  • abnormal dreams
  • pain
  • anxiety
  • confusional state
  • dry mouth
  • fall
  • abdominal pain
  • adrenal insufficiency
1 - 2 years:
  • anaemia
  • exostosis
  • hyperthyroidism
  • incontinence
  • intervertebral disc protrusion
  • drug ineffective
  • blood pressure increased
  • chest discomfort
  • chills
  • cough
2 - 5 years:
  • oedema
  • sleep apnoea syndrome
  • abscess limb
  • anaemia
  • blood creatinine increased
  • blood pressure increased
  • breast inflammation
  • breast pain
  • cardiac disorder
  • cardiomyopathy
5 - 10 years:
  • impaired healing
  • pneumonia
  • skin ulcer
  • lobar pneumonia
  • abdominal pain
  • accidental overdose
  • anaemia
  • anxiety
  • arthralgia
  • asthenia
10+ years:
  • chronic fatigue syndrome
  • depression
  • abdominal pain
  • anxiety
  • arthralgia
  • asthenia
  • back pain
  • bladder spasm
  • bronchitis
  • bunion
not specified:
  • pain
  • anxiety
  • nausea
  • fatigue
  • dyspnoea
  • back pain
  • arthralgia
  • anaemia
  • fall
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fatigue
  • fall
  • arthralgia
  • back pain
  • anaemia
  • pain in extremity
male:
  • pain
  • anxiety
  • fatigue
  • nausea
  • back pain
  • dyspnoea
  • asthenia
  • arthralgia
  • anaemia
  • depression

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • abdominal pain
  • agitation
  • antepartum haemorrhage
  • apnoea
  • choking
  • cleft palate
  • cough
  • crying
  • deafness
2-9:
  • respiratory failure
  • anaemia
  • heart rate increased
  • hypotension
  • overdose
  • pneumonitis
  • pulmonary oedema
  • pyrexia
  • respiratory depression
  • somnolence
10-19:
  • hypotension
  • pain
  • blood bilirubin increased
  • acute respiratory failure
  • deep vein thrombosis
  • haemorrhage intracranial
  • nausea
  • cholecystitis chronic
  • convulsion
  • headache
20-29:
  • pain
  • nausea
  • back pain
  • abdominal pain upper
  • injury
  • pulmonary embolism
  • vomiting
  • anxiety
  • headache
  • fatigue
30-39:
  • pain
  • fatigue
  • drug abuse
  • anaemia
  • nausea
  • depression
  • dyspnoea
  • abdominal pain
  • weight increased
  • arthralgia
40-49:
  • pain
  • anxiety
  • nausea
  • back pain
  • dyspnoea
  • fatigue
  • arthralgia
  • vomiting
  • chest pain
  • headache
50-59:
  • pain
  • anxiety
  • nausea
  • injury
  • fall
  • pyrexia
  • back pain
  • pain in extremity
  • diarrhoea
  • osteoarthritis
60+:
  • pain
  • dyspnoea
  • anaemia
  • fatigue
  • anxiety
  • fall
  • asthenia
  • nausea
  • pneumonia
  • arthralgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Vicodin and Benadryl?

Interactions between Vicodin and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Benadryl and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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