Review: taking Vicodin and Cymbalta together


Summary

Drug interactions are reported among people who take Vicodin and Cymbalta together. This review analyzes the effectiveness and drug interactions between Vicodin and Cymbalta. It is created by eHealthMe based on reports of 3,560 people who take the same drugs from FDA and social media, and is updated regularly.

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Vicodin

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from Vicodin 34,634 users)

Cymbalta

Cymbalta has active ingredients of duloxetine. It is often used in depression. (latest outcomes from Cymbalta 48,473 users)

On Jul, 20, 2016

3,560 people who take Vicodin, Cymbalta are studied.


Number of reports submitted per year:

Vicodin and Cymbalta drug interactions.

Drug effectiveness over time:

Vicodin:
  • < 1 month: 26.0% - (13 of 50 people)
  • 1 - 6 months: 34.0% - (20 of 58 people)
  • 6 - 12 months: 51.0% - (18 of 35 people)
  • 1 - 2 years: 38.0% - (28 of 73 people)
  • 2 - 5 years: 37.0% - (45 of 119 people)
  • 5 - 10 years: 38.0% - (26 of 67 people)
  • 10+ years: 36.0% - (13 of 36 people)
  • not specified: 0.0% - (0 of 3 people)
Cymbalta:
  • < 1 month: 12.0% - (6 of 49 people)
  • 1 - 6 months: 29.0% - (23 of 79 people)
  • 6 - 12 months: 42.0% - (22 of 52 people)
  • 1 - 2 years: 18.0% - (13 of 69 people)
  • 2 - 5 years: 28.0% - (31 of 109 people)
  • 5 - 10 years: 31.0% - (14 of 45 people)
  • 10+ years: 33.0% - (6 of 18 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Vicodin:
  • female: 36.0% - (124 of 342 people)
  • male: 39.0% - (39 of 99 people)
Cymbalta:
  • female: 29.0% - (96 of 330 people)
  • male: 20.0% - (19 of 93 people)

Drug effectiveness by age:

Vicodin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 33.0% - (12 of 36 people)
  • 30-39: 27.0% - (23 of 83 people)
  • 40-49: 41.0% - (62 of 149 people)
  • 50-59: 40.0% - (47 of 116 people)
  • 60+: 32.0% - (18 of 56 people)
Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 36.0% - (12 of 33 people)
  • 30-39: 18.0% - (14 of 75 people)
  • 40-49: 30.0% - (45 of 148 people)
  • 50-59: 33.0% - (38 of 113 people)
  • 60+: 9.0% - (5 of 53 people)

Most common drug interactions over time *:

< 1 month:
  • malaise
  • fall
  • feeling abnormal
  • anxiety
  • suicidal ideation
  • irritability
  • abnormal behaviour
  • hypertension
  • insomnia
  • pain in extremity
1 - 6 months:
  • dizziness
  • aspartate aminotransferase increased
  • alanine aminotransferase increased
  • blood alkaline phosphatase increased
  • pneumonia
  • headache
  • loss of consciousness
  • drug ineffective
  • pain
  • depression
6 - 12 months:
  • back pain
  • red face
  • anxiety
  • feeling abnormal
  • suicidal ideation
  • depressed mood
  • malaise
  • drug withdrawal syndrome
  • pain in extremity
  • abnormal behaviour
1 - 2 years:
  • depression
  • drug ineffective
  • insomnia
  • tinnitus
  • anxiety
  • arthralgia
  • fatigue
  • agitation
  • asthenia
  • confusional state
2 - 5 years:
  • depression
  • fatigue
  • anger
  • anxiety
  • dizziness
  • pain
  • insomnia
  • constipation
  • headache
  • pancreatitis
5 - 10 years:
  • sexual apathy
  • anxiety disorder due to a general medical condition
  • back injury
  • degenerative joint disease
  • lumbar spinal stenosis
  • major depressive disorder
  • depression
  • fatigue aggravated
  • nausea
  • drug withdrawal syndrome
10+ years:
  • high blood cholesterol
  • high blood sugar
  • nausea
  • fatigue
  • depression
  • fatigue aggravated
  • high blood pressure
  • muscle cramps aggravated
  • weight gain
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
not specified:
  • pain
  • anxiety
  • nausea
  • fall
  • back pain
  • depression
  • insomnia
  • arthralgia
  • fatigue
  • headache

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • fall
  • nausea
  • depression
  • arthralgia
  • back pain
  • insomnia
  • headache
  • dizziness
male:
  • pain
  • anxiety
  • back pain
  • depression
  • fall
  • nausea
  • fatigue
  • vomiting
  • weight decreased
  • dyspnoea

Most common drug interactions by age *:

0-1:
  • abortion induced
  • congenital central nervous system anomaly
  • congenital hydrocephalus
  • maternal drugs affecting foetus
  • meningomyelocele
  • neural tube defect
  • spina bifida
  • talipes
  • blood cholesterol increased
  • obesity
10-19:
  • cholecystitis chronic
  • pain
  • gallbladder disorder
  • pancreatitis
  • sphincter of oddi dysfunction
  • abdominal pain upper
  • headache
  • anger
  • anxiety
  • arthralgia
20-29:
  • pain
  • nausea
  • migraine
  • pneumonia
  • headache
  • abdominal pain upper
  • vomiting
  • deep vein thrombosis
  • cholecystitis chronic
  • insomnia
30-39:
  • pain
  • nausea
  • depression
  • anxiety
  • abdominal pain upper
  • fatigue
  • headache
  • weight increased
  • drug ineffective
  • abdominal pain
40-49:
  • pain
  • fatigue
  • fall
  • back pain
  • nausea
  • anxiety
  • headache
  • drug ineffective
  • vomiting
  • constipation
50-59:
  • pain
  • anxiety
  • fall
  • nausea
  • injury
  • insomnia
  • arthralgia
  • pyrexia
  • chest pain
  • back pain
60+:
  • pain
  • anxiety
  • fall
  • nausea
  • depression
  • back pain
  • dyspnoea
  • vomiting
  • arthralgia
  • hypertension

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Cymbalta (duloxetine) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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