Review: taking Vicodin and Cymbalta together


Summary

Drug interactions are reported among people who take Vicodin and Cymbalta together. This review analyzes the effectiveness and drug interactions between Vicodin and Cymbalta. It is created by eHealthMe based on reports of 4,504 people who take the same drugs from FDA and social media, and is updated regularly.

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Vicodin

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from Vicodin 40,314 users)

Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 58,912 users)

On Aug, 26, 2016

4,504 people who take Vicodin, Cymbalta are studied.


Number of reports submitted per year:

Vicodin and Cymbalta drug interactions.

Drug effectiveness over time:

Vicodin:
  • < 1 month: 25.0% - (9 of 35 people)
  • 1 - 6 months: 37.0% - (20 of 54 people)
  • 6 - 12 months: 54.0% - (17 of 31 people)
  • 1 - 2 years: 33.0% - (19 of 56 people)
  • 2 - 5 years: 41.0% - (33 of 80 people)
  • 5 - 10 years: 40.0% - (18 of 45 people)
  • 10+ years: 35.0% - (7 of 20 people)
  • not specified: 0.0% - (0 of 3 people)
Cymbalta:
  • < 1 month: 11.0% - (4 of 35 people)
  • 1 - 6 months: 29.0% - (21 of 72 people)
  • 6 - 12 months: 31.0% - (12 of 38 people)
  • 1 - 2 years: 23.0% - (12 of 52 people)
  • 2 - 5 years: 35.0% - (25 of 71 people)
  • 5 - 10 years: 25.0% - (7 of 28 people)
  • 10+ years: 45.0% - (5 of 11 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Vicodin:
  • female: 37.0% - (96 of 254 people)
  • male: 38.0% - (27 of 70 people)
Cymbalta:
  • female: 29.0% - (72 of 245 people)
  • male: 21.0% - (14 of 64 people)

Drug effectiveness by age:

Vicodin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 38.0% - (10 of 26 people)
  • 30-39: 30.0% - (21 of 70 people)
  • 40-49: 39.0% - (41 of 103 people)
  • 50-59: 45.0% - (37 of 81 people)
  • 60+: 30.0% - (13 of 43 people)
Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 40.0% - (10 of 25 people)
  • 30-39: 24.0% - (15 of 62 people)
  • 40-49: 26.0% - (27 of 101 people)
  • 50-59: 35.0% - (28 of 79 people)
  • 60+: 12.0% - (5 of 41 people)

Most common drug interactions over time *:

< 1 month:
  • malaise
  • fall
  • feeling abnormal
  • anxiety
  • irritability
  • suicidal ideation
  • insomnia
  • pain in extremity
  • abnormal behaviour
  • drug ineffective
1 - 6 months:
  • dizziness
  • pain
  • aspartate aminotransferase increased
  • anxiety
  • blood alkaline phosphatase increased
  • depression
  • alanine aminotransferase increased
  • drug ineffective
  • headache
  • loss of consciousness
6 - 12 months:
  • back pain
  • red face
  • anxiety
  • feeling abnormal
  • suicidal ideation
  • depressed mood
  • drug withdrawal syndrome
  • malaise
  • dizziness
  • hepatic function abnormal
1 - 2 years:
  • depression
  • drug ineffective
  • anxiety
  • insomnia
  • tinnitus
  • arthralgia
  • confusional state
  • amnesia
  • fatigue
  • agitation
2 - 5 years:
  • depression
  • fatigue
  • anger
  • pain
  • anxiety
  • dizziness
  • constipation
  • insomnia
  • headache
  • pancreatitis
5 - 10 years:
  • sexual apathy
  • anxiety disorder due to a general medical condition
  • back injury
  • degenerative joint disease
  • depression
  • lumbar spinal stenosis
  • major depressive disorder
  • anxiety
  • fatigue aggravated
  • nausea
10+ years:
  • high blood cholesterol
  • high blood sugar
  • nausea
  • fatigue
  • depression
  • fatigue aggravated
  • high blood pressure
  • muscle cramps aggravated
  • weight gain
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
not specified:
  • pain
  • anxiety
  • nausea
  • fall
  • back pain
  • depression
  • arthralgia
  • headache
  • fatigue
  • pain in extremity

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • fall
  • depression
  • arthralgia
  • back pain
  • drug ineffective
  • headache
  • fatigue
male:
  • pain
  • back pain
  • anxiety
  • depression
  • nausea
  • fall
  • dyspnoea
  • fatigue
  • headache
  • pneumonia

Most common drug interactions by age *:

0-1:
  • abortion induced
  • blood cholesterol increased
  • congenital central nervous system anomaly
  • congenital hydrocephalus
  • maternal drugs affecting foetus
  • meningomyelocele
  • neural tube defect
  • obesity
  • spina bifida
  • talipes
10-19:
  • pain
  • cholecystitis chronic
  • gallbladder disorder
  • pancreatitis
  • sphincter of oddi dysfunction
  • fatigue
  • anxiety
  • arthralgia
  • headache
  • pneumonia
20-29:
  • pain
  • nausea
  • deep vein thrombosis
  • pneumonia
  • abdominal pain upper
  • migraine
  • headache
  • cholecystitis chronic
  • vomiting
  • anxiety
30-39:
  • pain
  • nausea
  • depression
  • anxiety
  • fatigue
  • headache
  • dyspnoea
  • arthralgia
  • pulmonary embolism
  • vomiting
40-49:
  • pain
  • fatigue
  • back pain
  • drug ineffective
  • nausea
  • fall
  • anxiety
  • headache
  • pain in extremity
  • gait disturbance
50-59:
  • pain
  • anxiety
  • nausea
  • fall
  • insomnia
  • arthralgia
  • injury
  • diarrhoea
  • depression
  • headache
60+:
  • pain
  • anxiety
  • fall
  • nausea
  • dyspnoea
  • back pain
  • depression
  • arthralgia
  • fatigue
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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