Review: taking Vicodin and Cymbalta together


Summary

Drug interactions are reported among people who take Vicodin and Cymbalta together. This review analyzes the effectiveness and drug interactions between Vicodin and Cymbalta. It is created by eHealthMe based on reports of 6,148 people who take the same drugs from FDA and social media, and is updated regularly.

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Vicodin

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from Vicodin 45,484 users)

Cymbalta

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 89,413 users)

On Sep, 17, 2016

6,148 people who take Vicodin, Cymbalta are studied.


Number of reports submitted per year:

Vicodin and Cymbalta drug interactions.

Drug effectiveness over time:

Vicodin:
  • < 1 month: 25.0% - (9 of 35 people)
  • 1 - 6 months: 37.0% - (20 of 54 people)
  • 6 - 12 months: 53.0% - (17 of 32 people)
  • 1 - 2 years: 34.0% - (19 of 55 people)
  • 2 - 5 years: 41.0% - (33 of 80 people)
  • 5 - 10 years: 40.0% - (18 of 45 people)
  • 10+ years: 35.0% - (7 of 20 people)
  • not specified: 0.0% - (0 of 3 people)
Cymbalta:
  • < 1 month: 11.0% - (4 of 35 people)
  • 1 - 6 months: 29.0% - (21 of 72 people)
  • 6 - 12 months: 31.0% - (12 of 38 people)
  • 1 - 2 years: 23.0% - (12 of 52 people)
  • 2 - 5 years: 35.0% - (25 of 71 people)
  • 5 - 10 years: 25.0% - (7 of 28 people)
  • 10+ years: 45.0% - (5 of 11 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Vicodin:
  • female: 37.0% - (96 of 254 people)
  • male: 38.0% - (27 of 70 people)
Cymbalta:
  • female: 29.0% - (72 of 245 people)
  • male: 21.0% - (14 of 64 people)

Drug effectiveness by age:

Vicodin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 38.0% - (10 of 26 people)
  • 30-39: 30.0% - (21 of 70 people)
  • 40-49: 40.0% - (42 of 104 people)
  • 50-59: 45.0% - (37 of 81 people)
  • 60+: 30.0% - (13 of 43 people)
Cymbalta:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 40.0% - (10 of 25 people)
  • 30-39: 24.0% - (15 of 62 people)
  • 40-49: 27.0% - (28 of 102 people)
  • 50-59: 35.0% - (28 of 79 people)
  • 60+: 12.0% - (5 of 41 people)

Most common drug interactions over time *:

< 1 month:
  • feeling abnormal
  • malaise
  • anxiety
  • fall
  • suicidal ideation
  • drug ineffective
  • irritability
  • pain in extremity
  • nausea
  • drug withdrawal syndrome
1 - 6 months:
  • dizziness
  • pain
  • anxiety
  • drug ineffective
  • depression
  • headache
  • nausea
  • aspartate aminotransferase increased
  • fatigue
  • blood alkaline phosphatase increased
6 - 12 months:
  • back pain
  • anxiety
  • drug withdrawal syndrome
  • red face
  • suicidal ideation
  • depression
  • feeling abnormal
  • malaise
  • depressed mood
  • hyperhidrosis
1 - 2 years:
  • drug ineffective
  • depression
  • anxiety
  • insomnia
  • fatigue
  • tinnitus
  • confusional state
  • arthralgia
  • asthenia
  • hypoaesthesia
2 - 5 years:
  • depression
  • fatigue
  • anxiety
  • pain
  • anger
  • dizziness
  • constipation
  • headache
  • insomnia
  • weight decreased
5 - 10 years:
  • sexual apathy
  • drug withdrawal syndrome
  • anxiety
  • depression
  • anxiety disorder due to a general medical condition
  • back injury
  • degenerative joint disease
  • lumbar spinal stenosis
  • major depressive disorder
  • nausea
10+ years:
  • high blood cholesterol
  • high blood sugar
  • nausea
  • fatigue
  • depression
  • fatigue aggravated
  • high blood pressure
  • muscle cramps aggravated
  • weight gain
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
not specified:
  • pain
  • nausea
  • anxiety
  • fall
  • depression
  • drug ineffective
  • back pain
  • headache
  • fatigue
  • arthralgia

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • anxiety
  • fall
  • depression
  • drug ineffective
  • arthralgia
  • headache
  • fatigue
  • back pain
male:
  • pain
  • nausea
  • anxiety
  • back pain
  • depression
  • drug ineffective
  • fall
  • dyspnoea
  • vomiting
  • headache

Most common drug interactions by age *:

0-1:
  • abortion induced
  • blood cholesterol increased
  • congenital central nervous system anomaly
  • congenital hydrocephalus
  • maternal drugs affecting foetus
  • meningomyelocele
  • neural tube defect
  • obesity
  • spina bifida
  • talipes
2-9:
  • seizure
10-19:
  • pain
  • cholecystitis chronic
  • gallbladder disorder
  • fatigue
  • pancreatitis
  • sphincter of oddi dysfunction
  • anxiety
  • arthralgia
  • headache
  • pneumonia
20-29:
  • pain
  • nausea
  • deep vein thrombosis
  • pneumonia
  • migraine
  • vomiting
  • headache
  • abdominal pain upper
  • cholecystitis chronic
  • anxiety
30-39:
  • pain
  • nausea
  • depression
  • anxiety
  • headache
  • fatigue
  • vomiting
  • dyspnoea
  • dizziness
  • drug ineffective
40-49:
  • pain
  • drug ineffective
  • fatigue
  • nausea
  • anxiety
  • back pain
  • fall
  • headache
  • vomiting
  • gait disturbance
50-59:
  • pain
  • nausea
  • fall
  • anxiety
  • insomnia
  • arthralgia
  • headache
  • depression
  • dizziness
  • diarrhoea
60+:
  • pain
  • nausea
  • anxiety
  • fall
  • back pain
  • dyspnoea
  • arthralgia
  • fatigue
  • dizziness
  • weight decreased

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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