Review: taking Vyvanse and Wellbutrin together


Summary

Drug interactions are reported among people who take Vyvanse and Wellbutrin together. This review analyzes the effectiveness and drug interactions between Vyvanse and Wellbutrin. It is created by eHealthMe based on reports of 705 people who take the same drugs from FDA and social media, and is updated regularly.

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Vyvanse

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. (latest outcomes from Vyvanse 12,816 users)

Wellbutrin

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from Wellbutrin 69,048 users)

On Sep, 18, 2016

705 people who take Vyvanse, Wellbutrin are studied.


Number of reports submitted per year:

Vyvanse and Wellbutrin drug interactions.

Drug effectiveness over time:

Vyvanse:
  • < 1 month: 38.0% - (8 of 21 people)
  • 1 - 6 months: 34.0% - (15 of 43 people)
  • 6 - 12 months: 36.0% - (11 of 30 people)
  • 1 - 2 years: 56.0% - (25 of 44 people)
  • 2 - 5 years: 52.0% - (20 of 38 people)
  • 5 - 10 years: 50.0% - (2 of 4 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 25.0% - (1 of 4 people)
Wellbutrin:
  • < 1 month: 15.0% - (2 of 13 people)
  • 1 - 6 months: 28.0% - (11 of 39 people)
  • 6 - 12 months: 29.0% - (7 of 24 people)
  • 1 - 2 years: 33.0% - (10 of 30 people)
  • 2 - 5 years: 35.0% - (17 of 48 people)
  • 5 - 10 years: 55.0% - (11 of 20 people)
  • 10+ years: 60.0% - (6 of 10 people)
  • not specified: 33.0% - (1 of 3 people)

Drug effectiveness by gender:

Vyvanse:
  • female: 41.0% - (57 of 136 people)
  • male: 50.0% - (26 of 51 people)
Wellbutrin:
  • female: 36.0% - (49 of 136 people)
  • male: 31.0% - (16 of 51 people)

Drug effectiveness by age:

Vyvanse:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (3 of 9 people)
  • 20-29: 49.0% - (26 of 53 people)
  • 30-39: 51.0% - (28 of 54 people)
  • 40-49: 42.0% - (18 of 42 people)
  • 50-59: 24.0% - (6 of 25 people)
  • 60+: 50.0% - (2 of 4 people)
Wellbutrin:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 40.0% - (4 of 10 people)
  • 20-29: 34.0% - (17 of 50 people)
  • 30-39: 32.0% - (17 of 52 people)
  • 40-49: 37.0% - (17 of 45 people)
  • 50-59: 29.0% - (8 of 27 people)
  • 60+: 66.0% - (2 of 3 people)

Most common drug interactions over time *:

< 1 month:
  • headache
  • abscess
  • depression
  • drug ineffective
  • injection site erythema
  • injection site mass
  • musculoskeletal stiffness
  • rheumatoid arthritis
  • scar
  • surgery
1 - 6 months:
  • drug ineffective
  • nausea
  • anxiety
  • irritability
  • fatigue
  • anger
  • headache
  • mental impairment
  • sleep disorder
  • attention deficit/hyperactivity disorder
6 - 12 months:
  • mood swings
  • anxiety
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • conversion disorder
  • depression
  • depression aggravated
  • gastroparesis
  • headache
  • ibs
  • tremor
1 - 2 years:
  • fatigue
  • cervical spinal stenosis
  • dry eyes
  • joint pain
  • metallic taste
  • pain in jaw
  • spondylolisthesis acquired
  • thirst
  • anxiety
  • hallucinations, mixed
2 - 5 years:
  • dizziness
  • fatigue
  • pain - joints
  • female sexual dysfunction
  • photophobia
  • sweating - excessive
  • anxiety
  • appetite decreased
  • constipation
  • exhaustion, fatigue, lethargy, tiredness, weariness
5 - 10 years:
  • blurred vision
  • constipation
  • fatigue - chronic
  • hair loss
  • dizziness
  • fluid retention
  • memory loss
  • scalp tenderness
  • weight gain
  • wrist pain
10+ years:
  • headache - tension
  • anorgasmia
  • sexual dysfunction
  • spotting
not specified:
  • drug ineffective
  • fatigue
  • nausea
  • depression
  • insomnia
  • anxiety
  • headache
  • feeling abnormal
  • pain
  • completed suicide

Most common drug interactions by gender *:

female:
  • fatigue
  • drug ineffective
  • anxiety
  • depression
  • nausea
  • joint pain
  • dizziness
  • headache
  • cervical spinal stenosis
  • pain in jaw
male:
  • drug ineffective
  • insomnia
  • headache
  • fatigue
  • nausea
  • hyperhidrosis
  • anxiety
  • depression
  • fall
  • anger

Most common drug interactions by age *:

2-9:
  • aggression
  • drug administration error
  • drug ineffective
  • mood swings
  • abnormal behaviour
  • anger
  • negativism
  • weight decreased
10-19:
  • anger
  • insomnia
  • convulsion
  • drug ineffective
  • crying
  • depression
  • nausea
  • sexual dysfunction
  • suicidal ideation
  • disturbance in attention
20-29:
  • anxiety
  • drug ineffective
  • depression
  • fatigue
  • muscle spasms
  • overdose
  • tremor
  • stress
  • nausea
  • headache
30-39:
  • fatigue
  • feeling abnormal
  • headache
  • dizziness
  • drug effect decreased
  • nausea
  • abnormal behaviour
  • insomnia
  • pain
  • tremor
40-49:
  • fatigue
  • headache
  • drug ineffective
  • anxiety
  • nausea
  • hyperhidrosis
  • asthenia
  • depression
  • fatigue - chronic
  • rheumatoid arthritis
50-59:
  • fatigue
  • pain in jaw
  • cervical spinal stenosis
  • dry eyes
  • joint pain
  • metallic taste
  • spondylolisthesis acquired
  • thirst
  • completed suicide
  • drug ineffective
60+:
  • depression
  • fatigue
  • anxiety
  • drug ineffective
  • dysphonia
  • feeling abnormal
  • blood pressure increased
  • musculoskeletal disorder
  • chills
  • disturbance in attention

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Vyvanse (lisdexamfetamine dimesylate) is often used to treat attention deficit hyperactivity disorder. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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