Review: taking Xanax and Flexeril together


Summary

Drug interactions are reported among people who take Xanax and Flexeril together. This review analyzes the effectiveness and drug interactions between Xanax and Flexeril. It is created by eHealthMe based on reports of 3,066 people who take the same drugs from FDA and social media, and is updated regularly.

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Xanax

Xanax has active ingredients of alprazolam. It is often used in stress and anxiety. (latest outcomes from Xanax 58,024 users)

Flexeril

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,144 users)

On Jul, 22, 2016

3,066 people who take Xanax, Flexeril are studied.


Number of reports submitted per year:

Xanax and Flexeril drug interactions.

Drug effectiveness over time:

Xanax:
  • < 1 month: 33.0% - (3 of 9 people)
  • 1 - 6 months: 20.0% - (5 of 25 people)
  • 6 - 12 months: 60.0% - (6 of 10 people)
  • 1 - 2 years: 46.0% - (14 of 30 people)
  • 2 - 5 years: 52.0% - (25 of 48 people)
  • 5 - 10 years: 60.0% - (18 of 30 people)
  • 10+ years: 50.0% - (12 of 24 people)
  • not specified: 0.0% - (0 of 1 people)
Flexeril:
  • < 1 month: 18.0% - (6 of 32 people)
  • 1 - 6 months: 13.0% - (4 of 29 people)
  • 6 - 12 months: 15.0% - (2 of 13 people)
  • 1 - 2 years: 21.0% - (5 of 23 people)
  • 2 - 5 years: 21.0% - (7 of 32 people)
  • 5 - 10 years: 23.0% - (6 of 26 people)
  • 10+ years: 22.0% - (2 of 9 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Xanax:
  • female: 52.0% - (70 of 133 people)
  • male: 29.0% - (13 of 44 people)
Flexeril:
  • female: 20.0% - (25 of 123 people)
  • male: 16.0% - (7 of 43 people)

Drug effectiveness by age:

Xanax:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 60.0% - (9 of 15 people)
  • 30-39: 51.0% - (23 of 45 people)
  • 40-49: 40.0% - (28 of 69 people)
  • 50-59: 52.0% - (20 of 38 people)
  • 60+: 33.0% - (3 of 9 people)
Flexeril:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 14.0% - (2 of 14 people)
  • 30-39: 17.0% - (7 of 40 people)
  • 40-49: 22.0% - (15 of 67 people)
  • 50-59: 14.0% - (5 of 35 people)
  • 60+: 33.0% - (3 of 9 people)

Most common drug interactions over time *:

< 1 month:
  • memory impairment
  • dyspnoea
  • pain
  • vomiting
  • suicide attempt
  • drug toxicity
  • depression
  • intentional overdose
  • somnolence
  • injury
1 - 6 months:
  • pain
  • pulmonary embolism
  • completed suicide
  • death
  • deep vein thrombosis
  • detoxification
  • drug ineffective
  • syncope
  • anaemia
  • chest pain
6 - 12 months:
  • nausea
  • blood pressure increased
  • hormone level abnormal
  • anxiety
  • chest pain
  • vomiting
  • abnormal weight gain
  • agitation
  • anaemia
  • anxiety disorder
1 - 2 years:
  • nausea
  • pain
  • drug ineffective
  • completed suicide
  • detoxification
  • anxiety
  • confusional state
  • depression
  • dizziness
  • drug dependence
2 - 5 years:
  • depression
  • pain
  • anxiety
  • degenerative joint disease
  • nausea
  • suicide attempt
  • back injury
  • anxiety disorder due to a general medical condition
  • intentional overdose
  • lumbar spinal stenosis
5 - 10 years:
  • anxiety
  • anxiety disorder due to a general medical condition
  • back injury
  • degenerative joint disease
  • lumbar spinal stenosis
  • major depressive disorder
  • pain
  • emotional distress
  • heat intolerance
  • pancreatitis
10+ years:
  • confusional state
  • depression
  • joint pain
  • joint swelling
  • pain in fingers
  • stiffness in a joint
  • tenosynovitis stenosans
  • vaginal sloughing
  • wheezing
  • agitation
not specified:
  • pain
  • anxiety
  • depression
  • nausea
  • back pain
  • fatigue
  • dyspnoea
  • headache
  • fall
  • pain in extremity

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • back pain
  • depression
  • fatigue
  • dyspnoea
  • fall
  • diarrhoea
  • headache
male:
  • depression
  • pain
  • anxiety
  • insomnia
  • nausea
  • pain in extremity
  • arthralgia
  • back pain
  • headache
  • suicidal ideation

Most common drug interactions by age *:

0-1:
  • diabetes mellitus
2-9:
  • dyspnoea
  • angina pectoris
  • angina unstable
  • anorexia
  • asthma
  • blister
  • chest tightness
  • dermatitis bullous
  • drug dependence
  • drug toxicity
10-19:
  • completed suicide
  • cardiac arrest
  • respiratory arrest
  • cholecystitis chronic
  • gallbladder disorder
  • pain
  • pancreatitis
  • sphincter of oddi dysfunction
  • cardio-respiratory arrest
  • drug toxicity
20-29:
  • pain
  • anxiety
  • nausea
  • vomiting
  • injury
  • oedema peripheral
  • insomnia
  • pain in extremity
  • pyrexia
  • diarrhoea
30-39:
  • nausea
  • anxiety
  • depression
  • dyspnoea
  • arthralgia
  • pain
  • headache
  • back pain
  • completed suicide
  • asthenia
40-49:
  • pain
  • anxiety
  • depression
  • nausea
  • chest pain
  • back pain
  • headache
  • insomnia
  • dyspnoea
  • vomiting
50-59:
  • pain
  • anxiety
  • fatigue
  • depression
  • nausea
  • back pain
  • weight decreased
  • diarrhoea
  • headache
  • fall
60+:
  • pain
  • anxiety
  • fall
  • anhedonia
  • back pain
  • hypertension
  • osteoarthritis
  • osteomyelitis
  • diarrhoea
  • dyspnoea

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Xanax (alprazolam) is often used to treat stress and anxiety. Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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