Review: taking Zetia and Synthroid together


Summary

Drug interactions are reported among people who take Zetia and Synthroid together. This review analyzes the effectiveness and drug interactions between Zetia and Synthroid. It is created by eHealthMe based on reports of 3,998 people who take the same drugs from FDA and social media, and is updated regularly.

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Zetia

Zetia has active ingredients of ezetimibe. It is often used in high blood cholesterol. (latest outcomes from Zetia 27,544 users)

Synthroid

Synthroid has active ingredients of levothyroxine sodium. It is often used in hypothyroidism. (latest outcomes from Synthroid 107,543 users)

On Aug, 28, 2016

3,998 people who take Zetia, Synthroid are studied.


Number of reports submitted per year:

Zetia and Synthroid drug interactions.

Drug effectiveness over time:

Zetia:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 28.0% - (2 of 7 people)
  • 6 - 12 months: 33.0% - (1 of 3 people)
  • 1 - 2 years: 40.0% - (8 of 20 people)
  • 2 - 5 years: 33.0% - (8 of 24 people)
  • 5 - 10 years: 55.0% - (11 of 20 people)
  • 10+ years: 66.0% - (4 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Synthroid:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 66.0% - (2 of 3 people)
  • 6 - 12 months: 100.0% - (3 of 3 people)
  • 1 - 2 years: 33.0% - (3 of 9 people)
  • 2 - 5 years: 52.0% - (9 of 17 people)
  • 5 - 10 years: 63.0% - (14 of 22 people)
  • 10+ years: 84.0% - (27 of 32 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Zetia:
  • female: 42.0% - (24 of 57 people)
  • male: 43.0% - (10 of 23 people)
Synthroid:
  • female: 73.0% - (46 of 63 people)
  • male: 52.0% - (12 of 23 people)

Drug effectiveness by age:

Zetia:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 0 people)
  • 40-49: 50.0% - (5 of 10 people)
  • 50-59: 41.0% - (12 of 29 people)
  • 60+: 41.0% - (17 of 41 people)
Synthroid:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 0 people)
  • 20-29: 0.0% - (0 of 0 people)
  • 30-39: 0.0% - (0 of 1 people)
  • 40-49: 60.0% - (6 of 10 people)
  • 50-59: 68.0% - (22 of 32 people)
  • 60+: 69.0% - (30 of 43 people)

Most common drug interactions over time *:

< 1 month:
  • fatigue
  • myalgia
  • dizziness
  • nausea
  • pain in extremity
  • arthralgia
  • diarrhoea
  • pulmonary embolism
  • blood creatine phosphokinase increased
  • chest pain
1 - 6 months:
  • blood creatine phosphokinase increased
  • myalgia
  • pelvic pain
  • constipation
  • deep vein thrombosis
  • diarrhoea
  • low density lipoprotein increased
  • abdominal pain
  • rhabdomyolysis
  • back pain
6 - 12 months:
  • blood creatine phosphokinase increased
  • fatigue
  • headache
  • myalgia
  • nausea
  • thyroid fibrosis
  • abdominal distension
  • abdominal pain
  • abdominal pain upper
  • adverse event
1 - 2 years:
  • fatigue
  • headache
  • joint pain
  • muscle spasms
  • myocardial infarction
  • pneumonia
  • anxiety
  • cognitive disorder
  • depression
  • diverticulum
2 - 5 years:
  • nephrogenic systemic fibrosis
  • pain in extremity
  • bone pain
  • burning sensation
  • fatigue
  • gait disturbance
  • joint range of motion decreased
  • joint swelling
  • musculoskeletal stiffness
  • oedema peripheral
5 - 10 years:
  • angioedema
  • swollen tongue
  • arteriosclerosis
  • chronic fatigue syndrome
  • diarrhea
  • high blood pressure
  • joint pain
  • myalgia
  • short-term memory loss
  • abdominal pain lower
10+ years:
  • fatigue
  • angioedema
  • swollen tongue
  • short-term memory loss
  • abdominal pain lower
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • arthritis - neck
  • back pain - low
  • blind
  • blurred vision
not specified:
  • nausea
  • fatigue
  • dizziness
  • asthenia
  • dyspnoea
  • pain
  • headache
  • depression
  • arthralgia
  • back pain

Most common drug interactions by gender *:

female:
  • nausea
  • fatigue
  • dizziness
  • pain
  • dyspnoea
  • asthenia
  • headache
  • arthralgia
  • back pain
  • pain in extremity
male:
  • fatigue
  • asthenia
  • dyspnoea
  • oedema peripheral
  • pneumonia
  • dizziness
  • nausea
  • renal failure acute
  • depression
  • cardiac failure congestive

Most common drug interactions by age *:

0-1:
  • blood cholesterol increased
  • gallbladder operation
  • sensation of foreign body
  • type 2 diabetes mellitus
2-9:
  • abdominal pain upper
  • back pain
  • circulatory collapse
  • gastrointestinal pain
  • skin tightness
  • sleep disorder due to general medical condition, insomnia type
10-19:
  • apathy
  • arthritis
  • bladder cancer
  • blood cholesterol increased
  • bone disorder
  • burnout syndrome
  • cardiovascular disorder
  • cataract
  • depression
  • diabetes mellitus
20-29:
  • injury
  • anhedonia
  • anxiety
  • cholecystitis acute
  • emotional distress
  • fatigue
  • gallbladder non-functioning
  • general physical health deterioration
  • pain
  • abdominal pain upper
30-39:
  • dyspnoea
  • sleep apnoea syndrome
  • anxiety
  • blood creatine phosphokinase increased
  • asthenia
  • convulsion
  • deep vein thrombosis
  • myocardial infarction
  • oedema peripheral
  • electrolyte imbalance
40-49:
  • nausea
  • pain
  • nephrogenic systemic fibrosis
  • headache
  • oedema peripheral
  • vomiting
  • completed suicide
  • blood creatine phosphokinase increased
  • dyspnoea
  • gait disturbance
50-59:
  • depression
  • nausea
  • headache
  • pain
  • fatigue
  • asthenia
  • myocardial infarction
  • dizziness
  • back pain
  • chest pain
60+:
  • fatigue
  • nausea
  • dizziness
  • asthenia
  • dyspnoea
  • pain
  • arthralgia
  • pain in extremity
  • headache
  • fall

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zetia (ezetimibe) is often used to treat high blood cholesterol. Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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