Review: taking Zoloft and Benadryl together


Summary

Drug interactions are reported among people who take Zoloft and Benadryl together. This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on reports of 2,759 people who take the same drugs from FDA and social media, and is updated regularly.

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Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 97,228 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 43,259 users)

On Sep, 17, 2016

2,759 people who take Zoloft, Benadryl are studied.


Number of reports submitted per year:

Zoloft and Benadryl drug interactions.

Drug effectiveness over time:

Zoloft:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 16.0% - (4 of 24 people)
  • 6 - 12 months: 25.0% - (3 of 12 people)
  • 1 - 2 years: 25.0% - (3 of 12 people)
  • 2 - 5 years: 80.0% - (8 of 10 people)
  • 5 - 10 years: 71.0% - (10 of 14 people)
  • 10+ years: 62.0% - (5 of 8 people)
  • not specified: 100.0% - (1 of 1 people)
Benadryl:
  • < 1 month: 37.0% - (10 of 27 people)
  • 1 - 6 months: 63.0% - (7 of 11 people)
  • 6 - 12 months: 33.0% - (2 of 6 people)
  • 1 - 2 years: 50.0% - (4 of 8 people)
  • 2 - 5 years: 78.0% - (11 of 14 people)
  • 5 - 10 years: 60.0% - (6 of 10 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 33.0% - (1 of 3 people)

Drug effectiveness by gender:

Zoloft:
  • female: 40.0% - (30 of 74 people)
  • male: 33.0% - (5 of 15 people)
Benadryl:
  • female: 58.0% - (41 of 70 people)
  • male: 21.0% - (3 of 14 people)

Drug effectiveness by age:

Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 25.0% - (2 of 8 people)
  • 20-29: 28.0% - (6 of 21 people)
  • 30-39: 47.0% - (11 of 23 people)
  • 40-49: 60.0% - (12 of 20 people)
  • 50-59: 28.0% - (4 of 14 people)
  • 60+: 0.0% - (0 of 3 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 62.0% - (5 of 8 people)
  • 20-29: 61.0% - (11 of 18 people)
  • 30-39: 50.0% - (11 of 22 people)
  • 40-49: 36.0% - (7 of 19 people)
  • 50-59: 60.0% - (9 of 15 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • vomiting
  • diarrhoea
  • dyspnoea
  • heart disease congenital
  • maternal exposure during pregnancy
  • pneumonia
  • fallot's tetralogy
  • dehydration
  • anaemia
1 - 6 months:
  • thrombocytopenia
  • depressed level of consciousness
  • drug specific antibody present
  • haemorrhage intracranial
  • melaena
  • muscle contractions involuntary
  • respiratory arrest
  • interstitial lung disease
  • nausea
  • atrial septal defect
6 - 12 months:
  • maternal exposure during pregnancy
  • feeding disorder neonatal
  • microcephaly
  • respiratory disorder neonatal
  • small for dates baby
  • temperature regulation disorder
  • vanishing twin syndrome
  • foetal exposure during pregnancy
  • foetal growth restriction
  • premature baby
1 - 2 years:
  • maternal exposure during pregnancy
  • iron deficiency anemia
  • atrial septal defect
  • congenital anomaly
  • nausea
  • acute respiratory distress syndrome
  • cardiac failure congestive
  • cardiomegaly
  • croup infectious
  • cryptorchism
2 - 5 years:
  • congenital anomaly
  • coma
  • maternal exposure during pregnancy
  • respiratory arrest
  • anxiety
  • back pain
  • atrial septal defect
  • autism
  • fatigue
  • muscle spasms
5 - 10 years:
  • excessive thirst
  • urinary retention
  • hair loss
  • congenital diaphragmatic hernia
  • dry eyes
  • dry skin
  • maternal exposure during pregnancy
  • neonatal respiratory failure
  • neuropathy peripheral
  • palpation
10+ years:
  • ataxia
  • depression
  • myoclonus
  • ventricular septal defect
  • blurred vision
  • cervical spine pain
  • chronic hepatitis
  • crying - excessive (0-6 months)
  • double vision
  • drug-induced tremor
not specified:
  • nausea
  • pain
  • headache
  • fatigue
  • anxiety
  • dyspnoea
  • vomiting
  • pyrexia
  • depression
  • diarrhoea

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • headache
  • fatigue
  • vomiting
  • dyspnoea
  • anxiety
  • pyrexia
  • depression
  • diarrhoea
male:
  • fatigue
  • nausea
  • pain
  • headache
  • anxiety
  • asthenia
  • dyspnoea
  • back pain
  • depression
  • diarrhoea

Most common drug interactions by age *:

0-1:
  • feeding disorder neonatal
  • foetal exposure during pregnancy
  • microcephaly
  • respiratory disorder neonatal
  • small for dates baby
  • temperature regulation disorder
  • mitral valve incompetence
  • right ventricular hypertrophy
  • tricuspid valve incompetence
  • foetal growth restriction
2-9:
  • anticholinergic syndrome
  • serotonin syndrome
  • vomiting
  • aggression
  • attention deficit/hyperactivity disorder
  • enuresis
  • mental status changes
  • balance disorder
  • clonus
  • diarrhoea
10-19:
  • pain
  • paraesthesia
  • nausea
  • muscle spasms
  • dizziness
  • headache
  • vomiting
  • diarrhoea
  • patent ductus arteriosus
  • right ventricular hypertrophy
20-29:
  • headache
  • drug abuse
  • pain
  • dizziness
  • nausea
  • vomiting
  • anxiety
  • pain in extremity
  • pyrexia
  • abdominal pain
30-39:
  • drug abuse
  • depression
  • headache
  • fatigue
  • completed suicide
  • anxiety
  • pyrexia
  • nausea
  • chest pain
  • diabetes mellitus
40-49:
  • headache
  • pain
  • back pain
  • anxiety
  • nausea
  • arthralgia
  • asthenia
  • fatigue
  • pain in extremity
  • dyspnoea
50-59:
  • dyspnoea
  • nausea
  • fatigue
  • chest pain
  • headache
  • pain
  • pyrexia
  • drug abuse
  • vomiting
  • anaemia
60+:
  • nausea
  • fatigue
  • diarrhoea
  • asthenia
  • pneumonia
  • dehydration
  • pain
  • anaemia
  • dyspnoea
  • arthralgia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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