Zoloft and Benadryl drug interactions - from FDA reports


Summary

Drug interactions are reported among people who take Zoloft and Benadryl together. This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on reports of 2,745 people who take the same drugs from FDA, and is updated regularly.

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Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 99,105 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 44,713 users)

On Feb, 10, 2017

2,745 people who take Zoloft, Benadryl are studied.


Number of reports submitted per year:

Zoloft and Benadryl drug interactions.

Most common drug interactions over time *:

< 1 month:
  • nausea
  • vomiting
  • diarrhoea
  • anaemia
  • dyspnoea
  • aspartate aminotransferase increased
  • haemoglobin decreased
  • heart disease congenital
  • maternal exposure during pregnancy
  • pneumonia
1 - 6 months:
  • thrombocytopenia
  • depressed level of consciousness
  • drug specific antibody present
  • haemorrhage intracranial
  • melaena
  • muscle contractions involuntary
  • respiratory arrest
  • fatigue
  • interstitial lung disease
  • nausea
6 - 12 months:
  • maternal exposure during pregnancy
  • feeding disorder neonatal
  • microcephaly
  • respiratory disorder neonatal
  • small for dates baby
  • temperature regulation disorder
  • vanishing twin syndrome
  • foetal exposure during pregnancy
  • foetal growth restriction
  • premature baby
1 - 2 years:
  • maternal exposure during pregnancy
  • atrial septal defect
  • congenital anomaly
  • acute respiratory distress syndrome
  • cardiac failure congestive
  • cardiomegaly
  • croup infectious
  • cryptorchism
  • dermatitis atopic
  • dermatitis contact
2 - 5 years:
  • congenital anomaly
  • coma
  • maternal exposure during pregnancy
  • respiratory arrest
  • atrial septal defect
  • autism
  • anxiety
  • craniosynostosis
  • premature baby
  • strabismus
5 - 10 years:
  • congenital diaphragmatic hernia
  • maternal exposure during pregnancy
  • neonatal respiratory failure
  • premature baby
  • pulmonary hypoplasia
  • heart disease congenital
  • transposition of the great vessels
  • amnesia
  • anaemia
  • anomalous pulmonary venous connection
10+ years:
  • ventricular septal defect
  • chronic fatigue syndrome
  • sinusitis
  • ammonia increased
  • atrial septal defect
  • coarctation of the aorta
  • colitis
  • congenital anomaly
  • cough
  • insomnia
not specified:
  • nausea
  • pain
  • headache
  • fatigue
  • vomiting
  • anxiety
  • dyspnoea
  • pyrexia
  • diarrhoea
  • depression

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • headache
  • fatigue
  • vomiting
  • dyspnoea
  • anxiety
  • pyrexia
  • diarrhoea
  • depression
male:
  • fatigue
  • nausea
  • pain
  • headache
  • anxiety
  • asthenia
  • back pain
  • dyspnoea
  • depression
  • diarrhoea

Most common drug interactions by age *:

0-1:
  • feeding disorder neonatal
  • foetal exposure during pregnancy
  • microcephaly
  • respiratory disorder neonatal
  • small for dates baby
  • temperature regulation disorder
  • mitral valve incompetence
  • right ventricular hypertrophy
  • tricuspid valve incompetence
  • foetal growth restriction
2-9:
  • anticholinergic syndrome
  • serotonin syndrome
  • vomiting
  • aggression
  • attention deficit/hyperactivity disorder
  • enuresis
  • mental status changes
  • balance disorder
  • clonus
  • diarrhoea
10-19:
  • pain
  • paraesthesia
  • nausea
  • headache
  • muscle spasms
  • vomiting
  • anaemia
  • dizziness
  • anxiety
  • somnolence
20-29:
  • vomiting
  • nausea
  • headache
  • drug abuse
  • pain
  • dizziness
  • pyrexia
  • anxiety
  • pain in extremity
  • abdominal pain
30-39:
  • drug abuse
  • depression
  • headache
  • fatigue
  • pyrexia
  • completed suicide
  • anxiety
  • nausea
  • chest pain
  • diabetes mellitus
40-49:
  • headache
  • pain
  • back pain
  • nausea
  • anxiety
  • arthralgia
  • asthenia
  • fatigue
  • dyspnoea
  • pain in extremity
50-59:
  • dyspnoea
  • nausea
  • fatigue
  • pain
  • headache
  • pyrexia
  • chest pain
  • drug abuse
  • vomiting
  • anaemia
60+:
  • nausea
  • fatigue
  • diarrhoea
  • pain
  • pneumonia
  • asthenia
  • dehydration
  • anaemia
  • dyspnoea
  • vomiting

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Zoloft and Benadryl?

Interactions between Zoloft and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

Interactions between Benadryl and drugs from A to Z

a b c d e f g h i j k l m n o p q r s t u v w x y z

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:

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