Review: taking Zoloft and Benadryl together


Summary

Drug interactions are reported among people who take Zoloft and Benadryl together. This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on reports of 1,967 people who take the same drugs from FDA and social media, and is updated regularly.

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Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 86,060 users)

Benadryl

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Benadryl 33,627 users)

On Aug, 27, 2016

1,967 people who take Zoloft, Benadryl are studied.


Number of reports submitted per year:

Zoloft and Benadryl drug interactions.

Drug effectiveness over time:

Zoloft:
  • < 1 month: 12.0% - (1 of 8 people)
  • 1 - 6 months: 16.0% - (4 of 24 people)
  • 6 - 12 months: 25.0% - (3 of 12 people)
  • 1 - 2 years: 25.0% - (3 of 12 people)
  • 2 - 5 years: 80.0% - (8 of 10 people)
  • 5 - 10 years: 71.0% - (10 of 14 people)
  • 10+ years: 62.0% - (5 of 8 people)
  • not specified: 100.0% - (1 of 1 people)
Benadryl:
  • < 1 month: 37.0% - (10 of 27 people)
  • 1 - 6 months: 63.0% - (7 of 11 people)
  • 6 - 12 months: 33.0% - (2 of 6 people)
  • 1 - 2 years: 50.0% - (4 of 8 people)
  • 2 - 5 years: 78.0% - (11 of 14 people)
  • 5 - 10 years: 60.0% - (6 of 10 people)
  • 10+ years: 60.0% - (3 of 5 people)
  • not specified: 33.0% - (1 of 3 people)

Drug effectiveness by gender:

Zoloft:
  • female: 40.0% - (30 of 74 people)
  • male: 33.0% - (5 of 15 people)
Benadryl:
  • female: 58.0% - (41 of 70 people)
  • male: 21.0% - (3 of 14 people)

Drug effectiveness by age:

Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 25.0% - (2 of 8 people)
  • 20-29: 28.0% - (6 of 21 people)
  • 30-39: 47.0% - (11 of 23 people)
  • 40-49: 60.0% - (12 of 20 people)
  • 50-59: 28.0% - (4 of 14 people)
  • 60+: 0.0% - (0 of 3 people)
Benadryl:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 62.0% - (5 of 8 people)
  • 20-29: 61.0% - (11 of 18 people)
  • 30-39: 50.0% - (11 of 22 people)
  • 40-49: 36.0% - (7 of 19 people)
  • 50-59: 60.0% - (9 of 15 people)
  • 60+: 50.0% - (1 of 2 people)

Most common drug interactions over time *:

< 1 month:
  • dyspnoea
  • nausea
  • vomiting
  • maternal exposure during pregnancy
  • fallot's tetralogy
  • heart disease congenital
  • hyperthyroidism
  • hypothyroidism
  • pneumonia
  • diarrhoea
1 - 6 months:
  • thrombocytopenia
  • depressed level of consciousness
  • drug specific antibody present
  • haemorrhage intracranial
  • melaena
  • muscle contractions involuntary
  • respiratory arrest
  • dizziness
  • fatigue
  • atrial septal defect
6 - 12 months:
  • maternal exposure during pregnancy
  • congenital anomaly
  • premature baby
  • dry eyes
  • dry skin
  • hair loss
  • neuropathy peripheral
  • palpation
  • protein s increased
  • protein urine present
1 - 2 years:
  • iron deficiency anemia
  • maternal exposure during pregnancy
  • atrial septal defect
  • congenital anomaly
  • acute respiratory distress syndrome
  • cardiac failure congestive
  • cardiomegaly
  • croup infectious
  • cryptorchism
  • depression
2 - 5 years:
  • congenital anomaly
  • coma
  • maternal exposure during pregnancy
  • respiratory arrest
  • back pain
  • anxiety
  • atrial septal defect
  • autism
  • muscle spasms
  • craniosynostosis
5 - 10 years:
  • excessive thirst
  • urinary retention
  • hair loss
  • congenital diaphragmatic hernia
  • dry eyes
  • dry skin
  • maternal exposure during pregnancy
  • neonatal respiratory failure
  • neuropathy peripheral
  • palpation
10+ years:
  • ataxia
  • depression
  • myoclonus
  • blurred vision
  • cervical spine pain
  • chronic hepatitis
  • crying - excessive (0-6 months)
  • double vision
  • drug-induced tremor
  • fasciculations of muscle
not specified:
  • pain
  • nausea
  • headache
  • anxiety
  • fatigue
  • pyrexia
  • dyspnoea
  • depression
  • vomiting
  • asthenia

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • headache
  • anxiety
  • fatigue
  • pyrexia
  • dyspnoea
  • depression
  • vomiting
  • chest pain
male:
  • nausea
  • pain
  • headache
  • anxiety
  • fatigue
  • back pain
  • dyspnoea
  • pneumonia
  • depression
  • cardiomegaly

Most common drug interactions by age *:

0-1:
  • mitral valve incompetence
  • right ventricular hypertrophy
  • tricuspid valve incompetence
  • atrial septal defect
  • cerebral haemorrhage neonatal
  • congenital aortic valve incompetence
  • congenital pulmonary hypertension
  • neonatal respiratory distress syndrome
  • patent ductus arteriosus
  • pulmonary artery stenosis congenital
2-9:
  • vomiting
  • dyspnoea
  • aggression
  • attention deficit/hyperactivity disorder
  • autism spectrum disorder
  • balance disorder
  • blood pressure decreased
  • cardio-respiratory arrest
  • choking
  • cough
10-19:
  • pain
  • paraesthesia
  • dizziness
  • patent ductus arteriosus
  • right ventricular hypertrophy
  • headache
  • muscle spasms
  • death
  • nausea
  • convulsion
20-29:
  • headache
  • pain
  • anxiety
  • pyrexia
  • depression
  • dizziness
  • nausea
  • pain in extremity
  • insomnia
  • back pain
30-39:
  • depression
  • drug abuse
  • headache
  • anxiety
  • completed suicide
  • nausea
  • pyrexia
  • diabetes mellitus
  • fatigue
  • pain
40-49:
  • headache
  • pain
  • back pain
  • anxiety
  • arthralgia
  • nausea
  • asthenia
  • cardiomegaly
  • fall
  • dyspnoea
50-59:
  • chest pain
  • nausea
  • fatigue
  • dyspnoea
  • pyrexia
  • pain
  • headache
  • vomiting
  • anxiety
  • anaemia
60+:
  • nausea
  • pneumonia
  • pain
  • asthenia
  • fatigue
  • dehydration
  • diarrhoea
  • arthralgia
  • dyspnoea
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat hypersensitivity. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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