Review: taking Zoloft and Clozapine together


Summary

Drug interactions are reported among people who take Zoloft and Clozapine together. This review analyzes the effectiveness and drug interactions between Zoloft and Clozapine. It is created by eHealthMe based on reports of 1,822 people who take the same drugs from FDA and social media, and is updated regularly.

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Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 97,227 users)

Clozapine

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. (latest outcomes from Clozapine 26,154 users)

On Sep, 19, 2016

1,822 people who take Zoloft, Clozapine are studied.


Number of reports submitted per year:

Zoloft and Clozapine drug interactions.

Drug effectiveness over time:

Zoloft:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 2 people)
  • 2 - 5 years: 100.0% - (3 of 3 people)
  • 5 - 10 years: 50.0% - (2 of 4 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 0.0% - (0 of 0 people)
Clozapine:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 40.0% - (2 of 5 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Zoloft:
  • female: 40.0% - (2 of 5 people)
  • male: 44.0% - (4 of 9 people)
Clozapine:
  • female: 60.0% - (3 of 5 people)
  • male: 44.0% - (4 of 9 people)

Drug effectiveness by age:

Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 42.0% - (3 of 7 people)
  • 40-49: 100.0% - (2 of 2 people)
  • 50-59: 50.0% - (1 of 2 people)
  • 60+: 0.0% - (0 of 0 people)
Clozapine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 42.0% - (3 of 7 people)
  • 40-49: 50.0% - (1 of 2 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • lower respiratory tract infection
  • tachycardia
  • c-reactive protein increased
  • diarrhoea
  • pericardial effusion
  • pyrexia
  • eosinophilia
  • fatigue
  • asthenia
  • white blood cell count decreased
1 - 6 months:
  • pyrexia
  • cellulitis
  • convulsion
  • obsessive-compulsive disorder
  • rash
  • skin exfoliation
  • aggression
  • granulocytopenia
  • heart rate increased
  • loss of consciousness
6 - 12 months:
  • white blood cell count decreased
  • neutropenia
  • general physical health deterioration
  • salivary hypersecretion
  • agranulocytosis
  • obsessive-compulsive disorder
  • psychotic disorder
  • confusional state
  • electrocardiogram qt prolonged
  • granulocytopenia
1 - 2 years:
  • type 2 diabetes mellitus
  • death
  • granulocytopenia
  • blood cholesterol increased
  • malaise
  • catatonia
  • gastrooesophageal reflux disease
  • neuroleptic malignant syndrome
  • obesity
  • blood creatine phosphokinase increased
2 - 5 years:
  • vomiting
  • weight decreased
  • loss of consciousness
  • overdose
  • liver function test abnormal
  • alanine aminotransferase increased
  • malaise
  • white blood cell count increased
  • pneumonia
  • weight increased
5 - 10 years:
  • diarrhoea
  • neutrophil count decreased
  • white blood cell count decreased
  • malaise
  • schizophrenia
  • white blood cell count increased
  • haemoglobin decreased
  • vomiting
  • delusion
  • general physical health deterioration
10+ years:
  • type 2 diabetes mellitus
  • fall
  • myocardial infarction
  • neutrophil count increased
  • somnolence
  • white blood cell count decreased
  • cerebrovascular accident
  • general physical health deterioration
  • lung cancer metastatic
  • neutrophil count decreased
not specified:
  • white blood cell count increased
  • white blood cell count decreased
  • neutrophil count increased
  • antipsychotic drug level increased
  • vomiting
  • malaise
  • tachycardia
  • diabetes mellitus
  • neutrophil count decreased
  • haemoglobin decreased

Most common drug interactions by gender *:

female:
  • vomiting
  • white blood cell count decreased
  • overdose
  • weight decreased
  • antipsychotic drug level increased
  • tachycardia
  • loss of consciousness
  • white blood cell count increased
  • neutrophil count increased
  • diabetes mellitus
male:
  • white blood cell count increased
  • malaise
  • white blood cell count decreased
  • neutrophil count increased
  • psychotic disorder
  • death
  • pyrexia
  • hallucination, auditory
  • convulsion
  • neutrophil count decreased

Most common drug interactions by age *:

0-1:
  • foetal exposure during pregnancy
  • premature baby
  • cerebrovascular accident
  • muscular weakness
  • neoplasm malignant
  • respiratory disorder neonatal
  • talipes
  • tremor
2-9:
  • convulsion
  • tachycardia
  • vomiting
  • anoxic encephalopathy
  • loss of consciousness
  • cardiac arrest
  • cardio-respiratory arrest
  • hypoglycaemia
  • myocardial infarction
  • neutrophil count decreased
10-19:
  • sedation
  • somnolence
  • aggression
  • drug ineffective
  • general physical health deterioration
  • hallucination
  • anxiety
  • homicidal ideation
  • suicidal ideation
  • abnormal behaviour
20-29:
  • overdose
  • vomiting
  • loss of consciousness
  • tachycardia
  • weight decreased
  • liver function test abnormal
  • antipsychotic drug level increased
  • alanine aminotransferase increased
  • electrocardiogram qt prolonged
  • chest pain
30-39:
  • fatigue
  • white blood cell count increased
  • dizziness
  • fall
  • weight decreased
  • asthenia
  • headache
  • malaise
  • dyspnoea
  • neutrophil count increased
40-49:
  • white blood cell count decreased
  • neutrophil count decreased
  • diabetes mellitus
  • tachycardia
  • platelet count decreased
  • vomiting
  • type 2 diabetes mellitus
  • white blood cell count increased
  • neutropenia
  • haemoglobin decreased
50-59:
  • white blood cell count increased
  • malaise
  • death
  • type 2 diabetes mellitus
  • neutrophil count increased
  • pneumonia
  • hallucination
  • pyrexia
  • white blood cell count decreased
  • schizophrenia
60+:
  • death
  • neutrophil count increased
  • white blood cell count increased
  • pyrexia
  • malaise
  • pneumonia
  • fall
  • lower respiratory tract infection
  • chronic obstructive pulmonary disease
  • fatigue

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Clozapine (clozapine) is often used to treat schizophrenia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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