Review: taking Zoloft and Clozapine together


Summary

Drug interactions are reported among people who take Zoloft and Clozapine together. This review analyzes the effectiveness and drug interactions between Zoloft and Clozapine. It is created by eHealthMe based on reports of 1,322 people who take the same drugs from FDA and social media, and is updated regularly.

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Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 77,547 users)

Clozapine

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. (latest outcomes from Clozapine 21,472 users)

On Jul, 21, 2016

1,322 people who take Zoloft, Clozapine are studied.


Number of reports submitted per year:

Zoloft and Clozapine drug interactions.

Drug effectiveness over time:

Zoloft:
  • < 1 month: 0.0% - (0 of 0 people)
  • 1 - 6 months: 0.0% - (0 of 2 people)
  • 6 - 12 months: 0.0% - (0 of 0 people)
  • 1 - 2 years: 0.0% - (0 of 2 people)
  • 2 - 5 years: 100.0% - (3 of 3 people)
  • 5 - 10 years: 60.0% - (3 of 5 people)
  • 10+ years: 33.0% - (1 of 3 people)
  • not specified: 0.0% - (0 of 0 people)
Clozapine:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 1 people)
  • 6 - 12 months: 100.0% - (2 of 2 people)
  • 1 - 2 years: 0.0% - (0 of 1 people)
  • 2 - 5 years: 100.0% - (1 of 1 people)
  • 5 - 10 years: 50.0% - (3 of 6 people)
  • 10+ years: 66.0% - (2 of 3 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Zoloft:
  • female: 50.0% - (3 of 6 people)
  • male: 44.0% - (4 of 9 people)
Clozapine:
  • female: 66.0% - (4 of 6 people)
  • male: 44.0% - (4 of 9 people)

Drug effectiveness by age:

Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 0.0% - (0 of 2 people)
  • 30-39: 42.0% - (3 of 7 people)
  • 40-49: 100.0% - (3 of 3 people)
  • 50-59: 50.0% - (1 of 2 people)
  • 60+: 0.0% - (0 of 0 people)
Clozapine:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 1 people)
  • 20-29: 50.0% - (1 of 2 people)
  • 30-39: 42.0% - (3 of 7 people)
  • 40-49: 66.0% - (2 of 3 people)
  • 50-59: 100.0% - (2 of 2 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • lower respiratory tract infection
  • tachycardia
  • c-reactive protein increased
  • fatigue
  • body temperature increased
  • granulocytopenia
  • white blood cell count decreased
  • oxygen saturation decreased
  • tachypnoea
  • asthenia
1 - 6 months:
  • convulsion
  • obsessive-compulsive disorder
  • granulocytopenia
  • heart rate increased
  • salivary hypersecretion
  • anxiety
  • confusional state
  • pyrexia
  • suicidal ideation
  • abnormal behaviour
6 - 12 months:
  • white blood cell count decreased
  • neutropenia
  • general physical health deterioration
  • salivary hypersecretion
  • agranulocytosis
  • obsessive-compulsive disorder
  • confusional state
  • granulocytopenia
  • psychotic disorder
  • convulsion
1 - 2 years:
  • type 2 diabetes mellitus
  • granulocytopenia
  • death
  • gastrooesophageal reflux disease
  • blood cholesterol increased
  • delusion
  • emotional distress
  • hyperlipidaemia
  • obesity
  • obsessive-compulsive disorder
2 - 5 years:
  • vomiting
  • weight decreased
  • loss of consciousness
  • overdose
  • liver function test abnormal
  • alanine aminotransferase increased
  • white blood cell count increased
  • pneumonia
  • cardiac arrest
  • haemoglobin decreased
5 - 10 years:
  • c-reactive protein increased
  • claudication
  • diabetes mellitus
  • diabetic coma
  • diarrhoea
  • drug detoxification
  • dyspnoea
  • femur fracture
  • lack of strength, muscle weakness, weakness
  • leukopenia
10+ years:
  • pericardial effusion
  • type 2 diabetes mellitus
  • dyspnoea
  • respiratory failure
  • abscess
  • affective disorder
  • agitation
  • bladder obstruction
  • blood triglycerides increased
  • carbon dioxide increased
not specified:
  • diabetes mellitus
  • vomiting
  • tachycardia
  • antipsychotic drug level increased
  • white blood cell count decreased
  • type 2 diabetes mellitus
  • white blood cell count increased
  • death
  • weight increased
  • neutropenia

Most common drug interactions by gender *:

female:
  • vomiting
  • tachycardia
  • diabetes mellitus
  • antipsychotic drug level increased
  • white blood cell count decreased
  • diarrhoea
  • weight decreased
  • liver function test abnormal
  • type 2 diabetes mellitus
  • haemoglobin decreased
male:
  • convulsion
  • malaise
  • death
  • white blood cell count decreased
  • diabetes mellitus
  • pyrexia
  • white blood cell count increased
  • granulocytopenia
  • hallucination, auditory
  • sedation

Most common drug interactions by age *:

0-1:
  • cerebrovascular accident
  • muscular weakness
  • neoplasm malignant
  • tremor
2-9:
  • convulsion
  • anoxic encephalopathy
  • loss of consciousness
  • tachycardia
  • vomiting
  • cardio-respiratory arrest
  • hypoglycaemia
  • neutrophil count decreased
  • blood glucose decreased
  • blood pressure decreased
10-19:
  • somnolence
  • sedation
  • aggression
  • general physical health deterioration
  • anxiety
  • homicidal ideation
  • suicidal ideation
  • abnormal behaviour
  • agitation
  • anger
20-29:
  • vomiting
  • overdose
  • loss of consciousness
  • weight decreased
  • liver function test abnormal
  • tachycardia
  • alanine aminotransferase increased
  • antipsychotic drug level increased
  • electrocardiogram qt prolonged
  • chest pain
30-39:
  • diabetes mellitus
  • type 2 diabetes mellitus
  • abdominal pain
  • diabetic ketoacidosis
  • neutropenia
  • weight increased
  • neutrophil count increased
  • white blood cell count increased
  • malaise
  • rectal haemorrhage
40-49:
  • white blood cell count decreased
  • vomiting
  • type 2 diabetes mellitus
  • diabetes mellitus
  • tachycardia
  • neutropenia
  • platelet count decreased
  • diarrhoea
  • white blood cell count increased
  • neutrophil count decreased
50-59:
  • death
  • leukopenia
  • diabetes mellitus
  • granulocytopenia
  • type 2 diabetes mellitus
  • pneumonia
  • hydronephrosis
  • nephritis
  • orchitis
  • urinary incontinence
60+:
  • death
  • pyrexia
  • granulocytopenia
  • malaise
  • cough
  • fatigue
  • dementia
  • headache
  • influenza like illness
  • lower respiratory tract infection

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Clozapine (clozapine) is often used to treat schizophrenia. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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