Review: taking Zoloft and Tylenol together


Summary

Drug interactions are reported among people who take Zoloft and Tylenol together. This review analyzes the effectiveness and drug interactions between Zoloft and Tylenol. It is created by eHealthMe based on reports of 5,025 people who take the same drugs from FDA and social media, and is updated regularly.

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Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 86,060 users)

Tylenol

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Tylenol 63,439 users)

On Aug, 27, 2016

5,025 people who take Zoloft, Tylenol are studied.


Number of reports submitted per year:

Zoloft and Tylenol drug interactions.

Drug effectiveness over time:

Zoloft:
  • < 1 month: 0.0% - (0 of 8 people)
  • 1 - 6 months: 22.0% - (5 of 22 people)
  • 6 - 12 months: 0.0% - (0 of 6 people)
  • 1 - 2 years: 20.0% - (3 of 15 people)
  • 2 - 5 years: 56.0% - (9 of 16 people)
  • 5 - 10 years: 44.0% - (4 of 9 people)
  • 10+ years: 66.0% - (4 of 6 people)
  • not specified: 0.0% - (0 of 0 people)
Tylenol:
  • < 1 month: 33.0% - (5 of 15 people)
  • 1 - 6 months: 40.0% - (2 of 5 people)
  • 6 - 12 months: 22.0% - (2 of 9 people)
  • 1 - 2 years: 28.0% - (2 of 7 people)
  • 2 - 5 years: 15.0% - (2 of 13 people)
  • 5 - 10 years: 50.0% - (6 of 12 people)
  • 10+ years: 16.0% - (1 of 6 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Zoloft:
  • female: 30.0% - (18 of 59 people)
  • male: 30.0% - (7 of 23 people)
Tylenol:
  • female: 28.0% - (15 of 52 people)
  • male: 27.0% - (5 of 18 people)

Drug effectiveness by age:

Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 6 people)
  • 20-29: 31.0% - (5 of 16 people)
  • 30-39: 22.0% - (4 of 18 people)
  • 40-49: 41.0% - (7 of 17 people)
  • 50-59: 26.0% - (4 of 15 people)
  • 60+: 50.0% - (5 of 10 people)
Tylenol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 40.0% - (2 of 5 people)
  • 20-29: 30.0% - (4 of 13 people)
  • 30-39: 29.0% - (5 of 17 people)
  • 40-49: 7.0% - (1 of 14 people)
  • 50-59: 42.0% - (6 of 14 people)
  • 60+: 28.0% - (2 of 7 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • headache
  • vomiting
  • dehydration
  • abdominal pain
  • fatigue
  • anaemia
  • somnolence
  • malaise
  • tremor
1 - 6 months:
  • congenital anomaly
  • foetal exposure during pregnancy
  • pulmonary embolism
  • atrial septal defect
  • maternal exposure during pregnancy
  • patent ductus arteriosus
  • talipes
  • dyspnoea
  • chest pain
  • premature baby
6 - 12 months:
  • congenital anomaly
  • atrial septal defect
  • maternal exposure during pregnancy
  • patent ductus arteriosus
  • foetal exposure during pregnancy
  • ventricular septal defect
  • pain
  • pneumonia
  • premature baby
  • contusion
1 - 2 years:
  • atrial septal defect
  • patent ductus arteriosus
  • ventricular septal defect
  • congenital anomaly
  • foetal exposure during pregnancy
  • maternal exposure during pregnancy
  • tricuspid valve incompetence
  • coarctation of the aorta
  • cardiac failure congestive
  • fallot's tetralogy
2 - 5 years:
  • congenital anomaly
  • atrial septal defect
  • maternal exposure during pregnancy
  • foetal exposure during pregnancy
  • patent ductus arteriosus
  • depression
  • premature baby
  • sleep apnoea syndrome
  • headache
  • ventricular septal defect
5 - 10 years:
  • atrial septal defect
  • congenital anomaly
  • hypothermia
  • foetal exposure during pregnancy
  • patent ductus arteriosus
  • premature baby
  • maternal exposure during pregnancy
  • ventricular septal defect
  • heart disease congenital
  • developmental delay
10+ years:
  • congenital anomaly
  • foetal exposure during pregnancy
  • fallot's tetralogy
  • pulmonary valve incompetence
  • cardiac disorder
  • chest pain
  • muscle cramps
  • otitis media
  • abdominal pain
  • angina pectoris
not specified:
  • pain
  • nausea
  • anxiety
  • fatigue
  • depression
  • dyspnoea
  • fall
  • asthenia
  • anaemia
  • headache

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • anxiety
  • fatigue
  • depression
  • fall
  • dyspnoea
  • asthenia
  • diarrhoea
  • vomiting
male:
  • fatigue
  • pain
  • anxiety
  • nausea
  • depression
  • back pain
  • dyspnoea
  • headache
  • pneumonia
  • atrial septal defect

Most common drug interactions by age *:

0-1:
  • cleft palate
  • congenital anomaly
  • atrial septal defect
  • patent ductus arteriosus
  • right ventricular hypertrophy
  • foetal exposure during pregnancy
  • mitral valve incompetence
  • tricuspid valve incompetence
  • cognitive disorder
  • eustachian tube dysfunction
2-9:
  • atrial septal defect
  • patent ductus arteriosus
  • craniosynostosis
  • intracranial pressure increased
  • maternal exposure during pregnancy
  • speech disorder
  • cleft lip and palate
  • failure to thrive
  • holoprosencephaly
  • hypotelorism of orbit
10-19:
  • suicide attempt
  • pain
  • vomiting
  • nausea
  • suicidal ideation
  • blood triglycerides increased
  • depression
  • epistaxis
  • inflammatory bowel disease
  • irritable bowel syndrome
20-29:
  • pain
  • nausea
  • headache
  • pulmonary embolism
  • anxiety
  • fatigue
  • depression
  • hypotension
  • abdominal pain upper
  • injury
30-39:
  • anxiety
  • nausea
  • depression
  • pain
  • headache
  • type 2 diabetes mellitus
  • vomiting
  • asthenia
  • gastrooesophageal reflux disease
  • malaise
40-49:
  • nausea
  • pain
  • fatigue
  • anxiety
  • depression
  • back pain
  • diarrhoea
  • dyspnoea
  • arthralgia
  • vomiting
50-59:
  • pain
  • nausea
  • anxiety
  • depression
  • anaemia
  • headache
  • fatigue
  • dyspepsia
  • abdominal pain
  • oedema peripheral
60+:
  • fatigue
  • nausea
  • fall
  • pain
  • anxiety
  • pneumonia
  • asthenia
  • dyspnoea
  • diarrhoea
  • dizziness

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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