Review: taking Zoloft and Tylenol together


Summary

Drug interactions are reported among people who take Zoloft and Tylenol together. This review analyzes the effectiveness and drug interactions between Zoloft and Tylenol. It is created by eHealthMe based on reports of 4,078 people who take the same drugs from FDA and social media, and is updated regularly.

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Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 77,547 users)

Tylenol

Tylenol has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from Tylenol 63,439 users)

On Jul, 22, 2016

4,078 people who take Zoloft, Tylenol are studied.


Number of reports submitted per year:

Zoloft and Tylenol drug interactions.

Drug effectiveness over time:

Zoloft:
  • < 1 month: 0.0% - (0 of 9 people)
  • 1 - 6 months: 22.0% - (6 of 27 people)
  • 6 - 12 months: 0.0% - (0 of 11 people)
  • 1 - 2 years: 27.0% - (5 of 18 people)
  • 2 - 5 years: 65.0% - (13 of 20 people)
  • 5 - 10 years: 60.0% - (9 of 15 people)
  • 10+ years: 57.0% - (4 of 7 people)
  • not specified: 0.0% - (0 of 0 people)
Tylenol:
  • < 1 month: 31.0% - (5 of 16 people)
  • 1 - 6 months: 33.0% - (2 of 6 people)
  • 6 - 12 months: 41.0% - (5 of 12 people)
  • 1 - 2 years: 38.0% - (5 of 13 people)
  • 2 - 5 years: 10.0% - (2 of 19 people)
  • 5 - 10 years: 33.0% - (6 of 18 people)
  • 10+ years: 44.0% - (4 of 9 people)
  • not specified: 0.0% - (0 of 2 people)

Drug effectiveness by gender:

Zoloft:
  • female: 33.0% - (23 of 68 people)
  • male: 35.0% - (14 of 39 people)
Tylenol:
  • female: 36.0% - (23 of 63 people)
  • male: 18.0% - (6 of 32 people)

Drug effectiveness by age:

Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 0.0% - (0 of 7 people)
  • 20-29: 33.0% - (6 of 18 people)
  • 30-39: 24.0% - (6 of 25 people)
  • 40-49: 38.0% - (7 of 18 people)
  • 50-59: 34.0% - (8 of 23 people)
  • 60+: 62.0% - (10 of 16 people)
Tylenol:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 33.0% - (2 of 6 people)
  • 20-29: 43.0% - (7 of 16 people)
  • 30-39: 34.0% - (8 of 23 people)
  • 40-49: 6.0% - (1 of 15 people)
  • 50-59: 40.0% - (9 of 22 people)
  • 60+: 15.0% - (2 of 13 people)

Most common drug interactions over time *:

< 1 month:
  • nausea
  • vomiting
  • abdominal pain
  • headache
  • somnolence
  • dehydration
  • vision blurred
  • renal tubular necrosis
  • thrombocytopenia
  • gastroenteritis
1 - 6 months:
  • pulmonary embolism
  • chest pain
  • dyspnoea
  • deep vein thrombosis
  • muscular weakness
  • nausea
  • oedema peripheral
  • pain in extremity
  • back pain
  • hypoaesthesia
6 - 12 months:
  • tremor
  • depression
  • dizziness
  • pain
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
  • dyspnoea
  • vomiting
  • agitated depression
  • brain abscess
  • confusion aggravated
1 - 2 years:
  • pain
  • aorta hypoplasia
  • atrial septal defect
  • cardiac failure congestive
  • cerebral infarction
  • coarctation of the aorta
  • hypercholesterolaemia
  • patent ductus arteriosus
  • right ventricular hypertrophy
  • tricuspid valve incompetence
2 - 5 years:
  • depression
  • sleep apnoea syndrome
  • erectile dysfunction
  • headache
  • pain exacerbated
  • pulmonary arterial hypertension
  • tachycardia
  • dizziness
  • malnutrition
  • anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension
5 - 10 years:
  • hypothermia
  • pulmonary embolism
  • headache
  • diabetes mellitus
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • motion sickness
  • nausea
  • tiredness
  • urinary tract infection viral
  • abdominal pain
10+ years:
  • muscle cramps
  • abdominal pain
  • angina pectoris
  • cardiac disorder
  • cardiac failure congestive
  • chest pain
  • dizziness
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • nausea
  • sleep apnoea syndrome
not specified:
  • pain
  • nausea
  • anxiety
  • depression
  • fatigue
  • fall
  • dyspnoea
  • asthenia
  • weight decreased
  • anaemia

Most common drug interactions by gender *:

female:
  • nausea
  • pain
  • anxiety
  • depression
  • fatigue
  • fall
  • dyspnoea
  • oedema peripheral
  • asthenia
  • arthralgia
male:
  • pain
  • fatigue
  • anxiety
  • nausea
  • depression
  • back pain
  • dyspnoea
  • pneumonia
  • headache
  • weight decreased

Most common drug interactions by age *:

0-1:
  • pancreatitis
  • atrial septal defect
  • bradycardia neonatal
  • breast enlargement
  • bundle branch block
  • catheter related complication
  • cleft palate
  • congenital jaw malformation
  • convulsion
  • diabetes mellitus
2-9:
  • craniosynostosis
  • intracranial pressure increased
  • maternal exposure during pregnancy
  • speech disorder
  • atrial septal defect
  • bundle branch block right
  • dilatation ventricular
  • double outlet right ventricle
  • fallot's tetralogy
  • hypospadias
10-19:
  • suicide attempt
  • pain
  • suicidal ideation
  • vomiting
  • blood triglycerides increased
  • depression
  • inflammatory bowel disease
  • irritable bowel syndrome
  • multiple drug overdose
  • nausea
20-29:
  • pain
  • nausea
  • anxiety
  • depression
  • fatigue
  • pulmonary embolism
  • headache
  • abdominal pain upper
  • cholecystitis chronic
  • cholelithiasis
30-39:
  • anxiety
  • depression
  • nausea
  • type 2 diabetes mellitus
  • pain
  • asthenia
  • headache
  • diabetes mellitus
  • gastrooesophageal reflux disease
  • urinary tract infection
40-49:
  • nausea
  • pain
  • fatigue
  • depression
  • anxiety
  • back pain
  • arthralgia
  • dyspnoea
  • diarrhoea
  • vomiting
50-59:
  • pain
  • nausea
  • anxiety
  • depression
  • anaemia
  • headache
  • fatigue
  • dyspepsia
  • oedema peripheral
  • abdominal pain
60+:
  • fall
  • fatigue
  • nausea
  • pain
  • anxiety
  • pneumonia
  • asthenia
  • depression
  • dyspnoea
  • back pain

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Tylenol (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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