Review: taking Zyrtec and Phenergan together


Summary

Drug interactions are reported among people who take Zyrtec and Phenergan together. This review analyzes the effectiveness and drug interactions between Zyrtec and Phenergan. It is created by eHealthMe based on reports of 695 people who take the same drugs from FDA and social media, and is updated regularly.

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Zyrtec

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Zyrtec 34,371 users)

Phenergan

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. (latest outcomes from Phenergan 14,614 users)

On Aug, 26, 2016

695 people who take Zyrtec, Phenergan are studied.


Number of reports submitted per year:

Zyrtec and Phenergan drug interactions.

Drug effectiveness over time:

Zyrtec:
  • < 1 month: 0.0% - (0 of 1 people)
  • 1 - 6 months: 0.0% - (0 of 4 people)
  • 6 - 12 months: 0.0% - (0 of 1 people)
  • 1 - 2 years: 0.0% - (0 of 2 people)
  • 2 - 5 years: 33.0% - (1 of 3 people)
  • 5 - 10 years: 80.0% - (4 of 5 people)
  • 10+ years: 100.0% - (1 of 1 people)
  • not specified: 0.0% - (0 of 0 people)
Phenergan:
  • < 1 month: 66.0% - (4 of 6 people)
  • 1 - 6 months: 100.0% - (1 of 1 people)
  • 6 - 12 months: 100.0% - (1 of 1 people)
  • 1 - 2 years: 33.0% - (1 of 3 people)
  • 2 - 5 years: 66.0% - (2 of 3 people)
  • 5 - 10 years: 33.0% - (1 of 3 people)
  • 10+ years: 0.0% - (0 of 0 people)
  • not specified: 0.0% - (0 of 0 people)

Drug effectiveness by gender:

Zyrtec:
  • female: 31.0% - (5 of 16 people)
  • male: 100.0% - (1 of 1 people)
Phenergan:
  • female: 56.0% - (9 of 16 people)
  • male: 100.0% - (1 of 1 people)

Drug effectiveness by age:

Zyrtec:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 25.0% - (1 of 4 people)
  • 40-49: 40.0% - (2 of 5 people)
  • 50-59: 0.0% - (0 of 1 people)
  • 60+: 0.0% - (0 of 0 people)
Phenergan:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 2 people)
  • 10-19: 100.0% - (1 of 1 people)
  • 20-29: 50.0% - (2 of 4 people)
  • 30-39: 25.0% - (1 of 4 people)
  • 40-49: 100.0% - (5 of 5 people)
  • 50-59: 100.0% - (1 of 1 people)
  • 60+: 0.0% - (0 of 0 people)

Most common drug interactions over time *:

< 1 month:
  • gastritis
  • hypertension
  • nausea
  • pruritus
  • toxic epidermal necrolysis
  • vomiting
  • diabetes mellitus
  • diarrhoea
  • epilepsy
  • multi-organ failure
1 - 6 months:
  • chest pain
  • pain
  • oedema peripheral
  • dyspnoea exertional
  • hypoaesthesia
  • pain in extremity
  • pulmonary embolism
  • tenderness
  • dyspnoea
  • subclavian vein thrombosis
6 - 12 months:
  • herpes simplex
  • nephrolithiasis
  • sinusitis
  • cervical root pain
  • chronic fatigue syndrome
  • joint instability
  • lumbar pain
  • migraine
  • restless legs syndrome
  • sjogren's syndrome
1 - 2 years:
  • nausea
  • pain
  • abdominal pain
  • biliary dyskinesia
  • dyspepsia
  • gallbladder disorder
  • impaired gastric emptying
  • pain in extremity
  • vomiting
  • aggression aggravated
2 - 5 years:
  • cervical root pain
  • chronic fatigue syndrome
  • joint instability
  • lumbar pain
  • migraine
  • restless legs syndrome
  • sjogren's syndrome
  • tinnitus aggravated
5 - 10 years:
  • bradycardia
  • hypokalaemia
  • ibs
  • postural orthostatic tachycardia syndrome
  • seizure like phenomena
  • tachycardia - ventricular
  • aggression aggravated
  • anxiety
  • balance disorder
  • constipation
not specified:
  • pain
  • nausea
  • back pain
  • dyspnoea
  • vomiting
  • anxiety
  • headache
  • abdominal pain
  • arthralgia
  • diarrhoea

Most common drug interactions by gender *:

female:
  • pain
  • nausea
  • back pain
  • anxiety
  • vomiting
  • dyspnoea
  • abdominal pain
  • headache
  • arthralgia
  • pain in extremity
male:
  • nausea
  • dyspnoea
  • pain
  • chest pain
  • constipation
  • headache
  • vomiting
  • dehydration
  • anxiety
  • pyrexia

Most common drug interactions by age *:

2-9:
  • anger
  • anxiety
  • attention deficit/hyperactivity disorder
  • autism spectrum disorder
  • b-cell lymphoma
  • bipolar disorder
  • chronic sinusitis
  • conjunctivitis
  • cough
  • depression
10-19:
  • deep vein thrombosis
  • nausea
  • pain
  • abdominal pain
  • cholecystitis
  • cholecystitis chronic
  • depression
  • pulmonary embolism
  • ear haemorrhage
  • epistaxis
20-29:
  • cholecystitis chronic
  • pulmonary embolism
  • back pain
  • chest pain
  • nausea
  • vomiting
  • dyspnoea
  • injury
  • anxiety
  • pain
30-39:
  • gastritis
  • abdominal pain
  • headache
  • pain
  • anxiety
  • depression
  • nausea
  • emotional distress
  • deep vein thrombosis
  • pancreatitis acute
40-49:
  • pain
  • back pain
  • arthralgia
  • nausea
  • dyspnoea
  • pain in extremity
  • sinusitis
  • oedema peripheral
  • dehydration
  • intervertebral disc degeneration
50-59:
  • pain
  • nausea
  • dizziness
  • arthralgia
  • vomiting
  • back pain
  • dyspnoea
  • injury
  • anxiety
  • chest pain
60+:
  • anxiety
  • weight decreased
  • pain
  • nausea
  • back pain
  • diarrhoea
  • osteomyelitis
  • dysphagia
  • pleural effusion
  • spinal osteoarthritis

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat hypersensitivity. Phenergan (promethazine hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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