Review: taking Zyrtec and Zoloft together


Summary

Drug interactions are reported among people who take Zyrtec and Zoloft together. This review analyzes the effectiveness and drug interactions between Zyrtec and Zoloft. It is created by eHealthMe based on reports of 2,024 people who take the same drugs from FDA and social media, and is updated regularly.

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Zyrtec

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Zyrtec 34,371 users)

Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 86,060 users)

On Aug, 25, 2016

2,024 people who take Zyrtec, Zoloft are studied.


Number of reports submitted per year:

Zyrtec and Zoloft drug interactions.

Drug effectiveness over time:

Zyrtec:
  • < 1 month: 18.0% - (2 of 11 people)
  • 1 - 6 months: 26.0% - (4 of 15 people)
  • 6 - 12 months: 80.0% - (8 of 10 people)
  • 1 - 2 years: 40.0% - (11 of 27 people)
  • 2 - 5 years: 50.0% - (13 of 26 people)
  • 5 - 10 years: 43.0% - (10 of 23 people)
  • 10+ years: 75.0% - (9 of 12 people)
  • not specified: 50.0% - (1 of 2 people)
Zoloft:
  • < 1 month: 18.0% - (2 of 11 people)
  • 1 - 6 months: 36.0% - (8 of 22 people)
  • 6 - 12 months: 57.0% - (4 of 7 people)
  • 1 - 2 years: 55.0% - (10 of 18 people)
  • 2 - 5 years: 55.0% - (16 of 29 people)
  • 5 - 10 years: 52.0% - (10 of 19 people)
  • 10+ years: 80.0% - (16 of 20 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Zyrtec:
  • female: 45.0% - (46 of 102 people)
  • male: 50.0% - (12 of 24 people)
Zoloft:
  • female: 58.0% - (59 of 101 people)
  • male: 26.0% - (7 of 26 people)

Drug effectiveness by age:

Zyrtec:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 30.0% - (3 of 10 people)
  • 20-29: 44.0% - (8 of 18 people)
  • 30-39: 42.0% - (16 of 38 people)
  • 40-49: 54.0% - (18 of 33 people)
  • 50-59: 42.0% - (9 of 21 people)
  • 60+: 66.0% - (4 of 6 people)
Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 22.0% - (2 of 9 people)
  • 20-29: 52.0% - (10 of 19 people)
  • 30-39: 57.0% - (22 of 38 people)
  • 40-49: 54.0% - (18 of 33 people)
  • 50-59: 47.0% - (10 of 21 people)
  • 60+: 57.0% - (4 of 7 people)

Most common drug interactions over time *:

< 1 month:
  • erythema multiforme
  • rash
  • atrial fibrillation
  • dehydration
  • multi-organ failure
  • toxic epidermal necrolysis
  • cardiovascular disorder
  • drug hypersensitivity
  • lower respiratory tract infection
  • sepsis
1 - 6 months:
  • atrial septal defect
  • chest pain
  • oedema peripheral
  • pulmonary embolism
  • fatigue
  • dyspnoea
  • foetal exposure during pregnancy
  • depression
  • hypoaesthesia
  • insomnia
6 - 12 months:
  • insomnia
  • congenital anomaly
  • foetal exposure during pregnancy
  • anomalous pulmonary venous connection
  • atrial septal defect
  • maternal exposure during pregnancy
  • talipes
  • ventricular septal defect
  • acute sinusitis
  • cleft lip
1 - 2 years:
  • pulmonary embolism
  • bronchitis acute
  • irregular heartbeat
  • chest pain
  • dyspnoea exertional
  • hypoaesthesia
  • oedema peripheral
  • pain in extremity
  • tenderness
  • subclavian vein thrombosis
2 - 5 years:
  • pain
  • abdominal pain
  • cellulitis
  • back pain
  • biliary dyskinesia
  • diarrhoea
  • nausea
  • rash
  • congenital anomaly
  • depression
5 - 10 years:
  • slurred speech
  • depression
  • anxiety
  • cellulitis
  • femur fracture
  • infection
  • low turnover osteopathy
  • pain in extremity
  • adverse event
  • blister
10+ years:
  • cellulitis
  • rash
  • sleep inertia
  • hypersomnia
  • cluster headache
  • fatigue
  • sweating increased
  • anxiety and stress
  • asthma aggravated
  • blurred vision
not specified:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fall
  • fatigue
  • headache
  • chest pain
  • back pain
  • asthenia

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • depression
  • fatigue
  • fall
  • dyspnoea
  • diarrhoea
  • pain in extremity
  • back pain
male:
  • anxiety
  • pain
  • anaemia
  • chest pain
  • dyspnoea
  • nausea
  • injury
  • osteonecrosis of jaw
  • spinal osteoarthritis
  • headache

Most common drug interactions by age *:

0-1:
  • atrial septal defect
  • fallot's tetralogy
  • pulmonary valve stenosis congenital
  • right ventricle outflow tract obstruction
  • ventricular septal defect
  • heart disease congenital
  • left ventricular hypertrophy
  • bronchiolitis
  • congenital oral malformation
  • craniosynostosis
2-9:
  • drug ineffective
  • drug administration error
  • disease progression
  • dyspnoea
  • dystonia
  • faecal incontinence
  • heart rate increased
  • hypoxia
  • neck pain
  • neuroblastoma
10-19:
  • dyspnoea
  • suicide attempt
  • anxiety
  • injury
  • pain
  • abnormal behaviour
  • pulmonary embolism
  • urticaria
  • cholelithiasis
  • vomiting
20-29:
  • pulmonary embolism
  • abdominal pain
  • pain
  • chest pain
  • biliary dyskinesia
  • dyspnoea exertional
  • hypoaesthesia
  • pain in extremity
  • diarrhoea
  • dyspepsia
30-39:
  • pain
  • depression
  • dyspnoea
  • abdominal pain
  • injury
  • nausea
  • gallbladder disorder
  • rash
  • cholelithiasis
  • pulmonary embolism
40-49:
  • pain
  • headache
  • fatigue
  • anxiety
  • back pain
  • dyspnoea
  • nausea
  • chest pain
  • fall
  • arthralgia
50-59:
  • anxiety
  • nausea
  • pain
  • diarrhoea
  • fatigue
  • asthenia
  • depression
  • arthralgia
  • chest pain
  • headache
60+:
  • nausea
  • anxiety
  • pain
  • dyspnoea
  • chest pain
  • fall
  • spinal osteoarthritis
  • pain in jaw
  • fatigue
  • anaemia

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat hypersensitivity. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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