Review: taking Zyrtec and Zoloft together


Summary

Drug interactions are reported among people who take Zyrtec and Zoloft together. This review analyzes the effectiveness and drug interactions between Zyrtec and Zoloft. It is created by eHealthMe based on reports of 1,714 people who take the same drugs from FDA and social media, and is updated regularly.

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Zyrtec

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in hypersensitivity. (latest outcomes from Zyrtec 30,545 users)

Zoloft

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 77,547 users)

On Jul, 22, 2016

1,714 people who take Zyrtec, Zoloft are studied.


Number of reports submitted per year:

Zyrtec and Zoloft drug interactions.

Drug effectiveness over time:

Zyrtec:
  • < 1 month: 15.0% - (2 of 13 people)
  • 1 - 6 months: 45.0% - (10 of 22 people)
  • 6 - 12 months: 88.0% - (15 of 17 people)
  • 1 - 2 years: 38.0% - (12 of 31 people)
  • 2 - 5 years: 51.0% - (17 of 33 people)
  • 5 - 10 years: 45.0% - (11 of 24 people)
  • 10+ years: 66.0% - (8 of 12 people)
  • not specified: 50.0% - (1 of 2 people)
Zoloft:
  • < 1 month: 20.0% - (2 of 10 people)
  • 1 - 6 months: 37.0% - (10 of 27 people)
  • 6 - 12 months: 26.0% - (4 of 15 people)
  • 1 - 2 years: 60.0% - (12 of 20 people)
  • 2 - 5 years: 60.0% - (18 of 30 people)
  • 5 - 10 years: 54.0% - (12 of 22 people)
  • 10+ years: 68.0% - (20 of 29 people)
  • not specified: 0.0% - (0 of 1 people)

Drug effectiveness by gender:

Zyrtec:
  • female: 49.0% - (63 of 127 people)
  • male: 48.0% - (13 of 27 people)
Zoloft:
  • female: 56.0% - (70 of 125 people)
  • male: 27.0% - (8 of 29 people)

Drug effectiveness by age:

Zyrtec:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 23.0% - (3 of 13 people)
  • 20-29: 47.0% - (9 of 19 people)
  • 30-39: 36.0% - (15 of 41 people)
  • 40-49: 62.0% - (28 of 45 people)
  • 50-59: 43.0% - (10 of 23 people)
  • 60+: 84.0% - (11 of 13 people)
Zoloft:
  • 0-1: 0.0% - (0 of 0 people)
  • 2-9: 0.0% - (0 of 0 people)
  • 10-19: 25.0% - (3 of 12 people)
  • 20-29: 47.0% - (9 of 19 people)
  • 30-39: 63.0% - (26 of 41 people)
  • 40-49: 53.0% - (24 of 45 people)
  • 50-59: 52.0% - (12 of 23 people)
  • 60+: 28.0% - (4 of 14 people)

Most common drug interactions over time *:

< 1 month:
  • erythema multiforme
  • gastritis
  • drug hypersensitivity
  • depression
  • rash
  • sleep disorder
  • blood glucose increased
  • dyspnoea
  • feeling jittery
  • oedema peripheral
1 - 6 months:
  • chest pain
  • oedema peripheral
  • pulmonary embolism
  • fatigue
  • atrial septal defect
  • depression
  • dyspnoea
  • hypoaesthesia
  • insomnia
  • myocardial infarction
6 - 12 months:
  • insomnia
  • congenital anomaly
  • foetal exposure during pregnancy
  • headache
  • petechiae
  • sudden infant death syndrome
  • acute sinusitis
  • cerumen impaction
  • chills
  • dehydration
1 - 2 years:
  • pulmonary embolism
  • bronchitis acute
  • irregular heartbeat
  • chest pain
  • dyspnoea exertional
  • hypoaesthesia
  • oedema peripheral
  • pain in extremity
  • tenderness
  • subclavian vein thrombosis
2 - 5 years:
  • abdominal pain
  • biliary dyskinesia
  • pain
  • nausea
  • cellulitis
  • depression
  • diarrhoea
  • discharge from the vagina
  • hot flashes
  • rash
5 - 10 years:
  • slurred speech
  • depression
  • anxiety
  • diarrhoea
  • exhaustion, fatigue, lethargy, tiredness, weariness
  • sleep disorder
  • tongue coated
  • fatigue
  • insomnia
  • kidney small
10+ years:
  • cellulitis
  • rash
  • sleep inertia
  • hypersomnia
  • cluster headache
  • fatigue
  • sweating increased
  • anxiety and stress
  • asthma aggravated
  • blurred vision
not specified:
  • pain
  • anxiety
  • nausea
  • dyspnoea
  • fatigue
  • fall
  • chest pain
  • headache
  • back pain
  • asthenia

Most common drug interactions by gender *:

female:
  • pain
  • anxiety
  • nausea
  • depression
  • fatigue
  • fall
  • dyspnoea
  • diarrhoea
  • abdominal pain
  • pain in extremity
male:
  • anxiety
  • pain
  • anaemia
  • chest pain
  • dyspnoea
  • osteonecrosis of jaw
  • spinal osteoarthritis
  • injury
  • nausea
  • arteriosclerosis

Most common drug interactions by age *:

2-9:
  • drug administration error
  • drug ineffective
  • dystonia
  • neck pain
10-19:
  • suicide attempt
  • dyspnoea
  • anxiety
  • vomiting
  • abnormal behaviour
  • cholelithiasis
  • injury
  • loss of consciousness
  • non-cardiac chest pain
  • pleural effusion
20-29:
  • pulmonary embolism
  • abdominal pain
  • chest pain
  • pain in extremity
  • pain
  • biliary dyskinesia
  • nausea
  • abdominal pain upper
  • rash
  • dyspnoea exertional
30-39:
  • pain
  • depression
  • abdominal pain
  • dyspnoea
  • rash
  • cholelithiasis
  • injury
  • gallbladder disorder
  • gastritis
  • nausea
40-49:
  • pain
  • headache
  • fatigue
  • anxiety
  • back pain
  • chest pain
  • dyspnoea
  • fall
  • nausea
  • asthenia
50-59:
  • anxiety
  • nausea
  • diarrhoea
  • asthenia
  • pain
  • fatigue
  • depression
  • vomiting
  • pyrexia
  • arthralgia
60+:
  • nausea
  • pain
  • anxiety
  • chest pain
  • dyspnoea
  • spinal osteoarthritis
  • pain in jaw
  • osteonecrosis of jaw
  • anaemia
  • cardiac failure congestive

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat hypersensitivity. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for and how effective they are.

What is the drug used for and how effecitve is it:


NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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