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What could cause Insomnia for a 75-year old man who takes Celebrex, Simvastatin, Dexilant?





Summary: 448 male patients aged 75 (±5) who take the same drugs are studied.

This is a personalized study for a 75 year old male patient who has Inflammatory Pain, Blood Cholesterol Decreased, Acid Reflux. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Celebrex has active ingredients of celecoxib. It is often used in arthritis. (latest outcomes from Celebrex 74,521 users)

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. (latest outcomes from Simvastatin 80,812 users)

Dexilant has active ingredients of dexlansoprazole. It is often used in gastroesophageal reflux disease. (latest outcomes from Dexilant 1,541 users)

What are the conditions

Inflammatory pain can be treated by Meloxicam, Ibuprofen, Celebrex, Naproxen, Prednisone, Diclofenac Sodium. (latest reports from Inflammatory Pain 551 patients)

Blood cholesterol decreased can be treated by Simvastatin, Lipitor, Crestor, Pravastatin Sodium, Atorvastatin Calcium, Lovastatin. (latest reports from Blood Cholesterol Decreased 880 patients)

Acid reflux (stomach acids rise up) can be treated by Omeprazole, Nexium, Prilosec, Prevacid, Protonix, Prilosec Otc. (latest reports from Acid Reflux 10,551 patients)

What is the symptom

Insomnia has been reported by people with depression, quit smoking, high blood pressure, pain, stress and anxiety.(latest reports from Insomnia 135,811 patients)

On Dec, 19, 2014: 448 males aged 73 (±5) who take Celebrex, Simvastatin, Dexilant are studied

Celebrex, Simvastatin, Dexilant outcomes

Information of the patient in this study:

Age: 73

Gender: male

Conditions: Inflammatory Pain, Blood Cholesterol Decreased, Acid Reflux

Drugs taking:
- Celebrex - 200MG (celecoxib): used for < 1 month
- Simvastatin - 80MG (simvastatin): used for 5 - 10 years
- Dexilant - 60MG (dexlansoprazole): used for 1 - 6 months

Drug interactions have: severe insomnia

eHealthMe real world results:

Comparison with this patient's adverse outcomes:

InteractionNumber of reports on eHealthMe
Insomnia (sleeplessness)18 (4.02% of males aged 73 (±5) who take the drugs)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

Symptom (click a symptom for in-depth analysis)Number of reports on eHealthMe
Insomnia in Inflammatory Pain1 (12.50% of males aged 73 (±5) who have Inflammatory pain)
Insomnia in Blood Cholesterol Decreased2 (2.70% of males aged 73 (±5) who have Blood cholesterol decreased)
Insomnia in Acid Reflux8 (1.41% of males aged 73 (±5) who have Acid reflux)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effect (click a side effect for in-depth analysis)Number of reports on eHealthMe
Insomnia in Celebrex63 (1.64% of males aged 73 (±5) who take Celebrex)
Insomnia in Simvastatin121 (1.05% of males aged 73 (±5) who take Simvastatin)
Insomnia in Dexilant2 (3.45% of males aged 73 (±5) who take Dexilant)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Celebrex is effective100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
n/an/an/an/a0.00%
(0 of 1 people)
n/a
Simvastatin is effectiven/an/an/a0.00%
(0 of 1 people)
n/a100.00%
(2 of 2 people)
n/an/a
Dexilant is effectiven/an/an/an/an/an/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hallucination, Visual (seeing things that aren't there)Myocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)Skin Hypopigmentation (loss of skin colour)Ischaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)Muscular Weakness (muscle weakness)Hyperthyroidism (over activity of the thyroid gland)Blood Bilirubin IncreasedPain
Renal Failure Acute (rapid kidney dysfunction)Coronary Artery Disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)Atrial Fibrillation (fibrillation of the muscles of the atria of the heart)Chest PainMyocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)Ischaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)Anxiety
DiarrhoeaArthropathyAnaemia Haemolytic Autoimmune (condition in which the immune system attacks the red blood cells, resulting in fewer of these oxygen-transporting cells)Congestive Cardiomyopathy (weakening of heart muscle)Anaemia (lack of blood)Hypertension (high blood pressure)Neuropathy Peripheral (surface nerve damage)
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)Back PainDyspnoea (difficult or laboured respiration)Atrial Flutter (an abnormal heart rhythm that occurs in the atria of the heart)Musculoskeletal Discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)Gout (uric acid crystals building up in the body)Pneumonia
Cardiac Failure CongestiveHypertension (high blood pressure)Fatigue (feeling of tiredness)Dyspnoea (difficult or laboured respiration)Oedema Peripheral (superficial swelling)Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)Back Pain
Erythema Multiforme (type of hypersensitivity reaction)Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)Pulmonary Embolism (blockage of the main artery of the lung)Gastric Haemorrhage (bleeding stomach)Spinal Column Stenosis (narrowing of spinal column)Dyspnoea Exertional (breathlessness or shortness of breath)Myocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Insomnia (sleeplessness)Gout (uric acid crystals building up in the body)Deep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)Gastrointestinal Haemorrhage (bleeding gastrointestinal tract)Myalgia (muscle pain)Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)Dehydration (dryness resulting from the removal of water)
HypersensitivityIschaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)Exostosis (formation of new bone on the surface of a bone)Gastritis (inflammation of stomach)Panic DisorderPain In ExtremityCerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug Administration ErrorHyperthyroidism (over activity of the thyroid gland)Hypercholesterolaemia (high levels of cholesterol in the blood)Tachycardia (a heart rate that exceeds the range of 100 beats/min)Peptic Ulcer (stomach ulcer)Thyroid Disorder (thyroid diseases)Chest Pain
Headache (pain in head)Pain In ExtremityHypersensitivityCardiac Failure CongestivePalpitations (feelings or sensations that your heart is pounding or racing)Ventricular Fibrillation (abnormally irregular heart rhythm)Fall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

You are not alone! Join a related mobile support group:
- support group for people who take Celebrex and have Insomnia
- support group for people who take Dexilant and have Insomnia
- support group for people who have Insomnia and Inflammatory Pain
- support group for people who have Insomnia and Blood Cholesterol Decreased
- support group for people who have Insomnia and Acid Reflux
- support group for people who have Acid Reflux
- support group for people who have Blood Cholesterol Decreased
- support group for people who have Inflammatory Pain
- support group for people who have Insomnia
- support group for people who take Celebrex
- support group for people who take Dexilant
- support group for people who take Simvastatin

Recent conversations of related support groups:

  • Support group for people who have Insomnia
    My insomnia was provoked by a 'medicine cocktail', prescribed medications that were contraindicated. I just had a rough experience with Serotonin Syndrome, grateful to be alive.

Can you answer these questions (Ask a question):

More questions for: Acid Reflux, Blood Cholesterol Decreased, Inflammatory Pain, Insomnia

You may be interested at these reviews (Write a review):

  • Nardil side effects and my experience taking it
    I have been on many SSRI AND SNRI medications that quickly became ineffective. Was told by a doctor friend that she had been on an MAOI inhibitor for many years with good results. After going thru a horrible withdrawal detox from the SNRI I had been on and then a period of no med at all I was started on Nardil, as I needed assistance from Pfizer, the many turner in affording the medicine. My friend was on Parnate, a different brand of an MAOI.
    Within days, not weeks I felt the depression lifting. It was the most dramatic and fastest response I had ever had to any antidepressant .
    Then the fainting started, falls with resulting broken ribs, bedridden and alone I lost over25 lbs in two weeks. I was of normal weight for my height. After I was able to function again, I noticed that my legs were very weak. We cut my dosage from 3 pills daily to 2. That seemed to have stopped the faint spells. However I still had/have low blood pressure that I monitor at home. My Systolic BP was usually in the 70's and 80's. One of the lowest was shocking to me. It was 52/27.
    My son is a hospital RN and said they would never discharge a patient with Bp that low.
    He was very worried about me as I live alone. I fainted twice after climbing the 13 stairs to my bedroom. The first fall was very bad as I was unconscious and my ribs were severely injured/fractured completely around the front and back and was in terrific pain. I took to my bed and did not seek medical attn. my last ambulance ride to the hospital a mile from my house cost $1000 and since I have no income or relatives/friends to call for help, I just lay in bed I awful pain that was woes when I tried to get out of bed. Thus I lost 25 lbs of muscle, since I had very little body fat.
    It has been two months since that fall and still have one area of pain in the front left ribs and a swollen spleen. The doctor gave me no additional meds and just said to give my body more time to heal. So once again was changed to 2 pills daily instead of 3. The hypotension and fainting got better. But I am now left with very weak legs and fall easily and frequently. Guess I lost a lot of muscle mass with the weight loss. However after a lifetime of depression, Nardil works wonderfully for that which had been long-standing and severe for so many years. People noticed the change in me shortly after starting the Nardil. But I am stubborn about going off it despite all the side effects because it works so much better than any of the many others I had been put on over the years.
    I am soon going to start doing leg exercises with ankle weights, starting with light weights are first and gradually increasing the weight as I hopefully rebuild my muscles and strength.
    Also my vision has gotten blurry and I feel slightly retarded after the weeks in bed when I was breathing very shallowly due to the broken ribs and my brain was deprived of adequate oxygen.
    Prior to all this I had an IQ of 140. If they tested me now, I know I would be way down from that. Also doing lung/breathing exercises to expand my lungs so I can take in more air with each breath.
    So that is my story of Nardil, hypotension, and depression. I had to really suffer to remain on this med that worked so magically for me after so many failures. It meant that much to me to not be crippled by depression.
  • Ranitidine is bad juju
    Used 3-5 times per week for about 1 1/2 years. Noticed:
    shortness of breath
    contstricted throat
    bloating
    chest pain/pressure
    heart palpatations
    dryness - more so than usual

    I quit taking it and felt much better within 2-3 days.
  • A life of depression and fatigue
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • Loss of voice and stomach issues
    Prescribed to take 2 - 300 mg tablets of Clindamycin prior to dental procedure to to knee implant done a month and half before dental procedure. Took two pills one hour prior and immediate severe burning of throat, esophagous and stomach with constant nausea. Still have symptons - ie loss of voice, low grade nausea. have had multitude of tests - ie. EGD's, monometry, transesophageal (with transmitter to determine extent of now reflux) Have to eat small amounts of food at a time. Have lost 23 lbs. Affects my every day life - difficult to talk on phone, talking in groups - just limit my socialization. Could not work if I wanted to with voice. Throat is constantly sore.
  • Doxylamine succinate and severe restless legs and insomnia
    Could not sleep so took 2 doxylamine gel tablets. Got very sleepy but could not actually fall asleep. So I ended up, over the next few hours, taking 3 more. More sleepiness and more restless legs, and still couldn't sleep At All. Up the entire night but couldn't really do anything cause I was so sleepy. Maddening. Do not understand at all.

More reviews for: Acid Reflux, Blood Cholesterol Decreased, Inflammatory Pain, Insomnia

Comments from related studies:

  • From this study (5 months ago):

  • I have a relatively weak erection (estimate 50-60% of maximum erection potential) and tend to have a weak orgasm with only a moderate amount of ejaculate (even after 2-4 weeks of abstinence). I am in excellent cardiovascular health exercising 3-4 days a week on an elliptical, achieving sustained exercise heart rate in 70%-90% of maximum range. My resting heart rate is 50-55 beats per minute, my cholesterol and triglyceride levels are well controlled with exercise and zocor. My blood pressure is well controlled by Hyzaar 100/25. I have never tried medications such as Viagra, Cialis or Levitra for this problem. Perhaps they would help, but I feel the main reasons for my problems are my age (64) and the side effects of the combinations of drugs I take. Also, last year I had my testosterone level checked it was 399 (normal range 400-1200).Perhaps this is also part of my problem?? Thank you for any advice.

    Reply

  • From this study (7 months ago):

  • Tickle in throat about even with jawline. I feel like I could put my finger on it. Only tickles in 1 spot. Causes a coughing spasm so bad that people think I am choking. Sometimes tickle happens when I swallow causing the same coughing spasm. Sometimes I wheeze after one of the choking fits, and that lasts about 1/2 of an hour. Usually sucking on a piece of hard candy ends the coughing for awhile. I have been doing this for about 7 months. Swallow test performed and it is normal,

    Reply

  • From this study (7 months ago):

  • elevated procalcitonin >9.0! Can this be due to rapamune and/or prograf?

    Reply

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Drug effectiveness in real world:

In-depth study of side effects (who have it, when it happens and how):

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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