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From FDA reports: side effects of Letrozole

This is a study of Letrozole side effects. The study is created by eHealthMe based on reports of 9,442 people who take the same drug and have side effectsfrom FDA.

On Jan, 31, 2015: 9,442 people who reported to have side effects when taking Letrozole are studied

Trend of Letrozole's drug interactions, side effects, and effectiveness reports (8221050)

Information of the patient in this study:

Gender: female

Conditions: Breast Cancer

Drugs taking:
- Letrozole

Side effects have: Spondylitic Myelopathy, Myelomalacia

eHealthMe real world results:

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

Side effectNumber of reports
Spondylitic Myelopathy (an inflammation of the vertebra)14 (0.15%)
Myelomalacia (softening and damage of the spinal cord due to some injury like compression by disc extrusion)10 (0.11%)

Most common side effects experienced by people in the use of Letrozole:

Side effectNumber of reports
Bone Disorder2,290
Osteonecrosis Of Jaw (death of bone of jaw)2,222
Arthralgia (joint pain)2,212
Fatigue (feeling of tiredness)1,947
Osteonecrosis (death of bone)1,816
Dyspnoea (difficult or laboured respiration)1,692
Nausea (feeling of having an urge to vomit)1,622
Back Pain1,570

Most common side effects experienced by people in long term use of Letrozole:

Side effectNumber of reports
Bone Disorder168
Pain In Jaw142
Impaired Healing138
Osteomyelitis (infection of bone)136
Osteonecrosis (death of bone)136
Metastases To Bone (cancer spreads to bone)120
Arthralgia (joint pain)118
Osteonecrosis Of Jaw (death of bone of jaw)114

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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