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Review: taking Adderall and Tramadol together

Summary: drug interactions are reported among people who take Adderall and Tramadol together.

This review analyzes the effectiveness and drug interactions between Adderall and Tramadol. It is created by eHealthMe based on reports of 290 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 13, 2015: 290 people who take Adderall, Tramadol are studied

Adderall, Tramadol outcomes

Drug combinations in study:
- Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Adderall is effective33.33%
(5 of 15 people)
(9 of 19 people)
(7 of 14 people)
(14 of 21 people)
(9 of 19 people)
(2 of 3 people)
(4 of 4 people)
Tramadol is effective10.53%
(2 of 19 people)
(6 of 19 people)
(2 of 15 people)
(5 of 18 people)
(3 of 13 people)
(5 of 10 people)
(0 of 2 people)

Drug effectiveness by gender :

Adderall is effective57.75%
(41 of 71 people)
(8 of 23 people)
Tramadol is effective24.66%
(18 of 73 people)
(5 of 23 people)

Drug effectiveness by age :

Adderall is effectiven/an/an/a15.15%
(10 of 66 people)
(23 of 97 people)
(9 of 28 people)
(7 of 15 people)
Tramadol is effectiven/an/an/a12.31%
(8 of 65 people)
(10 of 99 people)
(3 of 28 people)
(2 of 15 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Mental Status ChangesMental Status ChangesFatigueInjuryPainDrowsinessDizzinessFatigue
Sinus TachycardiaAcneHot FlashesLung ConsolidationSphincter Of Oddi DysfunctionDizzinessEuphoric MoodNausea
Blood Potassium DecreasedDehydrationDyspnoeaPulmonary EmbolismGallbladder DisorderAnxietyMuscle FatiguePain
Confusional StateRenal Failure AcuteNauseaDepressionNauseaHeadacheHigh Blood PressureAnxiety
Renal Failure AcuteDyspepsiaSweating - ExcessiveConstipationCholecystitis ChronicNeuropathy - Sciatic NerveSweating - ExcessiveGallbladder Disorder
HallucinationDepressed MoodAgitationDifficulty In BreathingDepressionJock ItchHeadache
HypophagiaAbnormal BehaviourCognitive DeteriorationInsomniaPancreatitisPeripheral NeuropathyWeight Decreased
Urinary Tract InfectionBlood Potassium DecreasedImpaired MemoryFeeling JitteryAnxietyPain - BackHypoaesthesia
Electrolyte ImbalanceSubstance AbuseWeaknessButterfly RashDyspnoeaCholecystitis ChronicDyspepsia
DehydrationSinus TachycardiaPalpitations AggravatedPainful Red EyesPain In ExtremityEmotional DistressVomiting

Most common drug interactions by gender * :

FatigueDrug Toxicity
PainPulmonary Oedema
NauseaSerotonin Syndrome
AnxietyHepatitis C
Gallbladder DisorderOverdose
Cholecystitis ChronicErectile Dysfunction
Pulmonary EmbolismHeart Rate Increased

Most common drug interactions by age * :

n/an/aPainGallbladder DisorderPainHeadacheFatigueDepression
Cholecystitis ChronicNauseaHypoaesthesiaFatigueConstipationLimb Crushing Injury
Gallbladder DisorderPulmonary OedemaNauseaDyspepsiaHypoaesthesiaNeuralgia
PancreatitisDrug ToxicityMigraineCatatoniaAnxietyOedema Peripheral
Sphincter Of Oddi DysfunctionSerotonin SyndromeFatigueAnxietyNauseaJoint Swelling
FatiguePulmonary EmbolismLivedo ReticularisDrug DetoxificationInsomniaHypertonic Bladder
OverdoseAbdominal DiscomfortBone Marrow DisorderWithdrawal SyndromeDepressionHaemorrhage Intracranial
NauseaPainChest PainPainWhite Blood Cell Count DecreasedHip Fracture
Respiratory DepressionCholecystitis ChronicSystemic Lupus ErythematosusHeart Rate IrregularMuscle TwitchingPelvic Fracture
Cardiac ArrestInjuryPain In ExtremityInsomniaPainJaw Fracture

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Adderall
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate) is often used to treat attention deficit hyperactivity disorder. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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