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Review: taking Arava and Plaquenil together

Summary: drug interactions are reported among people who take Arava and Plaquenil together.

This review analyzes the effectiveness and drug interactions between Arava and Plaquenil. It is created by eHealthMe based on reports of 1,915 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 1, 2015: 1,915 people who take Arava, Plaquenil are studied

Arava, Plaquenil outcomes

Drug combinations in study:
- Arava (leflunomide)
- Plaquenil (hydroxychloroquine sulfate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Arava is effective0.00%
(0 of 4 people)
(1 of 13 people)
(0 of 4 people)
(0 of 1 people)
(2 of 9 people)
(0 of 2 people)
(1 of 3 people)
Plaquenil is effectiven/a28.57%
(2 of 7 people)
(0 of 4 people)
(1 of 6 people)
(4 of 15 people)
(0 of 5 people)
(0 of 4 people)

Drug effectiveness by gender :

Arava is effective13.79%
(4 of 29 people)
(0 of 7 people)
Plaquenil is effective12.12%
(4 of 33 people)
(3 of 8 people)

Drug effectiveness by age :

Arava is effectiven/an/an/an/a18.18%
(2 of 11 people)
(1 of 10 people)
(0 of 19 people)
(1 of 12 people)
Plaquenil is effectiven/an/an/an/a8.33%
(1 of 12 people)
(1 of 11 people)
(1 of 22 people)
(4 of 13 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DiarrhoeaPneumoniaPelvic PainNauseaNauseaGastritisAnorexiaPyrexia
PneumoniaLymphadenopathyVaginal HaemorrhagePneumoniaProgressive Multifocal LeukoencephalopathyCardiac FailureAscitesArthralgia
Drug Exposure During PregnancyLung NeoplasmSquamous Cell Carcinoma Of The CervixVomitingVomitingGastrointestinal DisorderAbdominal DistensionNausea
Abdominal PainOvarian CystCellulitisBeta Haemolytic Streptococcal InfectionHepatic CirrhosisRheumatoid ArthritisLymphedemaInjection Site Pain
Escherichia InfectionEscherichia InfectionNauseaCellulitisHepatitis FulminantMyocardial InfarctionWhite Blood Cell Count IncreasedRheumatoid Arthritis
Lung NeoplasmPseudomonas InfectionLung NeoplasmHepatic FailureDrug Exposure During PregnancyErythemaRheumatoid ArthritisInjection Site Erythema
Chest PainAppendicitis PerforatedLymphadenopathyDyspnoeaAscitesPainHepatic CirrhosisFatigue
Appendicitis PerforatedCellulitisPneumoniaPyrexiaBlood Alkaline Phosphatase IncreasedMental Status ChangesNauseaDrug Ineffective
VomitingNauseaOvarian CystHypertensionCellulitisConfusional StateBreast Cancer Stage IiDyspnoea
LymphadenopathyBeta Haemolytic Streptococcal InfectionEscherichia InfectionFatigueColitis IschaemicWeight IncreasedBreast CancerDiarrhoea

Most common drug interactions by gender * :

NauseaDrug Ineffective
Injection Site PainFatigue
Rheumatoid ArthritisDyspnoea
Injection Site ErythemaArthralgia
FatigueMyocardial Infarction

Most common drug interactions by age * :

n/an/aInjection Site UrticariaVaginal HaemorrhageDrug Exposure During PregnancyInjection Site ErythemaRheumatoid ArthritisPneumonia
Serum SicknessPelvic PainPyrexiaPyrexiaArthralgiaArthralgia
Drug Exposure During PregnancyDrug Exposure During PregnancyPregnancyNauseaInjection Site PainNausea
Injection Site RashSquamous Cell Carcinoma Of The CervixInjection Site PainFatigueDrug IneffectiveRheumatoid Arthritis
Injection Site PainHeadacheHypotensionDyspnoeaHeadachePyrexia
Injection Site HaemorrhageStaphylococcal AbscessDiarrhoeaInjection Site HaematomaDizzinessPancytopenia
DyspnoeaRenal Impairment NosGastroenteritisAlopeciaPainFall
Feeling HotSweating IncreasedMetabolic AcidosisHeadacheFatigueOedema Peripheral
Injection Site BurningTachycardia NosHypoxiaInjection Site PainPyrexiaDyspnoea
ErythemaMalaiseSepsisMyocardial InfarctionChillsPain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Arava
- support group for people who take Plaquenil

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Arava (leflunomide) is often used to treat rheumatoid arthritis. Plaquenil (hydroxychloroquine sulfate) is often used to treat systemic lupus erythematosus. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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