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Review: Arava and Plaquenil

This review analyzes the effectiveness and drug interactions between Arava and Plaquenil. It is created by eHealthMe based on reports of 1,913 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Arava and Plaquenil >>>

What are the drugs

Arava (latest outcomes from 16,321 users) has active ingredients of leflunomide. It is often used in rheumatoid arthritis.

Plaquenil (latest outcomes from 15,494 users) has active ingredients of hydroxychloroquine sulfate. It is often used in rheumatoid arthritis.

On Sep, 15, 2014: 1,913 people who take Arava, Plaquenil are studied

Arava, Plaquenil outcomes

Drug combinations in study:
- Arava (leflunomide)
- Plaquenil (hydroxychloroquine sulfate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Arava is effective0.00%
(0 of 4 people)
(1 of 12 people)
(0 of 3 people)
(0 of 1 people)
(2 of 9 people)
(0 of 2 people)
(1 of 3 people)
Plaquenil is effectiven/a33.33%
(2 of 6 people)
(0 of 4 people)
(1 of 6 people)
(3 of 14 people)
(0 of 5 people)
(0 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DiarrhoeaPneumoniaPelvic PainNauseaProgressive Multifocal LeukoencephalopathyGastritisAnorexiaPyrexia
PneumoniaLymphadenopathyVaginal HaemorrhagePneumoniaNauseaCardiac FailureAscitesArthralgia
Drug Exposure During PregnancyLung NeoplasmSquamous Cell Carcinoma Of The CervixVomitingVomitingGastrointestinal DisorderAbdominal DistensionNausea
Abdominal PainCellulitisCellulitisBeta Haemolytic Streptococcal InfectionHepatic CirrhosisRheumatoid ArthritisLymphedemaInjection Site Pain
Escherichia InfectionEscherichia InfectionNauseaCellulitisBlood Alkaline Phosphatase IncreasedMyocardial InfarctionWhite Blood Cell Count IncreasedRheumatoid Arthritis
Lung NeoplasmPseudomonas InfectionDrug Exposure During PregnancyHepatic FailureAscitesErythemaRheumatoid ArthritisInjection Site Erythema
Chest PainAppendicitis PerforatedBeta Haemolytic Streptococcal InfectionDyspnoeaHepatitis FulminantPainHepatic CirrhosisFatigue
Appendicitis PerforatedOvarian CystAppendicitis PerforatedPyrexiaDrug Exposure During PregnancyMental Status ChangesNauseaDrug Ineffective
VomitingNauseaEscherichia InfectionHypertensionColitis IschaemicConfusional StateBreast Cancer Stage IiDyspnoea
LymphadenopathyBeta Haemolytic Streptococcal InfectionHepatitis FulminantFatigueAstheniaWeight IncreasedBreast CancerDiarrhoea

Drug effectiveness by gender :

Arava is effective14.81%
(4 of 27 people)
(0 of 7 people)
Plaquenil is effective9.68%
(3 of 31 people)
(3 of 8 people)

Most common drug interactions by gender * :

NauseaDrug Ineffective
Injection Site PainFatigue
Rheumatoid ArthritisDyspnoea
Injection Site ErythemaArthralgia
FatigueMyocardial Infarction

Drug effectiveness by age :

Arava is effectiven/an/an/an/a18.18%
(2 of 11 people)
(1 of 6 people)
(0 of 19 people)
(1 of 11 people)
Plaquenil is effectiven/an/an/an/a8.33%
(1 of 12 people)
(1 of 7 people)
(1 of 22 people)
(3 of 12 people)

Most common drug interactions by age * :

n/an/aInjection Site UrticariaVaginal HaemorrhageDrug Exposure During PregnancyInjection Site ErythemaRheumatoid ArthritisArthralgia
Serum SicknessPelvic PainPyrexiaPyrexiaArthralgiaPneumonia
Drug Exposure During PregnancyDrug Exposure During PregnancyPregnancyNauseaInjection Site PainNausea
Injection Site RashSquamous Cell Carcinoma Of The CervixInjection Site PainFatigueDrug IneffectiveRheumatoid Arthritis
Injection Site PainHeadacheHypotensionDyspnoeaHeadachePyrexia
Injection Site HaemorrhageStaphylococcal AbscessDiarrhoeaInjection Site HaematomaDizzinessFall
DyspnoeaRenal Impairment NosGastroenteritisAlopeciaPainPancytopenia
Feeling HotSweating IncreasedMetabolic AcidosisInjection Site PainFatigueOedema Peripheral
Injection Site BurningTachycardia NosHypoxiaChest PainPyrexiaDyspnoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Arava and Plaquenil?

Comments from related studies:

  • From this study (5 months ago):

  • only since Methotrexate has increased to 12.5mg / week
    I take plaquenil 200mg 2 x day
    arava 20mg 1 x day
    celebrex 200mg 1 x day
    prednisolone 6mg x day
    methotrexate 12.5mg 1 x week
    megafol 5mg 2 x week


  • From this study (5 months ago):

  • Im not sure if the meds I take for RA is causing broken bone not to heal or if the RA itself is effecting it?



  • From this study (6 months ago):

  • I have been choking on medication and food. I had a barium swallow test that showed a narrowing of the esophagus.


Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

  • Can people with hypothyroidism take garcinia cambogia?
    I have hypothyroidism, ITP, and MCTD. With me having all of these issues and taking all these different medications, I was wondering if it would be safe for me to take a diet pill named garcinia cambogia.

  • So does hydroxychloroquine cause celiac desease?
    Been tested over the years for celiac and always negitive. Only had IBS. Took hydroxychloroquine for a year and it effected my vision. Then retested again for celiac because of authrits pain and now I'm positive for celiac.

  • What causes it? and why is it so painful?
    I can lift my arm out in front of me but not out to the side!! The diclofenac doesn't seem to help. Any suggestions? Has anyone been on benlysta?

More questions for: Arava, Plaquenil

You may be interested at these reviews (what is this?):

  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen ...

  • Plaquinil use shortness of breath
    Approximately 4 months after starting Plaquenil, I observed I was experiencing SOB while lifting the patient I was caring for, also had severe muscle weakness. I had been out of the country for several weeks and thought I might have picked up something while in The Dominican. I was also losing wei ...

More reviews for: Arava, Plaquenil

Complete drug side effects:

On eHealthMe, Arava (leflunomide) is often used to treat rheumatoid arthritis. Plaquenil (hydroxychloroquine sulfate) is often used to treat systemic lupus erythematosus. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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