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Review: Arava and Plaquenil





Summary: drug interactions are reported among people who take Arava and Plaquenil together.

This review analyzes the effectiveness and drug interactions between Arava and Plaquenil. It is created by eHealthMe based on reports of 1,914 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Arava and Plaquenil >>>

What are the drugs

Arava has active ingredients of leflunomide. It is often used in rheumatoid arthritis. (latest outcomes from Arava 16,327 users)

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. (view latest outcomes from 15,517 users)

On Nov, 28, 2014: 1,914 people who take Arava, Plaquenil are studied

Arava, Plaquenil outcomes

Drug combinations in study:
- Arava (leflunomide)
- Plaquenil (hydroxychloroquine sulfate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Arava is effective0.00%
(0 of 4 people)
8.33%
(1 of 12 people)
0.00%
(0 of 4 people)
0.00%
(0 of 1 people)
22.22%
(2 of 9 people)
0.00%
(0 of 2 people)
33.33%
(1 of 3 people)
n/a
Plaquenil is effectiven/a28.57%
(2 of 7 people)
0.00%
(0 of 4 people)
16.67%
(1 of 6 people)
21.43%
(3 of 14 people)
0.00%
(0 of 5 people)
0.00%
(0 of 4 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DiarrhoeaPneumoniaPelvic PainNauseaProgressive Multifocal LeukoencephalopathyGastritisAnorexiaPyrexia
PneumoniaLymphadenopathyVaginal HaemorrhagePneumoniaNauseaCardiac FailureAscitesArthralgia
Drug Exposure During PregnancyLung NeoplasmSquamous Cell Carcinoma Of The CervixVomitingVomitingGastrointestinal DisorderAbdominal DistensionNausea
Abdominal PainCellulitisCellulitisBeta Haemolytic Streptococcal InfectionHepatic CirrhosisRheumatoid ArthritisLymphedemaInjection Site Pain
Escherichia InfectionEscherichia InfectionNauseaCellulitisBlood Alkaline Phosphatase IncreasedMyocardial InfarctionWhite Blood Cell Count IncreasedRheumatoid Arthritis
Lung NeoplasmOvarian CystLung NeoplasmHepatic FailureAscitesErythemaRheumatoid ArthritisInjection Site Erythema
Chest PainAppendicitis PerforatedLymphadenopathyDyspnoeaHepatitis FulminantPainHepatic CirrhosisFatigue
Appendicitis PerforatedPseudomonas InfectionPneumoniaPyrexiaDrug Exposure During PregnancyMental Status ChangesNauseaDrug Ineffective
VomitingBeta Haemolytic Streptococcal InfectionOvarian CystHypertensionColitis IschaemicConfusional StateBreast Cancer Stage IiDyspnoea
LymphadenopathyNauseaEscherichia InfectionFatigueAstheniaWeight IncreasedBreast CancerDiarrhoea

Drug effectiveness by gender :

FemaleMale
Arava is effective14.29%
(4 of 28 people)
0.00%
(0 of 7 people)
Plaquenil is effective9.38%
(3 of 32 people)
37.50%
(3 of 8 people)

Most common drug interactions by gender * :

FemaleMale
PyrexiaAsthenia
NauseaDrug Ineffective
ArthralgiaNausea
Injection Site PainFatigue
Rheumatoid ArthritisDyspnoea
FatigueArthralgia
Injection Site ErythemaMyocardial Infarction
DyspnoeaPyrexia
DiarrhoeaPneumonia
PainPruritus

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Arava is effectiven/an/an/an/a18.18%
(2 of 11 people)
10.00%
(1 of 10 people)
0.00%
(0 of 19 people)
9.09%
(1 of 11 people)
Plaquenil is effectiven/an/an/an/a8.33%
(1 of 12 people)
9.09%
(1 of 11 people)
4.55%
(1 of 22 people)
25.00%
(3 of 12 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aInjection Site UrticariaVaginal HaemorrhageDrug Exposure During PregnancyInjection Site ErythemaRheumatoid ArthritisArthralgia
Serum SicknessPelvic PainPyrexiaPyrexiaArthralgiaPneumonia
Drug Exposure During PregnancyDrug Exposure During PregnancyPregnancyNauseaInjection Site PainNausea
Injection Site RashSquamous Cell Carcinoma Of The CervixInjection Site PainFatigueDrug IneffectiveRheumatoid Arthritis
Injection Site PainHeadacheHypotensionDyspnoeaHeadachePyrexia
Injection Site HaemorrhageStaphylococcal AbscessDiarrhoeaInjection Site HaematomaDizzinessFall
DyspnoeaRenal Impairment NosGastroenteritisAlopeciaPainPancytopenia
Feeling HotSweating IncreasedMetabolic AcidosisHeadacheFatigueOedema Peripheral
Injection Site BurningTachycardia NosHypoxiaInjection Site PainPyrexiaDyspnoea
ErythemaMalaiseSepsisMyocardial InfarctionChillsPain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Arava and Plaquenil?

You are not alone! Join a related mobile support group:
- support group for people who take Arava and Plaquenil
- support group for people who take Arava
- support group for people who take Plaquenil

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

  • What did the doctors say the cause of your low platelet count? did your drop in less than 24 hours?
    After getting decadron I got hot, eyes got red, had chest pressure and couldn't breath. First xray showed no pneumonia, no blood clots. They said it was a Collapsed lung then two days later, after pulmonary scan they said Pneumonia but couldn't explain drop in platelet count before diagnosis of pneumonia.
  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
  • Can people with hypothyroidism take garcinia cambogia? (1 answer)
    I have hypothyroidism, ITP, and MCTD. With me having all of these issues and taking all these different medications, I was wondering if it would be safe for me to take a diet pill named garcinia cambogia.
  • So does hydroxychloroquine cause celiac desease?
    Been tested over the years for celiac and always negitive. Only had IBS. Took hydroxychloroquine for a year and it effected my vision. Then retested again for celiac because of authrits pain and now I'm positive for celiac.
  • What causes it? and why is it so painful? (1 answer)
    I can lift my arm out in front of me but not out to the side!! The diclofenac doesn't seem to help. Any suggestions? Has anyone been on benlysta?

More questions for: Arava, Plaquenil

You may be interested at these reviews (Write a review):

  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Plaquinil use shortness of breath
    Approximately 4 months after starting Plaquenil, I observed I was experiencing SOB while lifting the patient I was caring for, also had severe muscle weakness. I had been out of the country for several weeks and thought I might have picked up something while in The Dominican. I was also losing weight without trying, A positive consequence as far as I was concerned. Generally I expect to see side effects when beginning a drug so it took me 9 more months of being tested for PFT's sleep studies, pulse ox while sleeping, many and various blood testsand cardiac testing. I was so sick of testing especially when all tests came back in normal limits. One day in a point of desperation I looked on line and there it was buried toward the end of side effects of plaquenil and most specifically for women in my age bracket in the 60% range. It can take up to a year for these to develop! I found my answer and immediately stopped the plaquenil, reported my findings to my doctor.

More reviews for: Arava, Plaquenil

Comments from related studies:

  • From this study (8 months ago):

  • only since Methotrexate has increased to 12.5mg / week
    I take plaquenil 200mg 2 x day
    arava 20mg 1 x day
    celebrex 200mg 1 x day
    prednisolone 6mg x day
    methotrexate 12.5mg 1 x week
    megafol 5mg 2 x week

    Reply

  • From this study (8 months ago):

  • Im not sure if the meds I take for RA is causing broken bone not to heal or if the RA itself is effecting it?

    Thanks

    Reply

  • From this study (9 months ago):

  • I have been choking on medication and food. I had a barium swallow test that showed a narrowing of the esophagus.

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Arava (leflunomide) is often used to treat rheumatoid arthritis. Plaquenil (hydroxychloroquine sulfate) is often used to treat rheumatoid arthritis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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