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Review: Benadryl and Clonazepam





Summary: drug interactions are reported among people who take Benadryl and Clonazepam together.

This review analyzes the effectiveness and drug interactions between Benadryl and Clonazepam. It is created by eHealthMe based on reports of 1,473 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Benadryl and Clonazepam >>>

What are the drugs

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (view latest outcomes from 29,367 users)

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Clonazepam 41,274 users)

On Dec, 16, 2014: 1,473 people who take Benadryl, Clonazepam are studied

Benadryl, Clonazepam outcomes

Drug combinations in study:
- Benadryl (diphenhydramine hydrochloride)
- Clonazepam (clonazepam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Benadryl is effective31.58%
(6 of 19 people)
41.67%
(5 of 12 people)
60.00%
(6 of 10 people)
45.45%
(5 of 11 people)
45.45%
(5 of 11 people)
40.00%
(6 of 15 people)
55.56%
(5 of 9 people)
100.00%
(1 of 1 people)
Clonazepam is effective26.67%
(4 of 15 people)
25.00%
(4 of 16 people)
28.57%
(2 of 7 people)
80.00%
(4 of 5 people)
43.48%
(10 of 23 people)
64.71%
(11 of 17 people)
80.00%
(8 of 10 people)
100.00%
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
HeadacheDepressionShort-term Memory LossHeart Rate IncreasedInjuryArthritisItchingPain
HypotensionPathological GamblingBlood Triglycerides IncreasedHigh Blood PressureCholelithiasisPseudoporphyriaBack Pain AggravatedNausea
Bk Virus InfectionPseudoporphyriaExhaustion, Fatigue, Lethargy, Tiredness, WearinessStomach PainPainFatigue - ChronicLightheadednessDepression
Cystitis HaemorrhagicInflammationHigh Blood SugarPerimenopauseBipolar DisorderMemory LossDizzinessAnxiety
HyperbilirubinaemiaArthritisWeight Gain - UnintentionalTeeth Grinding And ClenchingItchingConstipationAortic Valve StenosisHeadache
SepsisHomicideSweating - ExcessiveInability To CrawlItching - Burning EyesDepressionAccidental DeathFall
Cytomegalovirus InfectionHeart Rate IncreasedDrowsinessDisorientationStressUrine Flow DecreasedBreathing Difficulty - Lying DownInsomnia
Mucosal InflammationDysarthriaDiarrhoeaNeutrophil Count IncreasedMuscle TwitchingAnxietyBreathing SoundsDyspnoea
DehydrationAbortion SpontaneousFeeling JitteryLymphocyte Count DecreasedAngerFacial PainDermatitis AcneiformFatigue
Suicidal IdeationFacial Nerve PalsyLymphocyte Count DecreasedExcessive SkinInability To CrawlItchingHot FlashesWeight Increased

Drug effectiveness by gender :

FemaleMale
Benadryl is effective43.28%
(29 of 67 people)
47.62%
(10 of 21 people)
Clonazepam is effective45.83%
(33 of 72 people)
50.00%
(11 of 22 people)

Most common drug interactions by gender * :

FemaleMale
NauseaAnxiety
PainDepression
DepressionPain
FallDyspnoea
HeadacheWeight Increased
AnxietyInsomnia
InsomniaVomiting
FatigueFatigue
DyspnoeaNausea
Weight IncreasedBack Pain

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Benadryl is effectiven/an/a66.67%
(2 of 3 people)
38.10%
(8 of 21 people)
17.54%
(10 of 57 people)
13.46%
(7 of 52 people)
40.00%
(10 of 25 people)
25.00%
(2 of 8 people)
Clonazepam is effectiven/an/a50.00%
(2 of 4 people)
34.78%
(8 of 23 people)
21.05%
(12 of 57 people)
14.55%
(8 of 55 people)
48.00%
(12 of 25 people)
25.00%
(2 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Pulmonary HypertensionSuicidal IdeationSuicidal IdeationInsomniaNauseaHeadacheFallPain
Urethral StenosisDehydrationWeight IncreasedUrinary Tract InfectionDiabetes MellitusDepressionPainHypertension
Weight IncreasedGrand Mal ConvulsionNauseaNauseaAnxietyPainAnxietyDepression
Type 2 Diabetes MellitusSepsisAbdominal Pain UpperVomitingVomitingFallCoughFatigue
Obstruction GastricHypotensionFatigueAstheniaChest PainSuicidal IdeationDepressionAnxiety
Myocarditis Post InfectionViral InfectionWeight DecreasedPericardial EffusionPainNauseaInsomniaNausea
NephrolithiasisDisease ProgressionPyrexiaAbdominal Pain UpperDyspnoeaDyspnoeaPain In ExtremityAnaemia
PancreatitisDrug Administration ErrorHeadacheDyspnoeaCompleted SuicideAnxietyNauseaInsomnia
ConvulsionDepressionAnaemiaDizzinessBack PainPyrexiaDyspnoea
Stevens-johnson SyndromeDrug Withdrawal SyndromeUpper Respiratory Tract InfectionMuscle SpasmsHypotensionHeadacheFall

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Benadryl and Clonazepam?

You are not alone! Join a related mobile support group:
- support group for people who take Benadryl and Clonazepam
- support group for people who take Benadryl
- support group for people who take Clonazepam

Can you answer these questions (Ask a question):

  • Does benadryl work for pet dander? (1 answer)
    hi I have been taking Benadryl or pet dander? It seemed to work well even if I only take one tablet. Does anyone also find that taking one tablet does not make you drowsy? How often should I take one tablet of Benadryl which is 25 mg? has anyone found any other allergy medication that work or pet dander? Thank you very much.
  • What causes a headache only when coughing or shaking the head?
    Head hurts only when shaken or I cough. I suspect benadryl or amytriptaline
  • Does zoloft cause ringing in the ears, like tinnitus? i've been on it for a month and noticed the ringing in the ears about a week ago, and it's just constant ringing and it's driving me insane. (1 answer)
    I've been on most of the medications for more than a year and it hasn't been that bad getting used to them. But I've been on Zoloft and ambien for about a month now, and I've been noticing a lot of side effects. The one I just recently noticed and that has been driving me completely insane, is the ringing in the ears. It's been about a week now and I just don't know what to do anymore. If it is the Zoloft then I can finally just stop taking it and make this stop. If anyone has an answer or knows what to do, PLEASE help. I'm at my wits end.
  • Can my eye twitch be because of lexapro?
    So I have had symptoms of anxiety and depression due to a lot of stressors and disasters that happened in my life over the past two years. As my anxiety got worse after a breast biopsy, I started freaking out and thinking I may have MS because my sister has MS. So I went to my GP and she decided my symptoms do not follow the symptoms of MS or any similar problem and it should most likely be anxiety. She put me on Lexapro and Clonazepam. At first I was very hesitant to take medication but as my symptoms got worse I decided to give it a try. I was on Lexopro 5 mg for about two months and then I went to 10 mg, and I would take 1 or 2 Clonazepam a day. And this all started 5 months ago. And things seemed to be working just fine.Until about two months ago I started having this freaking annoying eye twitch on my upper left eyelid. I have had eye twitches before but they always go away after a couple of days or a week top. This one has been lasting for 2 months now and seems to be just getting worse. I went to the GP and my eye doctor and they still found no cause and said it's probably stress and anxiety. I have not been overly stressed and I get plenty of sleep, 10 hrs or more! and I stopped taking caffeine and alcohol after the twitch started. Any idea? Could it be because of medication? I also need to add I have had thumb twitching and severe spasms in my muscles around my right thumb starting in May (before taking any medication).
  • I have a-fib after taking benadryl. i've been off it for a few days, but flutters remain. how long does it last?
    I took 6 pills a day for a week, have been off medication for several days, but A-Fib symptoms continue.

More questions for: Benadryl, Clonazepam

You may be interested at these reviews (Write a review):

  • A life of depression and fatigue
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.

More reviews for: Benadryl, Clonazepam

Comments from related studies:

  • From this study (5 months ago):

  • I have a relatively weak erection (estimate 50-60% of maximum erection potential) and tend to have a weak orgasm with only a moderate amount of ejaculate (even after 2-4 weeks of abstinence). I am in excellent cardiovascular health exercising 3-4 days a week on an elliptical, achieving sustained exercise heart rate in 70%-90% of maximum range. My resting heart rate is 50-55 beats per minute, my cholesterol and triglyceride levels are well controlled with exercise and zocor. My blood pressure is well controlled by Hyzaar 100/25. I have never tried medications such as Viagra, Cialis or Levitra for this problem. Perhaps they would help, but I feel the main reasons for my problems are my age (64) and the side effects of the combinations of drugs I take. Also, last year I had my testosterone level checked it was 399 (normal range 400-1200).Perhaps this is also part of my problem?? Thank you for any advice.

    Reply

  • From this study (6 months ago):

  • 27 L knee operations, three massive L knee infections resulting in a third and final arthoplasty revision. Extensive soft tissue damage resulting in perminante subqutanious sutuers and locking full leg brace, also perminante.

    Daily swelling in the knee joint (4 to 6 cm daily). Constant pain as well as additional pain when walking.

    Reply

  • From this study (6 months ago):

  • Itching in extremeties with no rash apparent. Eyes watery and burning. Twitching is in left eyelid. Itching started 8 days ago. Lotion does not help much. Diphenhydramine does not help much.

    Reply

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Complete drug side effects:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Clonazepam (clonazepam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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