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Review: Benadryl and Zofran





Summary: drug interactions are reported among people who take Benadryl and Zofran together.

This review analyzes the effectiveness and drug interactions between Benadryl and Zofran. It is created by eHealthMe based on reports of 745 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Benadryl and Zofran >>>

What are the drugs

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (view latest outcomes from 29,367 users)

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. (view latest outcomes from 885 users)

On Nov, 25, 2014: 745 people who take Benadryl, Zofran are studied

Benadryl, Zofran outcomes

Drug combinations in study:
- Benadryl (diphenhydramine hydrochloride)
- Zofran (ondansetron hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Benadryl is effective60.00%
(3 of 5 people)
100.00%
(2 of 2 people)
n/an/a0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
n/a0.00%
(0 of 1 people)
Zofran is effective25.00%
(1 of 4 people)
100.00%
(3 of 3 people)
50.00%
(1 of 2 people)
n/an/a100.00%
(1 of 1 people)
n/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaFebrile NeutropeniaConstipationn/aCardiac ArrestBurning Eyesn/aNausea
DehydrationSepsisAnaemiaNephrogenic Systemic FibrosisVomiting
HyperglycaemiaCaecitisNausea And VomitingStomach PainPyrexia
PneumoniaPneumoniaThrombocytopeniaConstipationPain
HypotensionEscherichia InfectionEsophageal Stricture - BenignNauseaAnxiety
DizzinessClostridial InfectionNeoplasm MalignantDrug IneffectiveDiarrhoea
DyspnoeaEnterococcal BacteraemiaPneumoniaDehydration
Platelet Count DecreasedRespiratory FailureTumour EmbolismHypotension
AnorexiaBacterial Test PositiveColitisHeadache
Neutrophil Count DecreasedDermatitis AcneiformRenal FailureFatigue

Drug effectiveness by gender :

FemaleMale
Benadryl is effective75.00%
(6 of 8 people)
0.00%
(0 of 2 people)
Zofran is effective66.67%
(6 of 9 people)
0.00%
(0 of 2 people)

Most common drug interactions by gender * :

FemaleMale
NauseaPyrexia
VomitingHypotension
AnxietyDehydration
HeadachePneumonia
HypertensionPain
PainVomiting
Urinary Tract InfectionDiarrhoea
NeutropeniaNausea
DiarrhoeaFatigue
PyrexiaFebrile Neutropenia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Benadryl is effectiven/an/an/a33.33%
(1 of 3 people)
10.53%
(2 of 19 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
0.00%
(0 of 2 people)
Zofran is effectiven/an/an/a33.33%
(1 of 3 people)
5.26%
(1 of 19 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
33.33%
(1 of 3 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
ConstipationVomitingNauseaRenal FailureNauseaVomitingPyrexiaDiarrhoea
VomitingPleural EffusionHypotensionMulti-organ FailurePainPyrexiaNauseaNausea
Ejection Fraction DecreasedFebrile NeutropeniaVomitingSupraventricular TachycardiaHaemoglobin DecreasedNauseaNeutropeniaHypotension
Left Ventricular HypertrophyLymphadenopathyHeadacheInfluenza Like IllnessPyrexiaFatigueVomitingDehydration
HypoxiaDiarrhoeaHypersensitivityBronchitisHyperglycaemiaNeck PainAnaemiaFall
Oxygen Saturation DecreasedIrritabilityHodgkin's DiseaseCholecystitisVomitingChest PainFallFebrile Neutropenia
PyrexiaNauseaBlood Bilirubin IncreasedSinusitisDehydrationPainDehydrationUrinary Tract Infection
WheezingAbdominal PainRenal Failure AcuteCardiac Failure CongestiveCellulitisAstheniaDyspnoeaAsthenia
TachypnoeaFibrin D Dimer IncreasedPyrexiaInsomniaOedema PeripheralBack PainPneumoniaPneumonia
RashCystitis HaemorrhagicLymphadenopathyUrinary Tract InfectionHeadacheAnxietyFatigueSepsis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Benadryl and Zofran?

You are not alone! Join a related mobile support group:
- support group for people who take Benadryl and Zofran
- support group for people who take Benadryl
- support group for people who take Zofran

Can you answer these questions (Ask a question):

More questions for: Benadryl, Zofran

You may be interested at these reviews (Write a review):

  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night.

    I finally realized after suffering this over and over for months, that it only happened when I had taken benadryl.

    It seems that the benadryl causes it after taking it within one hour, I don't know why I didn't connect this until yesterday. Sometimes, more rarely, I also had arm and hand pain.

More reviews for: Benadryl, Zofran

Comments from related studies:

  • From this study (2 months ago):

  • Possible stomach blockage, pharmaceutical bezoar.
    Oxycontin 30 mg every 12 hours is far less effective than oxycodone 15 mg every 6 hours.

    Reply

  • From this study (2 years ago):

  • have had red itchy inflamation {rash like} swelling of throat and tongue shortness of breath chest pain numbness of fingers and toes feels cold then hot iv drip dry cough possible latex allergy uncontrollable belching

    Reply

  • From this study (3 years ago):

  • My patient has a milky white substance oozing spontaneously from his implanted port site after the infusion of pepcid, benadryl, zofran, and decadron followed by Cetuximab. Has this been reported before?

    Reply

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Complete drug side effects:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Zofran (ondansetron hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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