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Review: Benadryl and Zofran

This review analyzes the effectiveness and drug interactions between Benadryl and Zofran. It is created by eHealthMe based on reports of 743 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Benadryl (latest outcomes from 29,348 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

Zofran (latest outcomes from 875 users) has active ingredients of ondansetron hydrochloride. It is often used in nausea.

On Oct, 26, 2014: 743 people who take Benadryl, Zofran are studied

Benadryl, Zofran outcomes

Drug combinations in study:
- Benadryl (diphenhydramine hydrochloride)
- Zofran (ondansetron hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Benadryl is effective50.00%
(2 of 4 people)
100.00%
(2 of 2 people)
n/an/a0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
n/a0.00%
(0 of 1 people)
Zofran is effective25.00%
(1 of 4 people)
100.00%
(3 of 3 people)
0.00%
(0 of 1 people)
n/an/a100.00%
(1 of 1 people)
n/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaFebrile NeutropeniaRenal Failuren/aCardiac ArrestBurning Eyesn/aNausea
DehydrationSepsisNeoplasm MalignantNephrogenic Systemic FibrosisVomiting
HyperglycaemiaCaecitisTumour EmbolismStomach PainPyrexia
PneumoniaPneumoniaPneumoniaConstipationPain
HypotensionEscherichia InfectionThrombocytopeniaNauseaAnxiety
DizzinessClostridial InfectionAnaemiaDrug IneffectiveDiarrhoea
Platelet Count DecreasedEnterococcal BacteraemiaNauseaHypotension
AnorexiaRespiratory FailureConstipationDehydration
DyspnoeaBacterial Test PositiveStomach PainHeadache
CoughDermatitis AcneiformDrug IneffectiveFatigue

Drug effectiveness by gender :

FemaleMale
Benadryl is effective71.43%
(5 of 7 people)
0.00%
(0 of 2 people)
Zofran is effective62.50%
(5 of 8 people)
0.00%
(0 of 2 people)

Most common drug interactions by gender * :

FemaleMale
NauseaPyrexia
VomitingHypotension
AnxietyDehydration
HeadachePneumonia
PainNausea
Urinary Tract InfectionVomiting
HypertensionDiarrhoea
NeutropeniaPain
PyrexiaFatigue
DiarrhoeaFebrile Neutropenia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Benadryl is effectiven/an/an/a33.33%
(1 of 3 people)
11.11%
(1 of 9 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
0.00%
(0 of 2 people)
Zofran is effectiven/an/an/a33.33%
(1 of 3 people)
0.00%
(0 of 9 people)
66.67%
(2 of 3 people)
100.00%
(1 of 1 people)
33.33%
(1 of 3 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
ConstipationVomitingNauseaRenal FailureNauseaVomitingPyrexiaDiarrhoea
VomitingPleural EffusionHypotensionMulti-organ FailurePainPyrexiaNauseaNausea
Ejection Fraction DecreasedFebrile NeutropeniaVomitingSupraventricular TachycardiaHaemoglobin DecreasedNauseaNeutropeniaHypotension
Left Ventricular HypertrophyLymphadenopathyHeadacheInfluenza Like IllnessPyrexiaFatigueVomitingDehydration
HypoxiaDiarrhoeaHypersensitivityBronchitisCellulitisNeck PainAnaemiaFall
Oxygen Saturation DecreasedIrritabilityHodgkin's DiseaseCholecystitisVomitingChest PainFallFebrile Neutropenia
PyrexiaNauseaBlood Bilirubin IncreasedSinusitisHyperglycaemiaPainDehydrationUrinary Tract Infection
WheezingAbdominal PainRenal Failure AcuteCardiac Failure CongestiveDehydrationAstheniaDyspnoeaAsthenia
TachypnoeaFibrin D Dimer IncreasedPyrexiaInsomniaOedema PeripheralBack PainPneumoniaPneumonia
RashCystitis HaemorrhagicLymphadenopathyUrinary Tract InfectionHeadacheAnxietyFatigueAnxiety

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Benadryl and Zofran?

Get connected! Join a related mobile support group:
- support group for people who take Benadryl and Zofran
- support group for people who take Benadryl
- support group for people who take Zofran

Comments from related studies:

  • From this study (2 weeks ago):

  • Possible stomach blockage, pharmaceutical bezoar.
    Oxycontin 30 mg every 12 hours is far less effective than oxycodone 15 mg every 6 hours.

    Reply

  • From this study (2 years ago):

  • have had red itchy inflamation {rash like} swelling of throat and tongue shortness of breath chest pain numbness of fingers and toes feels cold then hot iv drip dry cough possible latex allergy uncontrollable belching

    Reply

  • From this study (3 years ago):

  • My patient has a milky white substance oozing spontaneously from his implanted port site after the infusion of pepcid, benadryl, zofran, and decadron followed by Cetuximab. Has this been reported before?

    Reply

Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Zofran (ondansetron hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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