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Review: taking Benadryl and Zofran together

Summary: drug interactions are reported among people who take Benadryl and Zofran together.

This review analyzes the effectiveness and drug interactions between Benadryl and Zofran. It is created by eHealthMe based on reports of 746 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,395 Benadryl users)

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. (latest outcomes from 895 Zofran users)

On Feb, 24, 2015: 746 people who take Benadryl, Zofran are studied

Benadryl, Zofran outcomes

Drug combinations in study:
- Benadryl (diphenhydramine hydrochloride)
- Zofran (ondansetron hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Benadryl is effective60.00%
(3 of 5 people)
(2 of 2 people)
(0 of 2 people)
(1 of 1 people)
(0 of 1 people)
Zofran is effective25.00%
(1 of 4 people)
(3 of 3 people)
(1 of 2 people)
(1 of 1 people)
(1 of 1 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PyrexiaFebrile NeutropeniaConstipationn/aNephrogenic Systemic FibrosisBurning Eyesn/aNausea
HyperglycaemiaCaecitisNausea And VomitingCardiac ArrestPyrexia
HypotensionEscherichia InfectionEsophageal Stricture - BenignHeadacheAnxiety
DizzinessClostridial InfectionNeoplasm MalignantLethargyDiarrhoea
DyspnoeaEnterococcal BacteraemiaPneumoniaDepressionDehydration
Platelet Count DecreasedRespiratory FailureTumour EmbolismSkin Burning SensationHypotension
AnorexiaBacterial Test PositiveColitisAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionHeadache
Neutrophil Count DecreasedDermatitis AcneiformRenal FailureChronic PancreatitisFatigue

Drug effectiveness by gender :

Benadryl is effective66.67%
(6 of 9 people)
(0 of 2 people)
Zofran is effective70.00%
(7 of 10 people)
(0 of 2 people)

Most common drug interactions by gender * :

Urinary Tract InfectionPain
DiarrhoeaFebrile Neutropenia

Drug effectiveness by age :

Benadryl is effectiven/an/an/a33.33%
(1 of 3 people)
(2 of 19 people)
(2 of 3 people)
(1 of 25 people)
(0 of 2 people)
Zofran is effectiven/an/an/a33.33%
(1 of 3 people)
(1 of 19 people)
(2 of 3 people)
(2 of 25 people)
(1 of 3 people)

Most common drug interactions by age * :

ConstipationVomitingNauseaRenal FailureNauseaVomitingNauseaDiarrhoea
VomitingPleural EffusionHypotensionMulti-organ FailurePainPyrexiaPyrexiaNausea
Ejection Fraction DecreasedFebrile NeutropeniaVomitingSupraventricular TachycardiaHaemoglobin DecreasedNauseaNeutropeniaHypotension
Left Ventricular HypertrophyLymphadenopathyHeadacheInfluenza Like IllnessPyrexiaFatigueVomitingDehydration
HypoxiaDiarrhoeaHypersensitivityBronchitisHyperglycaemiaNeck PainAnaemiaFall
Oxygen Saturation DecreasedIrritabilityHodgkin's DiseaseCholecystitisVomitingChest PainFallFebrile Neutropenia
PyrexiaNauseaBlood Bilirubin IncreasedSinusitisDehydrationPainDyspnoeaUrinary Tract Infection
WheezingAbdominal PainRenal Failure AcuteCardiac Failure CongestiveCellulitisAstheniaDehydrationAsthenia
TachypnoeaFibrin D Dimer IncreasedPyrexiaInsomniaOedema PeripheralBack PainPneumoniaPneumonia
RashCystitis HaemorrhagicLymphadenopathyUrinary Tract InfectionHeadacheAnxietyRespiratory FailureSepsis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Benadryl and Zofran?

You are not alone! Join a related mobile support group:
- support group for people who take Benadryl and Zofran
- support group for people who take Benadryl
- support group for people who take Zofran

Can you answer these questions (Ask a question):

More questions for: Benadryl, Zofran

You may be interested at these reviews (Write a review):

  • Sids/benedryl infant stopped breathing
    We are devastated. Our grand daughter was being breastfed and mother only took 1 tablet of Benedryl 25 mg and healthy baby girl died of SIDS following morning. Any information is appreciated.
  • Diphenhydramine and mental acuity
    For at least 10 years, I have taken diphenhydramine 50 mg. at bedtime for insomnia and allergies. The results have been that I sleep well with no hangover or any cognitive impairment. If I experience vertigo from allergies, I may take an additional 50 mg. but never exceeding 100 mg in a 24 hour period.

    After reading the report regarding an Alzheimer's study finding that after taking as little as 4mg diphenhydramine daily for more than 3 years, dementia rates were high.

    I stopped the diphenhydramine one night. I experienced symptoms of deep brain pulsating pain and severe insomnia. After 4 hours, I took 50 mg diphenhydramine and slept very well. The next night I took 37.5 mg. diphenhydramine, slept very well. However, some of my tasks require layers of mental challenges in which I became slower.

    My question is how did the study recipients obtain 4 mg doses of diphenhydramine when the standard over-the-counter (OTC) availability in tablets is 25 mg? How reliable is the information submitted from the study subjects? What manufacturer's diphendramine was used, or were there several?

    I felt sharper mentally when on 50 mg daily than so far on 37.5 mg.
  • Nightmares from miralax
    Used for an endoscopy prep, great for what it does but gave me horrid and vivid nightmares
  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless

More reviews for: Benadryl, Zofran

Comments from related studies:

  • From this study (5 months ago):

  • Possible stomach blockage, pharmaceutical bezoar.
    Oxycontin 30 mg every 12 hours is far less effective than oxycodone 15 mg every 6 hours.


  • From this study (2 years ago):

  • have had red itchy inflamation {rash like} swelling of throat and tongue shortness of breath chest pain numbness of fingers and toes feels cold then hot iv drip dry cough possible latex allergy uncontrollable belching


  • From this study (3 years ago):

  • My patient has a milky white substance oozing spontaneously from his implanted port site after the infusion of pepcid, benadryl, zofran, and decadron followed by Cetuximab. Has this been reported before?


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Complete drug side effects:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Zofran (ondansetron hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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