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Review: taking Claritin and Zyrtec together

Summary: drug interactions are reported among people who take Claritin and Zyrtec together.

This review analyzes the effectiveness and drug interactions between Claritin and Zyrtec. It is created by eHealthMe based on reports of 1,295 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Claritin has active ingredients of loratadine. It is often used in allergies. (latest outcomes from 24,202 Claritin users)

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. (latest outcomes from 29,963 Zyrtec users)

On Mar, 1, 2015: 1,295 people who take Claritin, Zyrtec are studied

Claritin, Zyrtec outcomes

Drug combinations in study:
- Claritin (loratadine)
- Zyrtec (cetirizine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Claritin is effective23.53%
(4 of 17 people)
(1 of 7 people)
(1 of 3 people)
(1 of 6 people)
(2 of 8 people)
(0 of 3 people)
(1 of 1 people)
(0 of 1 people)
Zyrtec is effective9.09%
(1 of 11 people)
(2 of 10 people)
(4 of 7 people)
(2 of 4 people)
(3 of 5 people)
(0 of 2 people)
(1 of 1 people)
(0 of 1 people)

Drug effectiveness by gender :

Claritin is effective25.00%
(7 of 28 people)
(3 of 17 people)
Zyrtec is effective34.62%
(9 of 26 people)
(4 of 15 people)

Drug effectiveness by age :

Claritin is effectiven/a0.00%
(0 of 12 people)
(0 of 2 people)
(1 of 8 people)
(2 of 10 people)
(5 of 21 people)
(2 of 3 people)
(0 of 8 people)
Zyrtec is effectiven/a12.50%
(1 of 8 people)
(0 of 1 people)
(2 of 7 people)
(2 of 10 people)
(6 of 17 people)
(1 of 3 people)
(1 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
SomnolenceRashReflux OesophagitisBedwettingDepressionDepressionAnxietyPain
Abnormal BehaviourHypertensionLiver DisorderOvarian CystPancreatitisAnxietyDelusionFatigue
HeadacheLiver DisorderLacunar InfarctionBreast Cancer FemalePainNightmareAmnesiaDepression
Mental DisorderReflux OesophagitisMyoclonusFatiguePost Cholecystectomy SyndromeSuicide AttemptAggressionNausea
Blood Pressure IncreasedElectrocardiogram Qt ProlongedHypokalaemiaEosinophilic PneumoniaPost-traumatic Stress DisorderArthralgiaAbnormal BehaviourArthralgia
Loss Of ConsciousnessLacunar InfarctionHypocalcaemiaPain - JointsAnxietyOsteoporosisDepressionAnxiety
UrticariaAtrial FlutterFatigueMuscle PainBiliary DyskinesiaBiopsy Breast AbnormalHallucinationBack Pain
PruritusAtrioventricular Block First DegreeCor Pulmonale ChronicAnxietyMouth UlcerationFibrocystic Breast DiseasePsychotic DisorderDrug Ineffective
HallucinationErysipelasTesticular FailureTicDrug IneffectiveMammogram AbnormalParanoiaDyspnoea
FatigueGeneralised OedemaRosaceaBedwettingIntentional OverdoseIrritabilitySinusitis

Most common drug interactions by gender * :

NauseaDrug Ineffective
Back PainDyspnoea
Pain In ExtremityAnxiety
SinusitisBack Pain

Most common drug interactions by age * :

SyncopeNightmarePainCholelithiasisFatigueBack PainFatigueNausea
FallDrug IneffectiveFatiguePulmonary EmbolismBronchitisDepressionDepressionVomiting
Blood Pressure IncreasedHallucination, VisualSomnolenceChest PainAbdominal PainPainNauseaDiarrhoea
AlopeciaPyrexiaMental DisorderCholecystitis ChronicFallSinusitisPainDizziness
Photosensitivity ReactionDrug HypersensitivityNauseaDepressionBlood Cholesterol IncreasedPain In ExtremityArthralgiaAnxiety
EpistaxisArthralgiaDeep Vein ThrombosisArthralgiaDrug IneffectiveAnxietyPain
Feeling AbnormalSuicidal IdeationVomitingContusionFatigueChest PainHypertension
PalpitationsLoss Of ConsciousnessDiarrhoeaSinusitisDyspnoeaConstipationDrug Ineffective
FallAbdominal Pain UpperLoss Of ConsciousnessDepressionArthralgiaVomitingDepression
Chest PainCholecystitis ChronicCholecystitisPain In ExtremityCoughPyrexiaAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Claritin and Zyrtec on

Do you take Claritin and Zyrtec?

You are not alone! Join a related mobile support group:
- support group for people who take Claritin and Zyrtec
- support group for people who take Claritin
- support group for people who take Zyrtec

Can you answer these questions (Ask a question):

More questions for: Claritin, Zyrtec

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More reviews for: Claritin, Zyrtec

Comments from related studies:

  • From this study (12 months ago):

  • Venlafaxine was started for major depression and anti-anxiety. Hives broke out 6 months after begin date of Venlafaxine. Allergist has prescribed/recommended the rest of the anti-histamine drugs. Hives and depression still linger.


  • From this study (2 years ago):

  • Developed sudden onset severe asthma while feeding a bird on my shoulder, in the zoo's bird aviary, 2 ½ years ago. Never had breathing problems in my life, but couldn’t breath after hour long choking spell I suffered when the bird flew away. From that night until my lung collapsed two months later, I was prescribed albuterol, duoneb, and prednisone (with constantly increasing doses because "asthma" was non-responsive). After treatment for middle right lobe collapse (mucus plug removal) I remained symptom free for a 18 months, using only Singular and allergy meds. I was diagnosed with prednisone allergy 3 days after leaving the hospital for the lung collapse, so I did not take anymore. When symptoms returned, a year and a half later, which has been a year ago now, they included rales, coughing up blood, and chronic pneumonia (hospitalized 10 times this past year). After 6 months, my digestive system became involved, and I developed tachycardia and heart pain/spasms. Been to 3 pulmonologists who diagnosed me with COPD and asthma, swallowing problems associated with recently discovered hiatal hernia causing choking/aspiration pneumonia, and aspiration of stomach acids. I was taken off the singular because it was believed to cause "shattered glass" appearance on xrays. Latest (4th) pulmonologist did broncoscopy with biopsy discovering eosinophilic pneumonia, but no COPD or aspiration. Over past year, I have been given i.v. steroids and benedryl in hospitals, and have followed with weekly steroid shots and taking benedryl at home, due to allergy to ingredient in the tablets. Yet, am still ending up in hospital every month, because shots not strong enough to keep me free from pneumonia, although extreme doses of prednisone 2 ½ years ago didn’t keep lung from collapsing either.


    jill akron on Nov, 8, 2012:

    im a 43 year old female,with asthmatics symtoms, and a hiatial hernia. live in misery lots, trouble breathing, been on prednisone on and off and use inhalors, 3 types.ive got acid reflux disease and take omeperolzole 20 mg 2x day......fought many times cuz" supposable asthma,,i found out in time that proton pump inhibitors after being on them for long period of time, can cause astmatic symtoms. so needless to say ive been on prednisone here and there....Only,, only to find out becuz i was diagnosed with a hiatial hernia( which can make u also have difficulty breathing) prednisone after taking it on and off and wondering y it was getting worse, i have had even worse breathing troubles( only to find out that prednisone has bad effect on a hiatial hernia and can only make it worse


    Andrea on Nov, 20, 2012:

    Female 45 y/o, NYC: after 5 years of severe asthma and a collapsed lung I finally determined I was severely allergic to my thyroid meds. Possibly to povidone an ingredient in the brand name thyroid medication Sinthroid. This ingredient is not in the generic brand and I seem to be ok now on the generic. So you see I NEVER HAD ASTHMA, I was having a severe allergic reaction. Since I have Hashimoto's Thyroiditus I may have issues with iodine. So you should check if u started any new meds around the time your breathing problems began. I also had a severe psychiatric response to medrol dose pack (methylprednisolone)and ended up in the psych ward. if you have a thyroid problem too much T3 or cytomel can also cause breathing problems as well. Last, weak adrenals will cause lung problems, check out the book "Adrenal fatigue-The 21st Century Stress Syndrome" by James Wilson


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Complete drug side effects:

On eHealthMe, Claritin (loratadine) is often used to treat allergies. Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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