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Review: Clonidine and Xanax

This review analyzes the effectiveness and drug interactions between Clonidine and Xanax. It is created by eHealthMe based on reports of 797 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Clonidine and Xanax >>>

What are the drugs

Clonidine hydrochloride (latest outcomes from 1,549 users) has active ingredients of clonidine hydrochloride. It is often used in high blood pressure.

Xanax (latest outcomes from 58,930 users) has active ingredients of alprazolam. It is often used in stress and anxiety.

On Oct, 13, 2014: 797 people who take Clonidine Hydrochloride, Xanax are studied

Clonidine Hydrochloride, Xanax outcomes

Drug combinations in study:
- Clonidine Hydrochloride (clonidine hydrochloride)
- Xanax (alprazolam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Clonidine Hydrochloride is effective20.00%
(1 of 5 people)
(1 of 6 people)
(2 of 3 people)
(1 of 4 people)
(4 of 7 people)
(1 of 1 people)
(2 of 3 people)
Xanax is effective25.00%
(1 of 4 people)
(2 of 2 people)
(1 of 3 people)
(3 of 4 people)
(3 of 7 people)
(3 of 4 people)
(5 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug IneffectiveMaternal Exposure During PregnancyDetoxificationDrug IneffectiveExhaustion, Fatigue, Lethargy, Tiredness, WearinessHigh Blood PressureCoronary Artery DiseaseNausea
Median Nerve InjuryAbortion SpontaneousPainDetoxificationInsomnia ExacerbatedNight SweatsCognitive DisorderAnxiety
OsteomyelitisVomitingSyncopeDizzinessVision BlurredJoint StiffnessDeliriumDepression
Drug DependenceSomnolenceCompleted SuicidePainSleepyNausea AggravatedDizzinessDrug Ineffective
Maternal Exposure During PregnancyAbdominal PainDrug IneffectiveCompleted SuicideSweating - ExcessiveDizziness PosturalDysuriaDrug Withdrawal Syndrome
PainNephrogenic Systemic FibrosisParaesthesiaSyncopeDrowsinessDementiaCarotid Artery StenosisDrug Dependence
DepressionGranulomaDrug DependenceParaesthesiaMucosal Dryness NosDrug DependenceAtrioventricular BlockPain
Gun Shot WoundMuscle TwitchingDizzinessDrug DependenceDry MouthDyspnoeaDelusional Disorder, Paranoid TypeHeadache
SurgerySkin ReactionBradycardiaNephrolithiasisDementiaPanic AttackMental Status ChangesAsthenia
Radius FractureSeizure ClusterDeathRashBack PainDrug AbuserBlue VisionChest Pain

Drug effectiveness by gender :

Clonidine Hydrochloride is effective52.63%
(10 of 19 people)
(2 of 10 people)
Xanax is effective65.00%
(13 of 20 people)
(5 of 10 people)

Most common drug interactions by gender * :

Drug IneffectiveDrug Withdrawal Syndrome
AnxietyDrug Dependence
DepressionDrug Ineffective
AstheniaOedema Peripheral
Drug Withdrawal SyndromeHeadache
Drug DependenceDehydration
Chest PainDyspnoea

Drug effectiveness by age :

Clonidine Hydrochloride is effectiven/an/an/a10.00%
(3 of 30 people)
(4 of 15 people)
(0 of 5 people)
(4 of 21 people)
(1 of 5 people)
Xanax is effectiven/an/an/a13.33%
(4 of 30 people)
(4 of 15 people)
(1 of 5 people)
(5 of 21 people)
(4 of 6 people)

Most common drug interactions by age * :

Neonatal DisorderAutismOverdose NosDrug Withdrawal SyndromeDrug DependenceChest PainAnxietyAsthenia
Metabolic AcidosisAnaphylactic ReactionPalpitationsNauseaDrug Withdrawal SyndromeNauseaDepressionDrug Ineffective
Neonatal HypotensionAggressionSweating IncreasedWeight DecreasedAnxietyDepressionDrug Withdrawal SyndromeDyspnoea
Oxygen Saturation DecreasedOverdoseVomiting NosDrug DependenceDepressionHeadacheNauseaWeakness
Ventricular FibrillationComaNauseaAnxietyNauseaAnxietyDrug DependenceNausea
Premature BabyHepatic FailureHeadacheFormicationDysarthriaDrug Withdrawal SyndromeOedema PeripheralTremor
Maternal Condition Affecting FoetusBrain DamageConvulsionDyskinesiaArthralgiaAstheniaArthralgiaBlood Pressure Increased
MalaiseUnresponsive To StimuliMuscle SpasmsHypertensionDizzinessDrug IneffectiveBlood Glucose Increased
Bradycardia NeonatalElectrocardiogram Qt ProlongedDrug AbuserPainSinus TachycardiaPyrexiaAnxiety
Congenital Tricuspid Valve AtresiaFeeling AbnormalPainDysuriaDehydrationBursitisOedema Peripheral

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Clonidine and Xanax?

Get connected! Join a related mobile support group:
- support group for people who take Clonidine and Xanax
- support group for people who take Clonidine Hydrochloride
- support group for people who take Xanax

Comments from related studies:

  • From this study (1 year ago):

  • I brush my hair once a day. After this brushing, the hair brush is COVERED in hair, and I must clean the brush at that time. The crown of my head shows moderate to sever hair loss, and I don't know what to do about this problem.


  • From this study (2 years ago):

  • I had a hysterectomy in 2009 but do not have hot flashes any more during the day, I just have night sweats every night. I will be soaked, not enough to change clothes but very sweaty and it does not seem to come from being hot. The Morphine I take is 30mg 3x per day and these are extended release. Then I take immediate release 15mg 3x per day. I have had a physical and complete blood work. Everything came back good. I also have joint pain.


    Kobe77 on Jan, 3, 2013:

    I am a 47 yr old female with tonic clonic sezuires. I was placed on Restoril from my Nerologist and had a very bad reaction to it. I became very confused and dizzy while in bed. Then i began to go into a gran mal sezuire. My husband took me to the hospitol and they advised that restrol can cause seziyres. So my question to this doctor was why would you give me this med and u know i have sezuires? I did not receive and answer except a letter in the mail stating that he was unable to treat me any going to the medical board on this guy.


    shannon on Apr, 13, 2013:

    RESTORILs generic is Temazepam...the "pam" drugs are usually always listed as a hypnotic/amnesic drug in the benzodiazapine family with the majority used to treat seizures....such as Versed, Ativan and Valium. Klonopin and Restoril are the same drug family....about the only difference is onset time of med, the duration it lasts and how much to give for the desired effect of deep, moderate or mild sedation....enough to cause amnesia for conscious sedation or relax the mind and brain impulses...other drugs like fentanyl and etomidate are given for full sedation as potentiants to make the drug appear stronger....alot of three of those are used widely in EMS (ambulance) to control seizures....the only reason I can offer as to why it would cause a seizure is a terrible adverse reaction to the med or an allergy. HOPE THAT HELPS...


    shannon on Apr, 13, 2013:

    Hysterectomy 2009,...

    Yours still may be hormone or endocrine related as both those issues can possibly cause night sweats from what Ive Ive said before....Im just a parameidc (23 yrs now) that loves to research medical issues and try to give a laymans answer wiith no big words....check into those two possibilities w your doctor.


  • From this study (2 years ago):

  • Extremely scared, a feeling of someone watching and wanting to hurt me. Seeing still objects moving (hung jeans)and hearing people talking saying their going to hurt me


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Complete drug side effects:

On eHealthMe, Clonidine Hydrochloride (clonidine hydrochloride) is often used to treat high blood pressure. Xanax (alprazolam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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