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Review: Cymbalta and B Complex Vitamin

This review analyzes the effectiveness and drug interactions between Cymbalta and B Complex Vitamin. It is created by eHealthMe based on 1,369 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 2, 2014: 1,369 people who reported to have interactions when taking Cymbalta, B Complex Vitamin are studied

Trend of Cymbalta, B Complex Vitamin's drug interactions, side effects and effectiveness reports (3487571)

Drug combinations in study:
- Cymbalta (duloxetine hydrochloride)
- B Complex Vitamin (folic acid)

eHealthMe real world results:

Most common interactions experienced by people in the use of Cymbalta, B Complex Vitamin:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Arthralgia (joint pain)459
Dyspnoea (difficult or laboured respiration)439
Nausea (feeling of having an urge to vomit)408
Fatigue (feeling of tiredness)375
Pain In Extremity306
Headache (pain in head)274

Most common interactions experienced by people in long term use of Cymbalta, B Complex Vitamin:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Arthralgia (joint pain)36
Biopsy Lip24
Drug Ineffective24
Cataract (clouding of the lens inside the eye)24
Joint Swelling24
Herpes Zoster24
Thyroid Neoplasm (tumour of thyroid)24
Oedema Peripheral (superficial swelling)24
Immune System Disorder24

How effective are the drugs:

not at allsomewhatmoderatehighvery high
B Complex Vitamin0.00%42.86%14.29%28.57%14.29%

Top conditions involved for these people * :

  1. Rheumatoid arthritis
  2. Depression
  3. Pain
  4. Hypertension
  5. Anxiety

Top co-used drugs for these people * :

  1. Methotrexate
  2. Humira
  3. Aspirin
  4. Prednisone
  5. Vitamin d

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: B Complex Vitamin, Cymbalta

You can also:

Complete drug side effects:

On eHealthMe, Cymbalta (duloxetine hydrochloride) is often used to treat depression. B Complex Vitamin (folic acid) is often used to treat energy increased. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (3 months ago):

  • I am checking to see if this particular combination of drugs would cause a false positive for any substance on a 12 panel instant drug panel, I used a home kit and it appeared to be so when I am not using any illicit substances whatsoever. I am very concerned as I am on a pain contract and need to be clean and am but am not really sure why this is happening to me. I believe it is to many medications at once.


  • From this study (7 months ago):

  • I could spend all night listing my symptoms therefore it would be easier for me to explain, I suffer from concentration, focusing, and daily life due to the side effects of some of my medication. About 5 months I started getting a callus like spot on the palm of my hands and on the bottom of my feet. Then all of a sudden I started getting blisters all over my hands and a cluster on the bottom of my feet which caused pain when I walked. Therefore over time the blisters either popped or dried up and the cycle would continue again. After weeks of dealing with my hands I forgot about my feet until one day my sister asked me if I experience the same thing on the bottom of my feet. I decided to look and it looked like a scab had grown over the bottom of my feet just like the palms of my hands. My doctor prescribed me some steroid cream which seemed to work for a while. Well needless to say I lost my insurance and have not been able to go in to get this checked out. Now it is starting to spread over the entire bottom of my feet as well as the sides of my feet. My hands have cleared up somehow on their own however there is still hard dry flaky skin that I try my best not to pick at as well as my feet.


  • From this study (1 year ago):

  • Have been taking the methotrexate 1 time a week 4 2.5 mg pills. Have taken twice so far. No reaction with vaginal discharge first round of pills. Have not had a period in 5 year, post menopausal. Very little discharge only with activity.


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related studies

- B Complex Vitamin side effects
- Cymbalta side effects



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