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Review: taking Depakote and Advil Pm together

Summary: drug interactions are reported among people who take Depakote and Advil Pm together.

This review analyzes the effectiveness and drug interactions between Depakote and Advil Pm. It is created by eHealthMe based on reports of 50 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Depakote and Advil Pm >>>

What are the drugs

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 30,947 Depakote users)

Advil pm has active ingredients of diphenhydramine hydrochloride; ibuprofen. It is often used in insomnia. (latest outcomes from 228 Advil pm users)

On Jan, 29, 2015: 50 people who take Depakote, Advil Pm are studied

Depakote, Advil Pm outcomes

Drug combinations in study:
- Depakote (divalproex sodium)
- Advil Pm (diphenhydramine hydrochloride; ibuprofen)

Drug effectiveness over time :


Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
InsomniaConvulsionConvulsionType 2 Diabetes Mellitusn/aPneumonian/aType 2 Diabetes Mellitus
HypersensitivityTardive DyskinesiaContusionImpaired Work AbilityPancreatitis AcuteDiabetes Mellitus
Blood Pressure Systolic IncreasedAnticonvulsant Drug Level DecreasedAlopeciaHyperglycaemiaOrthopnoeaDiabetes Mellitus Inadequate Control
ManiaHepatic Enzyme IncreasedDizzinessHyperglycaemic Hyperosmolar Nonketotic SyndromeRenal FailureVision Blurred
Anticonvulsant Drug Level DecreasedAlopeciaFatigueNeurogenic BladderRenal ImpairmentTremor
ConvulsionContusionVision BlurredSomnolenceType 2 Diabetes MellitusVomiting
Tardive DyskinesiaTremorTremorTremorRenal Failure Acute
FatigueVomitingNervous System DisorderDiarrhoea
VomitingCholecystitis ChronicPancreatitis

Drug effectiveness by gender :


Most common drug interactions by gender * :

Type 2 Diabetes MellitusType 2 Diabetes Mellitus
TremorDiabetes Mellitus
Vision BlurredAgitation
VomitingBack Pain
Lung InfectionClostridium Difficile Colitis
Renal Failure AcuteHypokalaemia
Diabetes Mellitus Inadequate ControlMental Status Changes
Diabetes MellitusAnaemia

Drug effectiveness by age :


Most common drug interactions by age * :

n/an/aMetaplasiaType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes MellitusRenal Failure AcuteVomiting
Endocardial FibrosisImpaired Work AbilityDepressionType 2 Diabetes MellitusLung InfectionNausea
Mobility DecreasedHyperglycaemiaDiabetes Mellitus Inadequate ControlConvulsionAspergillosisAgitation
Subcutaneous NoduleHyperglycaemic Hyperosmolar Nonketotic SyndromeDyspnoeaDiabetic ComplicationRespiratory FailureAsthenia
Extremity ContractureInjection Site MassDiabetic KetoacidosisComaSinus TachycardiaHypertension
Pain In ExtremitySomnolenceHypercholesterolaemiaDiabetes Mellitus Inadequate ControlHypernatraemiaClostridium Difficile Colitis
Skin FibrosisEye PainAnxietyOedema PeripheralDiabetic ComplicationCardio-respiratory Arrest
XerosisDrug IneffectiveBlood Cholesterol IncreasedMental DisorderFebrile NeutropeniaStaphylococcal Infection
FibrosisAdverse Drug ReactionUrticariaHeadacheParalysisHypokalaemia
Joint ContractureSquamous Cell Carcinoma Of SkinLoss Of EmploymentDiabetic ComaBacterial InfectionHypomagnesaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Depakote and Advil Pm on

Do you take Depakote and Advil Pm?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote and Advil Pm
- support group for people who take Advil Pm
- support group for people who take Depakote

Can you answer these questions (Ask a question):

More questions for: Advil Pm, Depakote

You may be interested at these reviews (Write a review):

  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • Depakote er affected by grapefruit
    I have taken Depakote ER for since 2005 for epilepsy. Once stabilized many years ago seizures and auras have not been bothering me. Until I recently ate three grapefruits over three days. After a few days, when the grapefruit cleared my system, the seizures and auras ceased. Therefore, grapefruit does affect how Depakote ER acts on your system.

More reviews for: Advil Pm, Depakote

Complete drug side effects:

On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Advil Pm (diphenhydramine hydrochloride; ibuprofen) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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