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Review: taking Depakote and Advil Pm together

Summary: drug interactions are reported among people who take Depakote and Advil Pm together.

This review analyzes the effectiveness and drug interactions between Depakote and Advil Pm. It is created by eHealthMe based on reports of 50 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Depakote and Advil Pm >>>

On Mar, 31, 2015: 50 people who take Depakote, Advil Pm are studied

Depakote, Advil Pm outcomes

Drug combinations in study:
- Depakote (divalproex sodium)
- Advil Pm (diphenhydramine hydrochloride; ibuprofen)

Drug effectiveness over time :


Drug effectiveness by gender :


Drug effectiveness by age :


Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
InsomniaConvulsionConvulsionType 2 Diabetes Mellitusn/aPneumonian/aType 2 Diabetes Mellitus
HypersensitivityTardive DyskinesiaContusionImpaired Work AbilityPancreatitis AcuteDiabetes Mellitus
Blood Pressure Systolic IncreasedAnticonvulsant Drug Level DecreasedAlopeciaHyperglycaemiaOrthopnoeaDiabetes Mellitus Inadequate Control
ManiaHepatic Enzyme IncreasedDizzinessHyperglycaemic Hyperosmolar Nonketotic SyndromeRenal FailureVision Blurred
Anticonvulsant Drug Level DecreasedAlopeciaFatigueNeurogenic BladderRenal ImpairmentTremor
ConvulsionContusionVision BlurredSomnolenceType 2 Diabetes MellitusVomiting
Tardive DyskinesiaTremorTremorTremorRenal Failure Acute
FatigueVomitingNervous System DisorderDiarrhoea
VomitingCholecystitis ChronicPancreatitis

Most common drug interactions by gender * :

Type 2 Diabetes MellitusType 2 Diabetes Mellitus
TremorDiabetes Mellitus
Vision BlurredAgitation
VomitingBack Pain
Lung InfectionClostridium Difficile Colitis
Renal Failure AcuteHypokalaemia
Diabetes Mellitus Inadequate ControlMental Status Changes
Diabetes MellitusAnaemia

Most common drug interactions by age * :

n/an/aMetaplasiaType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes MellitusRenal Failure AcuteVomiting
Endocardial FibrosisImpaired Work AbilityDepressionType 2 Diabetes MellitusLung InfectionNausea
Mobility DecreasedHyperglycaemiaDiabetes Mellitus Inadequate ControlConvulsionAspergillosisAgitation
Subcutaneous NoduleHyperglycaemic Hyperosmolar Nonketotic SyndromeDyspnoeaDiabetic ComplicationRespiratory FailureAsthenia
Extremity ContractureInjection Site MassDiabetic KetoacidosisComaSinus TachycardiaHypertension
Pain In ExtremitySomnolenceHypercholesterolaemiaDiabetes Mellitus Inadequate ControlHypernatraemiaClostridium Difficile Colitis
Skin FibrosisEye PainAnxietyOedema PeripheralDiabetic ComplicationCardio-respiratory Arrest
XerosisDrug IneffectiveBlood Cholesterol IncreasedMental DisorderFebrile NeutropeniaStaphylococcal Infection
FibrosisAdverse Drug ReactionUrticariaHeadacheParalysisHypokalaemia
Joint ContractureSquamous Cell Carcinoma Of SkinLoss Of EmploymentDiabetic ComaBacterial InfectionHypomagnesaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Depakote and Advil Pm?




You are not alone! Join a related support group:
- support group for people who take Advil Pm
- support group for people who take Depakote

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Advil Pm (diphenhydramine hydrochloride; ibuprofen) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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