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Review: taking Depakote and Trazodone together

Summary: drug interactions are reported among people who take Depakote and Trazodone together.

This review analyzes the effectiveness and drug interactions between Depakote and Trazodone. It is created by eHealthMe based on reports of 1,841 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. (latest outcomes from 30,947 Depakote users)

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from 6,651 Trazodone hydrochloride users)

On Feb, 6, 2015: 1,841 people who take Depakote, Trazodone Hydrochloride are studied

Depakote, Trazodone Hydrochloride outcomes

Drug combinations in study:
- Depakote (divalproex sodium)
- Trazodone Hydrochloride (trazodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote is effective50.00%
(3 of 6 people)
(2 of 14 people)
(1 of 7 people)
(3 of 8 people)
(6 of 11 people)
(4 of 6 people)
(4 of 5 people)
(1 of 1 people)
Trazodone Hydrochloride is effective28.57%
(2 of 7 people)
(2 of 15 people)
(0 of 8 people)
(2 of 8 people)
(6 of 12 people)
(4 of 7 people)
(2 of 4 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RashDrug Exposure During PregnancyType 2 Diabetes MellitusBack PainDrug Exposure During PregnancyType 2 Diabetes MellitusWeight IncreasedType 2 Diabetes Mellitus
DyspnoeaVentricular Septal DefectDiabetes MellitusType 2 Diabetes MellitusVentricular Septal DefectObesityDiabetes Mellitus Inadequate ControlDiabetes Mellitus
Weight IncreasedAtrial Septal DefectPainDiabetic NeuropathyType 2 Diabetes MellitusPancreatitisObesityWeight Increased
PyrexiaAggressionBack PainBlood Cholesterol IncreasedAtrial Septal DefectBlood Triglycerides IncreasedType 2 Diabetes MellitusNausea
FatigueAnxietySuicidal IdeationNeuropathy PeripheralRespiratory DistressDiabetes MellitusBreast MassBlood Cholesterol Increased
Confusional StateApnoeaNeuropathy PeripheralBlood Triglycerides IncreasedFoetal Distress SyndromePainPerirectal AbscessHeadache
ErythemaPainHeadacheMusculoskeletal DisorderApnoeaAbdominal Pain UpperThrombosisDepression
Ammonia IncreasedFoetal Distress SyndromeConstipationSpinal Column StenosisAnaemiaBack PainDiabetic NeuropathyObesity
Chest PainRespiratory DistressWeight IncreasedHyperglycaemiaObesityHyperglycaemiaBlood Glucose IncreasedSuicidal Ideation
PainAnaemiaNauseaHyperlipidaemiaHypertrophyWeight IncreasedProteinuriaDiabetes Mellitus Inadequate Control

Drug effectiveness by gender :

Depakote is effective42.86%
(18 of 42 people)
(6 of 16 people)
Trazodone Hydrochloride is effective27.91%
(12 of 43 people)
(6 of 18 people)

Most common drug interactions by gender * :

Type 2 Diabetes MellitusDiabetes Mellitus
Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedFatigue
NauseaBlood Cholesterol Increased
HeadacheWeight Increased
Blood Cholesterol IncreasedChest Pain
DizzinessSuicidal Ideation
Diabetes Mellitus Inadequate ControlInsomnia

Drug effectiveness by age :

Depakote is effectiven/an/a14.29%
(1 of 7 people)
(4 of 12 people)
(10 of 16 people)
(3 of 37 people)
(3 of 10 people)
(3 of 13 people)
Trazodone Hydrochloride is effectiven/an/a14.29%
(1 of 7 people)
(3 of 11 people)
(6 of 16 people)
(2 of 39 people)
(2 of 10 people)
(4 of 13 people)

Most common drug interactions by age * :

Muscular WeaknessSuicidal BehaviourNeuroleptic Malignant SyndromeDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusConfusional State
ConvulsionStaringCompartment SyndromeType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes Mellitus
AggressionWeight IncreasedDrug Administration ErrorWeight IncreasedObesityBlood Cholesterol IncreasedInsomniaTremor
TremorAggressionRhabdomyolysisBlood Cholesterol IncreasedWeight IncreasedNeuropathy PeripheralNeuropathy PeripheralNausea
Neoplasm MalignantDyspnoeaExtremity NecrosisHeadacheNauseaWeight IncreasedHyperglycaemiaConstipation
Cerebrovascular AccidentIntentional Self-injuryAggressionDizzinessDiabetes Mellitus Inadequate ControlBlood Triglycerides IncreasedDizzinessSuicidal Ideation
AgitationScreamingAgitationAbdominal PainBlood Cholesterol IncreasedDiabetic NeuropathyObesityMyocardial Infarction
Foaming At MouthHomicidal IdeationAngerObesityPancreatitisDiabetes Mellitus Inadequate ControlTremorFall
Tardive DyskinesiaAgitationWeight IncreasedSuicidal IdeationHypertensionChest PainOverdoseHeadache
BiteDepressionBlood Triglycerides IncreasedVision BlurredNauseaDepressionType 2 Diabetes Mellitus

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Depakote and Trazodone on

Do you take Depakote and Trazodone?

You are not alone! Join a related mobile support group:
- support group for people who take Depakote and Trazodone
- support group for people who take Depakote
- support group for people who take Trazodone Hydrochloride

Can you answer these questions (Ask a question):

  • Bipolar 2 since 1975. recently d/c'd lithium. looking for a treatment that will not make glaucoma condition worse (1 answer)
    I am trying to determine which medication to use now that my 40 year successful run with Lithium is over. (The kdneys say it's time to quit). However, I do not want to increase intraocular pressure by using a medication known to increase said pressure. Most importantly, I do not want to lose my livelihood or cause my family and friends unforeseen difficulty due to ineffective medications. I have little faith in the alternatives and see Depakote, Geodon, and Lamictal as poor seconds at
    best. Any suggestions???
  • Can viral myositis make my mysathenai gravis flare up? (1 answer)
    I am feeling weak, out of breath, and have difficulty walking due to my swelling, achiness, and slight pain! I was feeling fine just a few weeks ago......... had traveled and had no complaints........
  • Does xanax cause parkinson's or just cause similar symptoms?
    was on xanax at low dose for over two years, taken off Klonepin without taper and increased xanax use, used trazedone for several years and developed lack of affect, trouble writing, getting up and down. some symptoms are better since tapering off xanax and coming off Trazedone. see neurologists but they have more questions than answers. Symptoms are worse when anxious. suffer from depression and anxiety, both worse since tapering off xanax. i take low dose of atavan now.
  • How do i change the drugs listed for me?
    sleep disorders, disorientation, trouble concentrating
  • Can clyndamican cause a seizure while taking depakote
    I am currently taking Depakote Extended Realease 1000mgs at bedtime with Clyndamican an antibiotic. I have been feeling dizzy, fatigue, headaches, body aches, sore throat, and pain and pressure in my chest. I would like to know if these two medications mixed together are causing me these problems, and if it can cause me a seizure.

More questions for: Depakote, Trazodone Hydrochloride

You may be interested at these reviews (Write a review):

  • Pain meds that cause insomnia
    I currently take 7.5 mg of Vicoprofen for pain for my Anklyosing Spondylitis. I have tried Vicodin and Norco previously, but nothing worked as well as the Vicoprofen. I have never had to up my dosage and I am still getting the same level of relief as I was when I first started it over a year and a half ago. I swear by the Vicoprofen and would recommend it to anyone who has any type of related pain, but, there is one downfall. Every time I take my pain meds I get a huge burst of energy. My pain is usually worst at night, so I have no choice but to take it before bed. More times than not it causes me to suffer extreme insomnia, which is no fun. Up until recently I just suffered through it. I went and saw my primary today and told her about the issues and she suggested I try Trazodone to help ease my mind so I can fall asleep easier and faster. I'm really hoping it works because I don't want to have to switch pain meds because they work so well, but I can't go much longer only getting 2-3 hours of sleep during the week.
    I will wrote another review in a week or so regarding my experience taking the Trazodone with the Vicoprofen.
  • Does paxil use cause lymphoma or other types of cancer
    I have been taking Paxil daily since 1997. For 14 years, I have had severe itching, a constant low grade fever with chills and night sweats. The itching is constant and so extreme that I scratch until the top layer of skin is gone, leaving a large area of scabs. The lymphoma tumors just appeared 6 weeks ago. I was also recently diagnosed with myeloma. I feel that Paxil may be to blame. I do not have a family history of cancer. I have been taking Trazodone at bedtime for 14 years also, which might also be a cause.
  • Do not take trazodone (2 responses)
    I trusted a dr who mr that trazodone as safe.inow am impotent . Ease do not prescribe t o men .
  • Seizure patient was on depakote for 16 years now on keppra 1500 mg.
    I am 28 years old and been off depakote for 5 months. I started keppra to control my seizure disorder, which works great. But for the past year I have developed osteoarthritis in my thoracic, si joints, and lumbar. I get alot of muscle hypersensitivity and pain. Can any of this be due to long term effects of seizure meds?
  • Hit and miss sleep with dextroamphetamine
    Started drug 2 months ago and have seen an improvement in my focus. Ziprosidone for my depression causes me to get dead tired by 7 pm. Once I started taking Dextroamphetamine I started having insomnia 2 times a week. I think I would rather sleep early than stay up all night and then try and stay awake at work. So many drugs and even more side effects. Also Trazadone is no help for getting me to sleep. The only good side affect I have seen is I am down 26 pounds.

More reviews for: Depakote, Trazodone Hydrochloride

Comments from related studies:

  • From this study (4 months ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor


    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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