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Review: taking Depakote and Trazodone together

Summary: drug interactions are reported among people who take Depakote and Trazodone together.

This review analyzes the effectiveness and drug interactions between Depakote and Trazodone. It is created by eHealthMe based on reports of 1,841 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Depakote and Trazodone >>>

On Apr, 15, 2015: 1,841 people who take Depakote, Trazodone Hydrochloride are studied

Depakote, Trazodone Hydrochloride outcomes

Drug combinations in study:
- Depakote (divalproex sodium)
- Trazodone Hydrochloride (trazodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Depakote is effective50.00%
(3 of 6 people)
(2 of 14 people)
(1 of 7 people)
(3 of 8 people)
(6 of 11 people)
(4 of 6 people)
(4 of 5 people)
(1 of 1 people)
Trazodone Hydrochloride is effective28.57%
(2 of 7 people)
(2 of 15 people)
(0 of 8 people)
(2 of 8 people)
(6 of 12 people)
(4 of 7 people)
(2 of 4 people)

Drug effectiveness by gender :

Depakote is effective42.86%
(18 of 42 people)
(6 of 16 people)
Trazodone Hydrochloride is effective27.91%
(12 of 43 people)
(6 of 18 people)

Drug effectiveness by age :

Depakote is effectiven/an/a14.29%
(1 of 7 people)
(4 of 12 people)
(10 of 16 people)
(3 of 37 people)
(3 of 10 people)
(3 of 13 people)
Trazodone Hydrochloride is effectiven/an/a14.29%
(1 of 7 people)
(3 of 11 people)
(6 of 16 people)
(2 of 39 people)
(2 of 10 people)
(4 of 13 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RashDrug Exposure During PregnancyType 2 Diabetes MellitusBack PainDrug Exposure During PregnancyType 2 Diabetes MellitusWeight IncreasedType 2 Diabetes Mellitus
DyspnoeaVentricular Septal DefectDiabetes MellitusType 2 Diabetes MellitusVentricular Septal DefectObesityDiabetes Mellitus Inadequate ControlDiabetes Mellitus
Weight IncreasedAtrial Septal DefectPainDiabetic NeuropathyType 2 Diabetes MellitusPancreatitisObesityWeight Increased
PyrexiaAggressionBack PainBlood Cholesterol IncreasedAtrial Septal DefectBlood Triglycerides IncreasedType 2 Diabetes MellitusNausea
FatigueAnxietySuicidal IdeationNeuropathy PeripheralRespiratory DistressDiabetes MellitusBreast MassBlood Cholesterol Increased
Confusional StateApnoeaNeuropathy PeripheralBlood Triglycerides IncreasedFoetal Distress SyndromePainPerirectal AbscessHeadache
ErythemaPainHeadacheMusculoskeletal DisorderApnoeaAbdominal Pain UpperThrombosisDepression
Ammonia IncreasedFoetal Distress SyndromeConstipationSpinal Column StenosisAnaemiaBack PainDiabetic NeuropathyObesity
Chest PainRespiratory DistressWeight IncreasedHyperglycaemiaObesityHyperglycaemiaBlood Glucose IncreasedSuicidal Ideation
PainAnaemiaNauseaHyperlipidaemiaHypertrophyWeight IncreasedProteinuriaDiabetes Mellitus Inadequate Control

Most common drug interactions by gender * :

Type 2 Diabetes MellitusDiabetes Mellitus
Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedFatigue
NauseaBlood Cholesterol Increased
HeadacheWeight Increased
Blood Cholesterol IncreasedChest Pain
DizzinessSuicidal Ideation
Diabetes Mellitus Inadequate ControlInsomnia

Most common drug interactions by age * :

Muscular WeaknessSuicidal BehaviourNeuroleptic Malignant SyndromeDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusConfusional State
ConvulsionStaringCompartment SyndromeType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes Mellitus
AggressionWeight IncreasedDrug Administration ErrorWeight IncreasedObesityBlood Cholesterol IncreasedInsomniaTremor
TremorAggressionRhabdomyolysisBlood Cholesterol IncreasedWeight IncreasedNeuropathy PeripheralNeuropathy PeripheralNausea
Neoplasm MalignantDyspnoeaExtremity NecrosisHeadacheNauseaWeight IncreasedHyperglycaemiaConstipation
Cerebrovascular AccidentIntentional Self-injuryAggressionDizzinessDiabetes Mellitus Inadequate ControlBlood Triglycerides IncreasedDizzinessSuicidal Ideation
AgitationScreamingAgitationAbdominal PainBlood Cholesterol IncreasedDiabetic NeuropathyObesityMyocardial Infarction
Foaming At MouthHomicidal IdeationAngerObesityPancreatitisDiabetes Mellitus Inadequate ControlTremorFall
Tardive DyskinesiaAgitationWeight IncreasedSuicidal IdeationHypertensionChest PainOverdoseHeadache
BiteDepressionBlood Triglycerides IncreasedVision BlurredNauseaDepressionType 2 Diabetes Mellitus

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Depakote
- support group for people who take Trazodone Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Depakote (divalproex sodium) is often used to treat bipolar disorder. Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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