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Review: taking Diflucan and Valtrex together

Summary: drug interactions are reported among people who take Diflucan and Valtrex together.

This review analyzes the effectiveness and drug interactions between Diflucan and Valtrex. It is created by eHealthMe based on reports of 1,504 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Diflucan and Valtrex >>>

What are the drugs

Diflucan has active ingredients of fluconazole. It is often used in vaginal yeast infection. (latest outcomes from 17,700 Diflucan users)

Valtrex has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. (latest outcomes from 16,447 Valtrex users)

On Feb, 15, 2015: 1,504 people who take Diflucan, Valtrex are studied

Diflucan, Valtrex outcomes

Drug combinations in study:
- Diflucan (fluconazole)
- Valtrex (valacyclovir hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Diflucan is effective33.33%
(2 of 6 people)
(2 of 2 people)
(2 of 2 people)
(0 of 1 people)
Valtrex is effective50.00%
(2 of 4 people)
(2 of 2 people)
(1 of 1 people)
(4 of 4 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PneumoniaSepsisGraft Versus Host DiseaseDrowsinessBreath OdourHiatus HerniaWeight DecreasedPain
Renal Failure AcutePyrexiaPyrexiaGamblingHepatic FailureVitamin D DecreasedPyrexia
Febrile NeutropeniaThrombocytopeniaBlood Alkaline Phosphatase IncreasedLiver Function Test AbnormalVomitingMusculoskeletal DiscomfortNausea
PyrexiaFebrile NeutropeniaGamma-glutamyltransferase IncreasedSuicide AttemptWeight DecreasedDepressionAnxiety
SepsisVomitingDepressionPalpitationsHerpes SimplexInsomniaVomiting
NeutropeniaCytomegalovirus Test PositiveAcute Graft Versus Host DiseaseAnxietyGastrooesophageal Reflux DiseaseSuicide AttemptDiarrhoea
AnaemiaViral Haemorrhagic CystitisCholelithiasisBiliary DyskinesiaGastritisNightmarePneumonia
ThrombocytopeniaInterstitial Lung DiseaseDrug IneffectiveGallbladder Non-functioningDrowsinessHallucination, AuditoryAnaemia
PancytopeniaBlood Alkaline Phosphatase IncreasedCerebral ToxoplasmosisPainGerdHerpes ZosterFatigue
RashWhite Blood Cell Count DecreasedAnxietyCholecystitis ChronicDehydrationGastric DisorderFebrile Neutropenia

Drug effectiveness by gender :

Diflucan is effective44.44%
(4 of 9 people)
(2 of 2 people)
Valtrex is effective66.67%
(6 of 9 people)
(3 of 3 people)

Most common drug interactions by gender * :

VomitingFebrile Neutropenia
Febrile NeutropeniaPain
Osteonecrosis Of JawDiarrhoea

Drug effectiveness by age :

Diflucan is effectiven/an/a0.00%
(0 of 1 people)
(2 of 4 people)
(0 of 3 people)
(1 of 2 people)
(2 of 2 people)
(1 of 4 people)
Valtrex is effectiven/an/a100.00%
(1 of 1 people)
(1 of 2 people)
(2 of 4 people)
(1 of 2 people)
(3 of 3 people)
(1 of 4 people)

Most common drug interactions by age * :

DizzinessVomitingFebrile NeutropeniaChest PainFatiguePainPyrexiaPneumonia
FatigueDiarrhoeaBlood Bilirubin IncreasedNauseaAnaemiaPyrexiaPainPyrexia
Type 2 Diabetes MellitusMental Status ChangesPlatelet Count DecreasedDiarrhoeaDehydrationAnxietyAnxietyFebrile Neutropenia
Chest PainHypoxiaHaemoglobin DecreasedNeck PainDyspnoeaNauseaBack PainNausea
Cerumen ImpactionEpistaxisBlood Creatinine IncreasedAstheniaMulti-organ FailureOsteonecrosis Of JawVomitingDiarrhoea
Blood Cholesterol IncreasedSinusitis FungalRenal Failure AcuteCholecystitisGastrointestinal HaemorrhageGeneral Physical Health DeteriorationNeutropeniaAsthenia
Blood Triglycerides IncreasedTachycardiaAnxietyAbdominal Pain UpperNeutropeniaAnaemiaAnaemiaThrombocytopenia
Bundle Branch Block RightDisseminated Intravascular CoagulationPyrexiaPainProctalgiaVomitingOsteoarthritisVomiting
Back PainFebrile NeutropeniaDiarrhoeaDyspnoeaHyperglycaemiaHypertensionNauseaFatigue
AcidosisPneumoniaSepsisOedema PeripheralHeadacheFebrile NeutropeniaHypokalaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Diflucan and Valtrex on

Do you take Diflucan and Valtrex?

You are not alone! Join a related mobile support group:
- support group for people who take Diflucan and Valtrex
- support group for people who take Diflucan
- support group for people who take Valtrex

Can you answer these questions (Ask a question):

  • Can herpes simplex 1 cause vasculitis which would in turn cause peripheral neuropath
    I developed tingling and numbness in my feet (and soreness)over the past 2 years. I've had various tests: back mri, b-12, uric acid, ultrasound for pad,etc. Haven't been diagnosed yet. I thought it could result from the herpes simplex 1 flare-ups (3 or 4 per year) and that in turn could have vasculitis of the small vessels. What do you think?
  • I am taking valtrex for herpe type 1, and alco cefdinir for an ear/sinus problem. is it bad to mix the two?
    I have taken Valtrex for Herpe type 1 as I had a first small outbreak, and also was taking Cefdinir for a problem with my sinus/ear. My ENT told me I had a "kink" in my eustachian tube because my ear is constantly popping and there is drainage and mucus drains into my throat too much. I took these antibiotics last week at the time time without thinking about how it would effect me mixing the two. I have since still has problems with my congestion/ear, and now I am experiencing what feels like a yeast infection in the my genital area, and a dime-sized lump has appeared under the skin near my anus, slightly painful to touch. Wondering if it was a mistake to take the two together.
  • Can you get chills with multiple myeloma?
    Do multiple myeloma patients have the chills without fever? My husband was diagnosed 2 months ago and has had 2 months of chemo 2x weekly for 3 weeks. He has Velacade and a steroid Decadron. He has also had 3 rounds of cytoxan. Why is he getting chills?
  • Can valaciclovir make menstration late?
    my period is now 2 weeks, could this tablet be the cause of it?
  • Does marijuana help symptoms of keratitis
    dendritic ulcer herpes simplex 1 keratitis, cold sore virus in the eye

More questions for: Diflucan, Valtrex

You may be interested at these reviews (Write a review):

  • Acne while taking diflucan
    I've been taking Diflucan for three weeks for an uncontrollably itchy rash across my entire chest. The itching is 100% better and the rash 75% better, however, I now have large, hard, cystic acne on my cheeks and chin and all across my jawline. I will take the Diflucan once more next week then report back on the acne. BTW I am 52 years old and occasionally take Allegra.
  • Anyone else experiencing these rare & unbearable side effects from shingles treatment?
    The very day I start treatment I can't stop needing to urinate, can't sleep, and get very shaky and/or have tremors. My BUN/Creatinine levels only become abnormal immediately after I start taking the medication. Nothing helps the insomnia or restlessness.

    I've had an active Shingles infection for over a year (maybe much longer). I was born infected to Chicken Pox (which included related birth defects such as Bell's Palsy) along with a severe defect in a protein gene that makes up my primary immune system. Is anyone else experiencing this???????????????????????? If so please get in touch with me. Thank you.
  • My daughter got sjs after taking fluconazole!!
    My daughter swelled up in her neck, hands, and face. Had severe blistering of her skin especially on her face and vaginal area. Had a radh over 80% of her body. She was dizzy, sick to the stomach, and itched enterally. She also started vaginally bleeding severely.
  • Valtrex and warfarin
    Valtrex was prescribed to be taken every 8 hours. After 4 doses I became extremely cold while outside temperature is 80 degrees and also quite dizzy. I also take 5 mg. of warfarin daily. Although the herpes condition is not fully cleared, I plan to stop Valtrex. I believe the mix has caused my INR to rise too high. ny comments ? Its Sunday. No need to say more.
  • Valtrex 3 months systemic candida
    NOTE: IF YOU TAKE VALTREX FOR WHATEVER REASON, EITHER TAKE GOOD PROBIOTICS, OR GET ON A CANDIDA DIET. A MUST. You don't want to run the risk of messing up your colon with leaky gut syndrome after the yeast has done its damage. Please read the following story.

    My daughter has been autism spectrum her whole life but in December she really went crazy. She had PANDAS, (Pediatric autoimmune disorder associated with strep) Actually 3 bacterias and 17 viruses now associated with this syndrome. the antibodies to infant viruses and exposure to HSV1 (fever blisters) turned autoimmune and attacked the basal galia of her brain creating severe OCD, separation anxiety and irrational thoughts. The doctor put her on Valtrex 3 X day. He said it could produce yeast overgrowth take a probiotic. we did, one a day (not near enough) She had been cured! At 19 she came alive neighbors cried, her boss followed me to the car to say how great she was doing, talking, lively, social. etc. She started Valtrex 12/24/13. Life was good. I got her a smart phone (never thought she could use one) Then April of 2014 showed signs of hypoglycemia (yeast overgrowth)unknown at the time. Then May 1 had a nasty stomach bug. Went to family practice & ER. Its a bug going around. Well finally had the immunologist check for yeast, when she lost her memory and can't function without asking anything first. It's systemic Candida. The bloodtest showed the yeast was in her blood. You can also see it on her tongue. Causing memory loss, severe stomach upset, bloating, gas, burping. She cries every time she eats. We are on day 11 of Diflucan to kill the yeast. Oh yes, then the yeast dies and the toxins released by the critters produces symptons that are just as bad. Terrible fatigue, joint pain, low grade fever, flushed face. I went to the health food store and bought some homeopathic liquid that helps the symptoms.
    My daughter has been sick for ONE month.
    Will we return to Valtrex? yes. with caution. My daughter 'was here' from 12/24/13 to May 1 2014. Then I lost her to yeast. We will get her back.
    Just be sure and take probiotic, especially if you know you are prone to yeast infections. Once it is in your whole system, you would wish it was just an itch!

More reviews for: Diflucan, Valtrex

Comments from related studies:

  • From this study (2 years ago):

  • I take the diflucan, valtrex, and depoProvera intermittently, as needed. The others I take daily.


  • From this study (2 years ago):

  • I discontinued Welbutrin 6 months ago, and I discontinued
    by counting out the grains and decreasing over a one year period
    Cymbalta 4 weeks ago and panic attacks began


  • From this study (2 years ago):

  • shaky


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Diflucan (fluconazole) is often used to treat vaginal yeast infection. Valtrex (valacyclovir hydrochloride) is often used to treat genital herpes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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