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Review: Bupropion and Escitalopram

Summary: drug interactions are reported among people who take Bupropion and Escitalopram together.

This review analyzes the effectiveness and drug interactions between Bupropion and Escitalopram. It is created by eHealthMe based on reports of 3,805 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Bupropion and Escitalopram >>>

What are the drugs

Bupropion hydrochloride has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from Bupropion hydrochloride 6,711 users)

Escitalopram has active ingredients of escitalopram oxalate. It is often used in depression. (latest outcomes from Escitalopram 11,240 users)

On Dec, 19, 2014: 3,804 people who take Bupropion Hydrochloride, Escitalopram are studied

Bupropion Hydrochloride, Escitalopram outcomes

Drug combinations in study:
- Bupropion Hydrochloride (bupropion hydrochloride)
- Escitalopram (escitalopram oxalate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Bupropion Hydrochloride is effective26.67%
(8 of 30 people)
(21 of 74 people)
(7 of 32 people)
(30 of 66 people)
(43 of 80 people)
(31 of 50 people)
(16 of 30 people)
(0 of 1 people)
Escitalopram is effective20.00%
(3 of 15 people)
(14 of 65 people)
(12 of 35 people)
(24 of 61 people)
(49 of 111 people)
(30 of 48 people)
(19 of 28 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaDepressionNauseaAnxietyDepressionAnxietyWeight Gain - UnintentionalDepression
DepressionDizzinessType 2 Diabetes MellitusInsomniaHyperhidrosisSuicidal IdeationInsomniaPain
AgitationNauseaDiabetes MellitusEmotional DistressPainDiabetes MellitusPain In ExtremityNausea
ConvulsionSuicidal IdeationDepressionConvulsionHeadacheType 2 Diabetes MellitusPainFatigue
DizzinessHeadacheDizzinessDepressionWeight DecreasedPainOesophageal CandidiasisBack Pain
TremorPainSuicidal IdeationHeadacheInsomniaNauseaPancreatitisDiabetes Mellitus
Confusional StateFeeling AbnormalHyperglycaemiaFatigueSuicide AttemptInjuryPanic AttackWeight Increased
RashVomitingVertigoVomitingConvulsionVisual Acuity ReducedPneumoniaDizziness
AnxietyEmotional DistressDiplopiaDyskinesiaTardive DyskinesiaCerebrovascular AccidentWeight IncreasedSuicidal Ideation

Drug effectiveness by gender :

Bupropion Hydrochloride is effective44.32%
(121 of 273 people)
(35 of 89 people)
Escitalopram is effective42.75%
(118 of 276 people)
(33 of 87 people)

Most common drug interactions by gender * :

DizzinessSuicidal Ideation
Back PainHeadache
Weight IncreasedFatigue
FatigueWeight Decreased

Drug effectiveness by age :

Bupropion Hydrochloride is effective0.00%
(0 of 1 people)
(9 of 28 people)
(25 of 103 people)
(32 of 170 people)
(33 of 152 people)
(43 of 161 people)
(14 of 65 people)
Escitalopram is effective0.00%
(0 of 1 people)
(8 of 27 people)
(19 of 89 people)
(37 of 167 people)
(31 of 146 people)
(44 of 161 people)
(12 of 59 people)

Most common drug interactions by age * :

Type 2 Diabetes Mellitusn/aNauseaDizzinessDepressionDiabetes MellitusPainDepression
Suicidal IdeationFatigueDepressionDiabetes MellitusDepressionAnxietyFall
Pyoderma GangrenosumAnxietyHeadacheAnxietyPainDepressionAnxiety
Pelvic PainConvulsionNauseaType 2 Diabetes MellitusAnxietyNauseaNausea
Urinary Tract InfectionVomitingAnxietyDizzinessWeight IncreasedSpinal OsteoarthritisTremor
Uterine LeiomyomaAbdominal Pain UpperAbdominal PainNauseaType 2 Diabetes MellitusOsteonecrosis Of JawDrug Ineffective
Tremor NeonatalBiliary DyskinesiaCholelithiasisSuicidal IdeationSuicidal IdeationDyspnoeaPneumonia
Maternal Drugs Affecting FoetusAbdominal DiscomfortCompleted SuicideWeight IncreasedNauseaBack PainInsomnia
Extrapyramidal DisorderPainTremorFatigueDrug IneffectiveBone DisorderArthralgia
Weight IncreasedHypoaesthesiaFatigueHeadacheInsomniaPain In ExtremityDiarrhoea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Bupropion and Escitalopram?

You are not alone! Join a related mobile support group:
- support group for people who take Bupropion and Escitalopram
- support group for people who take Bupropion Hydrochloride
- support group for people who take Escitalopram

Can you answer these questions (Ask a question):

  • I am on 2 x daily rifampin and 4 x daily cephalixin 500mg and and awake exhausted after 8-9 hours sleep and the fatigue is unbelievable all day every day, is this "normal" or should i investigate ore (1 answer)
    Had total knee replacement 11/12, bad from the start, knee swollen/hot/painful/unstable for most of 2 years before a mechanically successful Revision that found a loose patella and both ends of the prostheses loose. In spite of 10-12 aspirations and almost as many samples sent to labs for testing the result was always "no growth after a week". Following the revision, 10 days after, surgeons office called and says yes you have a staph E infection. Immediate therapy with 6 weeks of 3 X day IV PLUS 2 x per day oral Rifampin.
    IV over but now on the 2 X day Rifampin PLUS 4 X day 500mg cephalexin and the fatigue is unbelievable. Wake up exhausted after 8 hours sleep, daily hour plus mid afternoon naps.
  • Has anyone been helped by taking lexapro and wellbutrin? (1 answer)
    I am the mom of a 22 year old who is trying to get through college and can't seem to find the right meds for depression. She is taking Lexapro and I am wondering if adding Wellbutrin will help.
  • Can my eye twitch be because of lexapro?
    So I have had symptoms of anxiety and depression due to a lot of stressors and disasters that happened in my life over the past two years. As my anxiety got worse after a breast biopsy, I started freaking out and thinking I may have MS because my sister has MS. So I went to my GP and she decided my symptoms do not follow the symptoms of MS or any similar problem and it should most likely be anxiety. She put me on Lexapro and Clonazepam. At first I was very hesitant to take medication but as my symptoms got worse I decided to give it a try. I was on Lexopro 5 mg for about two months and then I went to 10 mg, and I would take 1 or 2 Clonazepam a day. And this all started 5 months ago. And things seemed to be working just fine.Until about two months ago I started having this freaking annoying eye twitch on my upper left eyelid. I have had eye twitches before but they always go away after a couple of days or a week top. This one has been lasting for 2 months now and seems to be just getting worse. I went to the GP and my eye doctor and they still found no cause and said it's probably stress and anxiety. I have not been overly stressed and I get plenty of sleep, 10 hrs or more! and I stopped taking caffeine and alcohol after the twitch started. Any idea? Could it be because of medication? I also need to add I have had thumb twitching and severe spasms in my muscles around my right thumb starting in May (before taking any medication).
  • My mom is 88. she takes lexapro in the evening. she wakes up hallucinating. it's starting to get to her. what should i try for her?
    My mom has been taking Lexapro for about 2 1/2 to 3 months. She was taking it in the morning and her therapist felt it was making her drowsy. I began giving it to her before bed, and I believe that is when she started waking up during the night with hallucinations. I'm not sure if they are vivid dreams that carry over when she awakens, or if she wakes up and sees visions. I do not want to change her meds, if possible. This combination of Aricept, Namenda and Lexapro have allowed her to be sharper mentally than she has in a number of years. Except for the hallucinations, it's been nothing short of amazing. Please help. Thank you
  • My sister has been taking depakote cogentin and geodon and suffers with great memory loss inability to carry on a conversation and drops things all the time is this the effect of these drugs? (1 answer)
    Sister takes over 16 perscriptions but the ones mentioned are severe.. due to being bi-polar, and severe agoraphobia and anxiety with this now her life? Not being able to fully comprehend or remember anything? Dropping things and falling when under the full impact of this medication? I either need to get some acceptance or find answers to the effects this medicine is causing..afraid to change up her medicines but needless to say I am worried...

More questions for: Bupropion Hydrochloride, Escitalopram

You may be interested at these reviews (Write a review):

  • Intrsoccular pressure increase associated with wellbutrin
    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
  • Librium 25mg and wellbutrin 300mg for >1 month
    I've been taking librium twice daily, morning and night, for about 3 months now along with wellbutrin XL in the morning. I've basically had the mood of "I don't care" and a great boost in confidence.
  • Escitalopram /narcolepsy
    Began taking escitalopram one month ago. Having narcoleptic type sleep incidents as well as unwanted suicidal thoughts. Legs and arms also go out. Sleeping up to thirteen or more hours per day.
  • Bedwetting with paxil and wellbutrin
    I have been using both of these drugs and now have bedwetting issues 5 times a week on average. I would rate the bedwetting as moderate about a6/10 but my wife and I can live with this as she had made the comment " you are back to the man I married ". I started taking these due to depression about work and anxiety about work. We both think we can live with the bedwetting as no one needs to know about it
  • Wellbutrin caused my trigeminal neurlagia
    So I'm writing this to hopefully shed light to other users in the same position I was in. I had taken Wellbutrin for about 4 years. The pain experienced in my face was excruciatingly painful. It was just on one side of my face between my temple and upper lip. All the symptoms reflected Trigeminal Neuralgia. But even with an MRI nothing could be found. I suffered for 3 of those years with pain coming and going, not understanding what was going on. Finally one day I decided hell with Wellbutrin and just stopped taking it. It's been 6 months now and I have yet to have a single shred of pain. Coincidence? I doubt it.

More reviews for: Bupropion Hydrochloride, Escitalopram

Comments from related studies:

  • From this study (2 weeks ago):

  • Take 150mg of bupropion in the morning and 10 mg of escitalopram at night. Headache in forehead when I wake up in the morning, lessons as day goes on.


  • From this study (1 month ago):

  • moxohol on Nov, 18, 2014:

    I forgot: standardized grapeseed extract or "true cinnamon" (not chinese) stick will inhibit catabolism of ligaments and tendons. Both contain "oligomeric proanthocyanidins" (OPCs) which does this task. The USDA tested 5000 foodstuffs (2004) for the highest OPC content. Cinnamon (true or ceylon variety) came out tops. You also have to dump the Snickers bars for lentils or sweet potatoes ones. Ingesting simple sugars or fructose goes directly into the matrix of your collagen production & weakens the integrity of connective tissue (ask any doctor about it).


    moxohol on Nov, 18, 2014:

    Research "Baclofen". Searches to add to your primary search are "fibromyalgia", "bipolar disorder", "growth hormone stimulation", "insomnia". It says 80mg max dosage according to the drug labeling but I got involuntary shakes over it. 20mg per day is an established safety margin plus you get significant GH & IGF stimulation over time with usage & slow wave sleep. The drug is a GABA-b agonist. Price is pretty cheap least in Egypt (ex-pat' here)


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Complete drug side effects:

On eHealthMe, Bupropion Hydrochloride (bupropion hydrochloride) is often used to treat depression. Escitalopram (escitalopram oxalate) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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