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Review: taking Flexeril and Cymbalta together

Summary: drug interactions are reported among people who take Flexeril and Cymbalta together.

This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on reports of 1,636 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Flexeril and Cymbalta >>>

What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,458 Flexeril users)

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from 49,362 Cymbalta users)

On Feb, 24, 2015: 1,636 people who take Flexeril, Cymbalta are studied

Flexeril, Cymbalta outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Cymbalta (duloxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective20.00%
(4 of 20 people)
23.81%
(5 of 21 people)
23.08%
(3 of 13 people)
17.39%
(4 of 23 people)
29.41%
(10 of 34 people)
26.67%
(4 of 15 people)
66.67%
(2 of 3 people)
33.33%
(1 of 3 people)
Cymbalta is effective31.25%
(5 of 16 people)
21.95%
(9 of 41 people)
16.67%
(2 of 12 people)
31.82%
(7 of 22 people)
31.58%
(12 of 38 people)
33.33%
(1 of 3 people)
50.00%
(2 of 4 people)
50.00%
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Feeling AbnormalAnxietyDepressionNauseaDepressionCholecystitis ChronicFemur FracturePain
Aspartate Aminotransferase IncreasedDizzinessAnxietyDiabetic NeuropathyAnxietyPainColon AdenomaNausea
Alanine Aminotransferase IncreasedDepressionTemporomandibular Joint SyndromeDiabetic ComaMuscle TwitchingGallbladder DisorderCystitisDepression
HeadachePancreatic Duct StenosisVertigoHyperglycaemiaPainSphincter Of Oddi DysfunctionHypothyroidismFatigue
DepressionHypersensitivityOsteonecrosisHypoglycaemiaCholecystitis ChronicPancreatitisUrinary RetentionAnxiety
Weight DecreasedCellulitisOral HerpesMental Status ChangesPancreatitisMuscle SpasmsTooth DisorderArthralgia
NauseaHepatic CirrhosisArthropathyChronic HepatitisLoss Of ConsciousnessVision BlurredPostmenopausal HaemorrhageWeight Increased
Hepatic Enzyme IncreasedSphincter Of Oddi DysfunctionWoundConvulsionPsychotic DisorderMuscle TwitchingLymphoedemaHeadache
InsomniaChronic HepatitisCerebral CystCardiomyopathyFibromyalgiaTremorOsteoporosisInsomnia
AgitationBile Duct StenosisAphthous StomatitisHepatic CirrhosisGallbladder DisorderFatigueLow Turnover OsteopathyDyspnoea

Drug effectiveness by gender :

FemaleMale
Flexeril is effective26.55%
(30 of 113 people)
15.79%
(3 of 19 people)
Cymbalta is effective29.91%
(35 of 117 people)
15.00%
(3 of 20 people)

Most common drug interactions by gender * :

FemaleMale
PainDepression
NauseaAnxiety
DepressionFatigue
AnxietyPain
FatigueNausea
ArthralgiaChest Pain
Weight IncreasedPain In Extremity
HeadacheSuicidal Ideation
InsomniaNeuropathy Peripheral
DiarrhoeaDiabetes Mellitus

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/a28.57%
(4 of 14 people)
7.78%
(7 of 90 people)
8.79%
(8 of 91 people)
17.39%
(12 of 69 people)
18.18%
(2 of 11 people)
Cymbalta is effectiven/an/an/a33.33%
(5 of 15 people)
9.09%
(8 of 88 people)
9.78%
(9 of 92 people)
18.57%
(13 of 70 people)
25.00%
(3 of 12 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Meningomyelocelen/aGallbladder DisorderDiabetes MellitusNauseaPainPainPain
Neural Tube DefectCholecystitis ChronicType 2 Diabetes MellitusWeight IncreasedNauseaNauseaAnxiety
Spina BifidaSphincter Of Oddi DysfunctionConvulsionHeadacheFatigueArthralgiaFatigue
TalipesPainPulmonary EmbolismType 2 Diabetes MellitusDepressionDepressionDepression
Maternal Drugs Affecting FoetusPancreatitisInjuryDyspnoeaBack PainFatigueFall
Congenital HydrocephalusType 2 Diabetes MellitusAnxietyFatigueAnxietyAnxietyNeuropathy Peripheral
ObesityAnxietyDeathDepressionAstheniaInsomniaHypertension
Type 2 Diabetes MellitusScarDepressionVomitingPain In ExtremityHeadacheDizziness
Abortion InducedAbdominal DistensionPainArthralgiaChest PainWeight IncreasedAnaemia
Congenital Central Nervous System AnomalyDepressionAdverse Drug ReactionAbdominal PainDiarrhoeaHypertensionAnhedonia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Flexeril and Cymbalta on

Do you take Flexeril and Cymbalta?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Cymbalta
- support group for people who take Cymbalta
- support group for people who take Flexeril

Can you answer these questions (Ask a question):

  • Is there a drug interaction between paxil and flexeril?
    What is the drug interaction, if any between paxil and flexeril? I was taken off a low dosage of paxil two weeks or so ago an due to back issues was issued flexeril for spasms and pain. I try to avoid meds like this but really need it and wanted to know if it was safe. I read about major drug interaction between these two medications and that is why I suffered through pain because I was concerned. Please advise if I can take flexeril now.
  • Is bed wetting part of having syringomyelia
    i also use panadol osteo, mintec, apo-meloxicam. i have wetting the bed is was just now and then but it has started to become more frequent now, does any one else had this happen.
  • Will flexeril help with alcohol withdrawal anxiet????
    I have been suffering with alcohol withdrawals plus the flu the only meds that I have available is one flexor all will this help ease anxiety and let me sleep??
  • Can cymbalta cause dementia?
    I have been on Cymbalta for 5 years and was wondering if it has caused my Alzheimer's or dementia?
  • Does anyone taking isosorbide or ranexa have severe nightmares?
    I have horribly, terrifying nightmares, every night. They are all variations on a theme of terror.

More questions for: Cymbalta, Flexeril

You may be interested at these reviews (Write a review):

  • Terrible excessive sweating from hydrochlorothiazide
    I guess I fit the profile of who gets excessive sweating from HCTZ. I am a 65 year old female and suffered from excessive sweating for two years. With just very little exertion, I would pour sweat from the top of my head. It would run into my face and all over my hair. My hair would be ringing wet. I had heavy perspiration in the groin area and down my back also. I had to change clothing 2-3 times a day and wash up or shower that many times also. The doctor tried changing my Cymbalta and put me on Wellbutrin instead. It did absolutely no good. I went off the wellbutrin and back onto the Cymbalta. I did some research and saw that HCTZ could cause excessive sweating. Both my doctor and my pharmacist said that they had never heard of that. I went off the HCTZ, and my sweating stopped almost immediately. My doctor and my pharmacist were very surprised. I'm one of those people who frequently have different reactions to drugs than are typical. If you're having excessive perspiration and are on HCTZ, try going off of it. It just may be the culprit!
  • Cymbalta side effects
    Starting Cymbalta, side effects were dizzy,felt drugged. Helped with Arthritis pain. About six weeks after i started i developed rectal bleeding.Doctor had me stop Cymbalta and use Tramadol as needed for withdrawal.
  • Cardio version caused fingernail abnormalities
    Right hip fracture. When prepping for surgery AFIB was found. Surgery was cancelled and they attempted to get AFIB under control. Finally, cardioversion was performed. When my nails started to grow out they all had two horizontal lines that cause the nail to break when it grows out to that point.
  • Numbness between toes
    This summer I flip flops, with the strap between my toes, almost exclusively. When I switched this fall to regular shoes I noticed a strange, numb sensation between my big toe and second toe. At first I thought it had something to do with the flip flops and thought it would go away. It has been a few weeks now and this has not gone away, and if anything seems to cover a larger area. Oddly enough I mentioned this to a friend today and she says she has the same thing, between her second and third toe...both of us on our right feet. She is also on an antidepressant but couldn't remember which one, but we thought this was an odd coincidence. She explained it as sort of a sensation that there is a hole in your sock or shoe...and that made sense to me...there is still some sensation in the area but it is an odd feeling...something isn't quite right. I am doing some online research right now to try to figure out if this is common with Cymbalta or not?
  • Cymbalta caused joint pain
    I had taken Cymbalta for about 1.5 years and after taking it for a few months, I started having widespread joint pain. The joint pain has gotten worse and is becoming debilitating. Joint pain in the literature as a side affect of the drug but the joint pain seems to be permanent! I have not taken Cymbalta in a couple years but the joint pain has remained. I have had blood tests and my doctor says the tests show it is not arthritis.

More reviews for: Cymbalta, Flexeril

Comments from related studies:

  • From this study (6 months ago):

  • I've had all over pain for 4 months, starting with pains in left abdomen, spreading to left leg, upper back, and then right abdomen. MRI's,xrays,blood work all shows normal. Physical activity and stress worsens symptoms. Seen hernia doctor said was normal, Neurologist diagnosed me with high anxiety and put me on Cymbalta. Primary has me on the cyclobenzaprine for the pain which I was told to only take at night because I have extreme fatigue. My pain has decreased tremendously since being on the Cymbalta but now I have found my left nipple to leak white fluid and blood when stimulated, noticed it while showering.My left breast and area around breast seems extremely sore.

    Reply

    anonymous on Sep, 13, 2014:

    i have the same issue. i have breast pain all month long, even though i am not taking invega anymore. i have been completely off any antipsychotics for 8 months and nothing i got from my gynealogist seems to help. i have never had this before either.

    however, i have been told that when it bleeds, it could be a lot more serious. you should get this checked out.

    Reply

  • From this study (7 months ago):

  • Hepatitis c

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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