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Review: Flexeril and Cymbalta

This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on reports of 1,629 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Flexeril and Cymbalta >>>

What are the drugs

Flexeril (latest outcomes from 16,403 users) has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms.

Cymbalta (latest outcomes from 49,113 users) has active ingredients of duloxetine hydrochloride. It is often used in depression.

On Jul, 13, 2014: 1,629 people who take Flexeril, Cymbalta are studied

Flexeril, Cymbalta outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Cymbalta (duloxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective20.00%
(4 of 20 people)
25.00%
(5 of 20 people)
16.67%
(2 of 12 people)
18.18%
(4 of 22 people)
28.12%
(9 of 32 people)
30.77%
(4 of 13 people)
66.67%
(2 of 3 people)
33.33%
(1 of 3 people)
Cymbalta is effective31.25%
(5 of 16 people)
18.42%
(7 of 38 people)
16.67%
(2 of 12 people)
28.57%
(6 of 21 people)
33.33%
(12 of 36 people)
50.00%
(1 of 2 people)
50.00%
(2 of 4 people)
50.00%
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Feeling AbnormalAnxietyDepressionNauseaDepressionPainFemur FracturePain
Aspartate Aminotransferase IncreasedDepressionAnxietyDiabetic ComaAnxietySphincter Of Oddi DysfunctionColon AdenomaNausea
Alanine Aminotransferase IncreasedDizzinessTemporomandibular Joint SyndromeConvulsionMuscle TwitchingCholecystitis ChronicCystitisDepression
HeadacheHepatic CirrhosisVertigoDiabetic NeuropathyPainPancreatitisHypothyroidismFatigue
DepressionPancreatic Duct StenosisOsteonecrosisHyperglycaemiaCholecystitis ChronicGallbladder DisorderUrinary RetentionAnxiety
Weight DecreasedSphincter Of Oddi DysfunctionOral HerpesMental Status ChangesPancreatitisMuscle SpasmsTooth DisorderArthralgia
NauseaHypersensitivityArthropathyHypoglycaemiaLoss Of ConsciousnessDepressionPostmenopausal HaemorrhageWeight Increased
Hepatic Enzyme IncreasedChronic HepatitisWoundCardiomyopathyPsychotic DisorderMuscle TwitchingLymphoedemaHeadache
InsomniaCellulitisCerebral CystCardiac DisorderFibromyalgiaVision BlurredOsteoporosisInsomnia
AgitationBile Duct StenosisAphthous StomatitisBile Duct StenosisGallbladder DisorderFatigueLow Turnover OsteopathyDyspnoea

Drug effectiveness by gender :

FemaleMale
Flexeril is effective25.93%
(28 of 108 people)
17.65%
(3 of 17 people)
Cymbalta is effective28.57%
(32 of 112 people)
16.67%
(3 of 18 people)

Most common drug interactions by gender * :

FemaleMale
PainDepression
NauseaAnxiety
DepressionFatigue
AnxietyPain
FatigueNausea
ArthralgiaChest Pain
Weight IncreasedPain In Extremity
HeadacheSuicidal Ideation
InsomniaDiabetes Mellitus
DiarrhoeaHeadache

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/a23.08%
(3 of 13 people)
7.78%
(7 of 90 people)
9.20%
(8 of 87 people)
17.65%
(12 of 68 people)
11.11%
(1 of 9 people)
Cymbalta is effectiven/an/an/a28.57%
(4 of 14 people)
9.09%
(8 of 88 people)
7.95%
(7 of 88 people)
18.84%
(13 of 69 people)
30.00%
(3 of 10 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Meningomyelocelen/aGallbladder DisorderDiabetes MellitusNauseaPainPainPain
Neural Tube DefectCholecystitis ChronicType 2 Diabetes MellitusWeight IncreasedNauseaNauseaAnxiety
Spina BifidaSphincter Of Oddi DysfunctionConvulsionHeadacheFatigueArthralgiaFatigue
TalipesPainPulmonary EmbolismType 2 Diabetes MellitusDepressionDepressionDepression
Maternal Drugs Affecting FoetusPancreatitisDeathDyspnoeaBack PainFatigueFall
Congenital HydrocephalusType 2 Diabetes MellitusPainFatigueAnxietyAnxietyNeuropathy Peripheral
ObesityAnxietyAnxietyDepressionAstheniaHeadacheHypertension
Type 2 Diabetes MellitusScarDepressionVomitingPain In ExtremityInsomniaAnaemia
Abortion InducedAbdominal DistensionInjuryArthralgiaDiabetes MellitusWeight IncreasedAnhedonia
Congenital Central Nervous System AnomalyDepressionSuicidal IdeationAbdominal PainChest PainHypertensionDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Flexeril and Cymbalta
- group for people who take Cymbalta
- group for people who take Flexeril

Comments from related studies:

  • From this study (6 days ago):

  • I've had all over pain for 4 months, starting with pains in left abdomen, spreading to left leg, upper back, and then right abdomen. MRI's,xrays,blood work all shows normal. Physical activity and stress worsens symptoms. Seen hernia doctor said was normal, Neurologist diagnosed me with high anxiety and put me on Cymbalta. Primary has me on the cyclobenzaprine for the pain which I was told to only take at night because I have extreme fatigue. My pain has decreased tremendously since being on the Cymbalta but now I have found my left nipple to leak white fluid and blood when stimulated, noticed it while showering.My left breast and area around breast seems extremely sore.

    Reply

  • From this study (3 months ago):

  • The abnormal dreams & mild hallucinations came only after starting the methylprednisolone a few days ago. They happen primarily when I am sleeping. I woke up last night with very unusual dreams & head/brain pain, and was quite concerned. I had taken 1 methylprednisolone & 1 cymbalta before bed. Earlier in the day, I had taken 2 methylprednisolone & 2 tramadol before a nap, and had similar, though not as severe issues. Trying to figure out what the interaction problem is. I did not take the muscle relaxant (cyclopenzaprine) before bed since I started the cortico steroid pack.

    Reply

    britsarmymom on Apr, 26, 2014:

    Mother just survived near brush with respiratory arrest. Hallucinated at night on Tramadol, argumentative with RN who reported her to MD. He planned to ADD Seroquel 25 mg to Tramadol, Neurontin, Remeron and Ativan in rehab facility. She declined Tramadol and Seroquel and was still so sedated her pulse ox went down to 84 with long periods of apnea and need for constant obs with frequent rousing for airway. MAJOR struggle with RN to get 02 and MD agreed to no more Tramodol at night and absolutely no Seroquel. How many elderly are lost this way?

    Reply

  • From this study (6 months ago):

  • I am suffering from severe mood swings and nervousness. Sometimes I am so mad I want to rip something apart, most of the time my poor husband catches the brunt of it. My headaches are coming back, but I really want to get rid of the crazy mood swings before I hurt myself or someone else when i lose my temper maybe in a car driving, I will fly into a rage over little things...Please help me with this.
    What do I need to get OFF of OR ON...
    Thank you, Carolyn

    Reply

Post a new comment    OR    Read more comments

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More reviews for: Cymbalta, Flexeril

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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