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Review: Flexeril and Cymbalta





Summary: drug interactions are reported among people who take Flexeril and Cymbalta together.

This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on reports of 1,634 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Flexeril and Cymbalta >>>

What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,445 users)

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 49,275 users)

On Dec, 26, 2014: 1,634 people who take Flexeril, Cymbalta are studied

Flexeril, Cymbalta outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Cymbalta (duloxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective20.00%
(4 of 20 people)
25.00%
(5 of 20 people)
16.67%
(2 of 12 people)
17.39%
(4 of 23 people)
29.41%
(10 of 34 people)
26.67%
(4 of 15 people)
66.67%
(2 of 3 people)
33.33%
(1 of 3 people)
Cymbalta is effective31.25%
(5 of 16 people)
21.95%
(9 of 41 people)
16.67%
(2 of 12 people)
31.82%
(7 of 22 people)
33.33%
(12 of 36 people)
33.33%
(1 of 3 people)
50.00%
(2 of 4 people)
50.00%
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Feeling AbnormalAnxietyDepressionNauseaDepressionCholecystitis ChronicFemur FracturePain
Aspartate Aminotransferase IncreasedDizzinessAnxietyDiabetic NeuropathyAnxietyPainColon AdenomaNausea
Alanine Aminotransferase IncreasedDepressionTemporomandibular Joint SyndromeDiabetic ComaPainGallbladder DisorderCystitisDepression
HeadacheHepatic CirrhosisVertigoHyperglycaemiaMuscle TwitchingSphincter Of Oddi DysfunctionHypothyroidismFatigue
DepressionHypersensitivityOsteonecrosisHypoglycaemiaCholecystitis ChronicPancreatitisUrinary RetentionAnxiety
Weight DecreasedCellulitisOral HerpesMental Status ChangesPancreatitisMuscle SpasmsTooth DisorderArthralgia
NauseaSphincter Of Oddi DysfunctionArthropathyChronic HepatitisSphincter Of Oddi DysfunctionVision BlurredPostmenopausal HaemorrhageWeight Increased
Hepatic Enzyme IncreasedChronic HepatitisWoundConvulsionFibromyalgiaMuscle TwitchingLymphoedemaHeadache
InsomniaPancreatic Duct StenosisCerebral CystCardiomyopathyPsychotic DisorderTremorOsteoporosisInsomnia
AgitationBile Duct StenosisAphthous StomatitisHepatic CirrhosisGallbladder DisorderFatigueLow Turnover OsteopathyDyspnoea

Drug effectiveness by gender :

FemaleMale
Flexeril is effective26.13%
(29 of 111 people)
15.79%
(3 of 19 people)
Cymbalta is effective30.43%
(35 of 115 people)
15.00%
(3 of 20 people)

Most common drug interactions by gender * :

FemaleMale
PainDepression
NauseaAnxiety
DepressionFatigue
AnxietyPain
FatigueNausea
ArthralgiaChest Pain
Weight IncreasedPain In Extremity
HeadacheSuicidal Ideation
InsomniaNeuropathy Peripheral
DiarrhoeaDiabetes Mellitus

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/a28.57%
(4 of 14 people)
7.78%
(7 of 90 people)
8.79%
(8 of 91 people)
17.65%
(12 of 68 people)
10.00%
(1 of 10 people)
Cymbalta is effectiven/an/an/a33.33%
(5 of 15 people)
9.09%
(8 of 88 people)
9.78%
(9 of 92 people)
18.84%
(13 of 69 people)
27.27%
(3 of 11 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Meningomyelocelen/aGallbladder DisorderDiabetes MellitusNauseaPainPainPain
Neural Tube DefectCholecystitis ChronicType 2 Diabetes MellitusWeight IncreasedNauseaNauseaAnxiety
Spina BifidaSphincter Of Oddi DysfunctionConvulsionHeadacheFatigueArthralgiaFatigue
TalipesPainPulmonary EmbolismType 2 Diabetes MellitusDepressionDepressionFall
Maternal Drugs Affecting FoetusPancreatitisInjuryDyspnoeaBack PainFatigueDepression
Congenital HydrocephalusType 2 Diabetes MellitusAnxietyFatigueAnxietyAnxietyNeuropathy Peripheral
ObesityAnxietyDeathDepressionAstheniaHeadacheHypertension
Type 2 Diabetes MellitusScarDepressionVomitingPain In ExtremityInsomniaAnaemia
Abortion InducedAbdominal DistensionPainArthralgiaChest PainWeight IncreasedDizziness
Congenital Central Nervous System AnomalyDepressionAdverse Drug ReactionAbdominal PainDiarrhoeaHypertensionAnhedonia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Flexeril and Cymbalta?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Cymbalta
- support group for people who take Cymbalta
- support group for people who take Flexeril

Recent conversations of related support groups:

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  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
  • Cymbalta r/t autonomic neuropathy
    neurotin
    losartan 20 mg
    tired all the time, dizziness, chronic constipation, stomach pains, pins and needles, diabetic type 2 hx alcoholism resolved, gerd, early satiety

More questions for: Cymbalta, Flexeril

You may be interested at these reviews (Write a review):

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  • Numbness between toes
    This summer I flip flops, with the strap between my toes, almost exclusively. When I switched this fall to regular shoes I noticed a strange, numb sensation between my big toe and second toe. At first I thought it had something to do with the flip flops and thought it would go away. It has been a few weeks now and this has not gone away, and if anything seems to cover a larger area. Oddly enough I mentioned this to a friend today and she says she has the same thing, between her second and third toe...both of us on our right feet. She is also on an antidepressant but couldn't remember which one, but we thought this was an odd coincidence. She explained it as sort of a sensation that there is a hole in your sock or shoe...and that made sense to me...there is still some sensation in the area but it is an odd feeling...something isn't quite right. I am doing some online research right now to try to figure out if this is common with Cymbalta or not?
  • Cymbalta caused joint pain
    I had taken Cymbalta for about 1.5 years and after taking it for a few months, I started having widespread joint pain. The joint pain has gotten worse and is becoming debilitating. Joint pain in the literature as a side affect of the drug but the joint pain seems to be permanent! I have not taken Cymbalta in a couple years but the joint pain has remained. I have had blood tests and my doctor says the tests show it is not arthritis.

More reviews for: Cymbalta, Flexeril

Comments from related studies:

  • From this study (4 months ago):

  • I've had all over pain for 4 months, starting with pains in left abdomen, spreading to left leg, upper back, and then right abdomen. MRI's,xrays,blood work all shows normal. Physical activity and stress worsens symptoms. Seen hernia doctor said was normal, Neurologist diagnosed me with high anxiety and put me on Cymbalta. Primary has me on the cyclobenzaprine for the pain which I was told to only take at night because I have extreme fatigue. My pain has decreased tremendously since being on the Cymbalta but now I have found my left nipple to leak white fluid and blood when stimulated, noticed it while showering.My left breast and area around breast seems extremely sore.

    Reply

    anonymous on Sep, 13, 2014:

    i have the same issue. i have breast pain all month long, even though i am not taking invega anymore. i have been completely off any antipsychotics for 8 months and nothing i got from my gynealogist seems to help. i have never had this before either.

    however, i have been told that when it bleeds, it could be a lot more serious. you should get this checked out.

    Reply

  • From this study (5 months ago):

  • Hepatitis c

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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