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Review: Flexeril and Cymbalta

This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on 1,510 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 31, 2014: 1,510 people who reported to have interactions when taking Flexeril, Cymbalta are studied

Trend of Flexeril, Cymbalta's drug interactions, side effects and effectiveness reports (3590406)

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Cymbalta (duloxetine hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Flexeril, Cymbalta:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety805
Pain787
Arthralgia (joint pain)666
Nausea (feeling of having an urge to vomit)574
Dyspnoea (difficult or laboured respiration)568
Fatigue (feeling of tiredness)540
Depression538
Neuropathy Peripheral (surface nerve damage)402
Insomnia (sleeplessness)387
Weight Increased377

Most common interactions experienced by people in long term use of Flexeril, Cymbalta:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Hypoglycaemia (deficiency of glucose in the bloodstream)54
Anxiety51
Depression40
Lymphoedema (localized fluid retention and tissue swelling)38
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle)36
Colon Adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)32
Low Turnover Osteopathy (slow removal of old bone and its replacement by new bone)32
Menopausal Symptoms32
Osteoporosis (bones weak and more likely to break)32
Gastrointestinal Disorder (functional problems of gastrointestinal tract)32

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Flexeril0.00%33.33%38.10%14.29%14.29%
Cymbalta0.00%30.00%33.33%16.67%20.00%

Top conditions involved for these people * :

  1. Pain
  2. Depression
  3. Fibromyalgia
  4. Muscle spasms
  5. Anxiety

Top co-used drugs for these people * :

  1. Seroquel
  2. Ambien
  3. Lyrica
  4. Nexium
  5. Neurontin

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Cymbalta, Flexeril

You can also:

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (2 months ago):

  • I am suffering from severe mood swings and nervousness. Sometimes I am so mad I want to rip something apart, most of the time my poor husband catches the brunt of it. My headaches are coming back, but I really want to get rid of the crazy mood swings before I hurt myself or someone else when i lose my temper maybe in a car driving, I will fly into a rage over little things...Please help me with this.
    What do I need to get OFF of OR ON...
    Thank you, Carolyn

    Reply

  • From this study (2 months ago):

  • I just started taking this medicine. want to see if anyone has had these problems.

    Reply

  • From this study (4 months ago):

  • Fish Oil, Vitamin D, biotin, B12

    Reply

Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

More questions for: Cymbalta, Flexeril

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  • Cymbalta - since taking cymbalta i have been waking myself up due to tongue biting.
    Since I have been taking Cymbalta I wake myself up because of tongue biting. It is really painful. It is very strange. I think I must randomly clench my teeth and my tongue gets in the way.

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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