Review: taking Flexeril and Cymbalta together
Summary: drug interactions are reported among people who take Flexeril and Cymbalta together.
This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on reports of 1,636 people who take the same drugs from FDA and social media, and is updated regularly.
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Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,458 Flexeril users) Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from 49,362 Cymbalta users)
What are the drugs
Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from 16,458 Flexeril users)
Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from 49,362 Cymbalta users)
On Feb, 24, 2015: 1,636 people who take Flexeril, Cymbalta are studied
Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Cymbalta (duloxetine hydrochloride)
Drug effectiveness over time :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Flexeril is effective||20.00%|
(4 of 20 people)
(5 of 21 people)
(3 of 13 people)
(4 of 23 people)
(10 of 34 people)
(4 of 15 people)
(2 of 3 people)
(1 of 3 people)
|Cymbalta is effective||31.25%|
(5 of 16 people)
(9 of 41 people)
(2 of 12 people)
(7 of 22 people)
(12 of 38 people)
(1 of 3 people)
(2 of 4 people)
(1 of 2 people)
Most common drug interactions over time * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Feeling Abnormal||Anxiety||Depression||Nausea||Depression||Cholecystitis Chronic||Femur Fracture||Pain|
|Aspartate Aminotransferase Increased||Dizziness||Anxiety||Diabetic Neuropathy||Anxiety||Pain||Colon Adenoma||Nausea|
|Alanine Aminotransferase Increased||Depression||Temporomandibular Joint Syndrome||Diabetic Coma||Muscle Twitching||Gallbladder Disorder||Cystitis||Depression|
|Headache||Pancreatic Duct Stenosis||Vertigo||Hyperglycaemia||Pain||Sphincter Of Oddi Dysfunction||Hypothyroidism||Fatigue|
|Depression||Hypersensitivity||Osteonecrosis||Hypoglycaemia||Cholecystitis Chronic||Pancreatitis||Urinary Retention||Anxiety|
|Weight Decreased||Cellulitis||Oral Herpes||Mental Status Changes||Pancreatitis||Muscle Spasms||Tooth Disorder||Arthralgia|
|Nausea||Hepatic Cirrhosis||Arthropathy||Chronic Hepatitis||Loss Of Consciousness||Vision Blurred||Postmenopausal Haemorrhage||Weight Increased|
|Hepatic Enzyme Increased||Sphincter Of Oddi Dysfunction||Wound||Convulsion||Psychotic Disorder||Muscle Twitching||Lymphoedema||Headache|
|Insomnia||Chronic Hepatitis||Cerebral Cyst||Cardiomyopathy||Fibromyalgia||Tremor||Osteoporosis||Insomnia|
|Agitation||Bile Duct Stenosis||Aphthous Stomatitis||Hepatic Cirrhosis||Gallbladder Disorder||Fatigue||Low Turnover Osteopathy||Dyspnoea|
Drug effectiveness by gender :
|Flexeril is effective||26.55%|
(30 of 113 people)
(3 of 19 people)
|Cymbalta is effective||29.91%|
(35 of 117 people)
(3 of 20 people)
Most common drug interactions by gender * :
|Weight Increased||Pain In Extremity|
Drug effectiveness by age :
|Flexeril is effective||n/a||n/a||n/a||28.57%|
(4 of 14 people)
(7 of 90 people)
(8 of 91 people)
(12 of 69 people)
(2 of 11 people)
|Cymbalta is effective||n/a||n/a||n/a||33.33%|
(5 of 15 people)
(8 of 88 people)
(9 of 92 people)
(13 of 70 people)
(3 of 12 people)
Most common drug interactions by age * :
|Meningomyelocele||n/a||Gallbladder Disorder||Diabetes Mellitus||Nausea||Pain||Pain||Pain|
|Neural Tube Defect||Cholecystitis Chronic||Type 2 Diabetes Mellitus||Weight Increased||Nausea||Nausea||Anxiety|
|Spina Bifida||Sphincter Of Oddi Dysfunction||Convulsion||Headache||Fatigue||Arthralgia||Fatigue|
|Talipes||Pain||Pulmonary Embolism||Type 2 Diabetes Mellitus||Depression||Depression||Depression|
|Maternal Drugs Affecting Foetus||Pancreatitis||Injury||Dyspnoea||Back Pain||Fatigue||Fall|
|Congenital Hydrocephalus||Type 2 Diabetes Mellitus||Anxiety||Fatigue||Anxiety||Anxiety||Neuropathy Peripheral|
|Type 2 Diabetes Mellitus||Scar||Depression||Vomiting||Pain In Extremity||Headache||Dizziness|
|Abortion Induced||Abdominal Distension||Pain||Arthralgia||Chest Pain||Weight Increased||Anaemia|
|Congenital Central Nervous System Anomaly||Depression||Adverse Drug Reaction||Abdominal Pain||Diarrhoea||Hypertension||Anhedonia|
* Some reports may have incomplete information.
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Can you answer these questions (Ask a question):
- Is there a drug interaction between paxil and flexeril?
What is the drug interaction, if any between paxil and flexeril? I was taken off a low dosage of paxil two weeks or so ago an due to back issues was issued flexeril for spasms and pain. I try to avoid meds like this but really need it and wanted to know if it was safe. I read about major drug interaction between these two medications and that is why I suffered through pain because I was concerned. Please advise if I can take flexeril now.
- Is bed wetting part of having syringomyelia
i also use panadol osteo, mintec, apo-meloxicam. i have wetting the bed is was just now and then but it has started to become more frequent now, does any one else had this happen.
- Will flexeril help with alcohol withdrawal anxiet????
I have been suffering with alcohol withdrawals plus the flu the only meds that I have available is one flexor all will this help ease anxiety and let me sleep??
- Can cymbalta cause dementia?
I have been on Cymbalta for 5 years and was wondering if it has caused my Alzheimer's or dementia?
- Does anyone taking isosorbide or ranexa have severe nightmares?
I have horribly, terrifying nightmares, every night. They are all variations on a theme of terror.
You may be interested at these reviews (Write a review):
- Terrible excessive sweating from hydrochlorothiazide
I guess I fit the profile of who gets excessive sweating from HCTZ. I am a 65 year old female and suffered from excessive sweating for two years. With just very little exertion, I would pour sweat from the top of my head. It would run into my face and all over my hair. My hair would be ringing wet. I had heavy perspiration in the groin area and down my back also. I had to change clothing 2-3 times a day and wash up or shower that many times also. The doctor tried changing my Cymbalta and put me on Wellbutrin instead. It did absolutely no good. I went off the wellbutrin and back onto the Cymbalta. I did some research and saw that HCTZ could cause excessive sweating. Both my doctor and my pharmacist said that they had never heard of that. I went off the HCTZ, and my sweating stopped almost immediately. My doctor and my pharmacist were very surprised. I'm one of those people who frequently have different reactions to drugs than are typical. If you're having excessive perspiration and are on HCTZ, try going off of it. It just may be the culprit!
- Cymbalta side effects
Starting Cymbalta, side effects were dizzy,felt drugged. Helped with Arthritis pain. About six weeks after i started i developed rectal bleeding.Doctor had me stop Cymbalta and use Tramadol as needed for withdrawal.
- Cardio version caused fingernail abnormalities
Right hip fracture. When prepping for surgery AFIB was found. Surgery was cancelled and they attempted to get AFIB under control. Finally, cardioversion was performed. When my nails started to grow out they all had two horizontal lines that cause the nail to break when it grows out to that point.
- Numbness between toes
This summer I flip flops, with the strap between my toes, almost exclusively. When I switched this fall to regular shoes I noticed a strange, numb sensation between my big toe and second toe. At first I thought it had something to do with the flip flops and thought it would go away. It has been a few weeks now and this has not gone away, and if anything seems to cover a larger area. Oddly enough I mentioned this to a friend today and she says she has the same thing, between her second and third toe...both of us on our right feet. She is also on an antidepressant but couldn't remember which one, but we thought this was an odd coincidence. She explained it as sort of a sensation that there is a hole in your sock or shoe...and that made sense to me...there is still some sensation in the area but it is an odd feeling...something isn't quite right. I am doing some online research right now to try to figure out if this is common with Cymbalta or not?
- Cymbalta caused joint pain
I had taken Cymbalta for about 1.5 years and after taking it for a few months, I started having widespread joint pain. The joint pain has gotten worse and is becoming debilitating. Joint pain in the literature as a side affect of the drug but the joint pain seems to be permanent! I have not taken Cymbalta in a couple years but the joint pain has remained. I have had blood tests and my doctor says the tests show it is not arthritis.
Comments from related studies:
From this study (6 months ago):
From this study (7 months ago):
I've had all over pain for 4 months, starting with pains in left abdomen, spreading to left leg, upper back, and then right abdomen. MRI's,xrays,blood work all shows normal. Physical activity and stress worsens symptoms. Seen hernia doctor said was normal, Neurologist diagnosed me with high anxiety and put me on Cymbalta. Primary has me on the cyclobenzaprine for the pain which I was told to only take at night because I have extreme fatigue. My pain has decreased tremendously since being on the Cymbalta but now I have found my left nipple to leak white fluid and blood when stimulated, noticed it while showering.My left breast and area around breast seems extremely sore.
anonymous on Sep, 13, 2014:
i have the same issue. i have breast pain all month long, even though i am not taking invega anymore. i have been completely off any antipsychotics for 8 months and nothing i got from my gynealogist seems to help. i have never had this before either.
however, i have been told that when it bleeds, it could be a lot more serious. you should get this checked out.
Complete drug side effects:
On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Flexeril is used in:
- Cymbalta is used in:
Other drugs that are used to treat the same conditions:
- Flexeril alternatives:
- Cymbalta alternatives:
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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