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Review: taking Flexeril and Cymbalta together

Summary: drug interactions are reported among people who take Flexeril and Cymbalta together.

This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on reports of 1,636 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Flexeril and Cymbalta >>>

On Mar, 26, 2015: 1,636 people who take Flexeril, Cymbalta are studied

Flexeril, Cymbalta outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Cymbalta (duloxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective20.00%
(4 of 20 people)
(5 of 21 people)
(3 of 13 people)
(4 of 23 people)
(10 of 34 people)
(4 of 15 people)
(2 of 3 people)
(1 of 3 people)
Cymbalta is effective31.25%
(5 of 16 people)
(9 of 41 people)
(2 of 12 people)
(7 of 22 people)
(12 of 38 people)
(1 of 3 people)
(2 of 4 people)
(1 of 2 people)

Drug effectiveness by gender :

Flexeril is effective26.55%
(30 of 113 people)
(3 of 19 people)
Cymbalta is effective29.91%
(35 of 117 people)
(3 of 20 people)

Drug effectiveness by age :

Flexeril is effectiven/an/an/a28.57%
(4 of 14 people)
(7 of 90 people)
(8 of 91 people)
(12 of 69 people)
(2 of 11 people)
Cymbalta is effectiven/an/an/a33.33%
(5 of 15 people)
(8 of 88 people)
(9 of 92 people)
(13 of 70 people)
(3 of 12 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Feeling AbnormalAnxietyDepressionNauseaDepressionCholecystitis ChronicFemur FracturePain
Aspartate Aminotransferase IncreasedDizzinessAnxietyDiabetic NeuropathyAnxietyPainColon AdenomaNausea
Alanine Aminotransferase IncreasedDepressionTemporomandibular Joint SyndromeDiabetic ComaMuscle TwitchingGallbladder DisorderCystitisDepression
HeadachePancreatic Duct StenosisVertigoHyperglycaemiaPainSphincter Of Oddi DysfunctionHypothyroidismFatigue
DepressionHypersensitivityOsteonecrosisHypoglycaemiaCholecystitis ChronicPancreatitisUrinary RetentionAnxiety
Weight DecreasedCellulitisOral HerpesMental Status ChangesPancreatitisMuscle SpasmsTooth DisorderArthralgia
NauseaHepatic CirrhosisArthropathyChronic HepatitisLoss Of ConsciousnessVision BlurredPostmenopausal HaemorrhageWeight Increased
Hepatic Enzyme IncreasedSphincter Of Oddi DysfunctionWoundConvulsionPsychotic DisorderMuscle TwitchingLymphoedemaHeadache
InsomniaChronic HepatitisCerebral CystCardiomyopathyFibromyalgiaTremorOsteoporosisInsomnia
AgitationBile Duct StenosisAphthous StomatitisHepatic CirrhosisGallbladder DisorderFatigueLow Turnover OsteopathyDyspnoea

Most common drug interactions by gender * :

ArthralgiaChest Pain
Weight IncreasedPain In Extremity
HeadacheSuicidal Ideation
InsomniaNeuropathy Peripheral
DiarrhoeaDiabetes Mellitus

Most common drug interactions by age * :

Meningomyelocelen/aGallbladder DisorderDiabetes MellitusNauseaPainPainPain
Neural Tube DefectCholecystitis ChronicType 2 Diabetes MellitusWeight IncreasedNauseaNauseaAnxiety
Spina BifidaSphincter Of Oddi DysfunctionConvulsionHeadacheFatigueArthralgiaFatigue
TalipesPainPulmonary EmbolismType 2 Diabetes MellitusDepressionDepressionDepression
Maternal Drugs Affecting FoetusPancreatitisInjuryDyspnoeaBack PainFatigueFall
Congenital HydrocephalusType 2 Diabetes MellitusAnxietyFatigueAnxietyAnxietyNeuropathy Peripheral
Type 2 Diabetes MellitusScarDepressionVomitingPain In ExtremityHeadacheDizziness
Abortion InducedAbdominal DistensionPainArthralgiaChest PainWeight IncreasedAnaemia
Congenital Central Nervous System AnomalyDepressionAdverse Drug ReactionAbdominal PainDiarrhoeaHypertensionAnhedonia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Cymbalta
- support group for people who take Flexeril

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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