Review: Flexeril and Cymbalta
Summary: drug interactions are reported among people who take Flexeril and Cymbalta together.
This review analyzes the effectiveness and drug interactions between Flexeril and Cymbalta. It is created by eHealthMe based on reports of 1,634 people who take the same drugs from FDA and social media, and is updated regularly.
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Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,445 users) Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 49,275 users)
What are the drugs
Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,445 users)
Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. (latest outcomes from Cymbalta 49,275 users)
On Dec, 26, 2014: 1,634 people who take Flexeril, Cymbalta are studied
Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Cymbalta (duloxetine hydrochloride)
Drug effectiveness over time :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Flexeril is effective||20.00%|
(4 of 20 people)
(5 of 20 people)
(2 of 12 people)
(4 of 23 people)
(10 of 34 people)
(4 of 15 people)
(2 of 3 people)
(1 of 3 people)
|Cymbalta is effective||31.25%|
(5 of 16 people)
(9 of 41 people)
(2 of 12 people)
(7 of 22 people)
(12 of 36 people)
(1 of 3 people)
(2 of 4 people)
(1 of 2 people)
Most common drug interactions over time * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Feeling Abnormal||Anxiety||Depression||Nausea||Depression||Cholecystitis Chronic||Femur Fracture||Pain|
|Aspartate Aminotransferase Increased||Dizziness||Anxiety||Diabetic Neuropathy||Anxiety||Pain||Colon Adenoma||Nausea|
|Alanine Aminotransferase Increased||Depression||Temporomandibular Joint Syndrome||Diabetic Coma||Pain||Gallbladder Disorder||Cystitis||Depression|
|Headache||Hepatic Cirrhosis||Vertigo||Hyperglycaemia||Muscle Twitching||Sphincter Of Oddi Dysfunction||Hypothyroidism||Fatigue|
|Depression||Hypersensitivity||Osteonecrosis||Hypoglycaemia||Cholecystitis Chronic||Pancreatitis||Urinary Retention||Anxiety|
|Weight Decreased||Cellulitis||Oral Herpes||Mental Status Changes||Pancreatitis||Muscle Spasms||Tooth Disorder||Arthralgia|
|Nausea||Sphincter Of Oddi Dysfunction||Arthropathy||Chronic Hepatitis||Sphincter Of Oddi Dysfunction||Vision Blurred||Postmenopausal Haemorrhage||Weight Increased|
|Hepatic Enzyme Increased||Chronic Hepatitis||Wound||Convulsion||Fibromyalgia||Muscle Twitching||Lymphoedema||Headache|
|Insomnia||Pancreatic Duct Stenosis||Cerebral Cyst||Cardiomyopathy||Psychotic Disorder||Tremor||Osteoporosis||Insomnia|
|Agitation||Bile Duct Stenosis||Aphthous Stomatitis||Hepatic Cirrhosis||Gallbladder Disorder||Fatigue||Low Turnover Osteopathy||Dyspnoea|
Drug effectiveness by gender :
|Flexeril is effective||26.13%|
(29 of 111 people)
(3 of 19 people)
|Cymbalta is effective||30.43%|
(35 of 115 people)
(3 of 20 people)
Most common drug interactions by gender * :
|Weight Increased||Pain In Extremity|
Drug effectiveness by age :
|Flexeril is effective||n/a||n/a||n/a||28.57%|
(4 of 14 people)
(7 of 90 people)
(8 of 91 people)
(12 of 68 people)
(1 of 10 people)
|Cymbalta is effective||n/a||n/a||n/a||33.33%|
(5 of 15 people)
(8 of 88 people)
(9 of 92 people)
(13 of 69 people)
(3 of 11 people)
Most common drug interactions by age * :
|Meningomyelocele||n/a||Gallbladder Disorder||Diabetes Mellitus||Nausea||Pain||Pain||Pain|
|Neural Tube Defect||Cholecystitis Chronic||Type 2 Diabetes Mellitus||Weight Increased||Nausea||Nausea||Anxiety|
|Spina Bifida||Sphincter Of Oddi Dysfunction||Convulsion||Headache||Fatigue||Arthralgia||Fatigue|
|Talipes||Pain||Pulmonary Embolism||Type 2 Diabetes Mellitus||Depression||Depression||Fall|
|Maternal Drugs Affecting Foetus||Pancreatitis||Injury||Dyspnoea||Back Pain||Fatigue||Depression|
|Congenital Hydrocephalus||Type 2 Diabetes Mellitus||Anxiety||Fatigue||Anxiety||Anxiety||Neuropathy Peripheral|
|Type 2 Diabetes Mellitus||Scar||Depression||Vomiting||Pain In Extremity||Insomnia||Anaemia|
|Abortion Induced||Abdominal Distension||Pain||Arthralgia||Chest Pain||Weight Increased||Dizziness|
|Congenital Central Nervous System Anomaly||Depression||Adverse Drug Reaction||Abdominal Pain||Diarrhoea||Hypertension||Anhedonia|
* Some reports may have incomplete information.
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You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Cymbalta
- support group for people who take Cymbalta
- support group for people who take Flexeril
Recent conversations of related support groups:
- Support group for people who take Cymbalta
Now found out I have incompetent vein in leg which may be part of the problem had cystocopy and found cysts in kidney, then developed hypertension but no one will diagnose the pain. Now decided it is the same as diabetic neuropathy but as gp and consultant point out I am a long way from being diabetic with perfect blood glucose so thinks it's just guessing and hope
Can you answer these questions (Ask a question):
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I just find it odd that 2012, I didn't need a neck surgery, and now they want to do spine fusion. http://www.spine-health.com/treatment/spinal-fusion/interbody-cages-spine-fusion
- Requip cause dysphagia
an increase caused me not to be able to swallow at all
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Just had 2 infusions and now having diverticulitis again.
- Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
- Cymbalta r/t autonomic neuropathy
losartan 20 mg
tired all the time, dizziness, chronic constipation, stomach pains, pins and needles, diabetic type 2 hx alcoholism resolved, gerd, early satiety
You may be interested at these reviews (Write a review):
- Terrible excessive sweating from hydrochlorothiazide
I guess I fit the profile of who gets excessive sweating from HCTZ. I am a 65 year old female and suffered from excessive sweating for two years. With just very little exertion, I would pour sweat from the top of my head. It would run into my face and all over my hair. My hair would be ringing wet. I had heavy perspiration in the groin area and down my back also. I had to change clothing 2-3 times a day and wash up or shower that many times also. The doctor tried changing my Cymbalta and put me on Wellbutrin instead. It did absolutely no good. I went off the wellbutrin and back onto the Cymbalta. I did some research and saw that HCTZ could cause excessive sweating. Both my doctor and my pharmacist said that they had never heard of that. I went off the HCTZ, and my sweating stopped almost immediately. My doctor and my pharmacist were very surprised. I'm one of those people who frequently have different reactions to drugs than are typical. If you're having excessive perspiration and are on HCTZ, try going off of it. It just may be the culprit!
- Cymbalta side effects
Starting Cymbalta, side effects were dizzy,felt drugged. Helped with Arthritis pain. About six weeks after i started i developed rectal bleeding.Doctor had me stop Cymbalta and use Tramadol as needed for withdrawal.
- Cardio version caused fingernail abnormalities
Right hip fracture. When prepping for surgery AFIB was found. Surgery was cancelled and they attempted to get AFIB under control. Finally, cardioversion was performed. When my nails started to grow out they all had two horizontal lines that cause the nail to break when it grows out to that point.
- Numbness between toes
This summer I flip flops, with the strap between my toes, almost exclusively. When I switched this fall to regular shoes I noticed a strange, numb sensation between my big toe and second toe. At first I thought it had something to do with the flip flops and thought it would go away. It has been a few weeks now and this has not gone away, and if anything seems to cover a larger area. Oddly enough I mentioned this to a friend today and she says she has the same thing, between her second and third toe...both of us on our right feet. She is also on an antidepressant but couldn't remember which one, but we thought this was an odd coincidence. She explained it as sort of a sensation that there is a hole in your sock or shoe...and that made sense to me...there is still some sensation in the area but it is an odd feeling...something isn't quite right. I am doing some online research right now to try to figure out if this is common with Cymbalta or not?
- Cymbalta caused joint pain
I had taken Cymbalta for about 1.5 years and after taking it for a few months, I started having widespread joint pain. The joint pain has gotten worse and is becoming debilitating. Joint pain in the literature as a side affect of the drug but the joint pain seems to be permanent! I have not taken Cymbalta in a couple years but the joint pain has remained. I have had blood tests and my doctor says the tests show it is not arthritis.
Comments from related studies:
From this study (4 months ago):
From this study (5 months ago):
I've had all over pain for 4 months, starting with pains in left abdomen, spreading to left leg, upper back, and then right abdomen. MRI's,xrays,blood work all shows normal. Physical activity and stress worsens symptoms. Seen hernia doctor said was normal, Neurologist diagnosed me with high anxiety and put me on Cymbalta. Primary has me on the cyclobenzaprine for the pain which I was told to only take at night because I have extreme fatigue. My pain has decreased tremendously since being on the Cymbalta but now I have found my left nipple to leak white fluid and blood when stimulated, noticed it while showering.My left breast and area around breast seems extremely sore.
anonymous on Sep, 13, 2014:
i have the same issue. i have breast pain all month long, even though i am not taking invega anymore. i have been completely off any antipsychotics for 8 months and nothing i got from my gynealogist seems to help. i have never had this before either.
however, i have been told that when it bleeds, it could be a lot more serious. you should get this checked out.
Complete drug side effects:
On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Flexeril is used in:
- Cymbalta is used in:
Other drugs that are used to treat the same conditions:
- Flexeril alternatives:
- Cymbalta alternatives:
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
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