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Review: Flexeril and Zanaflex





Summary: drug interactions are reported among people who take Flexeril and Zanaflex together.

This review analyzes the effectiveness and drug interactions between Flexeril and Zanaflex. It is created by eHealthMe based on reports of 545 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Flexeril and Zanaflex >>>

What are the drugs

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. (latest outcomes from Flexeril 16,445 users)

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Zanaflex 7,305 users)

On Nov, 28, 2014: 545 people who take Flexeril, Zanaflex are studied

Flexeril, Zanaflex outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Zanaflex (tizanidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective18.18%
(2 of 11 people)
25.00%
(2 of 8 people)
0.00%
(0 of 3 people)
50.00%
(2 of 4 people)
100.00%
(1 of 1 people)
100.00%
(2 of 2 people)
66.67%
(2 of 3 people)
n/a
Zanaflex is effective27.27%
(3 of 11 people)
30.00%
(3 of 10 people)
50.00%
(1 of 2 people)
50.00%
(2 of 4 people)
66.67%
(2 of 3 people)
n/a50.00%
(1 of 2 people)
0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessFearEmotional DistressAnxietyCompleted SuicideDeep Vein ThrombosisVein DistendedPain
FatigueAnxietyPainDepressionIntentional OverdoseAnxietyStiffness In A JointAnxiety
EpilepsyDepressionAnxietySuicide AttemptMental DisorderDepressionHypokalaemiaDepression
Memory ImpairmentEmotional DistressVision BlurredDeep Vein ThrombosisAnxietyMyocardial InfarctionComplicated MigraineArthralgia
Breast CancerAnhedoniaIrritabilityEmotional DistressSuicide AttemptEmotional DistressSleep Disorder Due To General Medical Condition, Insomnia TypeNausea
Swelling Of The Ankles - Feet - LegsPathological GamblingLoss Of ConsciousnessMental DisorderDepressionPulmonary EmbolismHeadache
Vision BlurredInjuryMigrainePulmonary EmbolismDrowsinessDyspnoeaBack Pain
NauseaPainInsomniaIntentional OverdoseSleepyPain In ExtremityPain In Extremity
Lymphocyte Percentage DecreasedObsessive-compulsive DisorderHallucinationCompleted SuicideShort-term Memory LossHeart InjuryAsthenia
SomnolenceDyspnoeaDyspnoeaWeight IncreasedFlatulenceMyalgiaDyspnoea

Drug effectiveness by gender :

FemaleMale
Flexeril is effective36.84%
(7 of 19 people)
30.77%
(4 of 13 people)
Zanaflex is effective25.00%
(5 of 20 people)
53.85%
(7 of 13 people)

Most common drug interactions by gender * :

FemaleMale
PainDepression
AnxietyPain
HeadacheArthralgia
NauseaAnxiety
Chest PainHypoaesthesia
DepressionBack Pain
ArthralgiaEmotional Distress
AstheniaDrug Dependence
InsomniaNausea
Neck PainInjury

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Flexeril is effectiven/an/an/a8.33%
(1 of 12 people)
15.79%
(3 of 19 people)
8.33%
(1 of 12 people)
40.00%
(4 of 10 people)
33.33%
(2 of 6 people)
Zanaflex is effectiven/an/an/a16.67%
(2 of 12 people)
5.56%
(1 of 18 people)
23.08%
(3 of 13 people)
45.45%
(5 of 11 people)
16.67%
(1 of 6 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aAnxietyPulmonary EmbolismArthralgiaPainPainPneumonia
NauseaSinus TachycardiaAnxietyDepressionAnxietyOsteoarthritis
PainDeep Vein ThrombosisPain In ExtremityHeadacheDepressionPain
PyrexiaDizzinessHypertensionAnxietyArthralgiaMultiple Injuries
Drug IneffectivePainPainDrug DependenceDyspnoeaHeadache
Drug Withdrawal SyndromeGastrointestinal DisorderLymphadenopathyChest PainBack PainGastrooesophageal Reflux Disease
CoughCold SweatDrug Withdrawal SyndromeFallOsteonecrosis Of JawHypotension
DepressionArthralgiaHypoaesthesiaInsomniaHeadacheOedema Peripheral
Drug DependenceHypoaesthesiaNauseaNauseaSciaticaRenal Failure Acute
ChillsMuscle SpasmsVision BlurredDrug Withdrawal SyndromeBlood Calcium IncreasedMuscle Spasms

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Flexeril and Zanaflex?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Zanaflex
- support group for people who take Flexeril
- support group for people who take Zanaflex

Can you answer these questions (Ask a question):

  • Can nuvigil (vs adderall) be used simultaneously to help wean off 60mg/day of adderall? (1 answer)
    I have been on Adderall 30mg 2x daily for years!! I've had it lowered to 20mg, I've TRIED to go months without it (when not working) however I feel I've built up a tolerance level to the point that it's not as effective as it once was. My personal life has detoured WAY past anything an ADHD medication can possibly help as far as focusing on NEEDED tasks etc. I end up feeling wrapped up in what I'm doing at the moment that my anxiety increases due to all that I haven't been able to accomplish. I take various medications for various reasons, depression, anxiety, bulimia etc., and for the most part the doses have varied based on circumstances and current need at said time of prescription.. MY FAMILY HAS A HISTORY OF HEART DISEASE, And realizing that I'm already on the highest Adderall dosage scares me (and THEN as I think about it, it makes my heart race!). I've also noticed increased muscle spasms as well as extreme and intense pressure on my jaw (TMJ). MY QUESTION IS: does anyone have any experience LOWERING their Adderall dosage AND adding Nuvigil? The research I've done to date gives me impression that it could help balance out the more extreme effects of Adderall (60mg/day) but that the nuvigil would or could potentially help with the EXTREME exhaustion I feel as Adderall wears off. Some days I just crash, some days I sleep fine and others no matter how hard I tryyyy, I just CAN'T fall asleep, therefore making the next day worse! IDEALLY I'D LIKE TO BE MED FREE, right now I need them, but am hoping maybe I can speak with my doctor to lower Adderall and add Nuvigil to help wean me off the amphetamines as well as lower dosage intake. YES, a lot of the anxiety, sleeplessness and depression are related to current circumstances in my life, however, where I am is not where I want to be or where I'm headed.. Life is a journey, and all my meds have become a part of a journey I never thought I'd find myself taking. I don't want life/meds to define me, or create a me I no longer recognize, because scarily enough that seems to be a common pattern. As I overcome each and every daily obstacle, I also don't want to be "hooked" on my meds or needing "more" to wake up/sleep/function.. I'd like to work on finding a solution towards weaning off my meds NOW, and work my way off slowly, primarily the Adderall. I'm hoping by suggesting to my doctor and showing him my research he may agree (IF ITS EVEN A LOGICAL COMBO, CLEARLY IM NOT A DOCTOR) nuvigil could help me. I've already started taking less of my anti depressants, trazadone and xanax without discussing with doc because he is always busy.. My next appt I want to go in fully prepared with a plan and an overall goal to REDUCE my Adderall dose, but overall, I'm clueless!!! I have no idea what other meds other than nuvigil "could" potentially help if at all. I could be entirely wrong, Anyone with any experience using one vs other or both simultaneously, or anyone with constructive input, PLEASE COMMENT/SHARE!!
  • Why would i get copd since i never smoked?
    I have several autoimmune disorders, I was shocked to get the COPD diagnosis since I have never smoked but I had second hand smoke first 23 years of my life.
    My doctor said my Autoimmune Hepatitis and Primary Biliary Cholingitis set me up for COPD.
  • I cannot get a direct answer from any of my drs.,is my sciatic pain caused by my interstitail cystitus? (1 answer)
    I have had interstitail cystitus for almost four years now.I have been on every kind of drug,other than pain pills.I will not take them,I don't believe in them they only mask the problem and cause addiction.of course,just my belief.I have had d.s.m.o. repetitively for first year and a half twice a week.I have tried physical therapy .I have had five hydrodistention.I just recently had my first hydrodistention with botox injections.nothing has kept me out of pain .even when I am doing good I can only seem to reach a six in my pain level.my frequency average is and has been 30-40Times a day.I am,or,was a chef kitchen manager.could not perform and lost two jobs because of this disease.my flanks,my lower back ,my legs,my arms all ways in pain.pelvic pain is constant.I'd rather not go into further details way too personal.but this has taken my life.I am 35.I have led a fairly healthy life.I have no life now.I am seeking disability .Every Dr. I go to has a different option about the sciatic part of my problem some Dr.s are very sure and as a matter of fact about how it is in conjunction with I.c..others look at me like I'm nuts?why do I limp?why can't I get in and out of a car,or bend down and touch my toes,pick heavy stuff up.just to laugh at times hurts.this is my life ,I gotta wonder ,is there any one else out there going through the same symptoms and no relief?
  • Can raynauds syndrome cause moderate neuraopathy?
    I have been diagnosed with moderate neuropathy. After multiple blood tests and diabetes testing, the doctor concluded that the cause of the neuropathy is unknown, possible genetic. In talking with my family, I cannot identify anyone who has/had this diagnosis. I am receiving no treatment at this time for it. I do experience hip pain, which shoots down my thigh and into my knees when I am laying down to sleep. Any insights would be appreciated.
  • Can rituxan cause bipolar disorder?
    recently started rituxan. Now have bipolar disorder. Could there be any connection?

More questions for: Flexeril, Zanaflex

You may be interested at these reviews (Write a review):

  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • Spiriva caused me to swell up like a hippo.
    My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen I gained 29 pounds in two days. My doctor put me on lasix and potassium for several weeks. I quit using the spiriva when my other doctor asked if I was on any new meds. Spiriva was the only new medicine. When I stopped using it the swelling went away.
  • Chills while on tizanidine
    Extremely sensitive to cold and have chills several times a day
  • Off label use of drugs for peripheral neuropathy causing memory loss (1 response)
    I have peripheral neuropathy with standard symptoms of burning, tingling, stabbing pain on the tops of my feet. I have had this condition for over 15 years getting worse over time. The last 5 years I have seen a couple of doctors and through trial and error we settled on a combination of Savella and Methadone to dampen the pain which can go from a nuisance constant 2 to "I'm ready to cut off my feet" constant 8. Taking Savella and Methadone keeps me at a 2 or below except in the evenings when it can get to 5 or 6 and keep me awake. Over a period of a year or so, and I can't remember when it started, I was given Tizanidine, Pramipexole, Oxcarbazpine, Gabapentin and Lyrica (at separate times). I do not remember which of these I was on for the longest or at what point I noticed I was unable to remember what happened the day before, conversations I had with co-workers, decisions and agreements with my manager and things I had done earlier in the week or month. I'm sure a timeline could be put together but since I had lost short term memory I could not do it even now. When I finally figured out what was happening, I was close to losing my job as a Computer Hardware Engineer, which requires extreme concentration and memory. I stopped taking whatever I was on at the time and looked for anything to help me regain my memory and ability to concentrate. I am now taking herbal supplements and using iPhone apps to help me regain concentration and memory. After over 6 months of being off of these drugs I am close to having my previous facilities back. I cannot stress enough the importance of a doctor talking with their patients about memory loss and the ability to concentrate when taking these types of drugs. One of my doctors just gave me Topiramate to try and help with the evening pain and after reading the side effects I will not even try it. Better to be in pain and keep my job.

    What really bothers me is I think simply taking one additional pill of Savella will solve my pain issue, but my doctors scoff whenever I make a suggestion and try to put me on something else. After making a medication suggestion one doctor threatened to take me off all medication. I guess he showed me who's the boss. All this is causing me to trust doctors less and less.
  • Savella & synthroid hell! (3 responses)
    Within 15 minutes of taking Savella, the heat starts in my face and the sweating begins unrelentlessly. And the palpitations begin right away and later will be strong enough to wake me from sleep. Its horrible! I cant go anywhere! I cant tolerate any additional heat anywhere! And if I go out, I must bring a towel with me... it overwhelms me! I hate this!!

More reviews for: Flexeril, Zanaflex

Comments from related studies:

  • From this study (4 weeks ago):

  • peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????

    Reply

    mtntexas on May, 11, 2013:

    Just ask John Belushi

    Reply

    2cents on Mar, 6, 2013:

    I'll second that!

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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