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Review: taking Flexeril and Zanaflex together

Summary: drug interactions are reported among people who take Flexeril and Zanaflex together.

This review analyzes the effectiveness and drug interactions between Flexeril and Zanaflex. It is created by eHealthMe based on reports of 545 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 3, 2015: 545 people who take Flexeril, Zanaflex are studied

Flexeril, Zanaflex outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Zanaflex (tizanidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective18.18%
(2 of 11 people)
(2 of 8 people)
(0 of 3 people)
(2 of 4 people)
(1 of 1 people)
(2 of 2 people)
(2 of 3 people)
Zanaflex is effective27.27%
(3 of 11 people)
(3 of 10 people)
(1 of 2 people)
(2 of 4 people)
(2 of 3 people)
(1 of 2 people)
(0 of 1 people)

Drug effectiveness by gender :

Flexeril is effective36.84%
(7 of 19 people)
(4 of 13 people)
Zanaflex is effective25.00%
(5 of 20 people)
(7 of 13 people)

Drug effectiveness by age :

Flexeril is effectiven/an/an/a8.33%
(1 of 12 people)
(3 of 19 people)
(1 of 12 people)
(4 of 10 people)
(2 of 6 people)
Zanaflex is effectiven/an/an/a16.67%
(2 of 12 people)
(1 of 18 people)
(3 of 13 people)
(5 of 11 people)
(1 of 6 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessFearEmotional DistressAnxietyCompleted SuicideDeep Vein ThrombosisVein DistendedPain
FatigueAnxietyPainDepressionIntentional OverdoseAnxietyStiffness In A JointAnxiety
EpilepsyDepressionAnxietySuicide AttemptMental DisorderDepressionHypokalaemiaDepression
Memory ImpairmentEmotional DistressVision BlurredDeep Vein ThrombosisAnxietyMyocardial InfarctionComplicated MigraineArthralgia
Breast CancerAnhedoniaIrritabilityEmotional DistressSuicide AttemptEmotional DistressSleep Disorder Due To General Medical Condition, Insomnia TypeNausea
Swelling Of The Ankles - Feet - LegsPathological GamblingLoss Of ConsciousnessMental DisorderDepressionPulmonary EmbolismHeadache
Vision BlurredInjuryMigrainePulmonary EmbolismDrowsinessDyspnoeaBack Pain
NauseaPainInsomniaIntentional OverdoseSleepyPain In ExtremityPain In Extremity
Lymphocyte Percentage DecreasedObsessive-compulsive DisorderHallucinationCompleted SuicideShort-term Memory LossHeart InjuryAsthenia
SomnolenceDyspnoeaDyspnoeaWeight IncreasedFlatulenceMyalgiaDyspnoea

Most common drug interactions by gender * :

Chest PainHypoaesthesia
DepressionBack Pain
ArthralgiaEmotional Distress
AstheniaDrug Dependence
Neck PainInjury

Most common drug interactions by age * :

n/an/aAnxietyPulmonary EmbolismArthralgiaPainPainPneumonia
NauseaSinus TachycardiaAnxietyDepressionAnxietyOsteoarthritis
PainDeep Vein ThrombosisPain In ExtremityHeadacheDepressionPain
PyrexiaDizzinessHypertensionAnxietyArthralgiaMultiple Injuries
Drug IneffectivePainPainDrug DependenceDyspnoeaHeadache
Drug Withdrawal SyndromeGastrointestinal DisorderLymphadenopathyChest PainBack PainGastrooesophageal Reflux Disease
CoughCold SweatDrug Withdrawal SyndromeFallOsteonecrosis Of JawHypotension
DepressionArthralgiaHypoaesthesiaInsomniaHeadacheOedema Peripheral
Drug DependenceHypoaesthesiaNauseaNauseaSciaticaRenal Failure Acute
ChillsMuscle SpasmsVision BlurredDrug Withdrawal SyndromeBlood Calcium IncreasedMuscle Spasms

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Flexeril
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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