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Home > Flexeril > Zanaflex > Flexeril and Zanaflex

Review: Flexeril and Zanaflex

This review analyzes the effectiveness and drug interactions between Flexeril and Zanaflex. It is created by eHealthMe based on reports of 545 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Flexeril and Zanaflex >>>

What are the drugs

Flexeril (latest outcomes from 16,437 users) has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms.

Trend of flexeril reports

Zanaflex (latest outcomes from 7,302 users) has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms.

Trend of zanaflex reports

On Oct, 25, 2014: 545 people who take Flexeril, Zanaflex are studied

Flexeril, Zanaflex outcomes

Drug combinations in study:
- Flexeril (cyclobenzaprine hydrochloride)
- Zanaflex (tizanidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Flexeril is effective18.18%
(2 of 11 people)
(2 of 8 people)
(0 of 3 people)
(2 of 4 people)
(1 of 1 people)
(2 of 2 people)
(2 of 3 people)
Zanaflex is effective27.27%
(3 of 11 people)
(3 of 10 people)
(1 of 2 people)
(2 of 4 people)
(2 of 3 people)
(1 of 2 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessFearEmotional DistressAnxietyCompleted SuicideDeep Vein ThrombosisVein DistendedPain
FatigueAnxietyPainDepressionIntentional OverdoseAnxietyStiffness In A JointAnxiety
EpilepsyDepressionAnxietySuicide AttemptMental DisorderDepressionHypokalaemiaDepression
Memory ImpairmentEmotional DistressVision BlurredDeep Vein ThrombosisAnxietyMyocardial InfarctionComplicated MigraineArthralgia
Breast CancerAnhedoniaIrritabilityEmotional DistressSuicide AttemptEmotional DistressSleep Disorder Due To General Medical Condition, Insomnia TypeNausea
Swelling Of The Ankles - Feet - LegsPathological GamblingLoss Of ConsciousnessMental DisorderDepressionPulmonary EmbolismHeadache
Vision BlurredInjuryMigrainePulmonary EmbolismDrowsinessDyspnoeaBack Pain
NauseaPainInsomniaIntentional OverdoseSleepyPain In ExtremityPain In Extremity
Lymphocyte Percentage DecreasedObsessive-compulsive DisorderHallucinationCompleted SuicideShort-term Memory LossHeart InjuryAsthenia
SomnolenceDyspnoeaDyspnoeaWeight IncreasedFlatulenceMyalgiaDyspnoea

Drug effectiveness by gender :

Flexeril is effective36.84%
(7 of 19 people)
(4 of 13 people)
Zanaflex is effective25.00%
(5 of 20 people)
(7 of 13 people)

Most common drug interactions by gender * :

Chest PainHypoaesthesia
DepressionBack Pain
ArthralgiaEmotional Distress
AstheniaDrug Dependence
Neck PainInjury

Drug effectiveness by age :

Flexeril is effectiven/an/an/a8.33%
(1 of 12 people)
(3 of 19 people)
(1 of 12 people)
(4 of 10 people)
(2 of 6 people)
Zanaflex is effectiven/an/an/a16.67%
(2 of 12 people)
(1 of 18 people)
(3 of 13 people)
(5 of 11 people)
(1 of 6 people)

Most common drug interactions by age * :

n/an/aAnxietyPulmonary EmbolismArthralgiaPainPainPneumonia
NauseaSinus TachycardiaAnxietyDepressionAnxietyOsteoarthritis
PainDeep Vein ThrombosisPain In ExtremityHeadacheDepressionPain
PyrexiaDizzinessHypertensionAnxietyArthralgiaMultiple Injuries
Drug IneffectivePainPainDrug DependenceDyspnoeaHeadache
Drug Withdrawal SyndromeGastrointestinal DisorderLymphadenopathyChest PainBack PainGastrooesophageal Reflux Disease
CoughCold SweatDrug Withdrawal SyndromeFallOsteonecrosis Of JawHypotension
DepressionArthralgiaHypoaesthesiaInsomniaHeadacheOedema Peripheral
Drug DependenceHypoaesthesiaNauseaNauseaSciaticaRenal Failure Acute
ChillsMuscle SpasmsVision BlurredDrug Withdrawal SyndromeBlood Calcium IncreasedMuscle Spasms

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Flexeril and Zanaflex?

You are not alone! Join a related mobile support group:
- support group for people who take Flexeril and Zanaflex
- support group for people who take Flexeril
- support group for people who take Zanaflex

Comments from related studies:

  • From this study (3 days ago):

  • peanuts on Mar, 31, 2010:

    my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????


    jimmy on Apr, 29, 2013:

    Finally, I'd been reading thru here and finnaly, what doctor in the U.S. still prescribes cocaine? LOL


    jimmy on Apr, 29, 2013:

    IF you donT see my other comments, Never take Cymbalta or anything containing same ingrediants or speeding thru the same side effects durring their enjoyable living advertizements!


Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Flexeril (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Zanaflex (tizanidine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug studies:

More related studies for: Flexeril, Zanaflex

Recent related drug comparison:

More related comparisons for: Flexeril, Zanaflex

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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