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Review: taking Hydrocortisone and Melatonin together

Summary: drug interactions are reported among people who take Hydrocortisone and Melatonin together. This review analyzes the effectiveness and drug interactions between Hydrocortisone and Melatonin. It is created by eHealthMe based on reports of 83 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Hydrocortisone has active ingredients of hydrocortisone. It is often used in adrenal insufficiency. (latest outcomes from 13,795 Hydrocortisone users)

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from 2,696 Melatonin users)

On May, 16, 2015: 83 people who take Hydrocortisone, Melatonin are studied

Hydrocortisone, Melatonin outcomes

Drug combinations in study:
- Hydrocortisone (hydrocortisone)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hydrocortisone is effectiven/an/an/an/a0.00%
(0 of 1 people)
Melatonin is effectiven/an/an/an/a0.00%
(0 of 1 people)

Drug effectiveness by gender :

Hydrocortisone is effective0.00%
(0 of 1 people)
Melatonin is effective0.00%
(0 of 1 people)

Drug effectiveness by age :

Hydrocortisone is effectiven/an/an/an/a0.00%
(0 of 1 people)
Melatonin is effectiven/an/an/an/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Serotonin SyndromePsychomotor HyperactivityBrain Neoplasmn/an/an/an/aFatigue
Hyperthermia MalignantPhotophobiaPyrexia
Liver Function Test AbnormalScreamingLymphadenopathy
Body Temperature IncreasedSelf Esteem DecreasedGingival Swelling
International Normalised Ratio IncreasedSleep DisorderHot Flush
Renal ImpairmentPersonality ChangeAnxiety
TachycardiaNeurotoxicityImpaired Healing
HypotensionMyalgiaTooth Infection
Nervous System DisorderToothache

Most common drug interactions by gender * :

Suicidal IdeationAbdominal Pain Upper
SomnolenceIntervertebral Disc Protrusion
Muscle SpasmsBone Swelling

Most common drug interactions by age * :

n/aTachypnoeaPyrexiaPancytopeniaBrain NeoplasmNasopharyngitisMultiple FracturesMalaise
Feeling HotProctitisPancreatitisMetastases To Lymph NodesPyrexiaAphoniaInsomnia
PallorMeningitisHepatic FailureHepatic LesionMood AlteredFallDysphagia
Petit Mal EpilepsyNeuropathy PeripheralCardiac ArrestColon CancerSuicidal IdeationMuscle SpasmsScoliosis
Infusion Related ReactionSleep DisorderDizzinessViolence-related SymptomDelayed Recovery From AnaesthesiaAbdominal Pain Upper
FlushingAstheniaHyperhidrosisInfluenzaPostmenopausal HaemorrhageFatigue
HyponatraemiaInfectious PeritonitisConfusional StateFatigueDysphoniaInjury
GastroenteritisMuscular WeaknessNauseaArthralgiaAccidentCough
Multi-organ FailureParaesthesiaVentricular TachycardiaWeight IncreasedFoot FractureBone Lesion
HeadacheAngerSupraventricular TachycardiaChest PainPituitary TumourDiverticulum

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Hydrocortisone and Melatonin on

Do you take Hydrocortisone and Melatonin?


You are not alone! Join a related support group:
- support group for people who take Hydrocortisone
- support group for people who take Melatonin

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Hydrocortisone, Melatonin

You may be interested at these reviews (Write a review):

  • Melatonin and diarrhrea
    A lifetime of wakefulness during the night, almost never more than 7 hrs sleep and awake 2-4 times a night. Return to sleep easily. Doctors gave sleep aids. Usually somewhat ineffective and sometimes groggy mornings. So I decided to go the more natural route ... melatonin. Worse. It did not ...
  • I need advise, badly ckd!! (1 response)
    The orthostatic BP started in mid April, I was only dizzy upon wakening then it would subside. I have never been a big breakfast eater so I started doing that. We were in Disney later in April and I was extremely fatigued, to the point of not wanting to walk, Disney would be the first time I passe ...
  • Melatonin reduces essential tremor of the hand
    After taking Melatonin 1mg as a sleep aid for several nights, I noticed that my essential tremor of the hand was showing improvement. Within a week the tremor was almost unnoticeable, and I could print and write neatly, even when slightly stressed at work. I haven't seen this response reported any ...
  • Melatonin and diarrhea (1 response)
    I have had difficulty sleeping most of my life. Difficulty going to sleep and waking up multiple times during the night were a usual pattern for me. Testing for sleep apnea did not show a positive result. A friend said to try Melatonin that for him it worked fine. I tried it and the diarrhea st ...
  • Melatonin and skin dryness
    I've been having hard time to sleep, so I started taking Melatonin.

    It is OTC sleep aid with melatonin and herbal treatment (lemon balm and camomile).

    about three days after started taking the drug, my back of hands started showing red rashes, then neck and around lips.
    1 year ago -->

More reviews for: Hydrocortisone, Melatonin

Complete drug side effects:

On eHealthMe, Hydrocortisone (hydrocortisone) is often used to treat adrenal insufficiency. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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