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Review: Hydrocortisone and Melatonin

This review analyzes the effectiveness and drug interactions between Hydrocortisone and Melatonin. It is created by eHealthMe based on reports of 83 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Hydrocortisone and Melatonin >>>

What are the drugs

Hydrocortisone (what 13,780 Hydrocortisone users reported?) has active ingredients of hydrocortisone. It is used in adrenal insufficiency.

Melatonin (what 2,627 Melatonin users reported?) has active ingredients of melatonin. It is used in insomnia.

On Aug, 12, 2014: 83 people who take Hydrocortisone, Melatonin are studied

Hydrocortisone, Melatonin outcomes

Drug combinations in study:
- Hydrocortisone (hydrocortisone)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hydrocortisone is effectiven/an/an/an/a0.00%
(0 of 1 people)
Melatonin is effectiven/an/an/an/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Serotonin SyndromePsychomotor HyperactivityBrain Neoplasmn/an/an/an/aFatigue
Hyperthermia MalignantPhotophobiaPyrexia
Liver Function Test AbnormalScreamingLymphadenopathy
Body Temperature IncreasedSelf Esteem DecreasedGingival Swelling
International Normalised Ratio IncreasedSleep DisorderHot Flush
Renal ImpairmentPersonality ChangeAnxiety
TachycardiaNeurotoxicityImpaired Healing
HypotensionMyalgiaTooth Infection
Nervous System DisorderToothache

Drug effectiveness by gender :

Hydrocortisone is effective0.00%
(0 of 1 people)
Melatonin is effective0.00%
(0 of 1 people)

Most common drug interactions by gender * :

Suicidal IdeationAbdominal Pain Upper
SomnolenceIntervertebral Disc Protrusion
Muscle SpasmsBone Swelling

Drug effectiveness by age :

Hydrocortisone is effectiven/an/an/an/a0.00%
(0 of 1 people)
Melatonin is effectiven/an/an/an/a0.00%
(0 of 1 people)

Most common drug interactions by age * :

n/aTachypnoeaPyrexiaPancytopeniaBrain NeoplasmNasopharyngitisMultiple FracturesMalaise
Feeling HotProctitisPancreatitisMetastases To Lymph NodesPyrexiaAphoniaInsomnia
PallorMeningitisHepatic FailureHepatic LesionMood AlteredFallDysphagia
Petit Mal EpilepsyNeuropathy PeripheralCardiac ArrestColon CancerSuicidal IdeationMuscle SpasmsScoliosis
Infusion Related ReactionSleep DisorderDizzinessViolence-related SymptomDelayed Recovery From AnaesthesiaAbdominal Pain Upper
FlushingAstheniaHyperhidrosisInfluenzaPostmenopausal HaemorrhageFatigue
HyponatraemiaInfectious PeritonitisConfusional StateFatigueDysphoniaInjury
GastroenteritisMuscular WeaknessNauseaArthralgiaAccidentCough
Multi-organ FailureParaesthesiaVentricular TachycardiaWeight IncreasedFoot FractureBone Lesion
HeadacheAngerSupraventricular TachycardiaChest PainPituitary TumourDiverticulum

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Hydrocortisone and Melatonin
- group for people who take Hydrocortisone
- group for people who take Melatonin

Can you answer these questions (what is this?):

More questions for: Hydrocortisone, Melatonin

You may be interested at these reviews (what is this?):

  • Melatonin and diarrhea
    I have had difficulty sleeping most of my life. Difficulty going to sleep and waking up multiple times during the night were a usual pattern for me. Testing for sleep apnea did not show a positive result. A friend said to try Melatonin that for him it worked fine. I tried it and the diarrhea st ...

  • Melatonin and skin dryness
    I've been having hard time to sleep, so I started taking Melatonin. It is OTC sleep aid with melatonin and herbal treatment (lemon balm and camomile). about three days after started taking the drug, my back of hands started showing red rashes, then neck and around lips. a week after taking medica ...

  • Bad side effect of melatonin/imitrex use together
    I have taken melatonin for insomnia I've been experiencing recently (not a chronic condition). I haven't had any problems or interactions with my other regular medications while using the melatonin, other than drowsiness in the morning. Last night I had a migraine at bedtime, so took 50 mg. of imi ...

More reviews for: Hydrocortisone, Melatonin

Complete drug side effects:

On eHealthMe, Hydrocortisone (hydrocortisone) is often used to treat adrenal insufficiency. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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