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Review: taking Ibuprofen and Tramadol together

Summary: drug interactions are reported among people who take Ibuprofen and Tramadol together.

This review analyzes the effectiveness and drug interactions between Ibuprofen and Tramadol. It is created by eHealthMe based on reports of 3,198 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Ibuprofen and Tramadol >>>

On Apr, 12, 2015: 3,198 people who take Ibuprofen, Tramadol are studied

Ibuprofen, Tramadol outcomes

Drug combinations in study:
- Ibuprofen (ibuprofen)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ibuprofen is effective44.44%
(8 of 18 people)
(4 of 16 people)
(2 of 11 people)
(2 of 10 people)
(2 of 20 people)
(8 of 19 people)
(8 of 20 people)
(1 of 3 people)
Tramadol is effective41.67%
(10 of 24 people)
(3 of 17 people)
(6 of 21 people)
(6 of 23 people)
(6 of 16 people)
(6 of 13 people)
(0 of 3 people)
(2 of 3 people)

Drug effectiveness by gender :

Ibuprofen is effective32.56%
(28 of 86 people)
(7 of 31 people)
Tramadol is effective32.18%
(28 of 87 people)
(10 of 32 people)

Drug effectiveness by age :

Ibuprofen is effectiven/an/an/a7.81%
(5 of 64 people)
(6 of 63 people)
(14 of 67 people)
(7 of 83 people)
(3 of 10 people)
Tramadol is effectiven/an/an/a4.08%
(4 of 98 people)
(9 of 61 people)
(17 of 67 people)
(5 of 84 people)
(3 of 10 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
VomitingHaemorrhoidsNauseaPainPainDepressionLiver DisorderPain
PainAbdominal DistensionPainHaemorrhageDepressionAnxietyNauseaNausea
NauseaGastrooesophageal Reflux DiseaseConstipationDeep Vein ThrombosisAnxietyGastrooesophageal Reflux DiseaseTired EyesAnxiety
DiarrhoeaConstipationHyperkalaemiaInternational Normalised Ratio IncreasedDeep Vein ThrombosisConstipationDepressionFatigue
DyspnoeaDyspepsiaHepatic SteatosisRetroperitoneal HaematomaPulmonary EmbolismAbdominal DistensionMigraine Without AuraDepression
HypotensionOedemaMetabolic AcidosisPulmonary EmbolismHypertensionLiver DisorderFatigueBack Pain
Drug IneffectiveRectal HaemorrhageNight SweatsHaematomaCholecystitis ChronicDyspepsiaSuicidal IdeationDyspnoea
InsomniaFaeces HardArthralgiaHeadachePain In ExtremitySuicidal IdeationMuscle TwitchingVomiting
MelaenaDepressionPneumoniaOedema PeripheralOedema PeripheralFaeces HardPainFall
Gastrointestinal HaemorrhageSuicidal IdeationDiarrhoeaFatigueGallbladder Non-functioningNauseaLibido DecreasedDizziness

Most common drug interactions by gender * :

Pain In ExtremityInsomnia
Back PainDyspnoea
InjuryBack Pain

Most common drug interactions by age * :

Diabetes Mellitusn/aPainPainPainPainNauseaFatigue
Cholecystitis ChronicNauseaDepressionAnxietyAnxietyNausea
Abdominal PainAnxietyAnxietyNauseaDepressionPain
Gallbladder DisorderDeep Vein ThrombosisNauseaHeadachePainDyspnoea
AnxietyCholelithiasisHeadacheBack PainInsomniaAnxiety
InjuryPulmonary EmbolismChest PainDepressionDiarrhoeaFall
Pulmonary EmbolismCholecystitis ChronicPain In ExtremityDyspnoeaBack PainAsthenia
DepressionGallbladder DisorderDeep Vein ThrombosisAnaemiaHypoaesthesiaChest Pain
CholelithiasisInjuryDrug IneffectiveAbdominal PainVomitingDizziness
VomitingDepressionInjuryInsomniaOedema PeripheralVomiting

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Ibuprofen
- support group for people who take Tramadol

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Ibuprofen (ibuprofen) is often used to treat pain. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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