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Review: taking Ibuprofen and Cyclobenzaprine together

Summary: drug interactions are reported among people who take Ibuprofen and Cyclobenzaprine together.

This review analyzes the effectiveness and drug interactions between Ibuprofen and Cyclobenzaprine. It is created by eHealthMe based on reports of 2,548 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 24, 2015: 2,548 people who take Ibuprofen, Cyclobenzaprine Hydrochloride are studied

Ibuprofen, Cyclobenzaprine Hydrochloride outcomes

Drug combinations in study:
- Ibuprofen (ibuprofen)
- Cyclobenzaprine Hydrochloride (cyclobenzaprine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Ibuprofen is effective12.90%
(4 of 31 people)
(0 of 10 people)
(1 of 2 people)
(1 of 8 people)
(4 of 17 people)
(7 of 15 people)
(6 of 15 people)
(0 of 4 people)
Cyclobenzaprine Hydrochloride is effective25.71%
(9 of 35 people)
(4 of 14 people)
(2 of 2 people)
(3 of 14 people)
(8 of 18 people)
(7 of 9 people)
(2 of 4 people)
(1 of 3 people)

Drug effectiveness by gender :

Ibuprofen is effective20.99%
(17 of 81 people)
(6 of 21 people)
Cyclobenzaprine Hydrochloride is effective35.44%
(28 of 79 people)
(8 of 20 people)

Drug effectiveness by age :

Ibuprofen is effectiven/an/a0.00%
(0 of 3 people)
(3 of 21 people)
(7 of 64 people)
(7 of 42 people)
(6 of 20 people)
(0 of 20 people)
Cyclobenzaprine Hydrochloride is effectiven/an/a33.33%
(1 of 3 people)
(3 of 17 people)
(14 of 64 people)
(11 of 43 people)
(6 of 18 people)
(1 of 13 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyPainAcute Myocardial InfarctionSpinal Column StenosisAnxietyAnxietyMood SwingsPain
PainFatigueTherapeutic Response DecreasedEmotional DistressDepressionPainDepressionAnxiety
Emotional DistressAbdominal PainInfluenzaIntervertebral Disc DegenerationPulmonary EmbolismDepressionIntentional OverdoseNausea
Pulmonary EmbolismInjuryIntervertebral Disc DegenerationPulmonary EmbolismDeep Vein ThrombosisDeep Vein ThrombosisInsomniaBack Pain
DepressionPulmonary EmbolismInjuryDiabetes MellitusPainSwellingNauseaInjury
InjuryPalpitationsGeneral Physical Health DeteriorationIntervertebral DiscitisInjuryPulmonary EmbolismAggressionFatigue
Peripheral IschaemiaEmotional DistressPainInfectionNauseaVaricose VeinNightmareDepression
General Physical Health DeteriorationCholecystitis ChronicEmotional DistressAcute Myocardial InfarctionVomitingImpaired Driving AbilityMuscle TwitchingDyspnoea
DyspnoeaChest PainAnxietyFearLoss Of ConsciousnessMobility DecreasedSuicide AttemptPain In Extremity
Chest PainAnxietyDeep Vein ThrombosisGastrooesophageal Reflux DiseaseMental DisorderSuicidal IdeationAngerInsomnia

Most common drug interactions by gender * :

AnxietyBack Pain
Deep Vein ThrombosisAnaemia
Oedema PeripheralDyspnoea
Chest PainPain In Extremity

Most common drug interactions by age * :

Diabetes Mellitusn/aTachycardiaPainPainAnxietyPainPain
Metabolic AcidosisInjuryAnxietyPainAnxietyAnxiety
NauseaAnxietyPulmonary EmbolismNauseaBack PainBack Pain
Deep Vein ThrombosisDeep Vein ThrombosisDeep Vein ThrombosisDepressionNauseaDyspnoea
Cholecystitis ChronicEmotional DistressInjuryChest PainFatigueAnaemia
OverdosePulmonary EmbolismChest PainFatigueDiarrhoeaPain In Extremity
VomitingNauseaDepressionBack PainPain In ExtremityOsteoarthritis
Abdominal Pain UpperCholecystitis ChronicNauseaInjuryAnaemiaOedema Peripheral
Completed SuicideVomitingCholelithiasisDyspnoeaMusculoskeletal PainNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Cyclobenzaprine Hydrochloride
- support group for people who take Ibuprofen

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Ibuprofen (ibuprofen) is often used to treat pain. Cyclobenzaprine Hydrochloride (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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