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Review: taking Isoniazid and Rifampin together

Summary: drug interactions are reported among people who take Isoniazid and Rifampin together.

This review analyzes the effectiveness and drug interactions between Isoniazid and Rifampin. It is created by eHealthMe based on reports of 1,060 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Isoniazid has active ingredients of isoniazid. It is often used in tuberculosis. (latest outcomes from 7,571 Isoniazid users)

Rifampin has active ingredients of rifampin. It is often used in tuberculosis. (latest outcomes from 2,192 Rifampin users)

On Feb, 17, 2015: 1,060 people who take Isoniazid, Rifampin are studied

Isoniazid, Rifampin outcomes

Drug combinations in study:
- Isoniazid (isoniazid)
- Rifampin (rifampin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Isoniazid is effectiven/a44.44%
(4 of 9 people)
(3 of 3 people)
(1 of 1 people)
Rifampin is effectiven/a44.44%
(4 of 9 people)
(3 of 3 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Renal Failure AcutePyrexiaOcular IcterusMental DisorderDisturbance In AttentionStevens Johnson Syndromen/aPyrexia
PyrexiaRenal Failure AcuteConvulsionDisturbance In AttentionSomnolenceCondition Aggravated
HeadacheCytolytic HepatitisDeafnessSomnolenceMental DisorderRenal Failure Acute
Multi-organ FailureHepatitis FulminantOptic NeuropathyThrombocytopeniaDysarthriaThrombocytopenia
HepatitisNeutropeniaHypoacusisCerebral IschaemiaMeningismAspartate Aminotransferase Increased
Cytolytic HepatitisStevens-johnson SyndromePyrexiaFatigueRash GeneralisedImmune Reconstitution Syndrome
ConvulsionLeukopeniaHepatic FailureParaesthesiaTuberculoma Of Central Nervous SystemAlanine Aminotransferase Increased
Renal ImpairmentDrug EruptionHepatitis CholestaticHepatic Function Abnormal NosDrug EruptionLiver Function Tests Nos Abnormal
Stevens-johnson SyndromeDyspnoeaVisual ImpairmentHepatitis FulminantPyrexiaNausea
Liver DisorderEosinophiliaHepatic CirrhosisShockCondition AggravatedCough

Drug effectiveness by gender :

Isoniazid is effective77.78%
(7 of 9 people)
(1 of 4 people)
Rifampin is effective77.78%
(7 of 9 people)
(1 of 4 people)

Most common drug interactions by gender * :

Aspartate Aminotransferase IncreasedRenal Failure Acute
NauseaCondition Aggravated
Cytolytic HepatitisDyspnoea
Condition AggravatedThrombocytopenia
Alanine Aminotransferase IncreasedNeutropenia
Hepatitis FulminantCough
Hepatic FailureDrug Eruption
Hepatic EncephalopathyAspartate Aminotransferase Increased

Drug effectiveness by age :

Isoniazid is effectiven/an/a0.00%
(0 of 3 people)
(3 of 6 people)
(2 of 5 people)
(2 of 2 people)
(1 of 2 people)
Rifampin is effectiven/an/a0.00%
(0 of 3 people)
(3 of 6 people)
(2 of 5 people)
(2 of 2 people)
(1 of 2 people)

Most common drug interactions by age * :

Immune Reconstitution SyndromePyrexiaPyrexiaPyrexiaPyrexiaPyrexiaCondition AggravatedPyrexia
CoagulopathyParadoxical Drug ReactionDrug Level IncreasedNauseaImmune Reconstitution SyndromeVomitingRenal Failure AcuteThrombocytopenia
LymphadenitisHydrocephalusRenal Failure AcuteAspartate Aminotransferase IncreasedRenal Failure AcuteCondition AggravatedDrug EruptionLiver Function Tests Nos Abnormal
Brain OedemaAcinetobacter InfectionAcute Hepatic FailureHepatic FailureHepatitis FulminantHepatitis FulminantPyrexiaCondition Aggravated
PyrexiaStenotrophomonas InfectionLymphadenopathyImmune Reconstitution SyndromeDeep Vein ThrombosisHepatic EncephalopathyLeukopeniaRenal Failure Acute
Hepatic FailureCentral Nervous System InfectionParadoxical Drug ReactionAlanine Aminotransferase IncreasedLymphadenopathyAspartate Aminotransferase IncreasedNeutropeniaHepatocellular Damage
Bovine TuberculosisAcute Hepatic FailureThrombocytopeniaHepatic NecrosisGeneral Physical Health DeteriorationDiarrhoeaConvulsionCholestasis
Hepatic EncephalopathyPulmonary TuberculosisCytolytic HepatitisBlood Creatine Phosphokinase IncreasedCoughAnaemiaStevens-johnson SyndromePleural Effusion
Acute Hepatic FailureGrand Mal ConvulsionCoughVomitingCytolytic HepatitisHepatitisDyspnoeaHepatic Function Abnormal
Drug Exposure During PregnancyCardiac ArrestNight SweatsHepatomegalyPulmonary EmbolismCoughPruritusHepatic Failure

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Isoniazid and Rifampin on

Do you take Isoniazid and Rifampin?

You are not alone! Join a related mobile support group:
- support group for people who take Isoniazid and Rifampin
- support group for people who take Isoniazid
- support group for people who take Rifampin

Can you answer these questions (Ask a question):

  • How to treat tubercolosis pimples?
    I already cured from my abdominal TB and stop using anti tb drugs about a month now, but the acne still there. How to cure this pimple? I never had it before I use the drugs. Will salicylic acid works? Thanks.
  • as i have affected by leprosy, i am advised to take dapsone & refampin. after a period of 2 months, a brown leison is developed, lepra reaction type 2. i want to know, how to treat / remove it.
    I am 59. Affected by leprosy. The usual drugs, dapsone & rifampin caused a brown leision. After taking anti allergic drugs & steroid, it is not cured. Any guy with similar experience, please guide how to treat it. Any medicine or any other remedy
  • How to cure isoniazid c dif colitis (1 answer)
    Developed c dif colitis 4.5 mos into inh tx also have cvid as well as systemic lupus and ankylosing spondylitis... What can they give me?
  • Could isoniazid cause a normal people epilepsy? (1 answer)
    I got TB in 2011,I have took isoniazid and rifampin for 9 months. Last month, I found I became epilepsy.
  • Treatment for chronic q fever without heart noticeable problems together with chronic lyme disease
    Been on treatment with 200mg/day doxy only for 3 months, added 300mg/day rifadin for another 3 months. Had little or no improvement with doxy alone, had a little more when added rifadin. But always thought treatment was correct but dosage was not appropriate. Not enough. Had to stop because I got pregnant. Have been off for one year and got worst I ever been.

    Intend to restart. Need experienced patients and health personal to help me and my doctor to adjust dosage. In Portugal, where I live there aren't LLMD and there are no known doctors with experience in this two conditions combined.

    Infected somewhere around 1985 by a tick bite.

    Main symptoms (among many other intermittent ones):

    - Night fevers and sweats

    - Joint pain. Sometimes in just one place at a time, others all at the same time.

    - Memory and concentration issues

    - Dyslexia

    - Lost of smell

    - Extreme Fatigue

    - Muscle pain and stiffness, especially neck.

    - Cough

    - Constant flu-like chills

    - Mandibular extreme inflammation to the point I hardly open my mouth.

    Among others but my hand really hurt and I have to stop now.

    Thank you for your help.

More questions for: Isoniazid, Rifampin

You may be interested at these reviews (Write a review):

  • Isoniazid and deafness
    As a young girl I was put on Isoniazid, I didn't put 2 and 2 together but after taking the inh I started loosing my hearing to the point I'm completely deaf in my left ear. I have found a few people having report that they lost their hearing also. I'm just curious as to about how many people have had this problem.
  • Isoniazid: the downside continued
    I also have extreme fatigue. I can sleep 8 hours and then take a 4 hour nap. I have dizziness which seems to be increasing in the last few weeks. I have nausea on and off. I have diarrhea in the morning 45 minutes after taking it. Then I am mostly constipated for the rest of the day. It seems like my hair is thinning. My skin is drying out or becoming considerably less elastic.
  • Isoniazid--the downside
    Started taking Isonizaid approximately June 10. I am having fairly severe memory loss. I am having mental confusion. I am having depression. I have weight gain. I have liver pain, but it has lessened in the last month though it was severe in the first 3 months. I have digestive issues such as heartburn and constipation since I started it. I have very slow healing taking me nearly twice as long to heal. There's something else, but I can't remember it right now.

More reviews for: Isoniazid, Rifampin

Complete drug side effects:

On eHealthMe, Isoniazid (isoniazid) is often used to treat tuberculosis. Rifampin (rifampin) is often used to treat tuberculosis. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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