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Review: taking Benadryl and Lisinopril And Hydrochlorothiazide together

Summary: drug interactions are reported among people who take Benadryl and Lisinopril And Hydrochlorothiazide together.

This review analyzes the effectiveness and drug interactions between Benadryl and Lisinopril And Hydrochlorothiazide. It is created by eHealthMe based on reports of 109 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,395 Benadryl users)

Lisinopril and hydrochlorothiazide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. (latest outcomes from 5,063 Lisinopril and hydrochlorothiazide users)

On Feb, 25, 2015: 109 people who take Benadryl, Lisinopril And Hydrochlorothiazide are studied

Benadryl, Lisinopril And Hydrochlorothiazide outcomes

Drug combinations in study:
- Benadryl (diphenhydramine hydrochloride)
- Lisinopril And Hydrochlorothiazide (hydrochlorothiazide; lisinopril)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Benadryl is effective0.00%
(0 of 2 people)
(2 of 2 people)
(0 of 1 people)
(0 of 1 people)
(0 of 1 people)
Lisinopril And Hydrochlorothiazide is effective0.00%
(0 of 1 people)
(1 of 1 people)
(1 of 1 people)
(3 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Renal InjuryCardiac Failure Congestiven/aPancreatitis AggravatedCerebrovascular AccidentSinus TachycardiaFeeling AbnormalBack Pain
Renal FailureDermatitis Exfoliative NosHypersensitivitySyncopeSpeech DisorderChest Pain
AnxietyHepatorenal SyndromePruritusHypotensionSwollen TongueNausea
DisabilityCorneal PerforationRashDehydrationLoss Of ConsciousnessAsthenia
DepressionMethicillin-resistant Staphylococcal Aureus InfectionAnaemiaStressDyskinesiaPain
InjuryDiabetes Mellitus Inadequate ControlPain ExacerbatedPain ExacerbatedObstructive Airways DisorderFatigue
AnhedoniaPruritus NosNightmareAngerAnxiety
FearAtrial FibrillationAngerAbdominal Pain
PainAnxiety NecStressDyspnoea
Multi-organ FailureSepsis NosRestless Leg SyndromeArthralgia

Drug effectiveness by gender :

Benadryl is effective33.33%
(1 of 3 people)
(1 of 4 people)
Lisinopril And Hydrochlorothiazide is effective33.33%
(1 of 3 people)
(4 of 5 people)

Most common drug interactions by gender * :

Chest PainBack Pain
Back PainAbdominal Pain
AnxietyRed Blood Cell Sedimentation Rate Increased
AstheniaPancreatitis Acute
DepressionHaemoglobin Decreased
NauseaBlood Creatinine Increased
Cardiac Failure CongestiveDysuria
FatigueBlood Urea Increased

Drug effectiveness by age :

Benadryl is effectiven/an/an/an/a0.00%
(0 of 3 people)
(0 of 1 people)
(1 of 4 people)
(1 of 3 people)
Lisinopril And Hydrochlorothiazide is effectiven/an/an/an/a0.00%
(0 of 3 people)
(1 of 1 people)
(3 of 5 people)
(1 of 3 people)

Most common drug interactions by age * :

n/an/an/aMuscle SpasmsAngioedemaCompleted SuicideAlveolitis AllergicAbdominal Pain
Abdominal PainLip SwellingMuscle SpasmsInterstitial Lung DiseaseBack Pain
Maternal Exposure During PregnancyDrug HypersensitivityPainLung InfiltrationFall
NephrolithiasisSwollen TongueChest PainChest PainHeadache
Drug IneffectiveItchingRash GeneralisedDiarrhoeaAnaemia
NauseaItching - Burning EyesInfusion Related ReactionHypotensionBlood Urea Increased
HaemorrhageMuscle TwitchingCyanosisPruritusBlood Creatinine Increased
DiarrhoeaDiabetes MellitusRenal Cancer MetastaticDehydration
Chest DiscomfortVertigoNausea
Throat TightnessDepressionArthralgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Benadryl and Lisinopril And Hydrochlorothiazide?

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- support group for people who take Benadryl and Lisinopril And Hydrochlorothiazide
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Can you answer these questions (Ask a question):

More questions for: Benadryl, Lisinopril And Hydrochlorothiazide

You may be interested at these reviews (Write a review):

  • Diphenhydramine and mental acuity
    For at least 10 years, I have taken diphenhydramine 50 mg. at bedtime for insomnia and allergies. The results have been that I sleep well with no hangover or any cognitive impairment. If I experience vertigo from allergies, I may take an additional 50 mg. but never exceeding 100 mg in a 24 hour period.

    After reading the report regarding an Alzheimer's study finding that after taking as little as 4mg diphenhydramine daily for more than 3 years, dementia rates were high.

    I stopped the diphenhydramine one night. I experienced symptoms of deep brain pulsating pain and severe insomnia. After 4 hours, I took 50 mg diphenhydramine and slept very well. The next night I took 37.5 mg. diphenhydramine, slept very well. However, some of my tasks require layers of mental challenges in which I became slower.

    My question is how did the study recipients obtain 4 mg doses of diphenhydramine when the standard over-the-counter (OTC) availability in tablets is 25 mg? How reliable is the information submitted from the study subjects? What manufacturer's diphendramine was used, or were there several?

    I felt sharper mentally when on 50 mg daily than so far on 37.5 mg.
  • Frequent bowel movements while taking januvia
    i noticed while taking januvia i will have atleast 4-5 bowel movements a day. Before januvia I went 1 or two times a week. I once was unable to fill my perscription for more than a week and my movements went back to normal. As soon as I went back on the januvia I again was going 4-5 times a day.
  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.

More reviews for: Benadryl, Lisinopril And Hydrochlorothiazide

Comments from related studies:

  • From this study (9 months ago):

  • 27 L knee operations, three massive L knee infections resulting in a third and final arthoplasty revision. Extensive soft tissue damage resulting in perminante subqutanious sutuers and locking full leg brace, also perminante.

    Daily swelling in the knee joint (4 to 6 cm daily). Constant pain as well as additional pain when walking.


  • From this study (9 months ago):

  • Itching in extremeties with no rash apparent. Eyes watery and burning. Twitching is in left eyelid. Itching started 8 days ago. Lotion does not help much. Diphenhydramine does not help much.


  • From this study (2 years ago):

  • I have had a cough for several years. it seems to be getting worse. I cough so hard I sometimes gag and vomit. My dr put me on prilosec and it seems to have helped a little. Night time seems to be when it is the worse. Sometimes I bring up phlem and other times its like a dry tickling cough. I do not smoke or work in any chemical enviorment. It totally drains me. I have had surgery for the acid reflux @6-7 yrs ago for acid reflux where they tightened the muscle. Cant remember the name of it. The only thing that seems to help is hycadan cough syrup which I can take only at night but I dont always have it and I cant take it thru the day. Any help would be greatly appreciated.


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Complete drug side effects:

On eHealthMe, Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Lisinopril And Hydrochlorothiazide (hydrochlorothiazide; lisinopril) is often used to treat high blood pressure. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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