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Review: Loratadine and Benadryl

This review analyzes the effectiveness and drug interactions between Loratadine and Benadryl. It is created by eHealthMe based on reports of 1,307 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Loratadine and Benadryl >>>

What are the drugs

Loratadine (what 10,955 Loratadine users reported?) has active ingredients of loratadine. It is used in allergies.

Benadryl (what 29,327 Benadryl users reported?) has active ingredients of diphenhydramine hydrochloride. It is used in allergies.

On Aug, 27, 2014: 1,307 people who take Loratadine, Benadryl are studied

Loratadine, Benadryl outcomes

Drug combinations in study:
- Loratadine (loratadine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Loratadine is effective17.65%
(3 of 17 people)
(3 of 12 people)
(1 of 6 people)
(3 of 8 people)
(5 of 9 people)
(3 of 9 people)
(0 of 1 people)
(0 of 1 people)
Benadryl is effective45.00%
(9 of 20 people)
(6 of 13 people)
(1 of 2 people)
(3 of 5 people)
(4 of 8 people)
(4 of 8 people)
(0 of 1 people)
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessAcute Respiratory Distress SyndromeDemyelinationEosinophilic PneumoniaFatigueShort-term Memory LossShoulder PainNausea
HypotensionSmall Intestinal ObstructionH1n1 InfluenzaBone LossDrowsinessMenopausal SymptomsShort-term Memory LossPain
VomitingDisseminated Intravascular CoagulationPremature LabourRespiratory ArrestDrug Effect DecreasedRespiratory ArrestMenopausal SymptomsDyspnoea
BronchitisPneumonia Respiratory Syncytial ViralDyspepsiaDeathAsthmaDeathHeadache
AgranulocytosisPost Procedural HaemorrhageDehydrationGynaecomastiaDizzinessFatigue
ConvulsionHypotensionSystemic Inflammatory Response SyndromeBody Temperature FluctuationShortness Of BreathDepression
ThrombocytopeniaHypernatraemiaGastrooesophageal Reflux DiseasePain ExacerbatedAsthmaArthralgia
Pneumonia Respiratory Syncytial ViralBlood Bilirubin IncreasedAnxietyAcid RefluxBody Temperature FluctuationVomiting
Myocardial InfarctionPneumonitisLeukopeniaChest PainPain ExacerbatedPyrexia
Blood Pressure IncreasedBronchitisAutoimmune DisorderHeadacheRashAnxiety

Drug effectiveness by gender :

Loratadine is effective27.50%
(11 of 40 people)
(7 of 23 people)
Benadryl is effective38.46%
(15 of 39 people)
(12 of 20 people)

Most common drug interactions by gender * :

Pain In ExtremityDizziness
Oedema PeripheralPain Nos

Drug effectiveness by age :

Loratadine is effectiven/a50.00%
(2 of 4 people)
(1 of 5 people)
(1 of 15 people)
(5 of 21 people)
(4 of 23 people)
(3 of 12 people)
(2 of 23 people)
Benadryl is effectiven/a66.67%
(2 of 3 people)
(4 of 6 people)
(7 of 15 people)
(2 of 20 people)
(7 of 19 people)
(3 of 12 people)
(2 of 22 people)

Most common drug interactions by age * :

AggressionVomitingHeadacheCerebral InfarctionFallPainNauseaNausea
ConvulsionCoughPneumonitisCerebral HaemorrhageBronchitisNauseaChest PainAsthenia
Hyperkinetic SyndromeStatus EpilepticusHypotensionConvulsionDepressionDyspnoeaOedema PeripheralDyspnoea
Abdominal Pain NosHeart Rate IncreasedAcute Respiratory Distress SyndromeTransverse Sinus ThrombosisObesityArthralgiaDiarrhoeaFatigue
Tardive DyskinesiaNauseaFatiguePainBlood Cholesterol IncreasedVomitingPainDizziness
MydriasisSinusitisBlood Bilirubin IncreasedLoss Of ConsciousnessArthralgiaFatigueHeadacheCardiac Failure Congestive
NervousnessRespiratory Tract InfectionPyrexiaBlood Pressure IncreasedContusionBack PainPain In ExtremityVomiting
Drug IneffectiveHeadacheNauseaPyrexiaJoint SwellingAnxietyAnxietyDiarrhoea
ConstipationDrug IneffectiveLymphadenopathyHeadacheAnaemiaHeadacheDyspnoeaDrug Ineffective
Foaming At MouthHilar LymphadenopathyPainVomitingAbdominal PainDepressionRashMyalgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Loratadine and Benadryl
- group for people who take Benadryl
- group for people who take Loratadine

Comments from related studies:

  • From this study (8 months ago):

  • will any these come up positive


  • From this study (1 year ago):

  • I was on all of these and my daughter was just born a stillborn! I have had 2 previous births that were term and normal. I didn't have to take all of these with them!


  • From this study (1 year ago):

  • Experiencing neuropathy of feet which began after gout attack -- curious if any drug interaction may be partially responsible. Note -- newest refill of Atorvastatin is manufactured by Sandoz, but have not taken any yet.


Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Loratadine (loratadine) is often used to treat allergen. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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