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Review: taking Loratadine and Benadryl together

Summary: drug interactions are reported among people who take Loratadine and Benadryl together.

This review analyzes the effectiveness and drug interactions between Loratadine and Benadryl. It is created by eHealthMe based on reports of 1,311 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 30, 2015: 1,311 people who take Loratadine, Benadryl are studied

Loratadine, Benadryl outcomes

Drug combinations in study:
- Loratadine (loratadine)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Loratadine is effective17.65%
(3 of 17 people)
(3 of 12 people)
(1 of 7 people)
(3 of 9 people)
(5 of 9 people)
(3 of 9 people)
(1 of 3 people)
(0 of 1 people)
Benadryl is effective45.45%
(10 of 22 people)
(6 of 13 people)
(1 of 3 people)
(3 of 5 people)
(4 of 8 people)
(4 of 8 people)
(0 of 2 people)
(0 of 2 people)

Drug effectiveness by gender :

Loratadine is effective27.91%
(12 of 43 people)
(7 of 24 people)
Benadryl is effective38.10%
(16 of 42 people)
(12 of 21 people)

Drug effectiveness by age :

Loratadine is effectiven/a50.00%
(2 of 4 people)
(1 of 5 people)
(1 of 28 people)
(6 of 31 people)
(4 of 23 people)
(3 of 14 people)
(2 of 23 people)
Benadryl is effectiven/a66.67%
(2 of 3 people)
(4 of 6 people)
(7 of 28 people)
(3 of 30 people)
(7 of 19 people)
(3 of 14 people)
(2 of 22 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DizzinessAcute Respiratory Distress SyndromeDemyelinationEosinophilic PneumoniaFatigueShort-term Memory LossEar PainNausea
HypotensionSmall Intestinal ObstructionLeukopeniaBone LossDrowsinessMenopausal SymptomsEyes - Sensitive To LightPain
ConvulsionDisseminated Intravascular CoagulationPremature LabourBladder IrritationDrug Effect DecreasedRespiratory ArrestNausea And VomitingDyspnoea
ThrombocytopeniaPneumonia Respiratory Syncytial ViralDyspepsiaRespiratory ArrestAsthmaDeathEye FloatersHeadache
VomitingPost Procedural HaemorrhageDehydrationDeathGynaecomastiaDizzinessMenstruation - PainfulFatigue
BronchitisHypotensionSystemic Inflammatory Response SyndromeBody Temperature FluctuationShortness Of BreathShoulder PainDepression
AgranulocytosisHypernatraemiaGastrooesophageal Reflux DiseasePain ExacerbatedAsthmaHeadache - TensionArthralgia
InsomniaBlood Bilirubin IncreasedAnxietyAcid RefluxBody Temperature FluctuationPainVomiting
Pneumonia Respiratory Syncytial ViralPneumonitisH1n1 InfluenzaChest PainPain ExacerbatedEsophageal Stricture - BenignPyrexia
Acute Respiratory Distress SyndromeBronchitisCrohn's DiseaseHeadacheRashConstipationAnxiety

Most common drug interactions by gender * :

Pain In ExtremityDizziness
Oedema PeripheralPain Nos

Most common drug interactions by age * :

AggressionVomitingHeadacheCerebral HaemorrhageFallPainNauseaNausea
ConvulsionCoughPneumonitisConvulsionDepressionNauseaChest PainAsthenia
Hyperkinetic SyndromeStatus EpilepticusHypotensionCerebral InfarctionBronchitisDyspnoeaOedema PeripheralDyspnoea
Abdominal Pain NosHeart Rate IncreasedAcute Respiratory Distress SyndromeTransverse Sinus ThrombosisObesityArthralgiaDiarrhoeaFatigue
Tardive DyskinesiaNauseaFatiguePainArthralgiaVomitingPainDizziness
MydriasisSinusitisBlood Bilirubin IncreasedLoss Of ConsciousnessJoint SwellingFatigueHeadacheCardiac Failure Congestive
NervousnessRespiratory Tract InfectionPyrexiaBlood Pressure IncreasedAnaemiaBack PainPain In ExtremityVomiting
Drug IneffectiveHeadacheNauseaCognitive DisorderContusionAnxietyAnxietyDiarrhoea
ConstipationDrug IneffectiveLymphadenopathyPyrexiaBlood Cholesterol IncreasedHeadacheDyspnoeaDrug Ineffective
Foaming At MouthHilar LymphadenopathyPainVomitingMycosis FungoidesDepressionRashMyalgia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Benadryl
- support group for people who take Loratadine

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Loratadine (loratadine) is often used to treat allergies. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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